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Entry version 67 (07 Apr 2021)
Sequence version 4 (10 Apr 2019)
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Protein

SH3 domain-containing protein

Gene

EVPL

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EVPLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1P070

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000002108, Expressed in lung and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000003285

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1P070

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini394 – 451SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni882 – 901DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 99Sequence analysisAdd BLAST21
Coiled coili104 – 131Sequence analysisAdd BLAST28
Coiled coili173 – 193Sequence analysisAdd BLAST21
Coiled coili554 – 581Sequence analysisAdd BLAST28
Coiled coili957 – 991Sequence analysisAdd BLAST35
Coiled coili1010 – 1058Sequence analysisAdd BLAST49
Coiled coili1077 – 1111Sequence analysisAdd BLAST35
Coiled coili1195 – 1215Sequence analysisAdd BLAST21
Coiled coili1248 – 1296Sequence analysisAdd BLAST49
Coiled coili1315 – 1349Sequence analysisAdd BLAST35
Coiled coili1373 – 1437Sequence analysisAdd BLAST65
Coiled coili1463 – 1497Sequence analysisAdd BLAST35
Coiled coili1528 – 1562Sequence analysisAdd BLAST35
Coiled coili1570 – 1593Sequence analysisAdd BLAST24
Coiled coili1602 – 1636Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001780_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1P070

