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Protein

Mucin-6

Gene

MUC6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • antigen binding Source: AgBase
  • virion binding Source: AgBase

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-6
Alternative name(s):
Ovomucin, beta-subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
2741 Gal d Ovomucin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000412756‹1 – 1185Mucin-6Add BLAST›1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 31PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi223N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi930N-linked (GlcNAc...) (complex) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated with N-acetylglucosamine (6.7%), N-acetylgalactosamine (0.6%), galactose (1.8%), mannose (4.6%), N-acetylneuraminic acid (1.0%) and sulfate-containing glycans (0.7%).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1NBL0

PRoteomics IDEntifications database

More...
PRIDEi
F1NBL0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F1NBL0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000032057

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
F1NBL0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1NBL0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 201VWFD 1PROSITE-ProRule annotationAdd BLAST›201
Domaini257 – 312TIL 1Add BLAST56
Domaini351 – 563VWFD 2PROSITE-ProRule annotationAdd BLAST213
Domaini619 – 676TIL 2Add BLAST58
Domaini737 – 782TIL 3Add BLAST46
Domaini822 – 1030VWFD 3PROSITE-ProRule annotationAdd BLAST209

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7Z Eukaryota
ENOG4110XSA LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170714

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082885

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1NBL0

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F1NBL0

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF264 PTHR11339:SF264, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00094 VWD, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 1 hit
SM00216 VWD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F1NBL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CSTWGGGHFS TFDKYQYDFT GTCNYIFATV CDESSPDFNI QFRRGLDKKI
60 70 80 90 100
ARIIIELGPS VIIVEKDSIS VRSVGVIKLP YASNGIQIAP YGRSVRLVAK
110 120 130 140 150
LMEMELVVMW NNEDYLMVLT EKKYMGKTCG MCGNYDGYEL NDFVSEGKLL
160 170 180 190 200
DTYKFAALQK MDDPSEICLS EEISIPAIPH KKYAVICSQL LNLVSPTCSV
210 220 230 240 250
PKDGFVTRCQ LDMQDCSEPG QKNCTCSTLS EYSRQCAMSH QVVFNWRTEN
260 270 280 290 300
FCSVGKCSAN QIYEECGSPC IKTCSNPEYS CSSHCTYGCF CPEGTVLDDI
310 320 330 340 350
SKNRTCVHLE QCPCTLNGET YAPGDTMKAA CRTCKCTMGQ WNCKELPCPG
360 370 380 390 400
RCSLEGGSFV TTFDSRSYRF HGVCTYILMK SSSLPHNGTL MAIYEKSGYS
410 420 430 440 450
HSETSLSAII YLSTKDKIVI SQNELLTDDD ELKRLPYKSG DITIFKQSSM
460 470 480 490 500
FIQMHTEFGL ELVVQTSPVF QAYVKVSAQF QGRTLGLCGN YNGDTTDDFM
510 520 530 540 550
TSMDITEGTA SLFVDSWRAG NCLPAMERET DPCALSQLNK ISAETHCSIL
560 570 580 590 600
TKKGTVFETC HAVVNPTPFY KRCVYQACNY EETFPYICSA LGSYARTCSS
610 620 630 640 650
MGLILENWRN SMDNCTITCT GNQTFSYNTQ ACERTCLSLS NPTLECHPTD
660 670 680 690 700
IPIEGCNCPK GMYLNHKNEC VRKSHCPCYL EDRKYILPDQ STMTGGITCY
710 720 730 740 750
CVNGRLSCTG KLQNPAESCK APKKYISCSD SLENKYGATC APTCQMLATG
760 770 780 790 800
IECIPTKCES GCVCADGLYE NLDGRCVPPE ECPCEYGGLS YGKGEQIQTE
810 820 830 840 850
CEICTCRKGK WKCVQKSRCS STCNLYGEGH ITTFDGQRFV FDGNCEYILA
860 870 880 890 900
MDGCNVNRPL SSFKIVTENV ICGKSGVTCS RSISIYLGNL TIILRDETYS
910 920 930 940 950
ISGKNLQVKY NVKKNALHLM FDIIIPGKYN MTLIWNKHMN FFIKISRETQ
960 970 980 990 1000
ETICGLCGNY NGNMKDDFET RSKYVASNEL EFVNSWKENP LCGDVYFVVD
1010 1020 1030 1040 1050
PCSKNPYRKA WAEKTCSIIN SQVFSACHNK VNRMPYYEAC VRDSCGCDIG
1060 1070 1080 1090 1100
GDCECMCDAI AVYAMACLDK GICIDWRTPE FCPVYCEYYN SHRKTGSGGA
1110 1120 1130 1140 1150
YSYGSSVNCT WHYRPCNCPN QYYKYVNIEG CYNCSHDEYF DYEKEKCMPC
1160 1170 1180
AMQPTSVTLP TATQPTSPST SSASTVLTET TNPPV
Length:1,185
Mass (Da):132,217
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE19DF5A5B290D7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13 – 16DKYQ → PTRP in BAD22545 (Ref. 2) Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN02030346 Genomic DNA No translation available.
AB180913 mRNA Translation: BAD22545.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.20106

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN02030346 Genomic DNA No translation available.
AB180913 mRNA Translation: BAD22545.1
UniGeneiGga.20106

3D structure databases

ProteinModelPortaliF1NBL0
SMRiF1NBL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032057

Protein family/group databases

Allergomei2741 Gal d Ovomucin

PTM databases

iPTMnetiF1NBL0

Proteomic databases

PaxDbiF1NBL0
PRIDEiF1NBL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IR7Z Eukaryota
ENOG4110XSA LUCA
HOGENOMiHOG000170714
HOVERGENiHBG082885
InParanoidiF1NBL0
OrthoDBi12226at2759
PhylomeDBiF1NBL0
TreeFamiTF300299

Family and domain databases

InterProiView protein in InterPro
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF264 PTHR11339:SF264, 1 hit
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00094 VWD, 3 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 1 hit
SM00216 VWD, 3 hits
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC6_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1NBL0
Secondary accession number(s): Q6L608
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 3, 2011
Last modified: January 16, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
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