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Entry version 73 (13 Feb 2019)
Sequence version 3 (30 Nov 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

NOTCH1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi442Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi445Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi462Calcium 2UniRule annotation1
Metal bindingi463Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi465Calcium 2UniRule annotation1
Metal bindingi479Calcium 2UniRule annotation1
Metal bindingi480Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi500Calcium 3UniRule annotation1
Metal bindingi501Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi503Calcium 3UniRule annotation1
Metal bindingi517Calcium 3UniRule annotation1
Metal bindingi518Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-1912420 Pre-NOTCH Processing in Golgi
R-GGA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-GGA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-GGA-350054 Notch-HLH transcription pathway
R-GGA-8941856 RUNX3 regulates NOTCH signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1744 – 1765HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 67PROSITE-ProRule annotation
Disulfide bondi99 ↔ 108PROSITE-ProRule annotation
Disulfide bondi139 ↔ 148PROSITE-ProRule annotation
Disulfide bondi176 ↔ 185PROSITE-ProRule annotation
Disulfide bondi216 ↔ 225PROSITE-ProRule annotation
Disulfide bondi255 ↔ 264PROSITE-ProRule annotation
Disulfide bondi293 ↔ 302PROSITE-ProRule annotation
Disulfide bondi333 ↔ 342PROSITE-ProRule annotation
Disulfide bondi371 ↔ 380PROSITE-ProRule annotation
Disulfide bondi391 ↔ 408PROSITE-ProRule annotation
Disulfide bondi410 ↔ 419PROSITE-ProRule annotation
Disulfide bondi426 ↔ 439UniRule annotation
Disulfide bondi433 ↔ 448UniRule annotation
Disulfide bondi450 ↔ 459UniRule annotation
Disulfide bondi466 ↔ 477UniRule annotation
Disulfide bondi471 ↔ 486UniRule annotation
Disulfide bondi488 ↔ 497UniRule annotation
Disulfide bondi504 ↔ 515UniRule annotation
Disulfide bondi509 ↔ 524UniRule annotation
Disulfide bondi526 ↔ 535UniRule annotation
Disulfide bondi564 ↔ 573PROSITE-ProRule annotation
Disulfide bondi580 ↔ 590PROSITE-ProRule annotation
Disulfide bondi601 ↔ 610PROSITE-ProRule annotation
Disulfide bondi639 ↔ 648PROSITE-ProRule annotation
Disulfide bondi655 ↔ 665PROSITE-ProRule annotation
Disulfide bondi676 ↔ 685PROSITE-ProRule annotation
Disulfide bondi714 ↔ 723PROSITE-ProRule annotation
Disulfide bondi730 ↔ 740PROSITE-ProRule annotation
Disulfide bondi751 ↔ 760PROSITE-ProRule annotation
Disulfide bondi789 ↔ 798PROSITE-ProRule annotation
Disulfide bondi827 ↔ 836PROSITE-ProRule annotation
Disulfide bondi848 ↔ 865PROSITE-ProRule annotation
Disulfide bondi867 ↔ 876PROSITE-ProRule annotation
Disulfide bondi905 ↔ 914PROSITE-ProRule annotation
Disulfide bondi943 ↔ 952PROSITE-ProRule annotation
Disulfide bondi981 ↔ 990PROSITE-ProRule annotation
Disulfide bondi1019 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1057 ↔ 1066PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1104PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1132PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1152PROSITE-ProRule annotation
Disulfide bondi1181 ↔ 1190PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1228PROSITE-ProRule annotation
Disulfide bondi1265 ↔ 1274PROSITE-ProRule annotation
Disulfide bondi1286 ↔ 1303PROSITE-ProRule annotation
Disulfide bondi1305 ↔ 1314PROSITE-ProRule annotation
Disulfide bondi1346 ↔ 1355PROSITE-ProRule annotation
Disulfide bondi1384 ↔ 1393PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1435PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1NZ70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000002375 Expressed in 10 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000003746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 68EGF-likeInterPro annotationAdd BLAST40
Domaini69 – 109EGF-likeInterPro annotationAdd BLAST41
Domaini112 – 149EGF-likeInterPro annotationAdd BLAST38
Domaini150 – 186EGF-likeInterPro annotationAdd BLAST37
Domaini188 – 226EGF-likeInterPro annotationAdd BLAST39
Domaini228 – 265EGF-likeInterPro annotationAdd BLAST38
Domaini267 – 303EGF-likeInterPro annotationAdd BLAST37
Domaini305 – 343EGF-likeInterPro annotationAdd BLAST39
Domaini345 – 381EGF-likeInterPro annotationAdd BLAST37
Domaini382 – 420EGF-likeInterPro annotationAdd BLAST39
Domaini422 – 460EGF-likeInterPro annotationAdd BLAST39
Domaini462 – 498EGF-likeInterPro annotationAdd BLAST37
Domaini500 – 536EGF-likeInterPro annotationAdd BLAST37
Domaini538 – 574EGF-likeInterPro annotationAdd BLAST37
Domaini576 – 611EGF-likeInterPro annotationAdd BLAST36
Domaini613 – 649EGF-likeInterPro annotationAdd BLAST37
Domaini651 – 686EGF-likeInterPro annotationAdd BLAST36
Domaini688 – 724EGF-likeInterPro annotationAdd BLAST37
Domaini726 – 761EGF-likeInterPro annotationAdd BLAST36
Domaini763 – 799EGF-likeInterPro annotationAdd BLAST37
Domaini801 – 837EGF-likeInterPro annotationAdd BLAST37
Domaini839 – 877EGF-likeInterPro annotationAdd BLAST39
Domaini879 – 915EGF-likeInterPro annotationAdd BLAST37
Domaini917 – 953EGF-likeInterPro annotationAdd BLAST37
Domaini955 – 991EGF-likeInterPro annotationAdd BLAST37
Domaini993 – 1029EGF-likeInterPro annotationAdd BLAST37
Domaini1031 – 1067EGF-likeInterPro annotationAdd BLAST37
Domaini1069 – 1105EGF-likeInterPro annotationAdd BLAST37
Domaini1118 – 1153EGF-likeInterPro annotationAdd BLAST36
Domaini1155 – 1191EGF-likeInterPro annotationAdd BLAST37
Domaini1193 – 1229EGF-likeInterPro annotationAdd BLAST37
Domaini1231 – 1275EGF-likeInterPro annotationAdd BLAST45
Domaini1277 – 1315EGF-likeInterPro annotationAdd BLAST39
Domaini1317 – 1356EGF-likeInterPro annotationAdd BLAST40
Domaini1358 – 1394EGF-likeInterPro annotationAdd BLAST37
Domaini1397 – 1436EGF-likeInterPro annotationAdd BLAST40
Domaini1459 – 1499LNRInterPro annotationAdd BLAST41
Domaini1500 – 1541LNRInterPro annotationAdd BLAST42
Domaini1542 – 1581LNRInterPro annotationAdd BLAST40
Domaini1883 – 2123ANK_REP_REGIONInterPro annotationAdd BLAST241
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1937 – 1969ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2004 – 2036ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2037 – 2069ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2070 – 2102ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157157

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1NZ70

KEGG Orthology (KO)

More...
KOi
K02599

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351641

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01984 NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 32 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 23 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1NZ70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRCSAAHPR GGVHCPGLCA VPDALLLFPG VRCTQLAESC LNGGKCETFL
60 70 80 90 100
NGTEVCQCSS AHMGERCQLP NPCLSSPCKN AGTCIPLLRG STADYTCVCR
110 120 130 140 150
LGFTDELCLT PLDNACLNNP CRNGGTCDLV TLSEYKCRCP PGWSGKTCQQ
160 170 180 190 200
ADPCASNPCA NGGQCVPFEA HYICRCTAGF HGANCKQDVN ECNISPPVCK
210 220 230 240 250
NGGSCTNEVG TYQCSCKPAY TGQNCEHLYV PCNPSPCQNG GTCRQTGDTT
260 270 280 290 300
YDCTCLPGFT GQNCEENIDD CPGNNCRNGG TCVDGVNTYN CQCPPEWTGQ
310 320 330 340 350
YCTEDVDECQ LMPNACQNGG TCHNNHGGYN CVCVNGWTGE DCSENIDDCA
360 370 380 390 400
MAACFQGATC HDRVASFYCE CPHGRTGLLC HLDDACISNP CNEGSNCDTN
410 420 430 440 450
PVNGKAICTC PSGYMGPACN QDVDECSLGA NPCEHAGKCI NTQGSFQCQC
460 470 480 490 500
LQGYSGPRCE IDVNECLSNP CQNDATCLDQ IGEFQCICMP GYEGVYCEIN
510 520 530 540 550
TDECASSPCL HNGNCLDKIN EFHCECPTGF NGHLCQFDID ECASTPCKNG
560 570 580 590 600
AKCVDGPNTY SCECTEGFSG VHCEIDIDEC NPDPCHYGTC KDSIAAFTCL
610 620 630 640 650
CQPGYTGHRC DININECQSQ PCRNGGTCQD RDNAYNCLCL KGTTGPNCEI
660 670 680 690 700
NLDDCASNPC DYGKCIDKIN GYECTCEPGY TGRMCNINID ECASNPCHNG
710 720 730 740 750
GTCKDGINGF TCLCPEGFHD PKCLSEVNEC NSNPCIHGRC HDGLNGYRCD
760 770 780 790 800
CDPGWSGTNC DINNNECESN PCMNGGTCKD MTSGYICTCR EGFSGPNCQT
810 820 830 840 850
NINECASNPC LNQGTCIDDV AGYTCNCLLP YTGATCEDVL APCAGGPCKN
860 870 880 890 900
GGECRESEDY KRFSCSCPPG WQGQTCEIDI NECVKSPCRN GATCQNTNGS
910 920 930 940 950
YRCLCRVGFA GRNCDTDIDD CQPNPCHNGG SCSDGIGTFF CECLAGFRGL
960 970 980 990 1000
KCEEDINECA SNPCKNGANC TDCVNSYTCT CPSGFSGIHC ENNTPDCTES
1010 1020 1030 1040 1050
SCFNGGTCVD GINTFTCLCP SGFTGSYCEH NINECDSKPC LNGGTCQDSY
1060 1070 1080 1090 1100
GTYKCTCPQG YTGLNCQNLV RWCDSSPCKN GGKCWQTNNL YRCECNSGWT
1110 1120 1130 1140 1150
GLYCDVPSVS CEVAAKQQGI DVAHLCRNSG LCVDSGNTHF CRCQAGYTGS
1160 1170 1180 1190 1200
YCEEQVDECS PNPCQNGATC TDYLGGYSCE CVAGYHGVNC SEEINECLSH
1210 1220 1230 1240 1250
PCQNGGTCID LINTYKCSCP RGTQGVHCEI NVDDCSPFFD PVTLGPKCFN
1260 1270 1280 1290 1300
NGKCTDRVGG YSCICPPGFV GERCEGDVNE CLSNPCDARG TQNCVQRVND
1310 1320 1330 1340 1350
YKCECRPGYA GRRCDTVVDG CKGKPCRNGG TCAVASNTGR GFICKCPPGF
1360 1370 1380 1390 1400
VGATCENDSH TCGTLHCLNG GTCISMHKSS KCVCAAAFTG PECQYPASSP
1410 1420 1430 1440 1450
CISNPCYNGG TCEFLSDASP YYHCNCPANF NGLNCHILDF DFQGGFGQDI
1460 1470 1480 1490 1500
IPPKIEEKCE IAVCASYAGN KICDGKCNNH ACGWDGGDCS LNFNDPWKNC
1510 1520 1530 1540 1550
SQSLQCWKYF NDGKCDSQCN NAGCLYDGFD CQKYEGQCNP LYDQYCKDHF
1560 1570 1580 1590 1600
SDGHCDQGCN NFECEWDGLD CANNMPEKLA DGTLVVVVLI TPENLKNNSF
1610 1620 1630 1640 1650
NFLRELSRVL HTNVVFKKNA KGEYMIFPYY GNEEELKKHY IKRSTEDWAD
1660 1670 1680 1690 1700
MSSAVINKVK SSLYSRAGRR QKRELDQMDI RGSIVYLEID NRQCIQSSSQ
1710 1720 1730 1740 1750
CFQSATDVAA FLGALASLGN LNIPYKIEAV KSETAEPARN SQLYPMYVVV
1760 1770 1780 1790 1800
AALVLLAFIG VGVLVSRKRR REHGQLWFPE GFKVTESSKK KRREPLGEDS
1810 1820 1830 1840 1850
VGLKPLKNAS DGTLMDDNQN EWGDEETLDT KKFRFEEQAM LPDTDDQTDH
1860 1870 1880 1890 1900
RQWTQQHLDA ADLRISSMAP TPPQGEIDAD CMDVNVRGPD GFTPLMIASC
1910 1920 1930 1940 1950
SGGGLETGNS EEEDDAPAVI SDFIYQGASL HNQTDRTGET ALHLAARYSR
1960 1970 1980 1990 2000
SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL IRNRATDLDA
2010 2020 2030 2040 2050
RMHDGTTPLI LAARLAVEGM LEDLINCHAD VNAVDDLGKS ALHWAAAVNN
2060 2070 2080 2090 2100
VEAAVVLLKN GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT
2110 2120 2130 2140 2150
DHMDRLPRDI AQERMHHDIV RLLDEYNLVR SPPLHSGPLG APTLSPPLCS
2160 2170 2180 2190 2200
PSSYIGNLKP AVQGKKARKP STKGLSCNGK DSKDLKARRK KSQDGKGCLL
2210 2220 2230 2240 2250
DNSSVLSPVD SLESPHGYLS DVASPPLMTS PFQQSPSMPL NHLPGMPDAH
2260 2270 2280 2290 2300
MSINHLNMAG KQEMALGGSG RMAFEAVPPR LSHLPVSSPS TAMSNAPMNF
2310 2320 2330 2340 2350
SVGGAAGLSG QCDWLSRLQS GMVQNQYGAM RGGMQPGTHQ QAQNLQHGMM
2360 2370 2380 2390 2400
SSLHNGLPST SLSQMMSYQA MPSTRLASQP HLLQNQQMQQ MQQPGMQPQP
2410 2420 2430 2440 2450
GMQPQPGMQQ PQQQPQQQPQ PQQHHNPGSN ASGHMGQNFL GTELSQPDMQ
2460 2470 2480 2490 2500
PVSSSAMAVH TILPQDSQLL PTSLPSSLAQ PMTTTQFLTP PSQHSYSSPL
2510 2520 2530 2540 2550
DNTPSHQLQV PDHPFLTPSP ESPDQWSSSS PHSNVSDWSE GISSPPTSMQ
2560
SQMGHIPEAF K
Length:2,561
Mass (Da):276,332
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38547C1A800CA17C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AADN04000037 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001025466.1, NM_001030295.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Gga.54229
Gga.54754
Gga.55793
Gga.9548

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375

Database of genes from NCBI RefSeq genomes

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GeneIDi
395655

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
gga:395655

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000037 Genomic DNA No translation available.
RefSeqiNP_001025466.1, NM_001030295.1
UniGeneiGga.54229
Gga.54754
Gga.55793
Gga.9548

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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Protein-protein interaction databases

STRINGi9031.ENSGALP00000003746

Proteomic databases

PaxDbiF1NZ70

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375
GeneIDi395655
KEGGigga:395655

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4851

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000157157
InParanoidiF1NZ70
KOiK02599
OrthoDBi7525at2759
TreeFamiTF351641

Enzyme and pathway databases

ReactomeiR-GGA-1912420 Pre-NOTCH Processing in Golgi
R-GGA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-GGA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-GGA-350054 Notch-HLH transcription pathway
R-GGA-8941856 RUNX3 regulates NOTCH signaling

Gene expression databases

BgeeiENSGALG00000002375 Expressed in 10 organ(s), highest expression level in lung

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 32 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 23 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1NZ70_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1NZ70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: February 13, 2019
This is version 73 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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