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Entry version 81 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

NOTCH2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi442Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi459Calcium 2UniRule annotation1
Metal bindingi462Calcium 2UniRule annotation1
Metal bindingi476Calcium 2UniRule annotation1
Metal bindingi500Calcium 3UniRule annotation1
Metal bindingi514Calcium 3UniRule annotation1
Metal bindingi515Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation
Biological processDifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1654 – 1676HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500567548829 – 2432Sequence analysisAdd BLAST2404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 65PROSITE-ProRule annotation
Disulfide bondi76 ↔ 93PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi173 ↔ 182PROSITE-ProRule annotation
Disulfide bondi212 ↔ 221PROSITE-ProRule annotation
Disulfide bondi251 ↔ 260PROSITE-ProRule annotation
Disulfide bondi289 ↔ 298PROSITE-ProRule annotation
Disulfide bondi329 ↔ 338PROSITE-ProRule annotation
Disulfide bondi367 ↔ 376PROSITE-ProRule annotation
Disulfide bondi387 ↔ 404PROSITE-ProRule annotation
Disulfide bondi406 ↔ 415PROSITE-ProRule annotation
Disulfide bondi422 ↔ 436UniRule annotation
Disulfide bondi430 ↔ 445UniRule annotation
Disulfide bondi447 ↔ 456UniRule annotation
Disulfide bondi463 ↔ 474UniRule annotation
Disulfide bondi468 ↔ 483UniRule annotation
Disulfide bondi485 ↔ 494UniRule annotation
Disulfide bondi501 ↔ 512UniRule annotation
Disulfide bondi506 ↔ 521UniRule annotation
Disulfide bondi523 ↔ 532UniRule annotation
Disulfide bondi561 ↔ 570PROSITE-ProRule annotation
Disulfide bondi577 ↔ 587PROSITE-ProRule annotation
Disulfide bondi598 ↔ 607PROSITE-ProRule annotation
Disulfide bondi636 ↔ 645PROSITE-ProRule annotation
Disulfide bondi652 ↔ 662PROSITE-ProRule annotation
Disulfide bondi673 ↔ 682PROSITE-ProRule annotation
Disulfide bondi711 ↔ 720PROSITE-ProRule annotation
Disulfide bondi727 ↔ 737PROSITE-ProRule annotation
Disulfide bondi748 ↔ 757PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Disulfide bondi807 ↔ 824PROSITE-ProRule annotation
Disulfide bondi826 ↔ 835PROSITE-ProRule annotation
Disulfide bondi864 ↔ 873PROSITE-ProRule annotation
Disulfide bondi902 ↔ 911PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi978 ↔ 987PROSITE-ProRule annotation
Disulfide bondi1016 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1054 ↔ 1063PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1091PROSITE-ProRule annotation
Disulfide bondi1102 ↔ 1111PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1220 ↔ 1229PROSITE-ProRule annotation
Disulfide bondi1241 ↔ 1258PROSITE-ProRule annotation
Disulfide bondi1260 ↔ 1269PROSITE-ProRule annotation
Disulfide bondi1301 ↔ 1310PROSITE-ProRule annotation
Disulfide bondi1340 ↔ 1349PROSITE-ProRule annotation
Disulfide bondi1360 ↔ 1377PROSITE-ProRule annotation
Disulfide bondi1379 ↔ 1388PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1P236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000002922, Expressed in spleen and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1P236, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000039195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 66EGF-likeInterPro annotationAdd BLAST40
Domaini67 – 105EGF-likeInterPro annotationAdd BLAST39
Domaini108 – 146EGF-likeInterPro annotationAdd BLAST39
Domaini147 – 183EGF-likeInterPro annotationAdd BLAST37
Domaini185 – 222EGF-likeInterPro annotationAdd BLAST38
Domaini224 – 261EGF-likeInterPro annotationAdd BLAST38
Domaini263 – 299EGF-likeInterPro annotationAdd BLAST37
Domaini301 – 339EGF-likeInterPro annotationAdd BLAST39
Domaini341 – 377EGF-likeInterPro annotationAdd BLAST37
Domaini378 – 416EGF-likeInterPro annotationAdd BLAST39
Domaini418 – 457EGF-likeInterPro annotationAdd BLAST40
Domaini459 – 495EGF-likeInterPro annotationAdd BLAST37
Domaini497 – 533EGF-likeInterPro annotationAdd BLAST37
Domaini535 – 571EGF-likeInterPro annotationAdd BLAST37
Domaini573 – 608EGF-likeInterPro annotationAdd BLAST36
Domaini610 – 646EGF-likeInterPro annotationAdd BLAST37
Domaini648 – 683EGF-likeInterPro annotationAdd BLAST36
Domaini685 – 721EGF-likeInterPro annotationAdd BLAST37
Domaini723 – 758EGF-likeInterPro annotationAdd BLAST36
Domaini760 – 796EGF-likeInterPro annotationAdd BLAST37
Domaini798 – 836EGF-likeInterPro annotationAdd BLAST39
Domaini838 – 874EGF-likeInterPro annotationAdd BLAST37
Domaini876 – 912EGF-likeInterPro annotationAdd BLAST37
Domaini914 – 950EGF-likeInterPro annotationAdd BLAST37
Domaini952 – 988EGF-likeInterPro annotationAdd BLAST37
Domaini990 – 1026EGF-likeInterPro annotationAdd BLAST37
Domaini1028 – 1064EGF-likeInterPro annotationAdd BLAST37
Domaini1077 – 1112EGF-likeInterPro annotationAdd BLAST36
Domaini1114 – 1150EGF-likeInterPro annotationAdd BLAST37
Domaini1152 – 1188EGF-likeInterPro annotationAdd BLAST37
Domaini1190 – 1230EGF-likeInterPro annotationAdd BLAST41
Domaini1232 – 1270EGF-likeInterPro annotationAdd BLAST39
Domaini1272 – 1311EGF-likeInterPro annotationAdd BLAST40
Domaini1314 – 1350EGF-likeInterPro annotationAdd BLAST37
Domaini1351 – 1389EGF-likeInterPro annotationAdd BLAST39
Domaini1401 – 1441LNRInterPro annotationAdd BLAST41
Domaini1442 – 1477LNRInterPro annotationAdd BLAST36
Domaini1479 – 1520LNRInterPro annotationAdd BLAST42
Domaini1833 – 2038ANK_REP_REGIONInterPro annotationAdd BLAST206
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1852 – 1884ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1919 – 1951ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1952 – 1984ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1985 – 2017ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1723 – 1744DisorderedSequence analysisAdd BLAST22
Regioni2077 – 2155DisorderedSequence analysisAdd BLAST79
Regioni2192 – 2211DisorderedSequence analysisAdd BLAST20
Regioni2344 – 2432DisorderedSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2111 – 2125PolarSequence analysisAdd BLAST15
Compositional biasi2132 – 2155PolarSequence analysisAdd BLAST24
Compositional biasi2344 – 2368PolarSequence analysisAdd BLAST25
Compositional biasi2384 – 2413PolarSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000576_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSKPCLN

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022336, Notch_2
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF11936, DUF3454, 1 hit
PF00008, EGF, 24 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01985, NOTCH2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 20 hits
PS00022, EGF_1, 34 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1P236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGAGPAFA ALFGLVLAVL SRAEPAAALQ CMDDSKPCVN EGKCIPYQNG
60 70 80 90 100
TGYCKCREGY LGDYCQYRNP CESNTCKNGG TCETTSLIGK ATCKCAPGFT
110 120 130 140 150
GEDCQYSESH ICYVSQPCLN GGTCHPHSQE TYECVCPPGY TGKDCQWIDA
160 170 180 190 200
CTSQPCANGS TCTVSGHKFS CICQSGYTGQ KCEIDVNECA TSGLCHHGGT
210 220 230 240 250
CINLPGSFRC QCKPGYTGHR CESNYVPCSP SPCMNGGTCH QTSDFTFECN
260 270 280 290 300
CLPGFKGSIC EKNVDDCPNH NCQNGGICVD GVNTYNCRCP PQWTGQFCTE
310 320 330 340 350
DVDECQLQPN ACQNGGTCTN HNGGYACVCV NGWSGDDCSK NIDDCFTASC
360 370 380 390 400
ANGSTCIDRV ASFSCICPEG KAGLLCHLDD ACVSNPCQKG ALCDTNPVNG
410 420 430 440 450
HYICTCPQGH KGADCTEDVD ECAMANSNPC EHAGKCVNTE GSFHCECLKG
460 470 480 490 500
YTGPRCEMDI NECHSNPCQN DATCLDKIGG FTCLCMPGFK GVHCEEDIDE
510 520 530 540 550
CLSNPCVNNG ECLDKVNRFL CVCPPGFSGA VCQIDIDDCS STPCLNGAKC
560 570 580 590 600
IDHPNGYECQ CATGFTGVLC EENINNCDPD PCHHGECQDG IDSYTCICNP
610 620 630 640 650
GYMGAICSEQ INECHSNPCL HQGRCIDLVN GYQCNCLPGT SGVNCENNFD
660 670 680 690 700
DCASNPCVHG DCIDGINRYN CACKPGFTGP RCNVDIDECA SSPCNNGGTC
710 720 730 740 750
INEVNGFRCV CPEGYHHPHC QSQADGCLSN PCVHGNCTHI VSGYKCVCDP
760 770 780 790 800
GWIGDYCSTE GNECKSNPCQ NGGTCEDLLN GYRCTCRKGF KGVNCQVVVA
810 820 830 840 850
PCSPDPCENS GICQESPDSE GYTCQCAPGW EGERCTVDID ECLSKPCKNH
860 870 880 890 900
ALCHNIQGSY LCECRPGFTG GDCDSNIDDC LSNPCQNGAS CVDGINSFSC
910 920 930 940 950
ICLPGFHGDK CQTDTNECLS EPCRNGGTCT HYVNSYTCKC QPGFEGTNCE
960 970 980 990 1000
NNIDECTESS CFNGGTCVDG INSFTCQCPV GFTGPFCLME INECDSHPCL
1010 1020 1030 1040 1050
NKGSCVDSLG KYRCICPLGY TGKNCQTPMD LCSKSPCKNK GTCFQSGAQT
1060 1070 1080 1090 1100
RCDCPSGWTG AYCDVPNVSC QVAASQRGIT VDQLCQHSGH CLNVGNTHRC
1110 1120 1130 1140 1150
QCRVGYTGSY CEEQLDECDS SPCQNGATCR DHLGGYQCEC VPGYQGVNCE
1160 1170 1180 1190 1200
YEVDECQFQP CQNGGTCIDL VNHFRCSCPP GTRGRLCEEN VDDCISESGG
1210 1220 1230 1240 1250
PRCFNGGQCI DQIGGYSCLC LPGFAGERCE GDINECLSNP CNPRGSLDCI
1260 1270 1280 1290 1300
QLINDYTCIC RSAFTGRHCE SVIDVCPRKP CQNGGTCAVA SNMPDGFICQ
1310 1320 1330 1340 1350
CPPGYSGAKC EFSSHSTCGQ VKCKKGEQCI HTSSGPRCYC PRLAVGEECQ
1360 1370 1380 1390 1400
TNTGCASAPC QNGGSCHPRS QPPYYYCQCP AHAQGSQCEQ LVHPSQEPLG
1410 1420 1430 1440 1450
CLDSQCAEKA RDGYCDEDCN THACQWDGGD CSLTMEDPWA NCSSSLRCWM
1460 1470 1480 1490 1500
LFNGQCDEFC NTPECLFDNF ECQQNSRMCK YDKYCADHYG DGRCDQGCNS
1510 1520 1530 1540 1550
EECGWDGLDC AGDKAERLAE GTLIIVVLMR PDELLRDVRS FLRTLGTLLH
1560 1570 1580 1590 1600
TNLRIKLDSQ GNPMVFPYYG EKSAARSRRS VVVVRKHREL EQEVIGTRVF
1610 1620 1630 1640 1650
LEIDNRQCAE DSEQCFHNTE AAAALLAAQA IKGMLPYPFV SVQSEPLLPP
1660 1670 1680 1690 1700
KTQLLYLLAV AALIILLILL LGVMMAKRKR KHGSLWLPEG FILRRDPSNH
1710 1720 1730 1740 1750
KRREPVGEDA VGLKNLSVQI PEGNMADSGP TEHWAGDGGP QPKRVKTEDQ
1760 1770 1780 1790 1800
ALLPEADEQI DQRQWTQQHL EAADVCGSTS LALTPPQADQ EVDVLDVNVR
1810 1820 1830 1840 1850
GPDGCTPLML ASLRVGGSDI SEDDEDGEDS SANIITDLIY QGANLQAQTD
1860 1870 1880 1890 1900
RTGEMALHLA ARYSRADAAK RLLDAGADAN ARDNMGRTPL HAAVAADAQG
1910 1920 1930 1940 1950
VFQILIRNRV TDLDARMNDG TTPLILAARL AVEGMVAELI NCQADVNAVD
1960 1970 1980 1990 2000
DHGKSALHWA AAVNNVEATL VLLKNGANRD MQDNKEETPL FLAAREGSFE
2010 2020 2030 2040 2050
AAKILLDHFA NRDITDHMDR LPRDVAQDRM HHDIVQLLNE YNVAHSPTGH
2060 2070 2080 2090 2100
PGAMLNSALS PVICGPNRSF LNLKHASLSK KSRKPNAKGI MPTNLTKDAK
2110 2120 2130 2140 2150
RRRKKSLSES KGQFSESSVT LSPVDSLESP HAFASEPTSS PVMPSPGVLH
2160 2170 2180 2190 2200
SSPSSLLTAP SVQAAHSMSF SNLHEMQPLG RGSSTVLPSV SQLLSQHRTT
2210 2220 2230 2240 2250
PPSSGLGRLR PANVSTEWMN RMEMNESQYN EMFGMVPPVM HSHPSVSQQS
2260 2270 2280 2290 2300
GLVQADAKHL GVSRESLPPI MTFQLVPKGG INQQALPQQA QSNCAQNMAG
2310 2320 2330 2340 2350
PLSSMYQISD LAQLPSASFS MAAIPQQDGQ VPQTILPAYH QFQSSMGKYP
2360 2370 2380 2390 2400
TPPSQHSCYS SATERTPSHN RHLQGEHPYL TPSPESPDQW SSSSPHSASD
2410 2420 2430
WSDVATSPGN NQRGPAAAHV PEQQRNNMQV YA
Length:2,432
Mass (Da):262,133
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A10BD67E1995E87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2UG91A0A3Q2UG91_CHICK
Uncharacterized protein
NOTCH2
2,329Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AADN05000934 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001238962.1, NM_001252033.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSGALT00000039988; ENSGALP00000039195; ENSGALG00000002922

Database of genes from NCBI RefSeq genomes

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GeneIDi
374031

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
gga:374031

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000934 Genomic DNA No translation available.
RefSeqiNP_001238962.1, NM_001252033.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039195

Proteomic databases

PaxDbiF1P236

Genome annotation databases

EnsembliENSGALT00000039988; ENSGALP00000039195; ENSGALG00000002922
GeneIDi374031
KEGGigga:374031

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4853

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000155030
HOGENOMiCLU_000576_0_0_1
OMAiVSKPCLN
OrthoDBi7525at2759

Gene expression databases

BgeeiENSGALG00000002922, Expressed in spleen and 14 other tissues
ExpressionAtlasiF1P236, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022336, Notch_2
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF11936, DUF3454, 1 hit
PF00008, EGF, 24 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 2 hits
PRINTSiPR01452, LNOTCHREPEAT
PR01985, NOTCH2
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 20 hits
PS00022, EGF_1, 34 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1P236_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1P236
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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