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Entry version 62 (08 May 2019)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Collagen type IV alpha 5 chain

Gene

COL4A5

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-2214320 Anchoring fibril formation
R-BTA-3000157 Laminin interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type IV alpha 5 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:50084 COL4A5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N474

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000014575 Expressed in 10 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000019400

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1N474

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1308 – 1532Collagen IV NC1InterPro annotationAdd BLAST225

Keywords - Domaini

CollagenSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N474

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLFCDFN

Database of Orthologous Groups

More...
OrthoDBi
63831at2759

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1N474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGEPGSIIM SSLPGPKGNP GYPGPPGIQG PAGPPGIPGP IGPPGPPGLM
60 70 80 90 100
GPPGPPGLPG PKGNMGLNFQ GPKGEKGEQG LQGPPGPPGQ ISEQKRPIDV
110 120 130 140 150
EFQKGDQGLP GDRGPPGPPG IRGPPGPPGG VKGEKGEQGE PGKRGKPGKD
160 170 180 190 200
GENGQPGIPG LPGDPGYPGE PGRDGEKGQK GDTGLPGPPG LVIPRPGTGV
210 220 230 240 250
TVGEKGNIGL PGLPGDKGDR GFPGIQGPPG LPGPPGPAVI GPPGPPGFPG
260 270 280 290 300
ERGQKGDEGP PGISIPGSPG LDGQPGAPGP PGPPGPPGPH IPPSDKICEA
310 320 330 340 350
GPPGPPGSPG DRGLQGEQGM KGDKGDTCFN CIGTGVSGPP GQPGLPGLPG
360 370 380 390 400
PPGSLGFPGQ KGEKGHAGAT GPKGLSGIPG APGAPGFPGP KGEPGDILTF
410 420 430 440 450
PGMKGDKGDL GSPGAPGLPG LPGTPGQDGL PGLPGPKGEP GGMAFKGERG
460 470 480 490 500
PPGNPGLPGL PGNRGPMGPV GFGPPGPVGE KGVQGGAGNP GQPGIPGPKG
510 520 530 540 550
DPGQTITQPG KPGLPGHPGR DGEVGLPGEP GLPGQPGLPG IPGSKGEPGI
560 570 580 590 600
PGIGLPGPPG PKGFPGIPGP PGAPGSPGRI GLEGPSGPPG FPGPKGEPGF
610 620 630 640 650
GLPGPPGPPG LPGFKGILGP KGDRGFPGPQ GPPGQAGLDG LPGPKGDIGP
660 670 680 690 700
NGQPGPIGPP GLPGTGFQGP PGPPGIPGPI GQPGLHGLPG EKGDPGPPGF
710 720 730 740 750
DVSGPPGERG SPGIPGAPGP MGPPGSPGLP GKAGASGFPG AKGEIGMMGP
760 770 780 790 800
PGPPGPLGIP GRSGVPGLKG DDGLQGQPGL PGPAGEKGSK GEPGLPGLPG
810 820 830 840 850
PMDPDLLGSK GEKGDPGLPG IPGVAGPKGY QGLPGDPGQP GLSGQPGLPG
860 870 880 890 900
LAGPKGNPGL PGMPGLTGPP GLKGNMGDMG FPGPQGPKGS FGPPGVPGQP
910 920 930 940 950
GSPGLPGQKG EKGDPGISGI GLPGLPGAKG EPGLPGYPGN PGTKGSMGET
960 970 980 990 1000
GLPGLPGTPG AKGQPGLPGF PGTPGLPGPK GISGPPGNPG LPGEPGPVGG
1010 1020 1030 1040 1050
GGRPGPPGPP GEKGKPGQDG IPGPAGQKGE PGQPGFGIPG PRGLPGLSGQ
1060 1070 1080 1090 1100
KGDEGLPGIP GNPGLPGPKG EPGFHGFPGL QGPPGPPGSP GPALEGPKGS
1110 1120 1130 1140 1150
PGPQGPPGRP GPPGPEGPRG LPGSGAIKGE RGNPGQPGQP GLPGLKGDQG
1160 1170 1180 1190 1200
PPGLQGNPGR PGLNGMKGDP GLPGVPGFPG MKGPSGVPGS TGPEGDPGLI
1210 1220 1230 1240 1250
GPPGPPGLPG PSGQSIVIKG DAGPPGIPGQ PGLKGLQGLP GPQGLPGPIG
1260 1270 1280 1290 1300
PPGDPGRNGL PGFDGAGGRK GDPGLPGQPG TRGLDGPPGP DGLQGPPGPP
1310 1320 1330 1340 1350
GTSSIAHGFL ITRHSQTTDA PQCPQGTIQV YEGFSLLYVQ GNKRAHGQDL
1360 1370 1380 1390 1400
GTAGSCLRRF STMPFMFCNI NNVCNFASRN DYSYWLSTPE PMPMSMEPLK
1410 1420 1430 1440 1450
GQSIQPFISR CAVCEAPAVV IAVHSQTIQI PRCPQGWDSL WIGYSFMMHT
1460 1470 1480 1490 1500
SAGAEGSGQA LASPGSCLEE FRSAPFIECH GRGTCNYYAN SYSFWLATVD
1510 1520 1530
VSDMFSKPQS ETLKAGDLRT RISRCQVCMK RT
Length:1,532
Mass (Da):146,549
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58CE6A15C0E8596A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1M970A0A3Q1M970_BOVIN
Collagen type IV alpha 5 chain
1,538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M0M2A0A3Q1M0M2_BOVIN
Collagen type IV alpha 5 chain
1,535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000019400; ENSBTAP00000019400; ENSBTAG00000014575

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1N474
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019400

Proteomic databases

PaxDbiF1N474

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019400; ENSBTAP00000019400; ENSBTAG00000014575

Organism-specific databases

VGNCiVGNC:50084 COL4A5

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000162034
InParanoidiF1N474
OMAiFLFCDFN
OrthoDBi63831at2759
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-2214320 Anchoring fibril formation
R-BTA-3000157 Laminin interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions

Gene expression databases

BgeeiENSBTAG00000014575 Expressed in 10 organ(s), highest expression level in lung

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 16 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N474_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N474
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: May 8, 2019
This is version 62 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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