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Protein

Lactoylglutathione lyase

Gene

GLO1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 1 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase (GLO1)
  2. no protein annotated in this organism
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-70268 Pyruvate metabolism
UniPathwayi
UPA00619;UER00675

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
Alternative name(s):
Glyoxalase IUniRule annotation
Gene namesi
Name:GLO1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1N9Q2
PRIDEiF1N9Q2

Expressioni

Gene expression databases

BgeeiENSGALG00000010127 Expressed in 11 organ(s), highest expression level in kidney
ExpressionAtlasiF1N9Q2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016450

Structurei

3D structure databases

ProteinModelPortaliF1N9Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 173VOCInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the glyoxalase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IU7X Eukaryota
ENOG4111FDV LUCA
GeneTreeiENSGT00390000009312
InParanoidiF1N9Q2
KOiK01759
OrthoDBiEOG091G0GMY
TreeFamiTF105011

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1N9Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPSGLSDE AAYSACSEPD PSTKDFIFQQ TMLRVKDPKK SLDFYTRVLG
60 70 80 90 100
MTLLQKFDFP PMKFSLYFLG YEDKNDIPKD KAERTSWTFS RKATLELTHN
110 120 130 140 150
WGTENDEKQS YHNGNSDPRG FGHIGIAVPD VNKACKRFEE LGVKFVKKPD
160 170 180
DGKMKGLAFV QDPDGYWIEI LNPKHMVTLT
Length:180
Mass (Da):20,553
Last modified:November 30, 2016 - v3
Checksum:iE4E0E0F710FEE7A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1RZK1A0A1L1RZK1_CHICK
Uncharacterized protein
GLO1
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000139 Genomic DNA No translation available.
RefSeqiXP_419481.1, XM_419481.5
UniGeneiGga.7851

Genome annotation databases

EnsembliENSGALT00000016469; ENSGALP00000016450; ENSGALG00000010127
GeneIDi421428
KEGGigga:421428

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000139 Genomic DNA No translation available.
RefSeqiXP_419481.1, XM_419481.5
UniGeneiGga.7851

3D structure databases

ProteinModelPortaliF1N9Q2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016450

Proteomic databases

PaxDbiF1N9Q2
PRIDEiF1N9Q2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016469; ENSGALP00000016450; ENSGALG00000010127
GeneIDi421428
KEGGigga:421428

Organism-specific databases

CTDi2739

Phylogenomic databases

eggNOGiENOG410IU7X Eukaryota
ENOG4111FDV LUCA
GeneTreeiENSGT00390000009312
InParanoidiF1N9Q2
KOiK01759
OrthoDBiEOG091G0GMY
TreeFamiTF105011

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00675

ReactomeiR-GGA-70268 Pyruvate metabolism

Gene expression databases

BgeeiENSGALG00000010127 Expressed in 11 organ(s), highest expression level in kidney
ExpressionAtlasiF1N9Q2 baseline and differential

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1N9Q2_CHICK
AccessioniPrimary (citable) accession number: F1N9Q2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: October 10, 2018
This is version 52 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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