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Entry version 78 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Kalirin RhoGEF kinase

Gene

KALRN

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNucleotide-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kalirin RhoGEF kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KALRNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:30389, KALRN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MXJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000002640, Expressed in testis and 95 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000032241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MXJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1182 – 1357DHInterPro annotationAdd BLAST176
Domaini1369 – 1481PHInterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni611 – 638DisorderedSequence analysisAdd BLAST28
Regioni1495 – 1564DisorderedSequence analysisAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili641 – 661Sequence analysisAdd BLAST21
Coiled coili759 – 779Sequence analysisAdd BLAST21
Coiled coili820 – 847Sequence analysisAdd BLAST28
Coiled coili1158 – 1178Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi622 – 638Polar residuesSequence analysisAdd BLAST17
Compositional biasi1518 – 1544Polar residuesSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota
KOG0689, Eukaryota
KOG4240, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000373_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MXJ6

Database of Orthologous Groups

More...
OrthoDBi
5761at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit
cd00170, SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR028570, Kalirin/TRIO
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104, PTHR22826:SF104, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00435, Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00150, SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MXJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSKWDLIK PLLKTLQEAF PAEIHVALII KPDNFWQKQK TNFGSSKFIF
60 70 80 90 100
ETSMVSVEGL TKLVDPSQLT EEFDGSLDYN HEEWIELRLS LEEFFNSAVH
110 120 130 140 150
LLSRLEDLQE MLARKEFPVD VEGSRRLIDE HTQLKKKVLK APVEELDREG
160 170 180 190 200
QRLLQCIRCS DGFSGRNCIP GSADFQSLVP KITSLLDKLH STRQHLHQMW
210 220 230 240 250
HVRKLKLDQC FQLRLFEQDA EKMFDWISHN KELFLQSHTE IGVSYQHALD
260 270 280 290 300
LQTQHNHFAM NSMNAYVNIN RIMSVASRLS EAGHYASQQI KQISTQLDQE
310 320 330 340 350
WKSFAAALDE RSTILAMSAV FHQKAEQFLS GVDAWCKMCS EGGLPSEMQD
360 370 380 390 400
LELAIHHHQS LYEQVTQAYT EVSQDGKALL DVLQRPLSPG NSESLTATAN
410 420 430 440 450
YSKAVHQVLD VVHEVLHHQR RLESIWQHRK VRLHQRLQLC VFQQDVQQVL
460 470 480 490 500
DWIENHGEAF LSKHTGVGKS LHRARALQKR HDDFEEVAQN TYTNADKLLE
510 520 530 540 550
AAEQLAQTGE CDPEEIYKAA RHLEVRIQDF VRRVEQRKLL LDMSVSFHTH
560 570 580 590 600
TKELWTWMED LQKEMLEDVC ADSVDAVQEL IKQFQQQQTA TLDATLNVIK
610 620 630 640 650
EGEDLIQQLR SAPPSLGEPS EARDSAVSNN KTPHSSSISH IESVLQQLDD
660 670 680 690 700
AQVQMEELFH ERKIKLDIFL QLRIFEQYTI EVTAELDAWN EDLLRQMNDF
710 720 730 740 750
NTEDLTLAEQ RLQRHTERKL AMNNMTFEVI QQGQDLHQYI MEVQASGIEL
760 770 780 790 800
ICEKDIDLAA QVQELLEFLH EKQHELELNA EQTHKRLEQC LQLRHLQAEV
810 820 830 840 850
KQVLGWIRNG ESMLNASLVN ASSLSEAEQL QREHEQFQLA IESLFHATSL
860 870 880 890 900
QKTHQSALQV QQKAEALLQA GHYDADAIRE CAEKVALHWQ QLMLKMEDRL
910 920 930 940 950
KLVNASVAFY KTSEQVCSVL ESLEQEYRRD EDWCGGRDKL GPAAEIDHVI
960 970 980 990 1000
PLISKHLEQK EAFLKACTLA RRNAEVFLKY IHRNNVSMPS AASHTRGPEQ
1010 1020 1030 1040 1050
QVKAILSELL QRENRVLHFW TLKKRRLDQC QQYVVFERSA KQALDWIQET
1060 1070 1080 1090 1100
GEYYLSTHTS TGETTEETQE LLKEYGEFRV PAKQTKEKVK LLIQLADSFV
1110 1120 1130 1140 1150
EKGHIHATEI RKWVTTVDKH YRDFSLRMGK YRYSLEKALG VNTEDNKDLE
1160 1170 1180 1190 1200
LDIIPASLSD REVKLRDANH EVNEEKRKSA RKKEFIMAEL LQTEKAYVRD
1210 1220 1230 1240 1250
LHECLETYLW EMTSGVEEIP PGILNKEHII FGNIQEIYDF HNNIFLKELE
1260 1270 1280 1290 1300
KYEQLPEDVG HCFVTWADKF QMYVTYCKNK PDSNQLILEH AGTFFDEIQQ
1310 1320 1330 1340 1350
RHGLANSISS YLIKPVQRIT KYQLLLKELL TCCEEGKGEL KEGLEVMLSV
1360 1370 1380 1390 1400
PKRANDAMHV SMLEGFDENL DVQGELILQD AFQVWDPKSL IRKGRERHLF
1410 1420 1430 1440 1450
LFEISLVFSK EIKDSSGHTK YVYKNKLLTS ELGVTEHVEG DPCKFALWSG
1460 1470 1480 1490 1500
RTPSSDNKTV LKASNIETKQ EWIKNIREVI QERIIHLKGA LKEPIQLPKT
1510 1520 1530 1540 1550
PAKQRNNSKR DGVEDVDSQG DGSSQPDTIS IASRTSQNTA DSDKDGNLAP
1560
RWYLGPGDPF STYV
Length:1,564
Mass (Da):180,625
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EB41665747D8220
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000032306; ENSBTAP00000032241; ENSBTAG00000002640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1MXJ6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032241

Proteomic databases

PaxDbiF1MXJ6

Genome annotation databases

EnsembliENSBTAT00000032306; ENSBTAP00000032241; ENSBTAG00000002640

Organism-specific databases

VGNCiVGNC:30389, KALRN

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG0689, Eukaryota
KOG4240, Eukaryota
GeneTreeiENSGT00940000155248
HOGENOMiCLU_000373_2_0_1
InParanoidiF1MXJ6
OrthoDBi5761at2759
TreeFamiTF318080

Gene expression databases

BgeeiENSBTAG00000002640, Expressed in testis and 95 other tissues

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
cd00170, SEC14, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR028570, Kalirin/TRIO
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR22826:SF104, PTHR22826:SF104, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00435, Spectrin, 4 hits
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00150, SPEC, 7 hits
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MXJ6_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MXJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 78 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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