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Protein
Submitted name:

ATP binding cassette subfamily C member 11

Gene

ABCC11

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi541 – 548ATPPROSITE-ProRule annotation8
Nucleotide bindingi1176 – 1183ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP binding cassette subfamily C member 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:25470 ABCC11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei157 – 178HelicalSequence analysisAdd BLAST22
Transmembranei193 – 220HelicalSequence analysisAdd BLAST28
Transmembranei279 – 307HelicalSequence analysisAdd BLAST29
Transmembranei373 – 396HelicalSequence analysisAdd BLAST24
Transmembranei408 – 432HelicalSequence analysisAdd BLAST25
Transmembranei802 – 826HelicalSequence analysisAdd BLAST25
Transmembranei860 – 883HelicalSequence analysisAdd BLAST24
Transmembranei1042 – 1066HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N4I6

PRoteomics IDEntifications database

More...
PRIDEi
F1N4I6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000010858 Expressed in 5 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1N4I6 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000014417

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1N4I6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 437ABC transmembrane type-1InterPro annotationAdd BLAST280
Domaini496 – 729ABC transporterInterPro annotationAdd BLAST234
Domaini1142 – 1376ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162968

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N4I6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEGVYYG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01TC

TreeFam database of animal gene trees

More...
TreeFami
TF352085

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF168 PTHR24223:SF168, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1N4I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRRRMYWVP RSSGGLVNLG LDVDDDMVSG LSYKTITVED SPWRQQVREP
60 70 80 90 100
EAPGRGKYDA AWKTMIPFRP KPKFPEPQPL DDAGLFSYLT LSWLNPLMVR
110 120 130 140 150
GLRRSLDEDN IPQLSVHDAA DKNAKRLRLL WEEEVSRHGI DKASVLRVML
160 170 180 190 200
RFQRTRLIFD TIVSCCFSIT SVLGPILLMP KILEYAKNPS RDVAYGVGLC
210 220 230 240 250
LALFFTECLK SLSMCSCWVI NQRTGVRFRA AVFSFAFEKL MQFKSLTHIT
260 270 280 290 300
VGEAIGFFTT DVNCLYEGVY YGPLAVLTFL LLISCSITSC LVLGPIALIA
310 320 330 340 350
MLCYLLFLPL QAFLTRKLVE SQKHTSEVSD QRIRMTSEVL TSIKLIKMYT
360 370 380 390 400
WEKPFTKVIK DLRKKETKLL EKCGLIQSLT TVILFLAPSL SAVLLFLTHV
410 420 430 440 450
GLRLKLTISV AFTTVATLGP MRLSVFLTPF AVKGLTNSKS AADRFKKFFL
460 470 480 490 500
QESPVIYVKE LEDPRKPVVL EEATLSWRKT CPGIINGALE LEKNRYTPEG
510 520 530 540 550
MTRAQPPLSG LEPEAQGDTR GPELRKINLV LSKGTMLGVC GNTGSGKSSL
560 570 580 590 600
LSAILGQMHL LEGSVGVHGS LAYVPQQAWI IKGSVRENIL MGSQYDEAWY
610 620 630 640 650
LQVLHCCSLN HDLEILPFGD MTEIGERGLN LSGGQKQRIS LARAVYSDRE
660 670 680 690 700
LYLLDDPLSA VDAHVGKHIF EECFKKVLRR KTVILVTHQL QYLEFCDQII
710 720 730 740 750
LFEDGKICEK GIHSELIQKR GRYAQLIQKM HEKATQGVLQ GVAKTEEDLQ
760 770 780 790 800
LEGQAQTACQ EELLSENADP VLENQLSQKE KMEEGSLKWT VYHHYIQAGG
810 820 830 840 850
GYLICSMIFL LMVMLAFFPV FSFWWLSYWL GQGSGNNSSQ ESNWTTADPG
860 870 880 890 900
DILDNPQLPF YQLVFGLSGL LAILLGICLS LVFTKVMGKA STALHNKLFN
910 920 930 940 950
KSAPLMFAAP YLLQDRVCVG TRARCKGLES LDNLGTGFSR QGASLSLVTR
960 970 980 990 1000
VPQDSSVGPL PRVLEGSGVC LYICVSEKMR ERRVCPTMDN LPRYLRKPLV
1010 1020 1030 1040 1050
LVSAQSLGLS SANGRAGTMV HSIFQLTEHC KGYMHYYLSQ EVALTAALVA
1060 1070 1080 1090 1100
NVWILLISIG VVAWHLSATP FKGSCLDTSP LFQLASNFQA SVRIGSEAEA
1110 1120 1130 1140 1150
CLTAVERILQ YMKFENEMCV PEAPLHIEGA SCPRGWPQHG EITFQDYQMK
1160 1170 1180 1190 1200
YRDNTPIVLN GLSLTIHSQE VVGIVGRTGS GKSSLGVALF RLVEPAGGRI
1210 1220 1230 1240 1250
LIDGVDICSL SLEDLRSKFS VIPQDPVLLS GTIRFNLDPF HRCTDEQIWD
1260 1270 1280 1290 1300
ALKRTFLNKT ISKLPQGLQA EVTENGSNFS VGERQLLCIA RALLRSSKIV
1310 1320 1330 1340 1350
LIDEATASLD LEMDILIQHV IRESFRGCTV LIIAHRVTTI LNCDRILVMG
1360 1370 1380
NGKVVEFDKP EVLQRKPGST FAALLAIASS SMS
Length:1,383
Mass (Da):153,932
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75BEC9D610B8E5EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1B7A9E1B7A9_BOVIN
ATP binding cassette subfamily C me...
ABCC11
752Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DAAA02046330 Genomic DNA No translation available.
DAAA02046331 Genomic DNA No translation available.
DAAA02046332 Genomic DNA No translation available.
DAAA02046333 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000014417; ENSBTAP00000014417; ENSBTAG00000010858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046330 Genomic DNA No translation available.
DAAA02046331 Genomic DNA No translation available.
DAAA02046332 Genomic DNA No translation available.
DAAA02046333 Genomic DNA No translation available.

3D structure databases

SMRiF1N4I6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014417

Proteomic databases

PaxDbiF1N4I6
PRIDEiF1N4I6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014417; ENSBTAP00000014417; ENSBTAG00000010858

Organism-specific databases

VGNCiVGNC:25470 ABCC11

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000162968
InParanoidiF1N4I6
OMAiFEGVYYG
OrthoDBiEOG091G01TC
TreeFamiTF352085

Enzyme and pathway databases

ReactomeiR-BTA-382556 ABC-family proteins mediated transport

Gene expression databases

BgeeiENSBTAG00000010858 Expressed in 5 organ(s), highest expression level in testis
ExpressionAtlasiF1N4I6 baseline

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF168 PTHR24223:SF168, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N4I6_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N4I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: December 5, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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