UniProtKB - F1NZ70 (F1NZ70_CHICK)
Protein
Neurogenic locus notch homolog protein 1
Gene
NOTCH1
Organism
Gallus gallus (Chicken)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 442 | Calcium 1; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 445 | Calcium 1; via amide nitrogenUniRule annotation | 1 | |
Metal bindingi | 462 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 463 | Calcium 2; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 465 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 479 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 480 | Calcium 2; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 500 | Calcium 3UniRule annotation | 1 | |
Metal bindingi | 501 | Calcium 3; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 503 | Calcium 3UniRule annotation | 1 | |
Metal bindingi | 517 | Calcium 3UniRule annotation | 1 | |
Metal bindingi | 518 | Calcium 3; via carbonyl oxygenUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- chromatin DNA binding Source: Ensembl
- enzyme binding Source: Ensembl
- enzyme inhibitor activity Source: Ensembl
- identical protein binding Source: Ensembl
- Notch binding Source: Ensembl
- signaling receptor activity Source: InterPro
- transcription coactivator activity Source: Ensembl
GO - Biological processi
- aortic valve morphogenesis Source: Ensembl
- apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
- arterial endothelial cell differentiation Source: Ensembl
- atrioventricular node development Source: Ensembl
- auditory receptor cell fate commitment Source: Ensembl
- axon guidance Source: GO_Central
- branching morphogenesis of an epithelial tube Source: Ensembl
- cardiac left ventricle morphogenesis Source: Ensembl
- cardiac muscle cell proliferation Source: Ensembl
- cardiac right atrium morphogenesis Source: Ensembl
- cardiac right ventricle formation Source: Ensembl
- cardiac vascular smooth muscle cell development Source: Ensembl
- cell cycle arrest Source: Ensembl
- cell fate specification Source: Ensembl
- cell migration involved in endocardial cushion formation Source: Ensembl
- cellular response to follicle-stimulating hormone stimulus Source: Ensembl
- cellular response to vascular endothelial growth factor stimulus Source: Ensembl
- collecting duct development Source: Ensembl
- compartment pattern specification Source: Ensembl
- coronary artery morphogenesis Source: Ensembl
- coronary sinus valve morphogenesis Source: Ensembl
- coronary vein morphogenesis Source: Ensembl
- distal tubule development Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- endocardial cell differentiation Source: Ensembl
- endocardium morphogenesis Source: Ensembl
- endoderm development Source: Ensembl
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
- forebrain development Source: Ensembl
- foregut morphogenesis Source: Ensembl
- glial cell differentiation Source: Ensembl
- glomerular mesangial cell development Source: Ensembl
- growth involved in heart morphogenesis Source: Ensembl
- heart looping Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- humoral immune response Source: Ensembl
- inflammatory response to antigenic stimulus Source: Ensembl
- keratinocyte differentiation Source: Ensembl
- left/right axis specification Source: Ensembl
- liver development Source: Ensembl
- lung development Source: Ensembl
- mesenchymal cell development Source: Ensembl
- mitral valve formation Source: Ensembl
- negative regulation of anoikis Source: Ensembl
- negative regulation of biomineral tissue development Source: Ensembl
- negative regulation of BMP signaling pathway Source: Ensembl
- negative regulation of calcium ion-dependent exocytosis Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cardiac muscle hypertrophy Source: Ensembl
- negative regulation of cell adhesion molecule production Source: Ensembl
- negative regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
- negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
- negative regulation of cell proliferation involved in heart valve morphogenesis Source: Ensembl
- negative regulation of cell-substrate adhesion Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: Ensembl
- negative regulation of endothelial cell chemotaxis Source: Ensembl
- negative regulation of extracellular matrix constituent secretion Source: Ensembl
- negative regulation of glial cell proliferation Source: Ensembl
- negative regulation of growth rate Source: Ensembl
- negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
- negative regulation of myoblast differentiation Source: Ensembl
- negative regulation of myotube differentiation Source: Ensembl
- negative regulation of oligodendrocyte differentiation Source: Ensembl
- negative regulation of ossification Source: Ensembl
- negative regulation of osteoblast differentiation Source: Ensembl
- negative regulation of photoreceptor cell differentiation Source: Ensembl
- negative regulation of pro-B cell differentiation Source: Ensembl
- negative regulation of stem cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural tube development Source: Ensembl
- neuronal stem cell population maintenance Source: Ensembl
- Notch signaling pathway Source: GO_Central
- Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Source: Ensembl
- outflow tract morphogenesis Source: Ensembl
- pericardium morphogenesis Source: Ensembl
- positive regulation of aorta morphogenesis Source: Ensembl
- positive regulation of apoptotic process involved in morphogenesis Source: Ensembl
- positive regulation of astrocyte differentiation Source: Ensembl
- positive regulation of BMP signaling pathway Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of keratinocyte differentiation Source: Ensembl
- positive regulation of Notch signaling pathway Source: Ensembl
- positive regulation of Ras protein signal transduction Source: Ensembl
- positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
- positive regulation of transcription of Notch receptor target Source: Ensembl
- positive regulation of viral genome replication Source: Ensembl
- prostate gland epithelium morphogenesis Source: Ensembl
- pulmonary valve morphogenesis Source: Ensembl
- regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
- regulation of extracellular matrix assembly Source: Ensembl
- regulation of somitogenesis Source: Ensembl
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
- response to muramyl dipeptide Source: Ensembl
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
- skeletal muscle cell differentiation Source: Ensembl
- somatic stem cell division Source: Ensembl
- sprouting angiogenesis Source: Ensembl
- tube formation Source: Ensembl
- vasculogenesis involved in coronary vascular morphogenesis Source: Ensembl
- venous endothelial cell differentiation Source: Ensembl
- ventricular septum morphogenesis Source: Ensembl
- ventricular trabecula myocardium morphogenesis Source: Ensembl
Keywordsi
Molecular function | ActivatorARBA annotation, Developmental proteinARBA annotation |
Biological process | AngiogenesisARBA annotation, DifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation |
Ligand | CalciumUniRule annotation, Metal-bindingUniRule annotation |
Enzyme and pathway databases
Reactomei | R-GGA-1912420, Pre-NOTCH Processing in Golgi R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-GGA-2197563, NOTCH2 intracellular domain regulates transcription R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-GGA-350054, Notch-HLH transcription pathway R-GGA-8941856, RUNX3 regulates NOTCH signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic locus notch homolog protein 1ARBA annotationAlternative name(s): Notch 1 extracellular truncationARBA annotation Notch 1 intracellular domainARBA annotation |
Gene namesi | Name:NOTCH1Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Nucleus
- Nucleus ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- adherens junction Source: Ensembl
- cell surface Source: GO_Central
- cytoplasmic vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- MAML1-RBP-Jkappa- ICN1 complex Source: Ensembl
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1744 – 1765 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Membrane, NucleusARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 58 ↔ 67 | PROSITE-ProRule annotation | ||
Disulfide bondi | 99 ↔ 108 | PROSITE-ProRule annotation | ||
Disulfide bondi | 139 ↔ 148 | PROSITE-ProRule annotation | ||
Disulfide bondi | 176 ↔ 185 | PROSITE-ProRule annotation | ||
Disulfide bondi | 216 ↔ 225 | PROSITE-ProRule annotation | ||
Disulfide bondi | 255 ↔ 264 | PROSITE-ProRule annotation | ||
Disulfide bondi | 293 ↔ 302 | PROSITE-ProRule annotation | ||
Disulfide bondi | 333 ↔ 342 | PROSITE-ProRule annotation | ||
Disulfide bondi | 371 ↔ 380 | PROSITE-ProRule annotation | ||