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPSQINY

Database of Orthologous Groups

More...
OrthoDBi
68483at2759

TreeFam database of animal gene trees

More...
TreeFami
TF342779

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399, SSF75399, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1P070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKAVGKGSP SRSAPGRGSP AKPNKSSSND LAVLIARMQT NADQVEKDIL
60 70 80 90 100
DTQSLLAQDV SNEQKNKAFE FQAENARNLK EAETLLKDLF LDVDRAKRLK
110 120 130 140 150
HPQANEIEKD IQQLHERVTQ LCAEYRDLYE KLNVPDIGPR VDWTKILDQK
160 170 180 190 200
MKQVSAGQYG PGMSELEKQI AEHNILQKEI EAYGLQIKNL RCRDVTDLKS
210 220 230 240 250
QYKDLLKASI WRGQSLGSLY HHLQGCTKEL GYLTERQTCI LKQDWSDQMT
260 270 280 290 300
DVQSVRREYE DFKSKELLSQ EKFVNNLQDD GDRMIELKHP AVKPIQAHQE
310 320 330 340 350
ALKNEWQNFL NLCICQESQL KSVENYKKFQ DDAETVSRSL KKMSSDLDTK
360 370 380 390 400
YTKFNKDKLS PPGTHLKQAE KSIADLKKRS KEISPLKLRR MRSSQPLTLD
410 420 430 440 450
TLCDWDAGEV QLTRGDKYTL KDNSNPEMWV VQSSTGVVQE APSACFSIPP
460 470 480 490 500
PDPEAIDKLE LWGLCLGELR GTVCVPGLGW KMCSQTEPKL CLTAVLPKST
510 520 530 540 550
PVVQDDPQAD QLLGSLDRVG KDLVQVEKEV LNRVRSPVSY TDPTDDLARR
560 570 580 590 600
IKQQQETTKK LESLGAAKDA LQKECETYLS KKPTSTSASQ LPVTLNALRS
610 620 630 640 650
KYSDVSMLSS LYNEKAKAAL NLETQIENTD KIVSTFEAKL AQDSIIPASP
660 670 680 690 700
NALQDRANDL QKMKRDLVAQ EDCVLKLNRG LKDAEHSCSA VQNNFQEYCP
710 720 730 740 750
DLPRQKREVQ LLNDRYHAVA DQLDQREKTL RNISLTYQQF QNSNENLMFW
760 770 780 790 800
MNNLPKHQVK TTDGPSQINY KLQAQKRVLE EIESKEPEKN AVIRLSRNVQ
810 820 830 840 850
STLNDYELQA GKYSSSLDPA LTDFAAKRLR VTPLQESIQA QENDVSKHYM
860 870 880 890 900
ELAAENRQQL SRLEFAKKIV EKKEVHEDIQ SVHEQTQQSA NKAVPSRESE
910 920 930 940 950
GLKLQLEEER RNVARIEEDL EEHRNKLLML KTQRPIERVE EKEVVEYYRD
960 970 980 990 1000
PQLESSLTKM TQQIEEEGKK RQSLQEDIEV MSRKLAQMES EKKAVPAQLL
1010 1020 1030 1040 1050
TKEITKIEKD PNLDSQAASL RQEIRRLQEE SLAAASELEQ CKRELHVLER
1060 1070 1080 1090 1100
KQPNIREKVV VKELIKTEKN PEMLKSVRNL QLQIDEESFK RKSAEEAIVK
1110 1120 1130 1140 1150
VKSKIEEVEK LIDAAEPKII VKEVKQVEQD PELLKESSKL KALIEEERSK
1160 1170 1180 1190 1200
NLALAGELGE LQSQCSIAEK QKPRVEVKER VNEIFMVDPE TEKEIAHLKR
1210 1220 1230 1240 1250
ELQEVTLKRT KIDSEVEEAL AELSVLRSQK PEVELKEVIE EVVKHEKSPE
1260 1270 1280 1290 1300
ILREIDRLKQ QLNELVNTNG RTQEQLIRLQ GERDEWKRER SKVEMKLVNK
1310 1320 1330 1340 1350
EVIRYENDPL LEKEADRLRQ EVRSMSQKRR AAEDAIYDLQ NKYMLLERRK
1360 1370 1380 1390 1400
PEEKVIVQEV ILTQKDPKLR DEHNRLSRSL DEEVSNRRRL ERDVQQLRAL
1410 1420 1430 1440 1450
VEEQEKLLNF QEDRSKRLAL EKEMRQITLR IKELEESPAP VQEKIIMEEV
1460 1470 1480 1490 1500
VKLEKDPLLE QSASNLRLEL DREKMEVLNL QRECKNLQMQ VDVLQKAKSQ
1510 1520 1530 1540 1550
EKTIYKEVIR VEKDRALESE RARIWEQLSR ERGAKQKAEE EVRRLREKIE
1560 1570 1580 1590 1600
RAEGMKRTWA REETELQKAR NLAIQERASL ESELRELERQ KQQKVLFLRE
1610 1620 1630 1640 1650
ESKLLNQRTE SDRQKKKQLE QEFSMLEADI LREKDQIYNK ERFIRDLRSR
1660 1670 1680 1690 1700
VSREEINHET QMRETNLSTK ISILDPETGK DMSPYEAYKR GIIDRGQYIQ
1710 1720 1730 1740 1750
LQELECDWEE ITTLGPNGEI SVLLDKKSGK QYSIDDALRL RRITKEEYQL
1760 1770 1780 1790 1800
YRDGKIPISE FALLVAGESK PPPSLSIGSI ISKSPVQSPT TLQTQSFFPP
1810 1820 1830 1840 1850
GLQKGFGDDA SPIAGVYDTT TDTKYNIRTA VTKKLLDPMT AQKLLEAQAA
1860 1870 1880 1890 1900
TGGIIDLLSR DRLSVHKAIE RGLIDRTYMQ RLLNAQKAFT GIEDPVTKRR
1910 1920 1930 1940 1950
LSVGEAVQKG WMTKDSAFPY LEVQHLTGGL IDPKKTGRIP VLEAAQMGMI
1960 1970 1980 1990 2000
TGDLANRLQD ESSYEKDLID PITKEKINYK EAMALCQKDS LGSLLLLPAA
2010
SEGYQPYRSP KLSRFRH
Length:2,017
Mass (Da):232,625
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F7AA514648C5270
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000628 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000003290; ENSGALP00000003285; ENSGALG00000002108

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000628 Genomic DNA No translation available.

3D structure databases

SMRiF1P070
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003285

Proteomic databases

PaxDbiF1P070

Genome annotation databases

EnsembliENSGALT00000003290; ENSGALP00000003285; ENSGALG00000002108

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000153578
HOGENOMiCLU_001780_0_0_1
InParanoidiF1P070
OMAiGPSQINY
OrthoDBi68483at2759
TreeFamiTF342779

Enzyme and pathway databases

ReactomeiR-GGA-6809371, Formation of the cornified envelope

Gene expression databases

BgeeiENSGALG00000002108, Expressed in lung and 4 other tissues

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits
SUPFAMiSSF75399, SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1P070_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1P070
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: April 7, 2021
This is version 67 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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