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Entry version 73 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Plexin A3

Gene

PLXNA3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-399954, Sema3A PAK dependent Axon repulsion
R-BTA-399956, CRMPs in Sema3A signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Plexin A3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXNA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501852994619 – 1897Sequence analysisAdd BLAST1879

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1N173

PRoteomics IDEntifications database

More...
PRIDEi
F1N173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000008552, Expressed in ruminant reticulum and 94 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000030170

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1N173

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 488SemaInterPro annotationAdd BLAST482

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1272 – 1299Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01020000230384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001436_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1N173

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1N173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTIFILLFL LAAGQALGSR GPFPAFSVTD TSLTHLAVHR VTGEVFVGAV
60 70 80 90 100
NHIFKLAPNL TELRVHITGP VEDNARCYPP PSMRVCAHRL APVDNVNKLL
110 120 130 140 150
LIDYAARRLV ACGSIWQGIC QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS
160 170 180 190 200
MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT LSSRKLIRDE DGVDMFSLVY
210 220 230 240 250
QDEFVSSQIK IPSDTLSLYP AFDIYYVYGF VSASFVYFLT LQLDTQQTLL
260 270 280 290 300
DTAGEKFFTS KIVRMCSGDS EFYSYVEFPI GCSWHGVEYR LVQSAHLAKP
310 320 330 340 350
GLLLAQALGV PANEDVLFTV FSQGQKNRAS PPRQTILCLF TLSNINAHIR
360 370 380 390 400
RRIQSCYRGE GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV
410 420 430 440 450
IEGLPLLADS TDGMTSVAAY TYQQHSVVFI GTRGGSLKKV RVDSSQEAHL
460 470 480 490 500
YETVPVVDGS PILRDLLFSP DHRHIYLLSE KQVSQLPVET CEQYLSCAAC
510 520 530 540 550
LGSGDPHCGW CVLQHRCCRQ GACPGAVAPY GFAEVLSKCV QVHVWPNNVS
560 570 580 590 600
VTSPGVQLTV AMSNVPDLSV GVSCAFEEVT QSEAILLPSG ELRCPSPSLQ
610 620 630 640 650
ELRALTRGHG QWTGLGGGGG CCLSMAHMGS RGLTAGATRT VRLQLLSKET
660 670 680 690 700
GVRFAGADFV FYNCSVLQSC MSCVSSPYPC QWCKYRHVCT SQPHDCSFQE
710 720 730 740 750
GRVRNPEGCP EILPSGDLLI PVGVVQPLTL RAKNLPQPQS GQKNYECVVR
760 770 780 790 800
VQGRHQRVPA VRFNSSSVQC QNASYSYEGD EYGDTELDFS VVWDGDFPID
810 820 830 840 850
KPATFRALLY KCWAQRPSCG LCLKADPRFN CGWCISEHRC QLRAHCPAPK
860 870 880 890 900
TNWMHPNQKG ARCSHPRIAQ IHPVMGPKEG GTWITIVGEN LGLTSREVGL
910 920 930 940 950
RVAGVRCNSI PAEYISAERI VCEMEESLVP SPPPGPAELC VGDCSADFRT
960 970 980 990 1000
QSEQLYTFVT PTFDRVSPSR GPASGGTRLT ISGRALDAGS RVMVTVRDGE
1010 1020 1030 1040 1050
CQFVRRDAEA IVCISPVSTL GPSQAPIMLA IDRANISSPG VVYTYTQDPT
1060 1070 1080 1090 1100
VTRLEPMWSI INGSTAITVS GTHLLTVQEP RVRAKYRGIE TTNTCQVIND
1110 1120 1130 1140 1150
TAMLCKAPGI FLGQPQPQAQ GEHPDEFGFL LDHVQTARSL NRSSFTYYPD
1160 1170 1180 1190 1200
PSFEPLGPSG VLDIKPGSHV VLKGKNLIPV AAGSSRLNYT VLIGGQPCAL
1210 1220 1230 1240 1250
TVSDTQLLCD SPSQTGRQPV MVLVGGLEFW LGTLHITAER ALTLPAVVGL
1260 1270 1280 1290 1300
AVGGSLLLLA ITAVLVAYKR KTQDADRTLK RLQFQMDNLE SRVALECKEA
1310 1320 1330 1340 1350
FAELQTDINE LTNHMDGVQI PFLDYRTYAV RVLFPGIEAH PVLKELDTPP
1360 1370 1380 1390 1400
HVEKALRLFG QLLHSRAFVL TFIHTLEAQS SFSMRDRGTV ASLTMVALQS
1410 1420 1430 1440 1450
RLDYATGLLK QLLVDLIEKN LESKNHPKLL LRRTESVAEK MLTNWFTFLL
1460 1470 1480 1490 1500
HKFLKECAGE PLFLLYCAIK QQMEKGPIDA ITGEARYSLS EDKLIRQQID
1510 1520 1530 1540 1550
YKTLTLHCVC PESEGSAQVP VKVLNCDSIT QAKDKLLDAV YKGIPYSQRP
1560 1570 1580 1590 1600
KAEDMDLEWR QGRMARVILQ DEDITTKIEC DWKRVNSLAH YQVTDGSLVA
1610 1620 1630 1640 1650
LVPKQVSAYN MANSFTFTRS LSRYESLLRT ASSPDSLRSR APMITPDQET
1660 1670 1680 1690 1700
GTKLWHLVKN HDHADHREGD RGSKMVSEIY LTRLLATKGT LQKFVDDLFE
1710 1720 1730 1740 1750
TVFSTAHRGS ALPLAIKYMF DFLDEQADQR QIIDPDVRHT WKSNCLPLRF
1760 1770 1780 1790 1800
WVNVIKNPQF VFDIHKSSIT DACLSVVAQT FMDSCSTSEH RLGKDSPSNK
1810 1820 1830 1840 1850
LLYAKDIPNY KSWVERYYRD ITKMASISDQ DMDAYLVEQS RLHASDFNVL
1860 1870 1880 1890
SALSELYFYV TKYRQEVLSA LDRDASCRKH KLRQKLEQII GLVSSNS
Length:1,897
Mass (Da):210,141
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EB6917837168F41
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000030185; ENSBTAP00000030170; ENSBTAG00000008552

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1N173
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030170

Proteomic databases

PaxDbiF1N173
PRIDEiF1N173

Genome annotation databases

EnsembliENSBTAT00000030185; ENSBTAP00000030170; ENSBTAG00000008552

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230384
HOGENOMiCLU_001436_2_0_1
InParanoidiF1N173
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-BTA-399954, Sema3A PAK dependent Axon repulsion
R-BTA-399956, CRMPs in Sema3A signaling

Gene expression databases

BgeeiENSBTAG00000008552, Expressed in ruminant reticulum and 94 other tissues

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1N173_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1N173
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 73 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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