Disulfide bondi | 391 ↔ 408 | PROSITE-ProRule annotation | ||
Disulfide bondi | 410 ↔ 419 | PROSITE-ProRule annotation | ||
Disulfide bondi | 426 ↔ 439 | UniRule annotation | ||
Disulfide bondi | 433 ↔ 448 | UniRule annotation | ||
Disulfide bondi | 450 ↔ 459 | UniRule annotation | ||
Disulfide bondi | 466 ↔ 477 | UniRule annotation | ||
Disulfide bondi | 471 ↔ 486 | UniRule annotation | ||
Disulfide bondi | 488 ↔ 497 | UniRule annotation | ||
Disulfide bondi | 504 ↔ 515 | UniRule annotation | ||
Disulfide bondi | 509 ↔ 524 | UniRule annotation | ||
Disulfide bondi | 526 ↔ 535 | UniRule annotation | ||
Disulfide bondi | 564 ↔ 573 | PROSITE-ProRule annotation | ||
Disulfide bondi | 580 ↔ 590 | PROSITE-ProRule annotation | ||
Disulfide bondi | 601 ↔ 610 | PROSITE-ProRule annotation | ||
Disulfide bondi | 639 ↔ 648 | PROSITE-ProRule annotation | ||
Disulfide bondi | 655 ↔ 665 | PROSITE-ProRule annotation | ||
Disulfide bondi | 676 ↔ 685 | PROSITE-ProRule annotation | ||
Disulfide bondi | 714 ↔ 723 | PROSITE-ProRule annotation | ||
Disulfide bondi | 730 ↔ 740 | PROSITE-ProRule annotation | ||
Disulfide bondi | 751 ↔ 760 | PROSITE-ProRule annotation | ||
Disulfide bondi | 789 ↔ 798 | PROSITE-ProRule annotation | ||
Disulfide bondi | 827 ↔ 836 | PROSITE-ProRule annotation | ||
Disulfide bondi | 848 ↔ 865 | PROSITE-ProRule annotation | ||
Disulfide bondi | 867 ↔ 876 | PROSITE-ProRule annotation | ||
Disulfide bondi | 905 ↔ 914 | PROSITE-ProRule annotation | ||
Disulfide bondi | 943 ↔ 952 | PROSITE-ProRule annotation | ||
Disulfide bondi | 981 ↔ 990 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1019 ↔ 1028 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1057 ↔ 1066 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1095 ↔ 1104 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1122 ↔ 1132 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1143 ↔ 1152 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1181 ↔ 1190 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1219 ↔ 1228 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1265 ↔ 1274 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1286 ↔ 1303 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1305 ↔ 1314 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1346 ↔ 1355 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1384 ↔ 1393 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1426 ↔ 1435 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PaxDbi | F1NZ70 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000002375, Expressed in lung and 13 other tissues |
ExpressionAtlasi | F1NZ70, baseline and differential |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- Notch binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000003746 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 68 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 69 – 109 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 112 – 149 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 150 – 186 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 188 – 226 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 228 – 265 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 267 – 303 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 305 – 343 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 345 – 381 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 382 – 420 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 422 – 460 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 462 – 498 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 500 – 536 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 538 – 574 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 576 – 611 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 613 – 649 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 651 – 686 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 688 – 724 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 726 – 761 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 763 – 799 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 801 – 837 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 839 – 877 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 879 – 915 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 917 – 953 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 955 – 991 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 993 – 1029 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1031 – 1067 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1069 – 1105 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1118 – 1153 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 1155 – 1191 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1193 – 1229 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1231 – 1275 | EGF-likeInterPro annotationAdd BLAST | 45 | |
Domaini | 1277 – 1315 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 1317 – 1356 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 1358 – 1394 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1397 – 1436 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 1459 – 1499 | LNRInterPro annotationAdd BLAST | 41 | |
Domaini | 1500 – 1541 | LNRInterPro annotationAdd BLAST | 42 | |
Domaini | 1542 – 1581 | LNRInterPro annotationAdd BLAST | 40 | |
Domaini | 1883 – 2123 | ANK_REP_REGIONInterPro annotationAdd BLAST | 241 | |
Repeati | 1937 – 1969 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 2004 – 2036 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 2037 – 2069 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 2070 – 2102 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1788 – 1822 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 2160 – 2196 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 2386 – 2455 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 2484 – 2561 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2179 – 2196 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2406 – 2455 | PolarSequence analysisAdd BLAST | 50 | |
Compositional biasi | 2484 – 2512 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 2520 – 2554 | PolarSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the NOTCH family.ARBA annotation
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000157157 |
HOGENOMi | CLU_000576_0_0_1 |
InParanoidi | F1NZ70 |
OMAi | NEGSCLD |
OrthoDBi | 7525at2759 |
TreeFami | TF351641 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022362, Notch_1 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF11936, DUF3454, 1 hit PF00008, EGF, 25 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT PR01984, NOTCH1 |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 32 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 23 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 9 hits PS50258, LNR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1NZ70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRCSAAHPR GGVHCPGLCA VPDALLLFPG VRCTQLAESC LNGGKCETFL
60 70 80 90 100
NGTEVCQCSS AHMGERCQLP NPCLSSPCKN AGTCIPLLRG STADYTCVCR
110 120 130 140 150
LGFTDELCLT PLDNACLNNP CRNGGTCDLV TLSEYKCRCP PGWSGKTCQQ
160 170 180 190 200
ADPCASNPCA NGGQCVPFEA HYICRCTAGF HGANCKQDVN ECNISPPVCK
210 220 230 240 250
NGGSCTNEVG TYQCSCKPAY TGQNCEHLYV PCNPSPCQNG GTCRQTGDTT
260 270 280 290 300
YDCTCLPGFT GQNCEENIDD CPGNNCRNGG TCVDGVNTYN CQCPPEWTGQ
310 320 330 340 350
YCTEDVDECQ LMPNACQNGG TCHNNHGGYN CVCVNGWTGE DCSENIDDCA
360 370 380 390 400
MAACFQGATC HDRVASFYCE CPHGRTGLLC HLDDACISNP CNEGSNCDTN
410 420 430 440 450
PVNGKAICTC PSGYMGPACN QDVDECSLGA NPCEHAGKCI NTQGSFQCQC
460 470 480 490 500
LQGYSGPRCE IDVNECLSNP CQNDATCLDQ IGEFQCICMP GYEGVYCEIN
510 520 530 540 550
TDECASSPCL HNGNCLDKIN EFHCECPTGF NGHLCQFDID ECASTPCKNG
560 570 580 590 600
AKCVDGPNTY SCECTEGFSG VHCEIDIDEC NPDPCHYGTC KDSIAAFTCL
610 620 630 640 650
CQPGYTGHRC DININECQSQ PCRNGGTCQD RDNAYNCLCL KGTTGPNCEI
660 670 680 690 700
NLDDCASNPC DYGKCIDKIN GYECTCEPGY TGRMCNINID ECASNPCHNG
710 720 730 740 750
GTCKDGINGF TCLCPEGFHD PKCLSEVNEC NSNPCIHGRC HDGLNGYRCD
760 770 780 790 800
CDPGWSGTNC DINNNECESN PCMNGGTCKD MTSGYICTCR EGFSGPNCQT
810 820 830 840 850
NINECASNPC LNQGTCIDDV AGYTCNCLLP YTGATCEDVL APCAGGPCKN
860 870 880 890 900
GGECRESEDY KRFSCSCPPG WQGQTCEIDI NECVKSPCRN GATCQNTNGS
910 920 930 940 950
YRCLCRVGFA GRNCDTDIDD CQPNPCHNGG SCSDGIGTFF CECLAGFRGL
960 970 980 990 1000
KCEEDINECA SNPCKNGANC TDCVNSYTCT CPSGFSGIHC ENNTPDCTES
1010 1020 1030 1040 1050
SCFNGGTCVD GINTFTCLCP SGFTGSYCEH NINECDSKPC LNGGTCQDSY
1060 1070 1080 1090 1100
GTYKCTCPQG YTGLNCQNLV RWCDSSPCKN GGKCWQTNNL YRCECNSGWT
1110 1120 1130 1140 1150
GLYCDVPSVS CEVAAKQQGI DVAHLCRNSG LCVDSGNTHF CRCQAGYTGS
1160 1170 1180 1190 1200
YCEEQVDECS PNPCQNGATC TDYLGGYSCE CVAGYHGVNC SEEINECLSH
1210 1220 1230 1240 1250
PCQNGGTCID LINTYKCSCP RGTQGVHCEI NVDDCSPFFD PVTLGPKCFN
1260 1270 1280 1290 1300
NGKCTDRVGG YSCICPPGFV GERCEGDVNE CLSNPCDARG TQNCVQRVND
1310 1320 1330 1340 1350
YKCECRPGYA GRRCDTVVDG CKGKPCRNGG TCAVASNTGR GFICKCPPGF
1360 1370 1380 1390 1400
VGATCENDSH TCGTLHCLNG GTCISMHKSS KCVCAAAFTG PECQYPASSP
1410 1420 1430 1440 1450
CISNPCYNGG TCEFLSDASP YYHCNCPANF NGLNCHILDF DFQGGFGQDI
1460 1470 1480 1490 1500
IPPKIEEKCE IAVCASYAGN KICDGKCNNH ACGWDGGDCS LNFNDPWKNC
1510 1520 1530 1540 1550
SQSLQCWKYF NDGKCDSQCN NAGCLYDGFD CQKYEGQCNP LYDQYCKDHF
1560 1570 1580 1590 1600
SDGHCDQGCN NFECEWDGLD CANNMPEKLA DGTLVVVVLI TPENLKNNSF
1610 1620 1630 1640 1650
NFLRELSRVL HTNVVFKKNA KGEYMIFPYY GNEEELKKHY IKRSTEDWAD
1660 1670 1680 1690 1700
MSSAVINKVK SSLYSRAGRR QKRELDQMDI RGSIVYLEID NRQCIQSSSQ
1710 1720 1730 1740 1750
CFQSATDVAA FLGALASLGN LNIPYKIEAV KSETAEPARN SQLYPMYVVV
1760 1770 1780 1790 1800
AALVLLAFIG VGVLVSRKRR REHGQLWFPE GFKVTESSKK KRREPLGEDS
1810 1820 1830 1840 1850
VGLKPLKNAS DGTLMDDNQN EWGDEETLDT KKFRFEEQAM LPDTDDQTDH
1860 1870 1880 1890 1900
RQWTQQHLDA ADLRISSMAP TPPQGEIDAD CMDVNVRGPD GFTPLMIASC
1910 1920 1930 1940 1950
SGGGLETGNS EEEDDAPAVI SDFIYQGASL HNQTDRTGET ALHLAARYSR
1960 1970 1980 1990 2000
SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL IRNRATDLDA
2010 2020 2030 2040 2050
RMHDGTTPLI LAARLAVEGM LEDLINCHAD VNAVDDLGKS ALHWAAAVNN
2060 2070 2080 2090 2100
VEAAVVLLKN GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT
2110 2120 2130 2140 2150
DHMDRLPRDI AQERMHHDIV RLLDEYNLVR SPPLHSGPLG APTLSPPLCS
2160 2170 2180 2190 2200
PSSYIGNLKP AVQGKKARKP STKGLSCNGK DSKDLKARRK KSQDGKGCLL
2210 2220 2230 2240 2250
DNSSVLSPVD SLESPHGYLS DVASPPLMTS PFQQSPSMPL NHLPGMPDAH
2260 2270 2280 2290 2300
MSINHLNMAG KQEMALGGSG RMAFEAVPPR LSHLPVSSPS TAMSNAPMNF
2310 2320 2330 2340 2350
SVGGAAGLSG QCDWLSRLQS GMVQNQYGAM RGGMQPGTHQ QAQNLQHGMM
2360 2370 2380 2390 2400
SSLHNGLPST SLSQMMSYQA MPSTRLASQP HLLQNQQMQQ MQQPGMQPQP
2410 2420 2430 2440 2450
GMQPQPGMQQ PQQQPQQQPQ PQQHHNPGSN ASGHMGQNFL GTELSQPDMQ
2460 2470 2480 2490 2500
PVSSSAMAVH TILPQDSQLL PTSLPSSLAQ PMTTTQFLTP PSQHSYSSPL
2510 2520 2530 2540 2550
DNTPSHQLQV PDHPFLTPSP ESPDQWSSSS PHSNVSDWSE GISSPPTSMQ
2560
SQMGHIPEAF K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2ULK6 | A0A3Q2ULK6_CHICK | Neurogenic locus notch homolog prot... | NOTCH1 | 2,551 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000150 Genomic DNA No translation available. |
RefSeqi | NP_001025466.1, NM_001030295.1 |
Genome annotation databases
Ensembli | ENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375 |
GeneIDi | 395655 |
KEGGi | gga:395655 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000150 Genomic DNA No translation available. |
RefSeqi | NP_001025466.1, NM_001030295.1 |
3D structure databases
SMRi | F1NZ70 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000003746 |
Proteomic databases
PaxDbi | F1NZ70 |
Genome annotation databases
Ensembli | ENSGALT00000003754; ENSGALP00000003746; ENSGALG00000002375 |
GeneIDi | 395655 |
KEGGi | gga:395655 |
Organism-specific databases
CTDi | 4851 |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000157157 |
HOGENOMi | CLU_000576_0_0_1 |
InParanoidi | F1NZ70 |
OMAi | NEGSCLD |
OrthoDBi | 7525at2759 |
TreeFami | TF351641 |
Enzyme and pathway databases
Reactomei | R-GGA-1912420, Pre-NOTCH Processing in Golgi R-GGA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-GGA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-GGA-2197563, NOTCH2 intracellular domain regulates transcription R-GGA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-GGA-350054, Notch-HLH transcription pathway R-GGA-8941856, RUNX3 regulates NOTCH signaling |
Gene expression databases
Bgeei | ENSGALG00000002375, Expressed in lung and 13 other tissues |
ExpressionAtlasi | F1NZ70, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022362, Notch_1 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF11936, DUF3454, 1 hit PF00008, EGF, 25 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT PR01984, NOTCH1 |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 32 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 23 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 9 hits PS50258, LNR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1NZ70_CHICK | |
Accessioni | F1NZ70Primary (citable) accession number: F1NZ70 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | November 30, 2016 | |
Last modified: | April 7, 2021 | |
This is version 85 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |