UniProtKB - F1NSI5 (F1NSI5_CHICK)
Protein
Submitted name:
Telomeric repeat-binding factor 2
Gene
TERF2
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- double-stranded telomeric DNA binding Source: GO_Central
- G-rich strand telomeric DNA binding Source: GO_Central
- protein homodimerization activity Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- negative regulation of telomere maintenance via recombination Source: GO_Central
- negative regulation of telomeric D-loop disassembly Source: GO_Central
- protection from non-homologous end joining at telomere Source: GO_Central
- protein localization to chromosome, telomeric region Source: GO_Central
- regulation of telomere maintenance via telomerase Source: GO_Central
- RNA-dependent DNA biosynthetic process Source: GOC
- telomeric D-loop disassembly Source: GO_Central
- telomeric loop formation Source: GO_Central
Keywordsi
Biological process | Cell cycleARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Telomeric repeat-binding factor 2Imported |
Gene namesi | Name:TERF2Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear chromosome, telomeric region Source: InterPro
- shelterin complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSGALG00000000657, Expressed in spermatid and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 664 – 717 | HTH myb-typeInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 219 – 286 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 299 – 455 | DisorderedSequence analysisAdd BLAST | 157 | |
Regioni | 518 – 641 | DisorderedSequence analysisAdd BLAST | 124 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 237 – 258 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 402 – 430 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 544 – 571 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 578 – 603 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 614 – 628 | PolarSequence analysisAdd BLAST | 15 |
Phylogenomic databases
GeneTreei | ENSGT00940000158316 |
HOGENOMi | CLU_034265_1_1_1 |
OMAi | TVQESEW |
OrthoDBi | 605826at2759 |
TreeFami | TF333209 |
Family and domain databases
CDDi | cd11654, TRF2_RBM, 1 hit |
Gene3Di | 1.25.40.210, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR013867, Telomere_rpt-bd_fac_dimer_dom IPR036507, Telomere_rpt-bd_fac_dimer_sf IPR030657, TERF2 IPR031902, TERF2_RBM |
PANTHERi | PTHR46833, PTHR46833, 1 hit |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF16772, TERF2_RBM, 1 hit PF08558, TRF, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF63600, SSF63600, 1 hit |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit |
i Sequence
Sequence statusi: Complete.
F1NSI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAKRSRAAM EEQEKTSTRS DDREQAVNRW VLQFYFHQAV AAYRAGRNRD
60 70 80 90 100
FRQLRDVMQA LLVRPLEREP AVAQMLRVMQ FLSRIEEGEN LDCTFDKETE
110 120 130 140 150
LTPLESAIGI LQLIAKEFSV PEKKIELIHK VLKEAAVIVC IKNKEFSKAL
160 170 180 190 200
AVLKRHMEKD TGNQKKRTEL QTIIREKNRA HPIIKDFSYV NFQQYMFQFL
210 220 230 240 250
KTYVDTSEPL LVTMMKSLNS ERAEEPKRSS VTPESPSRTE DQEEAYEPLR
260 270 280 290 300
RVKHSVGTLR RAETAGGVAG APSCPEMAKD PTGAPEHVGT VKDAVRAPCP
310 320 330 340 350
AESTEDSQGA PRCAETARDV MGAPSPSEMT KDLLGAPKCT ETARDVVRAP
360 370 380 390 400
SPAESTKDPV GTPGHAETAR DVARAPSPAE TTKNLPGAPE CADTVKNTVR
410 420 430 440 450
APSPAERRKD LVRAPKRAET ARDVVRAPSP AERVKDTAGA SEPMKSASYP
460 470 480 490 500
TASQPRIAAV KSSKVFSVPV EISEQPAAAA PVHAGVSSRD LERTPFRTVT
510 520 530 540 550
TYGISVLREA FKMLSNSPDS DALFNKLDET DLPSPQQMSP SVSHRTKRRK
560 570 580 590 600
EEKNQGSETL DSPEIPHKSK RLFTISKMIM DQGSQCSKSS ESPDSSQERV
610 620 630 640 650
VSSAYRPVQE LPDQPVSTKR SSQQRWNSSY GEERKDSWSD EDELFTDAAL
660 670 680 690 700
TETSSNNSTV YGSKKQKWTV QESEWIKDGV RKYGEGRWKT ISEKYPFQNR
710
TSVQIKDRYR TMKKLGIA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000558 Genomic DNA No translation available. |
RefSeqi | NP_001258821.1, NM_001271892.1 |
Genome annotation databases
Ensembli | ENSGALT00000000932; ENSGALP00000000930; ENSGALG00000000657 |
GeneIDi | 395598 |
KEGGi | gga:395598 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000558 Genomic DNA No translation available. |
RefSeqi | NP_001258821.1, NM_001271892.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSGALT00000000932; ENSGALP00000000930; ENSGALG00000000657 |
GeneIDi | 395598 |
KEGGi | gga:395598 |
Organism-specific databases
CTDi | 7014 |
Phylogenomic databases
GeneTreei | ENSGT00940000158316 |
HOGENOMi | CLU_034265_1_1_1 |
OMAi | TVQESEW |
OrthoDBi | 605826at2759 |
TreeFami | TF333209 |
Gene expression databases
Bgeei | ENSGALG00000000657, Expressed in spermatid and 14 other tissues |
Family and domain databases
CDDi | cd11654, TRF2_RBM, 1 hit |
Gene3Di | 1.25.40.210, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR013867, Telomere_rpt-bd_fac_dimer_dom IPR036507, Telomere_rpt-bd_fac_dimer_sf IPR030657, TERF2 IPR031902, TERF2_RBM |
PANTHERi | PTHR46833, PTHR46833, 1 hit |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF16772, TERF2_RBM, 1 hit PF08558, TRF, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF63600, SSF63600, 1 hit |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1NSI5_CHICK | |
Accessioni | F1NSI5Primary (citable) accession number: F1NSI5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | December 2, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |