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UniProtKB - F1ND22 (F1ND22_CHICK)
Protein
IF rod domain-containing protein
Gene
NEFH
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- protein kinase binding Source: Ensembl
- structural constituent of cytoskeleton Source: GO_Central
- structural constituent of postsynaptic intermediate filament cytoskeleton Source: GO_Central
GO - Biological processi
- axon development Source: GO_Central
- cellular response to leukemia inhibitory factor Source: Ensembl
- intermediate filament bundle assembly Source: GO_Central
- microtubule cytoskeleton organization Source: Ensembl
- neurofilament bundle assembly Source: Ensembl
- neurofilament cytoskeleton organization Source: Ensembl
- peripheral nervous system neuron axonogenesis Source: Ensembl
- regulation of organelle transport along microtubule Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: IF rod domain-containing proteinInterPro annotation |
Gene namesi | Name:NEFHImported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- neurofilament Source: GO_Central
- postsynaptic intermediate filament cytoskeleton Source: Ensembl
Other locations
- axon Source: GO_Central
- neurofibrillary tangle Source: Ensembl
- postsynaptic density Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSGALG00000008085, Expressed in cerebellum and 4 other tissues |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000013107 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 384 | IF rodInterPro annotationAdd BLAST | 311 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 70 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 303 – 325 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 429 – 947 | DisorderedSequence analysisAdd BLAST | 519 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 78 – 112 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 148 – 189 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 194 – 214 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 328 – 355 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 308 – 325 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 433 – 466 | Acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 467 – 778 | Basic and acidic residuesSequence analysisAdd BLAST | 312 | |
Compositional biasi | 793 – 838 | Basic and acidic residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 853 – 935 | Basic and acidic residuesSequence analysisAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502QYDU, Eukaryota |
GeneTreei | ENSGT00940000161893 |
HOGENOMi | CLU_012560_7_2_1 |
InParanoidi | F1ND22 |
OMAi | IKMVEKS |
OrthoDBi | 898483at2759 |
TreeFami | TF330122 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR033183, NF-H |
PANTHERi | PTHR23214, PTHR23214, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1ND22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVLEALLV PPGGLRKEPS RLAPRSAASS SGFHSWPGPP GTVGRARGGG
60 70 80 90 100
GGSAAASSTE SLDSLNGEPR ARNEKELLQV LNDRFAGYIE RVRALEQQNR
110 120 130 140 150
ALAAEAAALR QQQAGRSAMG ELYARELRDM RGALVRLGAE KGQLRLERAR
160 170 180 190 200
LAEDVAALRG RLEEEARQRA ELEAAARGLA QRSAQEERAR GPLAERARAL
210 220 230 240 250
REEAELLRKQ HQEEVGALLR GARAELPAEP PASLRPGVTA ALRDLREQLE
260 270 280 290 300
GTAARSTLQA EEWFRVRLDK LSEVAKVNTD AMRVAQEEIS EYRRQLQSKT
310 320 330 340 350
TELEALKGTQ ESLERQRQDS EERHHADVLS YQETIQQLDN ELRNTKWEMA
360 370 380 390 400
AQLREYQDLL NVKMALDIEI AAYRKLLEGE EYRIETGFGM VSYPEVVPKA
410 420 430 440 450
PSIAANIKVK SEEKIKVVEK SEKETVIVEE QTEEIQVTEE VTEEEEAEKE
460 470 480 490 500
AEEEKAEEEK EEEKAEPEGE EEAKSPEKPE SPTKEEAKSP AVKSPEKPST
510 520 530 540 550
PSKEEAKSPT VKSPEKPSTP SKEEAKSPTV KSPEKPSTPS KEEDKSPAVK
560 570 580 590 600
SPEKPSTPSK EEAKSPAVKS PEKPSTPSKE EAKSPAVKSP EKPAPPSKEE
610 620 630 640 650
AKSPAVKSPE KPPVPSKEEA KSPPVKSPEK PATPLKEEAK TPTVKSPEKP
660 670 680 690 700
PTPTKEETKP PSVKSPEKPP TALKEEAKSP AVKSPEKPAT PSKEEAKSPA
710 720 730 740 750
VKSPEKPSTP PKEEAKTPAV KSPEKPTPPS KEEAKTPAAK SPEKPVSPSK
760 770 780 790 800
EEAKTPTVKS PEKAKSPAKE EAKSPQKEAA PAKEPVPAPP KEPKAPAKEE
810 820 830 840 850
QPKEEKAPPK PAAEGRKDEA PKKDAPAKAE EKPKEKAAAG PEPPAPQVKE
860 870 880 890 900
TKAASKPAEE GKAEKDAQPK PQQEGGKAAV KEPEKPKAEE KVEEPKKTVE
910 920 930 940
EPKKEKVEDP KSKPKDDSKA SKEPPKAEKP PSKEGKAPEP APAVGKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000505 Genomic DNA No translation available. |
RefSeqi | XP_415310.4, XM_415310.5 |
Genome annotation databases
Ensembli | ENSGALT00000013122; ENSGALP00000013107; ENSGALG00000008085 |
GeneIDi | 417020 |
KEGGi | gga:417020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000505 Genomic DNA No translation available. |
RefSeqi | XP_415310.4, XM_415310.5 |
3D structure databases
SMRi | F1ND22 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000013107 |
Genome annotation databases
Ensembli | ENSGALT00000013122; ENSGALP00000013107; ENSGALG00000008085 |
GeneIDi | 417020 |
KEGGi | gga:417020 |
Organism-specific databases
CTDi | 4744 |
Phylogenomic databases
eggNOGi | ENOG502QYDU, Eukaryota |
GeneTreei | ENSGT00940000161893 |
HOGENOMi | CLU_012560_7_2_1 |
InParanoidi | F1ND22 |
OMAi | IKMVEKS |
OrthoDBi | 898483at2759 |
TreeFami | TF330122 |
Gene expression databases
Bgeei | ENSGALG00000008085, Expressed in cerebellum and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR033183, NF-H |
PANTHERi | PTHR23214, PTHR23214, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1ND22_CHICK | |
Accessioni | F1ND22Primary (citable) accession number: F1ND22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | May 25, 2022 | |
This is version 78 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |