NOTCH1

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	442	Calcium 1; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	445	Calcium 1; via amide nitrogenUniRule annotation	1
Metal bindingⁱ	462	Calcium 2UniRule annotation	1
Metal bindingⁱ	463	Calcium 2; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	465	Calcium 2UniRule annotation	1
Metal bindingⁱ	479	Calcium 2UniRule annotation	1
Metal bindingⁱ	480	Calcium 2; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	500	Calcium 3UniRule annotation	1
Metal bindingⁱ	501	Calcium 3; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	503	Calcium 3UniRule annotation	1
Metal bindingⁱ	517	Calcium 3UniRule annotation	1
Metal bindingⁱ	518	Calcium 3; via carbonyl oxygenUniRule annotation	1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
chromatin DNA binding Source: Ensembl
enzyme binding Source: Ensembl
enzyme inhibitor activity Source: Ensembl
identical protein binding Source: Ensembl
Notch binding Source: Ensembl
signaling receptor activity Source: InterPro
transcription coactivator activity Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

aortic valve morphogenesis Source: Ensembl
apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
arterial endothelial cell differentiation Source: Ensembl
atrioventricular node development Source: Ensembl
auditory receptor cell fate commitment Source: Ensembl
axon guidance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
branching morphogenesis of an epithelial tube Source: Ensembl
cardiac left ventricle morphogenesis Source: Ensembl
cardiac muscle cell proliferation Source: Ensembl
cardiac right atrium morphogenesis Source: Ensembl
cardiac right ventricle formation Source: Ensembl
cardiac vascular smooth muscle cell development Source: Ensembl
cell cycle arrest Source: Ensembl
cell fate specification Source: Ensembl
cell migration involved in endocardial cushion formation Source: Ensembl
cellular response to follicle-stimulating hormone stimulus Source: Ensembl
cellular response to vascular endothelial growth factor stimulus Source: Ensembl
collecting duct development Source: Ensembl
compartment pattern specification Source: Ensembl
coronary artery morphogenesis Source: Ensembl
coronary sinus valve morphogenesis Source: Ensembl
coronary vein morphogenesis Source: Ensembl
distal tubule development Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
endocardial cell differentiation Source: Ensembl
endocardium morphogenesis Source: Ensembl
endoderm development Source: Ensembl
epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
forebrain development Source: Ensembl
foregut morphogenesis Source: Ensembl
glial cell differentiation Source: Ensembl
glomerular mesangial cell development Source: Ensembl
growth involved in heart morphogenesis Source: Ensembl
heart looping Source: Ensembl
homeostasis of number of cells within a tissue Source: Ensembl
humoral immune response Source: Ensembl
inflammatory response to antigenic stimulus Source: Ensembl
keratinocyte differentiation Source: Ensembl
left/right axis specification Source: Ensembl
liver development Source: Ensembl
lung development Source: Ensembl
mesenchymal cell development Source: Ensembl
mitral valve formation Source: Ensembl
negative regulation of anoikis Source: Ensembl
negative regulation of biomineral tissue development Source: Ensembl
negative regulation of BMP signaling pathway Source: Ensembl
negative regulation of calcium ion-dependent exocytosis Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
negative regulation of cardiac muscle hypertrophy Source: Ensembl
negative regulation of cell adhesion molecule production Source: Ensembl
negative regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
negative regulation of cell proliferation involved in heart valve morphogenesis Source: Ensembl
negative regulation of cell-substrate adhesion Source: Ensembl
negative regulation of cold-induced thermogenesis Source: Ensembl
negative regulation of endothelial cell chemotaxis Source: Ensembl
negative regulation of extracellular matrix constituent secretion Source: Ensembl
negative regulation of glial cell proliferation Source: Ensembl
negative regulation of growth rate Source: Ensembl
negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
negative regulation of myoblast differentiation Source: Ensembl
negative regulation of myotube differentiation Source: Ensembl
negative regulation of oligodendrocyte differentiation Source: Ensembl
negative regulation of ossification Source: Ensembl
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of photoreceptor cell differentiation Source: Ensembl
negative regulation of pro-B cell differentiation Source: Ensembl
negative regulation of stem cell differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neural tube development Source: Ensembl
neuronal stem cell population maintenance Source: Ensembl
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Source: Ensembl
outflow tract morphogenesis Source: Ensembl
pericardium morphogenesis Source: Ensembl
positive regulation of aorta morphogenesis Source: Ensembl
positive regulation of apoptotic process involved in morphogenesis Source: Ensembl
positive regulation of astrocyte differentiation Source: Ensembl
positive regulation of BMP signaling pathway Source: Ensembl
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of epithelial cell proliferation Source: Ensembl
positive regulation of epithelial to mesenchymal transition Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of keratinocyte differentiation Source: Ensembl
positive regulation of Notch signaling pathway Source: Ensembl
positive regulation of Ras protein signal transduction Source: Ensembl
positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
positive regulation of transcription of Notch receptor target Source: Ensembl
positive regulation of viral genome replication Source: Ensembl
prostate gland epithelium morphogenesis Source: Ensembl
pulmonary valve morphogenesis Source: Ensembl
regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
regulation of extracellular matrix assembly Source: Ensembl
regulation of somitogenesis Source: Ensembl
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
response to muramyl dipeptide Source: Ensembl
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
skeletal muscle cell differentiation Source: Ensembl
somatic stem cell division Source: Ensembl
sprouting angiogenesis Source: Ensembl
tube formation Source: Ensembl
vasculogenesis involved in coronary vascular morphogenesis Source: Ensembl
venous endothelial cell differentiation Source: Ensembl
ventricular septum morphogenesis Source: Ensembl
ventricular trabecula myocardium morphogenesis Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ActivatorARBA annotation, Developmental proteinARBA annotation
Biological process	AngiogenesisARBA annotation, DifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
Ligand	CalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-GGA-1912420, Pre-NOTCH Processing in Golgi R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-GGA-2197563, NOTCH2 intracellular domain regulates transcription R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-GGA-350054, Notch-HLH transcription pathway R-GGA-8941856, RUNX3 regulates NOTCH signaling

