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Entry version 58 (12 Aug 2020)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

AT-rich interaction domain 2

Gene

ARID2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT-rich interaction domain 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:26125, ARID2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N463

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000011087, Expressed in spermatocyte and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1N463, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000014719

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini448 – 527RFX-type winged-helixInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni745 – 768DisorderedSequence analysisAdd BLAST24
Regioni886 – 979DisorderedSequence analysisAdd BLAST94
Regioni1187 – 1209DisorderedSequence analysisAdd BLAST23
Regioni1244 – 1266DisorderedSequence analysisAdd BLAST23
Regioni1290 – 1389DisorderedSequence analysisAdd BLAST100
Regioni1500 – 1547DisorderedSequence analysisAdd BLAST48
Regioni1626 – 1651DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi925 – 979PolarSequence analysisAdd BLAST55
Compositional biasi1192 – 1209PolarSequence analysisAdd BLAST18
Compositional biasi1296 – 1311PolarSequence analysisAdd BLAST16
Compositional biasi1318 – 1389PolarSequence analysisAdd BLAST72
Compositional biasi1500 – 1543PolarSequence analysisAdd BLAST44
Compositional biasi1629 – 1651PolarSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003714_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N463

TreeFam database of animal gene trees

More...
TreeFami
TF106406

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR003150, DNA-bd_RFX
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02257, RFX_DNA_binding, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51526, RFX_DBD, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1N463-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHIHLTMNNG FIKSVLNIFY LEKYEKVHHF GEDDDEVPPG NPKPQLPIGA
60 70 80 90 100
IPSSYNYQQH SVSDYLRQSY GLSMDFNSPN DYNKLVLSLL SGLPNEVDFA
110 120 130 140 150
INVCTLLSNE SKHVMQLEKD PKIITLLLAN AGVFDDTLGS FSTVFGEEWK
160 170 180 190 200
EKTDRDFVKF WKDIVDDNEV RDLISDRNKS HEGTSGEWIW ESLFHPPRKL
210 220 230 240 250
GINDIEGQRV LQIAVILRNL SFEEGNVKLL AANRTCLRFL LLSAHSHFIS
260 270 280 290 300
LRQLGLDTLG NIAAELLLDP VDFKTTHLMF HTVTKCLMSR DRFLKMRGME
310 320 330 340 350
ILGNLCKAED NGVLICEYVD QDSYREIICH LTLPDVLLVI STLEVLYMLT
360 370 380 390 400
EMGDVACTKI AKVEKSIDML VCLVSMDIQM FGPDALAAVK LVEHPSSSHQ
410 420 430 440 450
VLSEIRPQAI EQVQTQTHVA SAPASRAVVA QHVAPPPGIV EIDSEKFACQ
460 470 480 490 500
WLNAHFEVNP DCSVSRAEMY SEYLSTCSKL ARGGILTSTG FYKCLRTVFP
510 520 530 540 550
NHTVKRVEDS SNNGQAHIHV VGVKRRAIPL PIQMYYQQQP VSTPVVRVDS
560 570 580 590 600
VPDVSPSPSP AGIPHGPQTV GNHFQRTPVT NQSSSLTATQ MSFPVQGVHT
610 620 630 640 650
VAQTVSRIPP NPSVHTHQQQ NAPVTVIQNK APIPCEVVKA TVIQNSIPQT
660 670 680 690 700
AVPVSIAVGG GAAQSSVVQN HSTGPQPVTV VNSQMLHHPS VIPQQSPLHT
710 720 730 740 750
VVPGQIPSGT PVTVIQQAVP QSHIFGRVQN IPACTSTVSQ GQQLITTSPQ
760 770 780 790 800
PVQTSSQQTS AGSQPQDTVI IAPPQYVTTS TSNIVSATSV QNFQVATGQM
810 820 830 840 850
VTIAGVPSPQ PSRVGFQNIA PKPLPSQQVS STVVQQPIQQ PQQPTQQSVV
860 870 880 890 900
IVSQPAQQGQ TYAPAIHQIV LANPAALPAG QAVQLTGQPN ITPSSSPSPV
910 920 930 940 950
PPTTNQVPTA MSSSSTPQPQ GPPPTVSQML SVKRQQQQQH SPAPPQQVQV
960 970 980 990 1000
QVQQPQQVQM QVQPQQTNAG VGQPASGESS LIKQLLLPKR GPSTPGGKLI
1010 1020 1030 1040 1050
LPAPQIPPPN NARAPSPQVV YQVANNQAAG FGVQGQTPAQ QLLVGQQNVQ
1060 1070 1080 1090 1100
LVQSAMPPTG GVQTVPISNL QILPGPLISN SPATIFQGTS GNQVTITVVP
1110 1120 1130 1140 1150
NTSFATATVS QGNTTQLIAP AGITMSGTQA GVGLQVQTLP ATQASPAGQS
1160 1170 1180 1190 1200
SCTTATPPFK GDKIICQKEE EAKEATGLHV HERKIEVMEN PSCRRGTTNT
1210 1220 1230 1240 1250
SNGDTKENEM QVGSLLNGRK YSDSSLPPSN SGKIQSEANQ CSLISNGPSL
1260 1270 1280 1290 1300
ELGENGASGK QNSEQMDMQD IKSDLKKPLV NGICDFDKGD GSHLSKNIPN
1310 1320 1330 1340 1350
HKTSNHVGNG EISPMEPQGT LDATQQDTAK GDQLERTSNG PILTLGVSPS
1360 1370 1380 1390 1400
VSSIQEASNV ATQQFSGTDL PNGPLASSLN SDVPQQRPSV VVSPHSATSV
1410 1420 1430 1440 1450
IQGHQIVAVP HSGSRVSHSP ALLSDVRSTN GTAECKTVKR PAEDNDRETV
1460 1470 1480 1490 1500
TGIPNKVGVR IVTISDPNNA GCSATMVAVP AGADPSTVAK VAIESAVQQK
1510 1520 1530 1540 1550
QQHPPTYVQN VVPQNTPMTP SPAVQIQSQP NSSQPSPFSA SSQHGDPVRK
1560 1570 1580 1590 1600
PGHNFMCLWQ SCKKWFQTPS QVFYHAATEH GGKDVYPGQC LWEGCEPFQR
1610 1620 1630 1640 1650
QRFSFITHLQ DKHCSKDALL AGLKQDEPGQ AGNQKSSTKQ PAVGGTSSTP
1660 1670 1680 1690 1700
RAQKAIVNHP SAALMALRRG SRNLVFRDFT DEKEGPITKH IRLTAALILK
1710 1720 1730 1740 1750
NIGKYSECGR RLLKRHENNL SVLAISNMEA SSTLAKCLYE LNFTVQSKEQ

EKDSEMLQ
Length:1,758
Mass (Da):189,098
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBE977BCFAA7B55C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1M6C3A0A3Q1M6C3_BOVIN
AT-rich interaction domain 2
ARID2
1,834Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000014719; ENSBTAP00000014719; ENSBTAG00000011087

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014719

Proteomic databases

PaxDbiF1N463

Genome annotation databases

EnsembliENSBTAT00000014719; ENSBTAP00000014719; ENSBTAG00000011087

Organism-specific databases

VGNCiVGNC:26125, ARID2

Phylogenomic databases

eggNOGiKOG2312, Eukaryota
GeneTreeiENSGT00390000016138
HOGENOMiCLU_003714_0_0_1
InParanoidiF1N463
TreeFamiTF106406

Enzyme and pathway databases

ReactomeiR-BTA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Gene expression databases

BgeeiENSBTAG00000011087, Expressed in spermatocyte and 19 other tissues
ExpressionAtlasiF1N463, baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003150, DNA-bd_RFX
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF02257, RFX_DNA_binding, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51526, RFX_DBD, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N463_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N463
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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