Nuclear receptor subfamily 3 group C member 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• identical protein binding Source: Ensembl
• nuclear receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription coactivator binding Source: Ensembl
• steroid binding Source: InterPro
• steroid hormone receptor activity Source: Ensembl
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• epithelial cell maturation Source: Ensembl
• intracellular steroid hormone receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lung alveolus development Source: Ensembl
• negative regulation of gene expression Source: Ensembl
• ovulation from ovarian follicle Source: Ensembl
• paracrine signaling Source: Ensembl
• progesterone receptor signaling pathway Source: Ensembl
• regulation of epithelial cell proliferation Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ATPase binding Source: Ensembl
• identical protein binding Source: Ensembl
• RNA polymerase II transcription coactivator binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTEVKSKETR APSSARDGAV LLQAPPSRGE AEGIDVALDG LLYPRSSDEE 
        60         70         80         90        100
EEEEENEEEE EEEEEPQQRE EEEEEEEEDR DCPSYRPGGG SLSKDCLDSV 
       110        120        130        140        150
LDTFLAPAAH AAPWSLFGPE VPEVPVAPMS RGPEQKAVDA GPGAPGPSQP 
       160        170        180        190        200
RPGAPLWPGA DSLNVAVKAR PGPEDASENR APGLPGAEER GFPERDAGPG 
       210        220        230        240        250
EGGLAPAAAA SPAAVEPGAG QDYLHVPILP LNSAFLASRT RQLLDVEAAY 
       260        270        280        290        300
DGSAFGPRSS PSVPAADLAE YGYPPPDGKE GPFAYGEFQS ALKIKEEGVG 
       310        320        330        340        350
LPAAPPPFLG AKAAPADFAQ PPRAGQEPSL ECVLYKAEPP LLPGAYGPPA 
       360        370        380        390        400
APDSLPSTSA APPGLYSPLG LNGHHQALGF PAAVLKEGLP QLCPPYLGYV 
       410        420        430        440        450
RPDTETSQSS QYSFESLPQK ICLICGDEAS GCHYGVLTCG SCKVFFKRAM 
       460        470        480        490        500
EGQHNYLCAG RNDCIVDKIR RKNCPACRLR KCCQAGMVLG GRKFKKLNKM 
       510        520        530        540        550
KVVRTLDVAL QQPAVLQDET QSLTQRLSFS PNQEIPFVPP MISVLRGIEP 
       560        570        580        590        600
EVVYAGYDNT KPETPSSLLT SLNHLCERQL LCVVKWSKLL PGFRNLHIDD 
       610        620        630        640        650
QITLIQYSWM SLMVFAMGWR SYKHVSGQML YFAPDLILNE QRMKESSFYS 
       660        670        680        690        700
LCLSMWQLPQ EFVRLQVSQE EFLCMKALLL LNTIPLEGLR SQSQFDEMRT 
       710        720        730        740        750
SYIRELVKAI GLRQKGVVAN SQRFYQLTKL MDSMHDLVKQ LHLFCLNTFL 
       760        770        780 
QSRALSVEFP EMMSEVIAAQ LPKILAGMVK PLLFHKK               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