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Entry version 64 (17 Jun 2020)
Sequence version 3 (14 Oct 2015)
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Protein

Down syndrome cell adhesion molecule homolog

Gene

DSCAM

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (PubMed:18216854).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Down syndrome cell adhesion molecule homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1621ExtracellularCuratedAdd BLAST1603
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1622 – 1642HelicalSequence analysisAdd BLAST21
Topological domaini1643 – 2034CytoplasmicCuratedAdd BLAST392

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043454319 – 2034Down syndrome cell adhesion molecule homologSequence analysisAdd BLAST2016

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi72 ↔ 128PROSITE-ProRule annotation
Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi171 ↔ 223PROSITE-ProRule annotation
Disulfide bondi272 ↔ 319PROSITE-ProRule annotation
Disulfide bondi361 ↔ 411PROSITE-ProRule annotation
Disulfide bondi454 ↔ 510PROSITE-ProRule annotation
Glycosylationi496N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi513N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi538N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi551 ↔ 601PROSITE-ProRule annotation
Glycosylationi582N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi643 ↔ 695PROSITE-ProRule annotation
Glycosylationi684N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi692N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi736N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi737 ↔ 792PROSITE-ProRule annotation
Glycosylationi774N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi821N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi835 ↔ 891PROSITE-ProRule annotation
Glycosylationi950N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1168N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1186N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1276N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1297N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1333 ↔ 1385PROSITE-ProRule annotation
Glycosylationi1367N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1514N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1NY98

PRoteomics IDEntifications database

More...
PRIDEi
F1NY98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

SDK1, SDK2, DSCAM and DSCAML1 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (PubMed:18216854).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000016138 Expressed in brain and 2 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1NY98 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000025946

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1NY98

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 145Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST107
Domaini151 – 242Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST92
Domaini251 – 321Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST71
Domaini339 – 427Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini433 – 526Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 618Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST89
Domaini622 – 711Ig-like C2-type 7PROSITE-ProRule annotationAdd BLAST90
Domaini716 – 809Ig-like C2-type 8PROSITE-ProRule annotationAdd BLAST94
Domaini813 – 909Ig-like C2-type 9PROSITE-ProRule annotationAdd BLAST97
Domaini911 – 1008Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini1013 – 1112Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1117 – 1213Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini1217 – 1311Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini1311 – 1403Ig-like C2-type 10PROSITE-ProRule annotationAdd BLAST93
Domaini1405 – 1499Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1500 – 1601Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST102

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQJM Eukaryota
ENOG410XQX7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154678

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001038_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1NY98

Database of Orthologous Groups

More...
OrthoDBi
14047at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043204 Basigin-like
IPR033027 DSCAM_chordates
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

The PANTHER Classification System

More...
PANTHERi
PTHR10075 PTHR10075, 1 hit
PTHR10075:SF51 PTHR10075:SF51, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

F1NY98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWMLAVALLH SISHGILTEN FLSHHAFPSL LLSLHFSHPS VFSEDLHASL
60 70 80 90 100
YFVNASLQEV VFASTTGTLV PCPAAGIPPV TLRWYLATGE EIYDVPGIRH
110 120 130 140 150
VHPNGTLQIF PFPPSSFNNL IHDNTYYCTA ENPSGKIRSQ DVHIKAVLRE
160 170 180 190 200
PYTVRVEDQK AMRGNVAVFK CIIPSSVEAY ITVVSWEKDT VSLVSGPRFL
210 220 230 240 250
ITSTGALYIL DVQNEDGLYN YRCITRHRYT GETRQSNSAR LFVSDPANSA
260 270 280 290 300
PSILDGFDHR KAMAGQRVEL PCKASGHPTP KYRWLKDNIP WEPDSRFRQT
310 320 330 340 350
VTGLLIENTR PSDSGNYVCE VWNNYGTAEM IGRLYVKQPL KATISPRKVK
360 370 380 390 400
SSVGSQVSLS CSVTGTEDQE LSWYRNGEII NPGNNVRITG INRENLIMDG
410 420 430 440 450
MAKSDGGAYQ CFVRKDKMSA QDYVQVILED GTPKIISAFS EKVVSPGEPV
460 470 480 490 500
SLMCNVKGTP LPTITWTLDE DPIVKDGSHR ISQIITSEGN VVSYLNISNT
510 520 530 540 550
QVRDGGVYRC TANNSAGVVL YQARINVRGP ASIRPMKNIT AIAGRDTYIH
560 570 580 590 600
CRVIGYPYYS IKWYKNSNLL PFNHRQVAFE NNGTLKLSDV QKEVDEGEYT
610 620 630 640 650
CNVLVQPQLS TSQSVHVTVK VPPFIQPFEF PRFSIGQRVF IPCVVVSGDL
660 670 680 690 700
PITITWQKDG RPIPASLGVT IDNIDFTSSL RISNLSLMHN GNYTCIARND
710 720 730 740 750
AAAVEHQSQL IVRVPPRFVV QPSDQDGIYG KAVILNCSAE GYPVPTIVWK
760 770 780 790 800
YSKGAGVPQF QPIALNGRIQ LLTNGSLLIK HVLEEDSGYY LCKVSNDVGA
810 820 830 840 850
DVSKSMYLTV KIPAMITSYP NTTLATQGQK KEMSCTAHGE KPIIVRWEKE
860 870 880 890 900
DRIINPEMSR YLVSTKEVGD EVISTLQILP TVREDSGFFS CHAINSYGED
910 920 930 940 950
RGIIQLTVQE PPDPPEIEIR EVRARSIALR WTMGFDGNSP ITGYDIECKN
960 970 980 990 1000
KSDSWDSVQR TKDVSPQLNQ ATIIDLHPSS TYNIRMYAKN RIGKSEASNE
1010 1020 1030 1040 1050
LTITTDEAAP DGPPQDVQLE PISSQSIRVT WKAPKKHLQN GIIRGYQIGY
1060 1070 1080 1090 1100
REYSAGGNFQ FNIISIDTTG DSEVYTLNNL KKFTQYGMVV QACNRAGIGP
1110 1120 1130 1140 1150
SSQEIITTTL EDVPSCPPGN VQATATSPET ISISWSTLAK ETLNGILQGF
1160 1170 1180 1190 1200
RVIYWANLLD GELGEIRNVT TTQPSLELDG LEKYTNYSIQ VLAFTRAGDG
1210 1220 1230 1240 1250
VRSEQIFTRT KEDVPGPPAG VKAAASSAST VFVSWLPPLK LNGIIRKYTV
1260 1270 1280 1290 1300
FCSHPYPTVI SEFEASPDSF SYRIPNLSRN RQYSVWVVAV TAAGRGNSSE
1310 1320 1330 1340 1350
IITVEPLAKA PARILTFSGT VTTPWMKDIV LPCKAVGDPA PTVKWMKDSN
1360 1370 1380 1390 1400
GTPSLVMIDG RRSIFSNGSF VIRTVKAEDS GYYSCVASNN WGSDEIILNL
1410 1420 1430 1440 1450
QVQVPPDQPR LTVSKTTSSS ITLSWIPGDN GGSSIRGYIL QYSEDNSEQW
1460 1470 1480 1490 1500
GSFPISPSER SYRLETLKCG TWYKFTLTAQ NGVGPGRISE IIEAKTLGKE
1510 1520 1530 1540 1550
PQFSKEQELF ASINTTRVRL NLIGWNDGGC PITSFTLEYR PFGTTVWTTA
1560 1570 1580 1590 1600
QRTSLSKSYI LYDLQEATWY ELQMRVCNSA GCAEKQAKFA TLNYDGSTIP
1610 1620 1630 1640 1650
PLIKSVVQSE EGLATNEGLK MLVTISCILV GVLLLFVMLL IVRRRRREQR
1660 1670 1680 1690 1700
LKRLRDAKSL AEMLMSKNTR TSDTLNKQQQ TLRMHIDIPR AQLLIEERDT
1710 1720 1730 1740 1750
METIDDRSTV LLTDADFGET SKQKSLTVTH TVHYQSVSQA TGPLVDVSDA
1760 1770 1780 1790 1800
RPGTNPTTRR SAKTGPTARN RYASQWTLNR PHPTISAHTL TTDWRLPTPR
1810 1820 1830 1840 1850
PAGSVDKESD SYSVSPSQDT DRARSSMVST ESASSTYEEL ARAYEHAKME
1860 1870 1880 1890 1900
EQLRHAKFTI TECFISDTSS EQLTAGTNDY TDSLTSSTPS ESGICRFTAS
1910 1920 1930 1940 1950
PPKPQDGGRV MNMAVPKAHR PGDLVHLPPY LRMDFLLNRG AQGASRDLGL
1960 1970 1980 1990 2000
GQACLEPQKS RTLKRPTVLE PIPMEASSTR EAQSWQPGAV ATLPQREGAE
2010 2020 2030
LGQAAKMSSS QESLLDSRGH LKGNNPYAKS YTLV
Length:2,034
Mass (Da):225,021
Last modified:October 14, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C0747DA3E5CF27C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN03000073 Genomic DNA No translation available.
AADN03000437 Genomic DNA No translation available.
AADN03000849 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000025993; ENSGALP00000025946; ENSGALG00000016138

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03000073 Genomic DNA No translation available.
AADN03000437 Genomic DNA No translation available.
AADN03000849 Genomic DNA No translation available.

3D structure databases

SMRiF1NY98
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025946

Proteomic databases

PaxDbiF1NY98
PRIDEiF1NY98

Genome annotation databases

EnsembliENSGALT00000025993; ENSGALP00000025946; ENSGALG00000016138

Phylogenomic databases

eggNOGiENOG410IQJM Eukaryota
ENOG410XQX7 LUCA
GeneTreeiENSGT00940000154678
HOGENOMiCLU_001038_0_1_1
InParanoidiF1NY98
OrthoDBi14047at2759
TreeFamiTF316846

Miscellaneous databases

Protein Ontology

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PROi
PR:F1NY98

Gene expression databases

BgeeiENSGALG00000016138 Expressed in brain and 2 other tissues
ExpressionAtlasiF1NY98 baseline and differential

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR043204 Basigin-like
IPR033027 DSCAM_chordates
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PANTHERiPTHR10075 PTHR10075, 1 hit
PTHR10075:SF51 PTHR10075:SF51, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSCAM_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1NY98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 14, 2015
Last modified: June 17, 2020
This is version 64 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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