UniProtKB - F1NMS0 (F1NMS0_CHICK)
Protein
RAC-PK-alpha
Gene
AKT1
Organism
Gallus gallus (Chicken)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- glucose metabolic process Source: UniProtKB-KW
- glycogen biosynthetic process Source: UniProtKB-KW
- protein kinase B signaling Source: InterPro
- response to growth hormone Source: AgBase
- response to insulin-like growth factor stimulus Source: AgBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Biological process | Carbohydrate metabolism, Glucose metabolismARBA annotation, Glycogen biosynthesisARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RAC-PK-alphaARBA annotation (EC:2.7.11.1ARBA annotation)Alternative name(s): RAC-alpha serine/threonine-protein kinaseARBA annotation |
Gene namesi | Name:AKT1Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Expressioni
Gene expression databases
Bgeei | ENSGALG00000011620, Expressed in spleen and 14 other tissues |
ExpressionAtlasi | F1NMS0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 93 | PHInterPro annotationAdd BLAST | 93 | |
Domaini | 135 – 393 | Protein kinaseInterPro annotationAdd BLAST | 259 | |
Domaini | 394 – 465 | AGC-kinase C-terminalInterPro annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 124 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 435 – 465 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 81 – 101 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0690, Eukaryota |
GeneTreei | ENSGT00940000158752 |
HOGENOMi | CLU_000288_11_0_1 |
InParanoidi | F1NMS0 |
TreeFami | TF102004 |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05594, STKc_PKB_alpha, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034676, Akt1 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039027, RAC_alpha IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF200, PTHR24351:SF200, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1NMS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GEYIKTWRPR YFLLKNDGTF IGYKERPQDV DQRESPLNNF SVAQCQLMKT
60 70 80 90 100
ERPKPNTFII RCLQWTTVIE RTFHVETPEE REEWTKAIQT VADSLKKQEE
110 120 130 140 150
EMMDFRSGSP SDNSGAEEME VSMTKPKHKV TMNEFEYLKL LGKGTFGKVI
160 170 180 190 200
LVKEKATGRY YAMKILKKEV IVAKDEVAHT LTENRVLQNS RHPFLTALKY
210 220 230 240 250
SFQTHDRLCF VMEYANGGEL FFHLSRERVF SEDRARFYGA EIVSALDYLH
260 270 280 290 300
SEKNVVYRDL KLENLMLDKD GHIKITDFGL CKEGIKDGAT MKTFCGTPEY
310 320 330 340 350
LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE KLFELILMEE
360 370 380 390 400
IRFPRTLSPE AKSLLSGLLK KDPKQRLGGG PDDAKEIMQH KFFAGIVWQD
410 420 430 440 450
VYEKKLVPPF KPQVTSETDT RYFDEEFTAQ MITITPPDQD DSMDCVDNER
460
RPHFPQFSYS ASGTA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2U4X3 | A0A3Q2U4X3_CHICK | RAC-PK-alpha | AKT1 | 480 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000303 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSGALT00000037443; ENSGALP00000036651; ENSGALG00000011620 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000303 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000036651 |
Proteomic databases
PaxDbi | F1NMS0 |
Genome annotation databases
Ensembli | ENSGALT00000037443; ENSGALP00000036651; ENSGALG00000011620 |
Phylogenomic databases
eggNOGi | KOG0690, Eukaryota |
GeneTreei | ENSGT00940000158752 |
HOGENOMi | CLU_000288_11_0_1 |
InParanoidi | F1NMS0 |
TreeFami | TF102004 |
Gene expression databases
Bgeei | ENSGALG00000011620, Expressed in spleen and 14 other tissues |
ExpressionAtlasi | F1NMS0, baseline and differential |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05594, STKc_PKB_alpha, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034676, Akt1 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039027, RAC_alpha IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF200, PTHR24351:SF200, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1NMS0_CHICK | |
Accessioni | F1NMS0Primary (citable) accession number: F1NMS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |