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Entry version 68 (02 Jun 2021)
Sequence version 2 (16 Nov 2011)
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Protein
Submitted name:

Ubiquitin conjugating enzyme E2 O

Gene

UBE2O

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin conjugating enzyme E2 OImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBE2OImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:36591, UBE2O

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N3I3

PRoteomics IDEntifications database

More...
PRIDEi
F1N3I3

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F1N3I3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000020115, Expressed in cerebellum and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1N3I3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000026793

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1N3I3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini955 – 1076UBC coreInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni83 – 112DisorderedSequence analysisAdd BLAST30
Regioni401 – 535DisorderedSequence analysisAdd BLAST135
Regioni712 – 772DisorderedSequence analysisAdd BLAST61
Regioni874 – 905DisorderedSequence analysisAdd BLAST32
Regioni1158 – 1249DisorderedSequence analysisAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 29Pro residuesSequence analysisAdd BLAST16
Compositional biasi39 – 53Polar residuesSequence analysisAdd BLAST15
Compositional biasi405 – 419Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi426 – 440Polar residuesSequence analysisAdd BLAST15
Compositional biasi463 – 477Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi488 – 515Polar residuesSequence analysisAdd BLAST28
Compositional biasi516 – 532Basic residuesSequence analysisAdd BLAST17
Compositional biasi728 – 742Acidic residuesSequence analysisAdd BLAST15
Compositional biasi874 – 895Basic and acidic residuesSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0895, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002088_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N3I3

Identification of Orthologs from Complete Genome Data

More...
OMAi
YESYMLQ

Database of Orthologous Groups

More...
OrthoDBi
808738at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325556

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00195, UBCc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR016135, UBQ-conjugating_enzyme/RWD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00179, UQ_con, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54495, SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50127, UBIQUITIN_CONJUGAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1N3I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPAASAPA APAPAQIPDV PPSPDAAPAS APAPASAADS GSGPSSDSGP
60 70 80 90 100
EAGSQRLLFS HDLVSGRYRG SVHFGLVRLI HGEDSDSEGE EEGRGSSGCS
110 120 130 140 150
EAGGAGHEEG RASPLRRGYV RVQWYPEGVK QHVKETKLKL EDRSVVPRDV
160 170 180 190 200
VRHMRSTDSQ CGTVIDVNID CAVKLIGTNC IVYPVNSKDL QHIWPFMYGD
210 220 230 240 250
YIAYDCWLGK VYDLKNQIIL KLSNGARCSM NTEDGAKLYD VCPHVSDSGL
260 270 280 290 300
FFDDSYGFYP GQVLIGPAKI FSSVQWLSGV KPVLSTKSKF RVVVEEVQVV
310 320 330 340 350
ELKVTWITKS FCPGGTDSVS PPPSVITQEN LGRVKRLGCF DHAQRQLGER
360 370 380 390 400
CLYVFPAKVE PAKIACECPE KHCAQGEGSV AKKVKRLLKK QLVRITSCSP
410 420 430 440 450
DVQCSRDHSM EDAGKKGAAK AKSETGSASP EETPDGSSSP VEMQDEGPEE
460 470 480 490 500
AHEAGEQLPP FLLKEGGDDR LHSAEQDADD EAADDTDDTS SVTSSASSTT
510 520 530 540 550
SSQSGSGTSR KKSIPLSIKN LKRKHKRKKN KITRDFKPGD RVAVEVVTTM
560 570 580 590 600
TSADVMWQDG SVECNIRSND LFPVHHLDNN EFCPGDFVVD KRVQSCPDPA
610 620 630 640 650
VYGVVQSGDH VGRTCMVKWF KLRPSGDDVE LIGEEEDVSV YDIADHPDFR
660 670 680 690 700
FRTTDIVIRI GNAEDGAPHK EDEPSVGQVA RVDVSSKVEV VWADNSKTII
710 720 730 740 750
LPQHLYNIES EIEESDYDSV EGSTSGASSD EWEDDSDSWE TDNGLVEDEH
760 770 780 790 800
PKIEEPPIPT AEQPAAPEED KGVVISEEAA TAAIQGAVAM AAPVAGLMEK
810 820 830 840 850
AGKDGPPKSF RELKEAIKIL ESLKNMTVEQ LLTGSPTSPT AEPEKPTREK
860 870 880 890 900
KFLDDIKKLQ ENLKKTLDNV AIAEEEKMEA VPETERKEDK PEGQSPVKAE
910 920 930 940 950
WPSETPVLCQ QCGGKPGVTF TSAKGEVFSV LEFAPSNHSF KKIEFQPPEA
960 970 980 990 1000
KKFFSTVRKE MALLATSLPD GIMVKTFEDR MDLFSALIKG PTRTPYEDGL
1010 1020 1030 1040 1050
YLFDIQLPNI YPAVPPHFCY LSQCSGRLNP NLYDNGKVCV SLLGTWIGKG
1060 1070 1080 1090 1100
TERWTSKSSL LQVLISIQGL ILVNEPYYNE AGFDSDRGLQ EGYENSRCYN
1110 1120 1130 1140 1150
EMALIRVVQS MTQLVRRPPE VFEQEIRQHF STGGWRLVNR IESWLETHAL
1160 1170 1180 1190 1200
LERAQALPNG LPKDSSSPEP PAVAELSDFG REEPEDGGLA PGEASQGSDS
1210 1220 1230 1240 1250
EGPASAPRDR TEQASEAPPD ASVPPSVKPK KRRKSYRSFL PEKSGYPDLG
1260 1270 1280
FPLFPLSKGF VKSIRGVLMQ FRAALTEAGM PESAGDK
Length:1,287
Mass (Da):140,387
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0711454F7D3D1DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3S5ZPL7A0A3S5ZPL7_BOVIN
Ubiquitin conjugating enzyme E2 O
UBE2O
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_002696213.1, XM_002696167.4
XP_015323759.1, XM_015468273.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000026793; ENSBTAP00000026793; ENSBTAG00000020115

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
789422

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:789422

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_002696213.1, XM_002696167.4
XP_015323759.1, XM_015468273.1

3D structure databases

SMRiF1N3I3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026793

PTM databases

SwissPalmiF1N3I3

Proteomic databases

PaxDbiF1N3I3
PRIDEiF1N3I3

Genome annotation databases

EnsembliENSBTAT00000026793; ENSBTAP00000026793; ENSBTAG00000020115
GeneIDi789422
KEGGibta:789422

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63893
VGNCiVGNC:36591, UBE2O

Phylogenomic databases

eggNOGiKOG0895, Eukaryota
GeneTreeiENSGT00940000160755
HOGENOMiCLU_002088_1_0_1
InParanoidiF1N3I3
OMAiYESYMLQ
OrthoDBi808738at2759
TreeFamiTF325556

Enzyme and pathway databases

ReactomeiR-BTA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSBTAG00000020115, Expressed in cerebellum and 95 other tissues
ExpressionAtlasiF1N3I3, baseline and differential

Family and domain databases

CDDicd00195, UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR016135, UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179, UQ_con, 1 hit
SUPFAMiSSF54495, SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127, UBIQUITIN_CONJUGAT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N3I3_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N3I3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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