Reactomeⁱ

R-GGA-1912420, Pre-NOTCH Processing in Golgi
R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-GGA-2197563, NOTCH2 intracellular domain regulates transcription
R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus
R-GGA-350054, Notch-HLH transcription pathway
R-GGA-8941856, RUNX3 regulates NOTCH signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurogenic locus notch homolog protein 1ARBA annotation Alternative name(s): Notch 1 extracellular truncationARBA annotation Notch 1 intracellular domainARBA annotation
Gene namesⁱ	Name:NOTCH1Imported
Organismⁱ	Gallus gallus (Chicken)Imported
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Chromosome 17

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	1744 – 1765	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	58 ↔ 67	PROSITE-ProRule annotation
Disulfide bondⁱ	99 ↔ 108	PROSITE-ProRule annotation
Disulfide bondⁱ	139 ↔ 148	PROSITE-ProRule annotation
Disulfide bondⁱ	176 ↔ 185	PROSITE-ProRule annotation
Disulfide bondⁱ	216 ↔ 225	PROSITE-ProRule annotation
Disulfide bondⁱ	255 ↔ 264	PROSITE-ProRule annotation
Disulfide bondⁱ	293 ↔ 302	PROSITE-ProRule annotation
Disulfide bondⁱ	333 ↔ 342	PROSITE-ProRule annotation
Disulfide bondⁱ	371 ↔ 380	PROSITE-ProRule annotation
Disulfide bondⁱ	391 ↔ 408	PROSITE-ProRule annotation
Disulfide bondⁱ	410 ↔ 419	PROSITE-ProRule annotation
Disulfide bondⁱ	426 ↔ 439	UniRule annotation
Disulfide bondⁱ	433 ↔ 448	UniRule annotation
Disulfide bondⁱ	450 ↔ 459	UniRule annotation
Disulfide bondⁱ	466 ↔ 477	UniRule annotation
Disulfide bondⁱ	471 ↔ 486	UniRule annotation
Disulfide bondⁱ	488 ↔ 497	UniRule annotation
Disulfide bondⁱ	504 ↔ 515	UniRule annotation
Disulfide bondⁱ	509 ↔ 524	UniRule annotation
Disulfide bondⁱ	526 ↔ 535	UniRule annotation
Disulfide bondⁱ	564 ↔ 573	PROSITE-ProRule annotation
Disulfide bondⁱ	580 ↔ 590	PROSITE-ProRule annotation
Disulfide bondⁱ	601 ↔ 610	PROSITE-ProRule annotation
Disulfide bondⁱ	639 ↔ 648	PROSITE-ProRule annotation
Disulfide bondⁱ	655 ↔ 665	PROSITE-ProRule annotation
Disulfide bondⁱ	676 ↔ 685	PROSITE-ProRule annotation
Disulfide bondⁱ	714 ↔ 723	PROSITE-ProRule annotation
Disulfide bondⁱ	730 ↔ 740	PROSITE-ProRule annotation
Disulfide bondⁱ	751 ↔ 760	PROSITE-ProRule annotation
Disulfide bondⁱ	789 ↔ 798	PROSITE-ProRule annotation
Disulfide bondⁱ	827 ↔ 836	PROSITE-ProRule annotation
Disulfide bondⁱ	848 ↔ 865	PROSITE-ProRule annotation
Disulfide bondⁱ	867 ↔ 876	PROSITE-ProRule annotation
Disulfide bondⁱ	905 ↔ 914	PROSITE-ProRule annotation
Disulfide bondⁱ	943 ↔ 952	PROSITE-ProRule annotation
Disulfide bondⁱ	981 ↔ 990	PROSITE-ProRule annotation
Disulfide bondⁱ	1019 ↔ 1028	PROSITE-ProRule annotation
Disulfide bondⁱ	1057 ↔ 1066	PROSITE-ProRule annotation
Disulfide bondⁱ	1095 ↔ 1104	PROSITE-ProRule annotation
Disulfide bondⁱ	1122 ↔ 1132	PROSITE-ProRule annotation
Disulfide bondⁱ	1143 ↔ 1152	PROSITE-ProRule annotation
Disulfide bondⁱ	1181 ↔ 1190	PROSITE-ProRule annotation
Disulfide bondⁱ	1219 ↔ 1228	PROSITE-ProRule annotation
Disulfide bondⁱ	1265 ↔ 1274	PROSITE-ProRule annotation
Disulfide bondⁱ	1286 ↔ 1303	PROSITE-ProRule annotation
Disulfide bondⁱ	1305 ↔ 1314	PROSITE-ProRule annotation
Disulfide bondⁱ	1346 ↔ 1355	PROSITE-ProRule annotation
Disulfide bondⁱ	1384 ↔ 1393	PROSITE-ProRule annotation
Disulfide bondⁱ	1426 ↔ 1435	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PaxDbⁱ	F1NZ70

PaxDbⁱ

F1NZ70

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSGALG00000002375, Expressed in lung and 13 other tissues
ExpressionAtlasⁱ	F1NZ70, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
identical protein binding Source: Ensembl
Notch binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000003746

