Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase

Gene

POLA1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-GGA-174411 Polymerase switching on the C-strand of the telomere
R-GGA-174430 Telomere C-strand synthesis initiation
R-GGA-68952 DNA replication initiation
R-GGA-68962 Activation of the pre-replicative complex
R-GGA-69091 Polymerase switching
R-GGA-69166 Removal of the Flap Intermediate
R-GGA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLA1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF1NR19

Expressioni

Gene expression databases

BgeeiENSGALG00000016312

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026266

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini397 – 735DNA_pol_B_exo1InterPro annotationAdd BLAST339
Domaini793 – 1251DNA_pol_BInterPro annotationAdd BLAST459
Domaini1291 – 1480zf-DNA_PolInterPro annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili294 – 321Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00550000074891
InParanoidiF1NR19
KOiK02320
OrthoDBiEOG091G00RR
TreeFamiTF103001

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

F1NR19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDAMPESG SFATSRSRRE RKSKRGQQEA LERLKKAKAG EKLKYEVEEF
60 70 80 90 100
TGVYDEIDEE QYSKIVRERQ DDDWIVDDDG IGYVEDGREI FDEDLDDDAL
110 120 130 140 150
GSSKKGKTGK TSTIGKKNVK KSVVAKPNTI KSMFIASAGK KNTDKTVDLS
160 170 180 190 200
KDDLLGDILQ DLNAETVQLS PPPILVLKRK RSAGMPLNPF SVQRQSPKVI
210 220 230 240 250
TPVSKKAPVQ LRKEARPPAS FHPKHPNYTA KSVTASEENE DTKYVQKATE
260 270 280 290 300
NGRVVKTKEE KAIEDDDQGM MDFDDEDFDE PMEAELMGAV PETAETLKRD
310 320 330 340 350
KEVEKKEMEQ LESKKKEASA LSHSLPDISC WDKVEEDEAD LVATDVQLDP
360 370 380 390 400
NLLPLVNGEN DDQVLRFYWL DAYEDQYSQP GVVFLFGKVW IESANTYVSC
410 420 430 440 450
CVTVKNIERT VYLLPRETEM DLSSGKETET PVTIMNVFKE FNDCISPKYK
460 470 480 490 500
IMKFKSKKVE KYYAFEIPDV PAKSEYLEVK YSAEYPRLPQ DLKGETFSHA
510 520 530 540 550
FGTNTSSLEL LLMSRKIKGP CWLEIKNPQP SNQSVSWCKV EAVAMKPGLV
560 570 580 590 600
NVVKDLPPPP PLVVMSFSMK TIQNPKTHQN EIVAMAALIH QKFPLDKAPP
610 620 630 640 650
QPPFQTHFCA VSKPNDCIFP YDFKEEIKKK NAKIEIAATE RTLLGFFLAK
660 670 680 690 700
IHKIDPDVVV GHNIYGFDLE VLLQRINVCK VPHWSKIGRL RRSNMPKLGG
710 720 730 740 750
RGGFGERNAA CGRMICDVEI SAKELIRCKS YHLSELVHQI LKTERVTILP
760 770 780 790 800
EEIRNLYSDS PHLLFMLENT WTDAKFILQI MCELNVLPLA LQITNISGNV
810 820 830 840 850
MSRTMMGGRS ERNEFLLLHA FYEKDYIVPD KQVFKKPLQK LVDEDEDFED
860 870 880 890 900
QNKSKIGKKK AAYAGGLVLD PKVGFYDKFI LLLDFNSLYP SIIQEFNICF
910 920 930 940 950
TTVQRLSSEA QKRAEVEEEE EIPELPDPSL EMGILPKEIR KLVERRRQVK
960 970 980 990 1000
QLMKQPDLNP DLYLQYDIRQ KALKLTANSM YGCLGFSYSR FYAKPLAALV
1010 1020 1030 1040 1050
THKGREILMH TKEMVQKMNL EVIYGDTDSI MINTNSTNLD EVFKLGNKIK
1060 1070 1080 1090 1100
SEVNKLYKLL EIDIDGVFKS LLLLKKKKYA ALTVEPTGDG KYVTKQELKG
1110 1120 1130 1140 1150
LDIVRRDWCD LAKETGNYVI GQILSDQPRD IIVENIQRRL IEIGENVING
1160 1170 1180 1190 1200
QIPVNQFEIN KALTKDPQDY PDKKSLPHVH VAMWINSQGG RKVKAGDTVS
1210 1220 1230 1240 1250
YIICQDGSNL SASQRAYAPE QLQKQDNLTI DTQYYLSQQI HPVVARICEP
1260 1270 1280 1290 1300
IEGIDSVLIA TWLGLDPSQF RVHHHYHKDE ENDALVGGPA QLTDEEKYRD
1310 1320 1330 1340 1350
CERFKFCCLK CGTENIYDNV FDCSGRFIEP SLQRCSKSEC EEPPFNHVVQ
1360 1370 1380 1390 1400
MNNKLLLDIR RYLKKYYNGW LICEDPTCQN RTRRLPLSFS RSGPICQACR
1410 1420 1430 1440 1450
KAILRPEYSD KALYTQLCFY RYIFDVEYAT DKVITEEDRE FVRRKPLRKE
1460 1470 1480 1490
VSEAYRKLKS TVDKCLSLSS YSEVNLGKLF SVSMGRSVGE PSSERQ
Length:1,496
Mass (Da):170,898
Last modified:November 30, 2016 - v3
Checksum:i2F87C805E633C126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000314 Genomic DNA No translation available.
RefSeqiXP_015158157.1, XM_015302671.1
UniGeneiGga.12097

Genome annotation databases

EnsembliENSGALT00000026316; ENSGALP00000026266; ENSGALG00000016312
GeneIDi418593
KEGGigga:418593

Similar proteinsi

Entry informationi

Entry nameiF1NR19_CHICK
AccessioniPrimary (citable) accession number: F1NR19
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: April 25, 2018
This is version 60 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health