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Protein
Submitted name:

Uncharacterized protein

Gene

ADGRG6

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • laminin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ADGRG6Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei860 – 883HelicalSequence analysisAdd BLAST24
Transmembranei895 – 916HelicalSequence analysisAdd BLAST22
Transmembranei922 – 944HelicalSequence analysisAdd BLAST23
Transmembranei964 – 985HelicalSequence analysisAdd BLAST22
Transmembranei1019 – 1049HelicalSequence analysisAdd BLAST31
Transmembranei1070 – 1089HelicalSequence analysisAdd BLAST20
Transmembranei1095 – 1117HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_500895423138 – 1250Sequence analysisAdd BLAST1213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000013803 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiF1P1B2 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 149CUBInterPro annotationAdd BLAST109
Domaini794 – 846GPSInterPro annotationAdd BLAST53
Domaini858 – 1118G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST261

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
KOiK08463
OrthoDBiEOG091G00P5

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1P1B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSHINEMWC CHWKWKLQHC LYLFILYIIC MQQAAHGCYN CRTVLTDPSG
60 70 80 90 100
VFTSPCYPSD YPNSQACKWI IRAPHGFIIQ LTFSDFDIEE APGCIYDSLT
110 120 130 140 150
LDNGESPMNL CGITAKGLSY NSTGNEMIVS FKSDFSIQKK GFNASYVRIA
160 170 180 190 200
VSLRNQKVII PQDPDADAVS VAETVLVPEL SQFTLCFEAT KSSSDDNDDW
210 220 230 240 250
KIFSYTDASS KEFFGFGKTA KGHFLSISDT QCILDNALPQ NAEFFTGTFE
260 270 280 290 300
QLCVVGDSFS GTIGVYAKSI YHNTYCPDMF GKVIPGNGRL VLGSNSNEVS
310 320 330 340 350
SLNGDIYNFR LWNFTMNAQT LANLSCDVKG NIVDWENEFW SIPTSALKAE
360 370 380 390 400
NNLSCGSYLI PSSAIEPTSC ANLGSLCQAT VNATTPTPPT VTTNMPDTNR
410 420 430 440 450
TDKPNNGGLF YRISITVFSY NSNSESKVHD VVAEWLNHTF QNWNYTVYVV
460 470 480 490 500
NISIQPGTIK EAVREKRNID SKRFEVLALL VYNATNNINL EEQDIRQKLI
510 520 530 540 550
NNNESIAEGY RLHTVEVDPV EKCLAEENPP NYFWPDTRPT VTNFTFCHGS
560 570 580 590 600
SVQIASRTCY LGLQNYTSYW GQPDLRNCTE NAADIANQLL NLTGEGQQLT
610 620 630 640 650
SDKVNDVVQK LKKIVNDEEI DESLGSTVVT IFSNILNSSD SVLAASSSEA
660 670 680 690 700
LKTIDALALK IQFTGPSMSI STRNLALGVS SVNSTSFKGS SFSVSPQNNA
710 720 730 740 750
SDFQIDFDKD QTNAIASVIL PPSLLKNLSQ DDFEVISRAQ FTFFNKNGLF
760 770 780 790 800
QDAETPGNLT SFVVACSIGN ITIRDLQEYV KITIKHTKIQ EDPKPTCVFW
810 820 830 840 850
DMAKNGGNGG WNPTGCKVQA DSNENETVCL CNHLTHFGVL MDLQGTATEI
860 870 880 890 900
DAQNTKILTF ITYIGCGISA IFSAATLLTY IAFEKLRRDY PSKILMNLST
910 920 930 940 950
ALLFLNLTFL LDGWIASFDI DGLCIAIAAL LHYFLLATFT WMGLEAVHMY
960 970 980 990 1000
IALVKVFNTY IRRYILKFCI IGWGLPALVI AIVLASTNKN ASRVYGKELY
1010 1020 1030 1040 1050
GRDATGQGGD DFCWIKNKVV FYVTCAGYFG IMFLLNVAMF VVVMVQICGR
1060 1070 1080 1090 1100
NGKRTNRTLK EEILRNLRSV VSLTFLLGMT WGFAFFAWGP LTLPFLYLFS
1110 1120 1130 1140 1150
IFNSLQGLFI FVFHCAMKEN VQKQWRRHLC CGRFRLADNS DWSKTATNII
1160 1170 1180 1190 1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKST TNTYCKRSSH TENIFVDKPP
1210 1220 1230 1240 1250
SKFAQEDGEQ TSIIPVHQVI DKVKGYCNSH SDNFYKNIIM SDTFSHSTKF
Length:1,250
Mass (Da):139,261
Last modified:November 30, 2016 - v2
Checksum:i6E0058FB17815A81
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1C8C2E1C8C2_CHICK
Uncharacterized protein
ADGRG6
1,167Annotation score:
A0A1L1S0M6A0A1L1S0M6_CHICK
Uncharacterized protein
ADGRG6
1,172Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000069 Genomic DNA No translation available.
RefSeqiNP_001026242.2, NM_001031071.2
UniGeneiGga.6511

Genome annotation databases

EnsembliENSGALT00000022408; ENSGALP00000022368; ENSGALG00000013803
GeneIDi421673
KEGGigga:421673

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000069 Genomic DNA No translation available.
RefSeqiNP_001026242.2, NM_001031071.2
UniGeneiGga.6511

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000022408; ENSGALP00000022368; ENSGALG00000013803
GeneIDi421673
KEGGigga:421673

Organism-specific databases

CTDi57211

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
KOiK08463
OrthoDBiEOG091G00P5

Gene expression databases

BgeeiENSGALG00000013803 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiF1P1B2 baseline and differential

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1P1B2_CHICK
AccessioniPrimary (citable) accession number: F1P1B2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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