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Protein

Aspartate aminotransferase

Gene

GOT1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-GGA-70263 Gluconeogenesis
R-GGA-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferaseUniRule annotation (EC:2.6.1.1UniRule annotation)
Gene namesi
Name:GOT1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000007484 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 404Aminotran_1_2InterPro annotationAdd BLAST374

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
GeneTreeiENSGT00390000014081
OMAiELFKEWT
OrthoDBiEOG091G06G3
TreeFamiTF314089

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F1NTM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASIFAAVP RAPPVAVFKL TADFREDGDS RKVNLGVGAY RTDEGQPWVL
60 70 80 90 100
PVVRKVEQLI AGDGSLNHEY LPILGLPEFR ANASRIALGD DSPAIAQKRV
110 120 130 140 150
GSVQGLGGTG ALRIGAEFLR RWYNGNNNTA TPVYVSSPTW ENHNSVFMDA
160 170 180 190 200
GFKDIRTYRY WDAAKRGLDL QGLLDDMEKA PEFSIFILHA CAHNPTGTDP
210 220 230 240 250
TPDEWKQIAA VMKRRCLFPF FDSAYQGFAS GSLDKDAWAV RYFVSEGFEL
260 270 280 290 300
FCAQSFSKNF GLYNERVGNL SVVGKDEDSV QRVLSQMEKI VRTTWSNPPS
310 320 330 340 350
QGARIVATTL TSPQLFAEWK DNVKTMADRV LLMRSELRSR LESLGTPGTW
360 370 380 390 400
NHITDQIGMF SFTGLNPKQV EYMIKEKHIY LMASGRINMC GLTTKNLDYV
410
AKSIHEAVTK IQ
Length:412
Mass (Da):45,908
Last modified:June 26, 2013 - v2
Checksum:i5C5BEE684F9BA1F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P00504AATC_CHICK
Aspartate aminotransferase, cytopla...
GOT1
412Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000054 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000012100; ENSGALP00000012086; ENSGALG00000007484

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000054 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012100; ENSGALP00000012086; ENSGALG00000007484

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
GeneTreeiENSGT00390000014081
OMAiELFKEWT
OrthoDBiEOG091G06G3
TreeFamiTF314089

Enzyme and pathway databases

ReactomeiR-GGA-70263 Gluconeogenesis
R-GGA-70614 Amino acid synthesis and interconversion (transamination)

Gene expression databases

BgeeiENSGALG00000007484 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1NTM7_CHICK
AccessioniPrimary (citable) accession number: F1NTM7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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