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Entry version 74 (02 Dec 2020)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Telomeric repeat-binding factor 2

Gene

TERF2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycleARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Telomeric repeat-binding factor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TERF2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000000657, Expressed in spermatid and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 717HTH myb-typeInterPro annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni219 – 286DisorderedSequence analysisAdd BLAST68
Regioni299 – 455DisorderedSequence analysisAdd BLAST157
Regioni518 – 641DisorderedSequence analysisAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 258PolyampholyteSequence analysisAdd BLAST22
Compositional biasi402 – 430PolyampholyteSequence analysisAdd BLAST29
Compositional biasi544 – 571PolyampholyteSequence analysisAdd BLAST28
Compositional biasi578 – 603PolarSequence analysisAdd BLAST26
Compositional biasi614 – 628PolarSequence analysisAdd BLAST15

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158316

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_034265_1_1_1

Identification of Orthologs from Complete Genome Data

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OMAi
TVQESEW

Database of Orthologous Groups

More...
OrthoDBi
605826at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333209

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11654, TRF2_RBM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR013867, Telomere_rpt-bd_fac_dimer_dom
IPR036507, Telomere_rpt-bd_fac_dimer_sf
IPR030657, TERF2
IPR031902, TERF2_RBM

The PANTHER Classification System

More...
PANTHERi
PTHR46833, PTHR46833, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF16772, TERF2_RBM, 1 hit
PF08558, TRF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF63600, SSF63600, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294, HTH_MYB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1NSI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAKRSRAAM EEQEKTSTRS DDREQAVNRW VLQFYFHQAV AAYRAGRNRD
60 70 80 90 100
FRQLRDVMQA LLVRPLEREP AVAQMLRVMQ FLSRIEEGEN LDCTFDKETE
110 120 130 140 150
LTPLESAIGI LQLIAKEFSV PEKKIELIHK VLKEAAVIVC IKNKEFSKAL
160 170 180 190 200
AVLKRHMEKD TGNQKKRTEL QTIIREKNRA HPIIKDFSYV NFQQYMFQFL
210 220 230 240 250
KTYVDTSEPL LVTMMKSLNS ERAEEPKRSS VTPESPSRTE DQEEAYEPLR
260 270 280 290 300
RVKHSVGTLR RAETAGGVAG APSCPEMAKD PTGAPEHVGT VKDAVRAPCP
310 320 330 340 350
AESTEDSQGA PRCAETARDV MGAPSPSEMT KDLLGAPKCT ETARDVVRAP
360 370 380 390 400
SPAESTKDPV GTPGHAETAR DVARAPSPAE TTKNLPGAPE CADTVKNTVR
410 420 430 440 450
APSPAERRKD LVRAPKRAET ARDVVRAPSP AERVKDTAGA SEPMKSASYP
460 470 480 490 500
TASQPRIAAV KSSKVFSVPV EISEQPAAAA PVHAGVSSRD LERTPFRTVT
510 520 530 540 550
TYGISVLREA FKMLSNSPDS DALFNKLDET DLPSPQQMSP SVSHRTKRRK
560 570 580 590 600
EEKNQGSETL DSPEIPHKSK RLFTISKMIM DQGSQCSKSS ESPDSSQERV
610 620 630 640 650
VSSAYRPVQE LPDQPVSTKR SSQQRWNSSY GEERKDSWSD EDELFTDAAL
660 670 680 690 700
TETSSNNSTV YGSKKQKWTV QESEWIKDGV RKYGEGRWKT ISEKYPFQNR
710
TSVQIKDRYR TMKKLGIA
Length:718
Mass (Da):80,105
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ED4D5CF8DB71805
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000558 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001258821.1, NM_001271892.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000000932; ENSGALP00000000930; ENSGALG00000000657

Database of genes from NCBI RefSeq genomes

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GeneIDi
395598

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395598

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000558 Genomic DNA No translation available.
RefSeqiNP_001258821.1, NM_001271892.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSGALT00000000932; ENSGALP00000000930; ENSGALG00000000657
GeneIDi395598
KEGGigga:395598

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7014

Phylogenomic databases

GeneTreeiENSGT00940000158316
HOGENOMiCLU_034265_1_1_1
OMAiTVQESEW
OrthoDBi605826at2759
TreeFamiTF333209

Gene expression databases

BgeeiENSGALG00000000657, Expressed in spermatid and 14 other tissues

Family and domain databases

CDDicd11654, TRF2_RBM, 1 hit
Gene3Di1.25.40.210, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR013867, Telomere_rpt-bd_fac_dimer_dom
IPR036507, Telomere_rpt-bd_fac_dimer_sf
IPR030657, TERF2
IPR031902, TERF2_RBM
PANTHERiPTHR46833, PTHR46833, 1 hit
PfamiView protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF16772, TERF2_RBM, 1 hit
PF08558, TRF, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF63600, SSF63600, 1 hit
PROSITEiView protein in PROSITE
PS51294, HTH_MYB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1NSI5_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1NSI5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: December 2, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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