STRINGⁱ

9031.ENSGALP00000003746

Structureⁱ

3D structure databases

SMRⁱ	F1NZ70
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	29 – 68	EGF-likeInterPro annotationAdd BLAST	40
Domainⁱ	69 – 109	EGF-likeInterPro annotationAdd BLAST	41
Domainⁱ	112 – 149	EGF-likeInterPro annotationAdd BLAST	38
Domainⁱ	150 – 186	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	188 – 226	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	228 – 265	EGF-likeInterPro annotationAdd BLAST	38
Domainⁱ	267 – 303	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	305 – 343	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	345 – 381	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	382 – 420	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	422 – 460	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	462 – 498	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	500 – 536	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	538 – 574	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	576 – 611	EGF-likeInterPro annotationAdd BLAST	36
Domainⁱ	613 – 649	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	651 – 686	EGF-likeInterPro annotationAdd BLAST	36
Domainⁱ	688 – 724	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	726 – 761	EGF-likeInterPro annotationAdd BLAST	36
Domainⁱ	763 – 799	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	801 – 837	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	839 – 877	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	879 – 915	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	917 – 953	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	955 – 991	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	993 – 1029	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1031 – 1067	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1069 – 1105	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1118 – 1153	EGF-likeInterPro annotationAdd BLAST	36
Domainⁱ	1155 – 1191	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1193 – 1229	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1231 – 1275	EGF-likeInterPro annotationAdd BLAST	45
Domainⁱ	1277 – 1315	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	1317 – 1356	EGF-likeInterPro annotationAdd BLAST	40
Domainⁱ	1358 – 1394	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	1397 – 1436	EGF-likeInterPro annotationAdd BLAST	40
Domainⁱ	1459 – 1499	LNRInterPro annotationAdd BLAST	41
Domainⁱ	1500 – 1541	LNRInterPro annotationAdd BLAST	42
Domainⁱ	1542 – 1581	LNRInterPro annotationAdd BLAST	40
Domainⁱ	1883 – 2123	ANK_REP_REGIONInterPro annotationAdd BLAST	241
Repeatⁱ	1937 – 1969	ANKPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	2004 – 2036	ANKPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	2037 – 2069	ANKPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	2070 – 2102	ANKPROSITE-ProRule annotationAdd BLAST	33

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1788 – 1822	DisorderedSequence analysisAdd BLAST	35
Regionⁱ	2160 – 2196	DisorderedSequence analysisAdd BLAST	37
Regionⁱ	2386 – 2455	DisorderedSequence analysisAdd BLAST	70
Regionⁱ	2484 – 2561	DisorderedSequence analysisAdd BLAST	78

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	2179 – 2196	PolyampholyteSequence analysisAdd BLAST	18
Compositional biasⁱ	2406 – 2455	PolarSequence analysisAdd BLAST	50
Compositional biasⁱ	2484 – 2512	PolarSequence analysisAdd BLAST	29
Compositional biasⁱ	2520 – 2554	PolarSequence analysisAdd BLAST	35

Sequence similaritiesⁱ

Belongs to the NOTCH family.ARBA annotation

Keywords - Domainⁱ

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

eggNOGⁱ	KOG1217, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157157
HOGENOMⁱ	CLU_000576_0_0_1
InParanoidⁱ	F1NZ70
OMAⁱ	NEGSCLD
Database of Orthologous Groups More...OrthoDBⁱ	7525at2759
TreeFamⁱ	TF351641

Family and domain databases

Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022362, Notch_1 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796, Ank_2, 2 hits PF11936, DUF3454, 1 hit PF00008, EGF, 25 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits
PIRSFⁱ	PIRSF002279, Notch, 1 hit
PRINTSⁱ	PR01452, LNOTCHREPEAT PR01984, NOTCH1
SMARTⁱ	View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 32 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit
SUPFAMⁱ	SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 3 hits
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 23 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 9 hits PS50258, LNR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

F1NZ70-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGRCSAAHPR GGVHCPGLCA VPDALLLFPG VRCTQLAESC LNGGKCETFL 
        60         70         80         90        100
NGTEVCQCSS AHMGERCQLP NPCLSSPCKN AGTCIPLLRG STADYTCVCR 
       110        120        130        140        150
LGFTDELCLT PLDNACLNNP CRNGGTCDLV TLSEYKCRCP PGWSGKTCQQ 
       160        170        180        190        200
ADPCASNPCA NGGQCVPFEA HYICRCTAGF HGANCKQDVN ECNISPPVCK 
       210        220        230        240        250
NGGSCTNEVG TYQCSCKPAY TGQNCEHLYV PCNPSPCQNG GTCRQTGDTT 
       260        270        280        290        300
YDCTCLPGFT GQNCEENIDD CPGNNCRNGG TCVDGVNTYN CQCPPEWTGQ 
       310        320        330        340        350
YCTEDVDECQ LMPNACQNGG TCHNNHGGYN CVCVNGWTGE DCSENIDDCA 
       360        370        380        390        400
MAACFQGATC HDRVASFYCE CPHGRTGLLC HLDDACISNP CNEGSNCDTN 
       410        420        430        440        450
PVNGKAICTC PSGYMGPACN QDVDECSLGA NPCEHAGKCI NTQGSFQCQC 
       460        470        480        490        500
LQGYSGPRCE IDVNECLSNP CQNDATCLDQ IGEFQCICMP GYEGVYCEIN 
       510        520        530        540        550
TDECASSPCL HNGNCLDKIN EFHCECPTGF NGHLCQFDID ECASTPCKNG 
       560        570        580        590        600
AKCVDGPNTY SCECTEGFSG VHCEIDIDEC NPDPCHYGTC KDSIAAFTCL 
       610        620        630        640        650
CQPGYTGHRC DININECQSQ PCRNGGTCQD RDNAYNCLCL KGTTGPNCEI 
       660        670        680        690        700
NLDDCASNPC DYGKCIDKIN GYECTCEPGY TGRMCNINID ECASNPCHNG 
       710        720        730        740        750
GTCKDGINGF TCLCPEGFHD PKCLSEVNEC NSNPCIHGRC HDGLNGYRCD 
       760        770        780        790        800
CDPGWSGTNC DINNNECESN PCMNGGTCKD MTSGYICTCR EGFSGPNCQT 
       810        820        830        840        850
NINECASNPC LNQGTCIDDV AGYTCNCLLP YTGATCEDVL APCAGGPCKN 
       860        870        880        890        900
GGECRESEDY KRFSCSCPPG WQGQTCEIDI NECVKSPCRN GATCQNTNGS 
       910        920        930        940        950
YRCLCRVGFA GRNCDTDIDD CQPNPCHNGG SCSDGIGTFF CECLAGFRGL 
       960        970        980        990       1000
KCEEDINECA SNPCKNGANC TDCVNSYTCT CPSGFSGIHC ENNTPDCTES 
      1010       1020       1030       1040       1050
SCFNGGTCVD GINTFTCLCP SGFTGSYCEH NINECDSKPC LNGGTCQDSY 
      1060       1070       1080       1090       1100
GTYKCTCPQG YTGLNCQNLV RWCDSSPCKN GGKCWQTNNL YRCECNSGWT 
      1110       1120       1130       1140       1150
GLYCDVPSVS CEVAAKQQGI DVAHLCRNSG LCVDSGNTHF CRCQAGYTGS 
      1160       1170       1180       1190       1200
YCEEQVDECS PNPCQNGATC TDYLGGYSCE CVAGYHGVNC SEEINECLSH 
      1210       1220       1230       1240       1250
PCQNGGTCID LINTYKCSCP RGTQGVHCEI NVDDCSPFFD PVTLGPKCFN 
      1260       1270       1280       1290       1300
NGKCTDRVGG YSCICPPGFV GERCEGDVNE CLSNPCDARG TQNCVQRVND 
      1310       1320       1330       1340       1350
YKCECRPGYA GRRCDTVVDG CKGKPCRNGG TCAVASNTGR GFICKCPPGF 
      1360       1370       1380       1390       1400
VGATCENDSH TCGTLHCLNG GTCISMHKSS KCVCAAAFTG PECQYPASSP 
      1410       1420       1430       1440       1450
CISNPCYNGG TCEFLSDASP YYHCNCPANF NGLNCHILDF DFQGGFGQDI 
      1460       1470       1480       1490       1500
IPPKIEEKCE IAVCASYAGN KICDGKCNNH ACGWDGGDCS LNFNDPWKNC 
      1510       1520       1530       1540       1550
SQSLQCWKYF NDGKCDSQCN NAGCLYDGFD CQKYEGQCNP LYDQYCKDHF 
      1560       1570       1580       1590       1600
SDGHCDQGCN NFECEWDGLD CANNMPEKLA DGTLVVVVLI TPENLKNNSF 
      1610       1620       1630       1640       1650
NFLRELSRVL HTNVVFKKNA KGEYMIFPYY GNEEELKKHY IKRSTEDWAD 
      1660       1670       1680       1690       1700
MSSAVINKVK SSLYSRAGRR QKRELDQMDI RGSIVYLEID NRQCIQSSSQ 
      1710       1720       1730       1740       1750
CFQSATDVAA FLGALASLGN LNIPYKIEAV KSETAEPARN SQLYPMYVVV 
      1760       1770       1780       1790       1800
AALVLLAFIG VGVLVSRKRR REHGQLWFPE GFKVTESSKK KRREPLGEDS 
      1810       1820       1830       1840       1850
VGLKPLKNAS DGTLMDDNQN EWGDEETLDT KKFRFEEQAM LPDTDDQTDH 
      1860       1870       1880       1890       1900
RQWTQQHLDA ADLRISSMAP TPPQGEIDAD CMDVNVRGPD GFTPLMIASC 
      1910       1920       1930       1940       1950
SGGGLETGNS EEEDDAPAVI SDFIYQGASL HNQTDRTGET ALHLAARYSR 
      1960       1970       1980       1990       2000
SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL IRNRATDLDA 
      2010       2020       2030       2040       2050
RMHDGTTPLI LAARLAVEGM LEDLINCHAD VNAVDDLGKS ALHWAAAVNN 
      2060       2070       2080       2090       2100
VEAAVVLLKN GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT 
      2110       2120       2130       2140       2150
DHMDRLPRDI AQERMHHDIV RLLDEYNLVR SPPLHSGPLG APTLSPPLCS 
      2160       2170       2180       2190       2200
PSSYIGNLKP AVQGKKARKP STKGLSCNGK DSKDLKARRK KSQDGKGCLL 
      2210       2220       2230       2240       2250
DNSSVLSPVD SLESPHGYLS DVASPPLMTS PFQQSPSMPL NHLPGMPDAH 
      2260       2270       2280       2290       2300
MSINHLNMAG KQEMALGGSG RMAFEAVPPR LSHLPVSSPS TAMSNAPMNF 
      2310       2320       2330       2340       2350
SVGGAAGLSG QCDWLSRLQS GMVQNQYGAM RGGMQPGTHQ QAQNLQHGMM 
      2360       2370       2380       2390       2400
SSLHNGLPST SLSQMMSYQA MPSTRLASQP HLLQNQQMQQ MQQPGMQPQP 
      2410       2420       2430       2440       2450
GMQPQPGMQQ PQQQPQQQPQ PQQHHNPGSN ASGHMGQNFL GTELSQPDMQ 
      2460       2470       2480       2490       2500
PVSSSAMAVH TILPQDSQLL PTSLPSSLAQ PMTTTQFLTP PSQHSYSSPL 
      2510       2520       2530       2540       2550
DNTPSHQLQV PDHPFLTPSP ESPDQWSSSS PHSNVSDWSE GISSPPTSMQ 
      2560 
SQMGHIPEAF K

