UniProtKB - F1N1Y8 (F1N1Y8_BOVIN)
Protein
Submitted name:
CBFA2/RUNX1 partner transcriptional co-repressor 3
Gene
CBFA2T3
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription corepressor activity Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: InterPro
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: CBFA2/RUNX1 partner transcriptional co-repressor 3Imported |
Gene namesi | Name:CBFA2T3Imported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:80260, CBFA2T3 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSBTAG00000010927, Expressed in skeletal muscle tissue and 15 other tissues |
ExpressionAtlasi | F1N1Y8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 206 | TAFHInterPro annotationAdd BLAST | 96 | |
Domaini | 496 – 532 | MYND-typeInterPro annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 49 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 224 – 282 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 382 – 403 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 543 – 593 | DisorderedSequence analysisAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 435 – 477 | Sequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 28 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 226 – 254 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 578 – 593 | Pro-richSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the CBFA2T family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | ENOG502QTD6, Eukaryota |
GeneTreei | ENSGT00950000183176 |
HOGENOMi | CLU_022077_2_0_1 |
InParanoidi | F1N1Y8 |
OrthoDBi | 334242at2759 |
TreeFami | TF106303 |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
InterProi | View protein in InterPro IPR013289, CBFA2T1/2/3 IPR013292, CBFA2T3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01878, MTG16PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F1N1Y8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDSPAEVKT QPRATPPSMP PPPPAASQGA TRHPSFTPHT NREDGPAMSL
60 70 80 90 100
PHGRFHGCLK WSMVCLLMNG SSHSPTAISG APSTPNGFSN GPATSCTAAL
110 120 130 140 150
STQQLPPACG ARQLSKLKRF LATLQQFGSD ISPEIGERVR TLVLGLVNST
160 170 180 190 200
LTIEEFHSKL QEATNFPLRP FVIPFLKANL PLLQRELLHC ARLAKQSPAQ
210 220 230 240 250
YLAQHEQALL DADASSPVDS SELLLEVNDN GKRRTPDRTK ENGSDRDPLH
260 270 280 290 300
PDHLSKRPCT LSPAQRYSPS NGLPHPPPPP HYRLEDMAMA HHFRDSYRHL
310 320 330 340 350
DPRELRERHR QLAMHGSRPE EVIDHRLTER EWAEEWKHLN NLLNCIMDMA
360 370 380 390 400
EKTRRSLTVL RRCQEADREE LNHWIRRCSD VAEDSKKGPG PTARPLGSSV
410 420 430 440 450
GTEGAQLDVH REFMPRTLSG YMPEEIWRKA EEAVNEVKRQ AMSELQKAVS
460 470 480 490 500
DAERKAHELI STERAKMERA LAEARRQASE DALTVVNQQE DSSESCWNCG
510 520 530 540 550
RKASETCSGC NAARYCGSFC QHKDWEKHHH VCGQSLQGPA AAVAEPVPGQ
560 570 580 590
SDTATGLGPC LPPAAASPSE AGSTGPSRPG SPGPPGPLDA APR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LYI7 | A0A3Q1LYI7_BOVIN | CBFA2/RUNX1 partner transcriptional... | CBFA2T3 | 631 | Annotation score: | ||
A0A3Q1LUS1 | A0A3Q1LUS1_BOVIN | CBFA2/RUNX1 partner transcriptional... | CBFA2T3 | 605 | Annotation score: |
Sequence databases
RefSeqi | XP_005192723.1, XM_005192666.3 XP_005192726.1, XM_005192669.3 XP_005218830.1, XM_005218773.3 XP_005218833.1, XM_005218776.3 |
Genome annotation databases
Ensembli | ENSBTAT00000014515; ENSBTAP00000014515; ENSBTAG00000010927 |
GeneIDi | 523815 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005192723.1, XM_005192666.3 XP_005192726.1, XM_005192669.3 XP_005218830.1, XM_005218773.3 XP_005218833.1, XM_005218776.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014515 |
Proteomic databases
PaxDbi | F1N1Y8 |
PRIDEi | F1N1Y8 |
Genome annotation databases
Ensembli | ENSBTAT00000014515; ENSBTAP00000014515; ENSBTAG00000010927 |
GeneIDi | 523815 |
Organism-specific databases
CTDi | 863 |
VGNCi | VGNC:80260, CBFA2T3 |
Phylogenomic databases
eggNOGi | ENOG502QTD6, Eukaryota |
GeneTreei | ENSGT00950000183176 |
HOGENOMi | CLU_022077_2_0_1 |
InParanoidi | F1N1Y8 |
OrthoDBi | 334242at2759 |
TreeFami | TF106303 |
Gene expression databases
Bgeei | ENSBTAG00000010927, Expressed in skeletal muscle tissue and 15 other tissues |
ExpressionAtlasi | F1N1Y8, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
InterProi | View protein in InterPro IPR013289, CBFA2T1/2/3 IPR013292, CBFA2T3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01878, MTG16PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1N1Y8_BOVIN | |
Accessioni | F1N1Y8Primary (citable) accession number: F1N1Y8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |