Forkhead box O3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin DNA binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• mitochondrial transcription factor activity Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antral ovarian follicle growth Source: Ensembl
• brain morphogenesis Source: Ensembl
• cellular response to oxidative stress Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator Source: Ensembl
• extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• glucose homeostasis Source: Ensembl
• initiation of primordial ovarian follicle growth Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• neuronal stem cell population maintenance Source: Ensembl
• oocyte maturation Source: Ensembl
• ovulation from ovarian follicle Source: Ensembl
• positive regulation of autophagy Source: Ensembl
• positive regulation of muscle atrophy Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• regulation of neural precursor cell proliferation Source: Ensembl
• regulation of reactive oxygen species metabolic process Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to fatty acid Source: Ensembl
• response to starvation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAEAPASPAP ISPLEVELDP EFEPQSRPRS CTWPLQRPEL QGSPAKPSGE 
        60         70         80         90        100
AAADSMIPEE EDDEDDEDGG GRAGSAMAIG GGGGGPLGSG LLLEDSARLL 
       110        120        130        140        150
APGGQDPGSG PAPAAGALSG GTQTPLQPQQ PLPPPQPGTA GGSGQPRKCS 
       160        170        180        190        200
SRRNAWGNLS YADLITRAIE SSPDKRLTLS QIYEWMVRCV PYFKDKGDSN 
       210        220        230        240        250
SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG KSGKAPRRRA 
       260        270        280        290        300
VSMDNSNKYT KSRGRAAKKK AALQTAPESA DDSPSQLSKW PGSPTSRSSD 
       310        320        330        340        350
ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDA PLSPMLYSSS 
       360        370        380        390        400
ASLSPSVSKP CTVELPRLTD MAGTMNLNDG LADNLMDDLL DNIALPASQP 
       410        420        430        440        450
SPPGGLMQRS SSFPYTTKGS GLGSPTSSFS SAVFGPSSLN SLRQSPMQTI 
       460        470        480        490        500
QENKPATFSS MSHYGNQTLQ DLLTSDSLSH SDVMMTQSDP LMSQASTAVS 
       510        520        530        540        550
AQNSRRNVML RSDPMMSFAA QPNQGSLVNQ NLLHHQHQTQ GALGGSRALS 
       560        570        580        590        600
NSVSNMGLSD SSSLGSAKHQ QQSPVSQSMQ TLSDSVSGSS LYSTSANLPV 
       610        620        630        640        650
MGHEKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV 
       660        670 
VGLNVGSFTG AKQASSQSWV PG                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