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Entry version 58 (07 Apr 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Sacsin molecular chaperone

Gene

SACS

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sacsin molecular chaperoneImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SACSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34260, SACS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

AcetylationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N4J2

PRoteomics IDEntifications database

More...
PRIDEi
F1N4J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000001867, Expressed in intercostal muscle and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1N4J2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000002433

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 64Ubiquitin-likeInterPro annotationAdd BLAST59
Domaini4302 – 4380JInterPro annotationAdd BLAST79
Domaini4447 – 4563HEPNInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4243 – 4297DisorderedSequence analysisAdd BLAST55
Regioni4401 – 4425DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4341 – 4361Sequence analysisAdd BLAST21
Coiled coili4505 – 4525Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4247 – 4263PolarSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQPY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000100_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N4J2

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGEVFCY

TreeFam database of animal gene trees

More...
TreeFami
TF331145

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623, DnaJ_domain
IPR036890, HATPase_C_sf
IPR007842, HEPN_dom
IPR036869, J_dom_sf
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05168, HEPN, 1 hit
PF00240, ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00748, HEPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565, SSF46565, 1 hit
SSF54236, SSF54236, 1 hit
SSF55874, SSF55874, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076, DNAJ_2, 1 hit
PS50910, HEPN, 1 hit
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1N4J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDRWLRVTV LPGCAGCRTV AVPASWTVRD VKRRLAAETG FPASEQKLWL
60 70 80 90 100
GGRQLSDWIK IGDLTSQNCH LFVNLQSKGL KGGGRFGQTT PPLVDFLKDI
110 120 130 140 150
LRRYPEGGQI LKELIQNAED AGATEVKFLY DETQYGTQTL WSKDMAQYQG
160 170 180 190 200
PALYVYNNAV FTPEDWHGIQ EIARSRKKDD PLKVGRFGIG FNSVYHITDV
210 220 230 240 250
PCIFSGDQIG MLDPHQTLFG PHESGQCWNL RDDSKEISEL SDQFAPFIGL
260 270 280 290 300
FGSTKETFVK GSFPGTFFRF PLRRQPSQLS GTLYNKQKVL ELFESFQADA
310 320 330 340 350
DTVLLFLKNV QDVSLHVREA DGSEKLVFRV TAREPAAPAP ERPGAVEALG
360 370 380 390 400
AALSDYCERV PSGGVTCVTY PVSIVLEDGD AQGARETSWL VCNSVGGRGL
410 420 430 440 450
SAQLDALADE LRFVPVIGIA TPLSGLAEEH GAAGFSGKAF CFLPLPPGEE
460 470 480 490 500
SRTGLPVHVS GFFGLTDNRR SIKWRELDQW RDPAAVWNEL LVLSVVPRAY
510 520 530 540 550
AALILDAVAR LRAGCSPGLP LSVAGVYGLW PDAAQVKLPW RPALEPLFQE
560 570 580 590 600
LFQHEVLPSL GGHWVPLEQA CFSDLDEGLD YAPAVLRFLQ RSGKEVVRVP
610 620 630 640 650
AHLAAAAQLM ASSAGPLTQV TPAWTRQVLR KVGLGGASAP ERLHLLEFVL
660 670 680 690 700
SDQAYSELLG LELLPLQSGA FLPFSSSACD QDVIYIASEE HPRSLFPGLE
710 720 730 740 750
GRFLLDNLKP HLLAALKEAA QTRGRPCTQL QLLNTDRFAR LIKEVMNTFW
760 770 780 790 800
PGRELIVQWY PCDEDRKHPS VSWLRMVWKH LYVHFSEDLT LFDEMPLIPR
810 820 830 840 850
TPLEEGQTCV ELIRLRAPSL VILDDESEAQ LPEFLADVVQ KLGGIVLKKL
860 870 880 890 900
DASIQHPLIK KYIHLPSPSA VLHIMEKMPL QKLCNQVASL LPTHKDALRK
910 920 930 940 950
FLANLTESSE KEKRIIQELT IFKRINHSSS QGLSSYTRLK GCRVLHPAAT
960 970 980 990 1000
LPAGLRLSIS VVDSSDEATI RLANLLKVEK VRTTSCLKLI LKDIESTFYS
1010 1020 1030 1040 1050
QEEVTHLVLW VLENLSSLKS ENPNVLDWLT PLKFIQLPPG RLVMASELFD
1060 1070 1080 1090 1100
PDIEVLKDLF YDEEEACFPP SAFTSPDILH SLRQIGLKNE ASLKEKDVVQ
1110 1120 1130 1140 1150
VAKKIEALQA SSCPNQDTLL KKARTLLLVL NKNPALLHSC EGKATLKKIK
1160 1170 1180 1190 1200
WVPACKERPP NYPGSLVWKG DLCELCAPPD MCDAAHAILV GSSLPLVESV
1210 1220 1230 1240 1250
HVNLEKALGI LTKPGINAVL KHFKIVVDWY TSKTFSDEDY YQFQHILLEI
1260 1270 1280 1290 1300
YGFMHDHLNE GKDAFRALKF PWVWTGKKFC PLAQAVIKPF HDLDLQPYLH
1310 1320 1330 1340 1350
SVPKTMAKFH QLFKACGSIE ELTADHISMV IQKVYLKSDQ DLSDQESKQN
1360 1370 1380 1390 1400
LHLMLNIIRW LYSNQIPASP NTPVPIHHSK NPSKLIMKPI HECCYCDIKV
1410 1420 1430 1440 1450
DDLNDLLEDS VEPIILVHED IPMKTAEWLK VPCLSTRLIN PENMGFEQSG
1460 1470 1480 1490 1500
QREPLTVRIK NILEEYPSVS DIFKELLQNA DDANATECSF MIDMRRNMDI
1510 1520 1530 1540 1550
RENLLDPGMA ACHGPALWSF NNSQFSDSDF VNITRLGESL KRAEVDKVGK
1560 1570 1580 1590 1600
FGLGFNSVYH ITDIPVIMSR EFMIMFDPNI NHISKHIKDR SNPGIKINWS
1610 1620 1630 1640 1650
KQQKRLRKFP NQFKPFMNVF DCQLPLTVEA PYSYSGTLFR LSFRTQQEAK
1660 1670 1680 1690 1700
VSEVSSTCYN TADIYSLVDE FSLCGHRLII FTQNVTSMYL KYLKIEETNP
1710 1720 1730 1740 1750
SLAQDTIVIK KKPCSTKALT APVISVLKEA AKLMKTCGTS NKKLPAEAPK
1760 1770 1780 1790 1800
SSCILQITVE EFHHVFRRIA DLQSPLFRGP EDDPAALFEM AKVGQSKKPS
1810 1820 1830 1840 1850
DELPQKTVDC TTWLICTCMD TGEALRFSLS ESGRRLGLVP CGAVAVLLAE
1860 1870 1880 1890 1900
VQDQKWAVRP QAGEVFCYLP LRIKTGLPVH INGCFAVTSN RKEIWKTDTK
1910 1920 1930 1940 1950
GRWNTTFMRH VVVKAYLEAL SVLRELAASG ELTDYTYHTV WPDPDLVHDD
1960 1970 1980 1990 2000
FSVICQGFYE DIAHGKGKDL TRVFSDGSMW VSMKNVRFLD DSILKRRDVG
2010 2020 2030 2040 2050
PAAFKIFLKY LKKTGSKNLC AVELPSSVKL GFEEAGCKQI LLENTFSERQ
2060 2070 2080 2090 2100
FFSEVFFPNI QEIEAELRDP LMNFVLNEKV DEFSGILRVT PCIPCSLEGH
2110 2120 2130 2140 2150
PLVLPSRLIH PEGRVAKLFD TKDGRFPYGS TQDYLNPIIL IKLVQLGMAK
2160 2170 2180 2190 2200
DDILWDDMLE RAESVAEINK SDHGAACLRS SILLSLIDEK LKIRDPRAKD
2210 2220 2230 2240 2250
FAATYQTIPF LPFLTKPAGF SLDWKGNSFK PETMFAATDL YIAEHQDIVC
2260 2270 2280 2290 2300
LLQPILNENS HSFRGCGSVP LAVKEFLGLL RKPTVELVVN QLREVAKSVD
2310 2320 2330 2340 2350
DGITLYQENI TNACYKYLHE AMMQNDSTKT AVTEKLKTFS FILVENAYVN
2360 2370 2380 2390 2400
SEKVAFHLNF EAAPYLYQLP NKYKNNFREL FESVGVRQSF TVEDFALVLE
2410 2420 2430 2440 2450
SIAQEKETKQ VTEENFQLCR RIISEGIWSL IREKKQEFCE KNYGHILLPD
2460 2470 2480 2490 2500
TNLKLLPAKS LCYNDCPWIK VKDSTVKYCH ADIPREVAVK LGAVPKRHKA
2510 2520 2530 2540 2550
LERYASNVCF TTLGSEFGQK EKLTSRIKSI LNAYPSEKEM LKELLQNADD
2560 2570 2580 2590 2600
AKATEICFVF DPRQHPVDRI FDDKWAPLQG PALCVYNNQP FTEDDVRGIQ
2610 2620 2630 2640 2650
NLGRGTKEGN PCKTGQYGVG FNSVYHITDC PSFISGNDIL CIFDPHARYA
2660 2670 2680 2690 2700
PGATSVSPGR MFRDLDADFR TQFSDVLDLY LGTHFKLDNC TMFRFPLRNA
2710 2720 2730 2740 2750
EMAKVSEISS VPSSDRMVQN LLDKLRSDGA ELLMFLNHME KISICEIDKA
2760 2770 2780 2790 2800
TGALNVLYSV KGNITDGDRL KRKQFHASVI DSVTKKRQLP DIPVQQVTYT
