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Protein

Mucin-6

Gene

MUC6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.1 Publication

GO - Molecular functioni

  • antigen binding Source: AgBase
  • virion binding Source: AgBase

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-6
Alternative name(s):
Ovomucin, beta-subunit
Gene namesi
Name:MUC6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2741 Gal d Ovomucin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000412756‹1 – 1185Mucin-6Add BLAST›1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 31PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi930N-linked (GlcNAc...) (complex) asparagine1 Publication1

Post-translational modificationi

N-glycosylated with N-acetylglucosamine (6.7%), N-acetylgalactosamine (0.6%), galactose (1.8%), mannose (4.6%), N-acetylneuraminic acid (1.0%) and sulfate-containing glycans (0.7%).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiF1NBL0
PRIDEiF1NBL0

PTM databases

iPTMnetiF1NBL0

Interactioni

Subunit structurei

Multimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032057

Structurei

3D structure databases

ProteinModelPortaliF1NBL0
SMRiF1NBL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 201VWFD 1PROSITE-ProRule annotationAdd BLAST›201
Domaini257 – 312TIL 1Add BLAST56
Domaini351 – 563VWFD 2PROSITE-ProRule annotationAdd BLAST213
Domaini619 – 676TIL 2Add BLAST58
Domaini737 – 782TIL 3Add BLAST46
Domaini822 – 1030VWFD 3PROSITE-ProRule annotationAdd BLAST209

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IR7Z Eukaryota
ENOG4110XSA LUCA
HOGENOMiHOG000170714
HOVERGENiHBG082885
InParanoidiF1NBL0
PhylomeDBiF1NBL0
TreeFamiTF300299

Family and domain databases

InterProiView protein in InterPro
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF264 PTHR11339:SF264, 1 hit
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00094 VWD, 3 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 1 hit
SM00216 VWD, 3 hits
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 3 hits

Sequencei

Sequence statusi: Fragment.

F1NBL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CSTWGGGHFS TFDKYQYDFT GTCNYIFATV CDESSPDFNI QFRRGLDKKI
60 70 80 90 100
ARIIIELGPS VIIVEKDSIS VRSVGVIKLP YASNGIQIAP YGRSVRLVAK
110 120 130 140 150
LMEMELVVMW NNEDYLMVLT EKKYMGKTCG MCGNYDGYEL NDFVSEGKLL
160 170 180 190 200
DTYKFAALQK MDDPSEICLS EEISIPAIPH KKYAVICSQL LNLVSPTCSV
210 220 230 240 250
PKDGFVTRCQ LDMQDCSEPG QKNCTCSTLS EYSRQCAMSH QVVFNWRTEN
260 270 280 290 300
FCSVGKCSAN QIYEECGSPC IKTCSNPEYS CSSHCTYGCF CPEGTVLDDI
310 320 330 340 350
SKNRTCVHLE QCPCTLNGET YAPGDTMKAA CRTCKCTMGQ WNCKELPCPG
360 370 380 390 400
RCSLEGGSFV TTFDSRSYRF HGVCTYILMK SSSLPHNGTL MAIYEKSGYS
410 420 430 440 450
HSETSLSAII YLSTKDKIVI SQNELLTDDD ELKRLPYKSG DITIFKQSSM
460 470 480 490 500
FIQMHTEFGL ELVVQTSPVF QAYVKVSAQF QGRTLGLCGN YNGDTTDDFM
510 520 530 540 550
TSMDITEGTA SLFVDSWRAG NCLPAMERET DPCALSQLNK ISAETHCSIL
560 570 580 590 600
TKKGTVFETC HAVVNPTPFY KRCVYQACNY EETFPYICSA LGSYARTCSS
610 620 630 640 650
MGLILENWRN SMDNCTITCT GNQTFSYNTQ ACERTCLSLS NPTLECHPTD
660 670 680 690 700
IPIEGCNCPK GMYLNHKNEC VRKSHCPCYL EDRKYILPDQ STMTGGITCY
710 720 730 740 750
CVNGRLSCTG KLQNPAESCK APKKYISCSD SLENKYGATC APTCQMLATG
760 770 780 790 800
IECIPTKCES GCVCADGLYE NLDGRCVPPE ECPCEYGGLS YGKGEQIQTE
810 820 830 840 850
CEICTCRKGK WKCVQKSRCS STCNLYGEGH ITTFDGQRFV FDGNCEYILA
860 870 880 890 900
MDGCNVNRPL SSFKIVTENV ICGKSGVTCS RSISIYLGNL TIILRDETYS
910 920 930 940 950
ISGKNLQVKY NVKKNALHLM FDIIIPGKYN MTLIWNKHMN FFIKISRETQ
960 970 980 990 1000
ETICGLCGNY NGNMKDDFET RSKYVASNEL EFVNSWKENP LCGDVYFVVD
1010 1020 1030 1040 1050
PCSKNPYRKA WAEKTCSIIN SQVFSACHNK VNRMPYYEAC VRDSCGCDIG
1060 1070 1080 1090 1100
GDCECMCDAI AVYAMACLDK GICIDWRTPE FCPVYCEYYN SHRKTGSGGA
1110 1120 1130 1140 1150
YSYGSSVNCT WHYRPCNCPN QYYKYVNIEG CYNCSHDEYF DYEKEKCMPC
1160 1170 1180
AMQPTSVTLP TATQPTSPST SSASTVLTET TNPPV
Length:1,185
Mass (Da):132,217
Last modified:May 3, 2011 - v1
Checksum:iAE19DF5A5B290D7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti13 – 16DKYQ → PTRP in BAD22545 (Ref. 2) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN02030346 Genomic DNA No translation available.
AB180913 mRNA Translation: BAD22545.1
UniGeneiGga.20106

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN02030346 Genomic DNA No translation available.
AB180913 mRNA Translation: BAD22545.1
UniGeneiGga.20106

3D structure databases

ProteinModelPortaliF1NBL0
SMRiF1NBL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032057

Protein family/group databases

Allergomei2741 Gal d Ovomucin

PTM databases

iPTMnetiF1NBL0

Proteomic databases

PaxDbiF1NBL0
PRIDEiF1NBL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IR7Z Eukaryota
ENOG4110XSA LUCA
HOGENOMiHOG000170714
HOVERGENiHBG082885
InParanoidiF1NBL0
PhylomeDBiF1NBL0
TreeFamiTF300299

Family and domain databases

InterProiView protein in InterPro
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF264 PTHR11339:SF264, 1 hit
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00094 VWD, 3 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 1 hit
SM00216 VWD, 3 hits
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMUC6_CHICK
AccessioniPrimary (citable) accession number: F1NBL0
Secondary accession number(s): Q6L608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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