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Entry version 48 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Paralemmin 2

Gene

PALM2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Paralemmin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PALM2Imported
Synonyms:PALM2AKAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:56978, PALM2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N1T2

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F1N1T2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000046602, Expressed in cumulus cell and 78 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1N1T2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000019246

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 265DisorderedSequence analysisAdd BLAST24
Regioni278 – 306DisorderedSequence analysisAdd BLAST29
Regioni363 – 401DisorderedSequence analysisAdd BLAST39
Regioni415 – 444DisorderedSequence analysisAdd BLAST30
Regioni536 – 629DisorderedSequence analysisAdd BLAST94
Regioni715 – 887DisorderedSequence analysisAdd BLAST173
Regioni952 – 1020DisorderedSequence analysisAdd BLAST69
Regioni1043 – 1135DisorderedSequence analysisAdd BLAST93
Regioni1183 – 1212DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 34Sequence analysisAdd BLAST34
Coiled coili70 – 107Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi427 – 444Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi583 – 599Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi611 – 629Polar residuesSequence analysisAdd BLAST19
Compositional biasi715 – 738Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi765 – 780Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi783 – 805Polar residuesSequence analysisAdd BLAST23
Compositional biasi852 – 873Polar residuesSequence analysisAdd BLAST22
Compositional biasi952 – 996Polar residuesSequence analysisAdd BLAST45
Compositional biasi1052 – 1069Polar residuesSequence analysisAdd BLAST18
Compositional biasi1098 – 1112Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paralemmin family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSC7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038333_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N1T2

Database of Orthologous Groups

More...
OrthoDBi
275462at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105402

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004965, Paralemmin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03285, Paralemmin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F1N1T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAELHKER LQAIAEKRKR QTEIEGKRQE LDEQILLLQH SKSKVLREKW
60 70 80 90 100
LLQGIPAGTA EEEEARRRQS EEDEFRVKQL EDNIQRLEQE IQALESEESQ
110 120 130 140 150
ISAKEQIILE KLKETEKSFK DFQKSFSSAD GDAVNHISSQ LPDLPILCSR
160 170 180 190 200
TAEPSPEQDG TSRAAAVYAM EINVEKDKQT GETKILSTST IGPEGVHQRG
210 220 230 240 250
VKVFDDGTKV VYEVHSGGTI VENGVHTLSS KDVEELIQKA GQSSLRGGHV
260 270 280 290 300
SERTGIADGS LSHPKEHMLC KEAKLEMVHK SRKDHSSGNP GQQAPAPSTE
310 320 330 340 350
GPEANLDQPV TMIFMGYQNI EDEEETKKVL GYDETIKAEL VLIDEDDEKS
360 370 380 390 400
LREKTVTDVS TIDGNAAELV SGRPISDTTE PSSPEGKEES LATEPAPGVG
410 420 430 440 450
WESVLLTRDD ITSEAIASSS ADMTVKKPPE LSEDDTRLKH ERDNCSAKAL
460 470 480 490 500
ESITSSLPPD HKNMEIEVSV AECKSVTGIT STPHSMDHPS PFYSTPHNGL
510 520 530 540 550
LADHHESLDN DVAREIRYLD EVLEANCCDS AVDGTYNGTS SPEPGAAILA
560 570 580 590 600
GSPSPPTPAA VQPEVTETAA GRQAPPHLEL HQSDSDTMAE GRRANGHPPE
610 620 630 640 650
QPRDVLGDSL QVPVSPSSST SSRCSSRDGE VTLTTLKKEA KFELRAFHED
660 670 680 690 700
KKPSKLFEDD ESEKEQYRVR KVRPSEEMLE LEKERRELIR SQAVKKNPGI
710 720 730 740 750
AAKWWNPPQE KTIEEQLDEE HLESHKKYKE RKERRAQQEQ LLMQQQQQQP
760 770 780 790 800
PPQLCTAPAP SREHPSVTDH PKEDIVTEQI DFSAARKQFQ QMENSRQTVA
810 820 830 840 850
RGQSTPRLFS IKPFYKPLGS INSDKTLTIS RPASVGAPPE DSSAAKGQKA
860 870 880 890 900
HCAPESQSSG GGGQGSTAPQ GKEGPYSEPS KRGPLSKLWA EDGEFTSARA
910 920 930 940 950
VLTVVKDDDP GILDQFSRSV NVSLTQEELD SGLDELSVRS QDTTVLETLS
960 970 980 990 1000
NDFSMDNISD SGASNETTNA LQENSLADFS LPQTPQTDNP SEGRGEGVSK
1010 1020 1030 1040 1050
SFSDHGFYSP LSTLGDSASV DDPLEYQAGL LVQNAIQQAI AEQIDRAGSE
1060 1070 1080 1090 1100
TTKGGAEQQG PQVSQEKAGP RAPSSEKPQS MFEPPQVSSP VQEKRDVLPK
1110 1120 1130 1140 1150
ILSTEDRVLR ERGPSQPLPA VQPSGPINME ETRPEGSYFS KYSEAAELRS
1160 1170 1180 1190 1200
TASLLATQES DVMVGPFKLR SRKQRTLSMI EEEIPSSPGK GRGAEAAEAS
1210 1220 1230 1240
LAEYPEPQGK ECPITALPSI VLQNCSRENR ESQTSSIPHT
Length:1,240
Mass (Da):135,810
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5004D0E15E08B92D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MY58A0A3Q1MY58_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
1,334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1NLQ9A0A3Q1NLQ9_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
1,102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LPG1A0A3Q1LPG1_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
1,097Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1N1T3F1N1T3_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
855Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M6L0A0A3Q1M6L0_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
920Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M9M4A0A3Q1M9M4_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MGG2A0A3Q1MGG2_BOVIN
Paralemmin 2
PALM2 PALM2AKAP2
871Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000019246; ENSBTAP00000019246; ENSBTAG00000014471

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019246

PTM databases

SwissPalmiF1N1T2

Proteomic databases

PaxDbiF1N1T2

Genome annotation databases

EnsembliENSBTAT00000019246; ENSBTAP00000019246; ENSBTAG00000014471

Organism-specific databases

VGNCiVGNC:56978, PALM2

Phylogenomic databases

eggNOGiENOG502QSC7, Eukaryota
GeneTreeiENSGT00940000161837
HOGENOMiCLU_038333_1_0_1
InParanoidiF1N1T2
OrthoDBi275462at2759
TreeFamiTF105402

Gene expression databases

BgeeiENSBTAG00000046602, Expressed in cumulus cell and 78 other tissues
ExpressionAtlasiF1N1T2, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004965, Paralemmin
PfamiView protein in Pfam
PF03285, Paralemmin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N1T2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N1T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 48 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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