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Protein

Receptor protein-tyrosine kinase

Gene

ERBB4

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei738ATPUniRule annotation1
Active sitei830Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi711 – 719ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1227986 Signaling by ERBB2
R-GGA-1236394 Signaling by ERBB4
R-GGA-1250196 SHC1 events in ERBB2 signaling
R-GGA-1250342 PI3K events in ERBB4 signaling
R-GGA-1250347 SHC1 events in ERBB4 signaling
R-GGA-1251985 Nuclear signaling by ERBB4
R-GGA-1253288 Downregulation of ERBB4 signaling
R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-1963640 GRB2 events in ERBB2 signaling
R-GGA-1963642 PI3K events in ERBB2 signaling
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-6785631 ERBB2 Regulates Cell Motility
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-8863795 Downregulation of ERBB2 signaling
R-GGA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:ERBB4Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei639 – 662HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF1P258

Expressioni

Gene expression databases

BgeeiENSGALG00000003126

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039169

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini705 – 972Protein kinaseInterPro annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
InParanoidiF1P258
OMAiRTRIDSN
OrthoDBiEOG091G00EY
PhylomeDBiF1P258
TreeFamiTF106002

Family and domain databases

Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

F1P258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGSVCKVS PSPSVCAGTE NKLSSLSDLE QQYRALRKYY ENCEVVMGNL
60 70 80 90 100
EITSIEHNRD LSFLRSIREV TGYVLVALNQ FEYLPLENLR IVRGTKLYED
110 120 130 140 150
RYALAIFLNY RKDGNFGLRE LGLKNLTEIL NGGVYVGQNK FLCFADTIHW
160 170 180 190 200
QDIVRNPWAS NFTLVPTNGS SGCGRCHKSC TGRCWGPTEN HCQTLTKTVC
210 220 230 240 250
AEQCDGRCYG PYVSDCCHRE CAGGCSGPKD TDCFACMNFN DSGACVTQCP
260 270 280 290 300
QTFVYNPTTF QLEHNHNAKY TYGAFCVKKC PHNFVVDSSS CVRACPSSKM
310 320 330 340 350
EVEENGIKMC KPCTDICPKA CDGIGTGSLV SAQTVDSSNI DKFINCTKIN
360 370 380 390 400
GNLIFLVTGI HGDPYHTIAA INPEKLNIFQ TVREITGYLN IQSWPENMTD
410 420 430 440 450
FRVFSNLVTI GGRALYSGLS LLILKQQGIT SLQFQSLKQI SAGNIYITDN
460 470 480 490 500
SNLCYYHTVN WTSLFSTPSQ KTVIHRNKKA ENCTADGMVC NELCSSDGCW
510 520 530 540 550
GPGPDQCLSC KRFIRGRTCI ESCNLYDGEF REFANGSVCM ECDPQCEKME
560 570 580 590 600
DNMITCYGPG PDHCTKCFHF KDGPNCVEKC PDGLQGANSF IFKYADEDRE
610 620 630 640 650
CHPCHPNCTQ GCRGPASHDC IYYPWTRQST LPQHARTPLI AAGVIGGLFI
660 670 680 690 700
IVIMGLTFAV YVRRKSIKKK RALRRFLETE LVEPLTPSGT APNQAQLRIL
710 720 730 740 750
KETELKRVKV LGSGAFGTVY KGIWVPEGET VKIPVAIKIL NETTGPKANV
760 770 780 790 800
EFMDEALIMA SMDHPHLVRL LGVCLSPTIQ LVTQLMPHGC LLDYVHEHKD
810 820 830 840 850
NIGSQLLLNW CVQIAKGMMY LEERRLVHRD LAARNVLVKS PNHVKITDFG
860 870 880 890 900
LARLLEGDEK EYNADGGKMP IKWMALECIH YRKFTHQSDV WSYGVTIWEL
910 920 930 940 950
MTFGGKPYDG IPTREIPDLL EKGERLPQPP ICTIDVYMVM VKCWMIDADS
960 970 980 990 1000
RPKFKELAAE FSRMARDPQR YLVIQGDDRM KLPSPNDSKF FQNLLDEEDL
1010 1020 1030 1040 1050
EDMMDAEEYL VPQAFNIPPP IYTSRTRIDS NRNQFVYRDG GYAAEQGVPM
1060 1070 1080 1090 1100
PYRAPGCIIP EAPVAQGATA EIFEDTCCNG TLRKQVATLA KEDSSTQRYS
1110 1120 1130 1140 1150
ADPTVFIPER VIRGELDEDG YMTPMRDKPK TDYLNPVEEN PFVSRRKNGD
1160 1170 1180 1190 1200
LQAVDNPEYH NAPNGQPKAE DEYVNEPLYL NTFANTLENA EYLKNNLPEK
1210 1220 1230 1240 1250
AKKAFDNPDY WNHSLPPRST LQHPDYLQEY STKYFYKQNG RIRPIVAENP
1260 1270
EYLSEFSLKP GTVLPPPPYR HRNTVV
Length:1,276
Mass (Da):143,690
Last modified:May 3, 2011 - v1
Checksum:iDA5AE597035A0C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000204 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000039962; ENSGALP00000039169; ENSGALG00000003126

Similar proteinsi

Entry informationi

Entry nameiF1P258_CHICK
AccessioniPrimary (citable) accession number: F1P258
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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