2810 2820 2830 2840 2850
MDTEDSEGSL TSWLICNRSG FSSMDKVSKS VVSAHKNQDI TLFPRGGVAA
2860 2870 2880 2890 2900
CITHNYKKPH RVFCFLPLSL ETGLPFHVNG HFALDSARRN LWRDDNGVGV
2910 2920 2930 2940 2950
RSDWNSSLMT ALIAPAYVEL LAQLKKRYFS GSDPTLSVLQ STPIHVVKDT
2960 2970 2980 2990 3000
LKKFLSFFPV NRLDLQPDLY CLVKALYSCI HDDMKRLLPV VRAPSIDGSD
3010 3020 3030 3040 3050
LHSAVIITWV NMSTSNKTRP FFDNLLQDEL QHLKNADYNI TTRKTVAENV
3060 3070 3080 3090 3100
YRLKHLLLEI GFNLVYNCDE TANLYHCLVD ANIPVSYVTP ADVRAFLMTF
3110 3120 3130 3140 3150
SSPDTNCHIG KLPCRLQQTN LKLFHSLKLL VDYCFKDTEE SEFEVEGLPL
3160 3170 3180 3190 3200
LITLDSVLQT FDAKRPKFLT TYHELIPSRK DLFMNTLYLK YSNILLNCKV
3210 3220 3230 3240 3250
AKVFDISSFA DLLPSVLPRE YKTKSCTKWK DSFASESWLK NAWHFISESM
3260 3270 3280 3290 3300
NVKEDQEETK PAFDAVMDTL RDWALLPGTK FTVSANQLVV PEGDVLLPLS
3310 3320 3330 3340 3350
LMHIAVFPNA QTDKVFHALM KAGCIQLALN KICSKDSAFV PLLSSHTANI
3360 3370 3380 3390 3400
ESPTSILKAV HYMVQTSTFR TEKLVENDFE ALLMYFNCNL NHLMSQDDIK
3410 3420 3430 3440 3450
ILKSLPCYKS ISGRYMSIAK FGTCYVLTKS IPSAEVEKWT QSSSSAFLEE
3460 3470 3480 3490 3500
KIHLKELYEL LGCVPVDDLE VYLKHLLPKI ENLSYDAKLE HLIYLKNRLS
3510 3520 3530 3540 3550
NVEELSEIKE QLFEKLEGLL IIHDANNRLK QAKHFYDRTV RVFEVMLPEK
3560 3570 3580 3590 3600
LFIPKDFFKK LEQLIKPKNQ VAFMTSWVEF LRNIGLKHIL SQQQLLQFAK
3610 3620 3630 3640 3650
EISVRANTEN WSKETLQNTV DILLHHIFQE RTDLFVGDFL KELSLIPFLC
3660 3670 3680 3690 3700
PERAPAEFIR FHPQYQEVNG TLPLIRFSGA QVNPKFKQCD VLQLLWTSCP
3710 3720 3730 3740 3750
ILPEKATPLS IREQAGSDLG PQEQLEQVLS LLNVNLDPPV DKVINNCRNV
3760 3770 3780 3790 3800
CNITTLDEDM VRTRAKVLRS IYEFLSAEKR EFRFQLRGVA FVMVEDGWKL
3810 3820 3830 3840 3850
LKPEEVVINL EYESDFKPYL YKLPLELGTF HQLFKHLGTE DVISTKQYVE
3860 3870 3880 3890 3900
VLSRIFKNSE GKQLDPNEMR TVKRVVSGLF RSLQNDSVKV RGDLENIRDL
3910 3920 3930 3940 3950
ALYLPSQDGR LVRSSILVFD DAPHYKSRIQ GSIGVQMLVD LSQCYLGKDH
3960 3970 3980 3990 4000
GFHTKLIMLF PQKLRPRLLS SILEEQLDEE TPRVCQFGAL CSLQGRLQLL
4010 4020 4030 4040 4050
LSSEQFIAGL VRIMKHENDN AFLANEEKAI RLCKALREGL KVSCFEKLQT
4060 4070 4080 4090 4100
TLRVKGFNPI PQSRSETFAF LKRFGNAVIL LYIQHSDSKD INFLLALAMT
4110 4120 4130 4140 4150
LKSATDNLIS DTSYLIAMLG CNDIYRISEK LDSLGVKYDS SEPSKLELPM
4160 4170 4180 4190 4200
PGTPIPAEIH YTLLMDPMNV FYPGEYVGYL VDAEGGDIYG SYQPTYTYAI
4210 4220 4230 4240 4250
IVQEVEREDA DNSSFLGKIY QIDIGYSEYK IVSSLDLYKF SRPEESSQSR
4260 4270 4280 4290 4300
DSAPSTPTSP TEFLAPGLRS VPPLFPGREG LKTPSSKHHS PKKLKATSLP
4310 4320 4330 4340 4350
EILKEVTSVV EQAWKLPESE RKKIIRRLYL KWHPDKNPED HDMANEVFKH
4360 4370 4380 4390 4400
LQNEINRLEK QAFLDQNADR ASRRTFPTSA TRFQSEKFSF QRFYTSWNQE
4410 4420 4430 4440 4450
ATSHKSERQQ QNKEKGPPPA GQTYSQRFFV PPTFKTVGNP VEARRWLRQA
4460 4470 4480 4490 4500
RANFSAARND LHKNANEWVC FKCFLSAKLA LIAADYAVRG KSDKDVKPTA
4510 4520 4530 4540 4550
LAQKIEEYSQ QLEGLTNDVH TLEAYGVDSL KTRYPDLLPF PQIPNDRFTS
4560 4570
EVAMRVMECT ACIIIKLENF IQQKV
Length:4,575
Mass (Da):517,643
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E5D5D470589D759
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1M820A0A3Q1M820_BOVIN
Sacsin molecular chaperone
SACS
4,578Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LNN9A0A3Q1LNN9_BOVIN
Sacsin molecular chaperone
SACS
4,431Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000002433; ENSBTAP00000002433; ENSBTAG00000001867