Length:2,561

Mass (Da):276,332

Last modified:November 30, 2016 - v3

Checksum:ⁱ38547C1A800CA17C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A3Q2ULK6	A0A3Q2ULK6_CHICK		Neurogenic locus notch homolog prot... Neurogenic locus notch homolog protein 1 (Notch 1 extracellular truncation) (Notch 1 intracellular domain)	NOTCH1	2,551	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AADN05000150 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001025466.1, NM_001030295.1

Genome annotation databases

Ensemblⁱ	ENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375
GeneIDⁱ	395655
KEGGⁱ	gga:395655

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1NZ70	NOTCH-1 (Fragment)		CHICK		1194	UniRef100_F1NZ70

Protein	Similar proteins		Species	Score	Length	Source
F1NZ70	NOTCH-1 (Fragment)		CHICK		1194	UniRef90_F1NZ70
NOTC1 protein (Fragment)		Green crombec		2557
NOTC1 protein (Fragment)		short-legged ground-roller		2554
NOTC1 protein (Fragment)		TROML		2551
NOTC1 protein (Fragment)		rufous-naped whistler		2551
+76

Protein	Similar proteins		Species	Score	Length	Source
F1NZ70	Neurogenic locus notch homolog protein 1	)	HUMAN		2555	UniRef50_P46531
Neurogenic locus notch homolog protein 1		HORSE		2581
Neurogenic locus notch homolog protein 1		PANPA		2573
Neurogenic locus notch homolog protein 1		RHIRO		2560
Neurogenic locus notch homolog protein 1		MACMU		2556
+163

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AADN05000150 Genomic DNA No translation available.
RefSeqⁱ	NP_001025466.1, NM_001030295.1

3D structure databases

SMRⁱ	F1NZ70
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000003746

STRINGⁱ

9031.ENSGALP00000003746

Proteomic databases

PaxDbⁱ	F1NZ70

PaxDbⁱ

F1NZ70

Genome annotation databases

Ensemblⁱ	ENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375
GeneIDⁱ	395655
KEGGⁱ	gga:395655

Organism-specific databases

CTDⁱ	4851

CTDⁱ

4851

Phylogenomic databases

eggNOGⁱ	KOG1217, Eukaryota
GeneTreeⁱ	ENSGT00940000157157
HOGENOMⁱ	CLU_000576_0_0_1
InParanoidⁱ	F1NZ70
OMAⁱ	NEGSCLD
OrthoDBⁱ	7525at2759
TreeFamⁱ	TF351641

Enzyme and pathway databases

Reactomeⁱ	R-GGA-1912420, Pre-NOTCH Processing in Golgi R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-GGA-2197563, NOTCH2 intracellular domain regulates transcription R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-GGA-350054, Notch-HLH transcription pathway R-GGA-8941856, RUNX3 regulates NOTCH signaling

Reactomeⁱ

R-GGA-1912420, Pre-NOTCH Processing in Golgi
R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-GGA-2197563, NOTCH2 intracellular domain regulates transcription
R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus
R-GGA-350054, Notch-HLH transcription pathway
R-GGA-8941856, RUNX3 regulates NOTCH signaling

Gene expression databases

Bgeeⁱ	ENSGALG00000002375, Expressed in lung and 13 other tissues
ExpressionAtlasⁱ	F1NZ70, baseline and differential

Family and domain databases

Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022362, Notch_1 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom
Pfamⁱ	View protein in Pfam PF12796, Ank_2, 2 hits PF11936, DUF3454, 1 hit PF00008, EGF, 25 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits
PIRSFⁱ	PIRSF002279, Notch, 1 hit
PRINTSⁱ	PR01452, LNOTCHREPEAT PR01984, NOTCH1
SMARTⁱ	View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 32 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit
SUPFAMⁱ	SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 3 hits
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 23 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 9 hits PS50258, LNR, 3 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1NZ70_CHICK
Accessionⁱ	F1NZ70Primary (citable) accession number: F1NZ70
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	November 30, 2016
	Last modified:	April 7, 2021
	This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

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UniRef

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Annotation systems

Supporting data

UniProtKB - F1NZ70 (F1NZ70_CHICK)

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Neurogenic locus notch homolog protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

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Endoplasmic reticulum

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