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002433

Proteomic databases

PaxDbiF1N4J2
PRIDEiF1N4J2

Genome annotation databases

EnsembliENSBTAT00000002433; ENSBTAP00000002433; ENSBTAG00000001867

Organism-specific databases

VGNCiVGNC:34260, SACS

Phylogenomic databases

eggNOGiENOG502QQPY, Eukaryota
GeneTreeiENSGT00390000016695
HOGENOMiCLU_000100_0_0_1
InParanoidiF1N4J2
OMAiVGEVFCY
TreeFamiTF331145

Gene expression databases

BgeeiENSBTAG00000001867, Expressed in intercostal muscle and 18 other tissues
ExpressionAtlasiF1N4J2, baseline and differential

Family and domain databases

Gene3Di1.10.287.110, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR001623, DnaJ_domain
IPR036890, HATPase_C_sf
IPR007842, HEPN_dom
IPR036869, J_dom_sf
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF05168, HEPN, 1 hit
PF00240, ubiquitin, 1 hit
SMARTiView protein in SMART
SM00748, HEPN, 1 hit
SUPFAMiSSF46565, SSF46565, 1 hit
SSF54236, SSF54236, 1 hit
SSF55874, SSF55874, 3 hits
PROSITEiView protein in PROSITE
PS50076, DNAJ_2, 1 hit
PS50910, HEPN, 1 hit
PS50053, UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N4J2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N4J2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: April 7, 2021
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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