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Protein

Estrogen receptor

Gene

ESR1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi183 – 258Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandLipid-binding, Metal-binding, Steroid-bindingUniRule annotation, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1251985 Nuclear signaling by ERBB4
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-383280 Nuclear Receptor transcription pathway
R-BTA-5689896 Ovarian tumor domain proteases
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-BTA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-BTA-8939211 ESR-mediated signaling
R-BTA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptorUniRule annotation
Short name:
ERUniRule annotation
Alternative name(s):
ER-alphaUniRule annotation
Estradiol receptorUniRule annotation
Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesi
Name:ESR1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:53791 ESR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiF1MX59

Expressioni

Gene expression databases

BgeeiENSBTAG00000007159

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 258Nuclear receptorInterPro annotationAdd BLAST76
Domaini312 – 548NR LBDInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
OMAiEAGPPAF
OrthoDBiEOG091G03V4
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1MX59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQA NELEPLNRPQ LKIPLERPLG EVYMDSSKPA
60 70 80 90 100
VYNYPEGAAY DFNAAAPASA PVYGQSGLPY GPGSEAAAFG ANGLGAFPPL
110 120 130 140 150
NSVSPSPLVL LHPPPQPLSP FLHPHGQQVP VFLENQNSYS KLRKAGGPSY
160 170 180 190 200
YRPNSDNRRQ GGRERLASTS DKGSMAMESA KETRYCAVCN DYASGYHYGV
210 220 230 240 250
WSCEGCKAFF KRSIQGHNDY MCPATNQCTI DKNRRKSCQA CRLRKCYEVG
260 270 280 290 300
MMKGGIRKDR RGGRMLKHKR QRDDGEGRNE AVPSGDMRAA NLWPSPIMIK
310 320 330 340 350
HTKKNSPVLS LTADQMISAL LEAEPPIIYS EYDPTRPFSE ASMMGLLTNL
360 370 380 390 400
ADRELVHMIN WAKRVPGFVD LALHDQVHLL ECAWLEILMI GLVWRSMEHP
410 420 430 440 450
GKLLFAPNLL LDRNQGKCVE GMVEIFDMLL ATSSRFRMMN LQGEEFVCLK
460 470 480 490 500
SIILLNSGVY TFLSSTLRSL EEKDHIHRVL DKITDTLIHL MAKAGLTLQQ
510 520 530 540 550
QHRRLAQLLL ILSHFRHMSN KGMEHLYSMK CKNVVPLYDL LLEMLDAHRL
560 570 580 590
HAPANFGSAP PEDVNQSQLA PTGCTSSHSL QTYYITGEAE NFPSTV
Length:596
Mass (Da):66,511
Last modified:November 16, 2011 - v2
Checksum:iF80AA7C20EC4B696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02027176 Genomic DNA No translation available.
DAAA02027177 Genomic DNA No translation available.
DAAA02027178 Genomic DNA No translation available.
DAAA02027179 Genomic DNA No translation available.
DAAA02027180 Genomic DNA No translation available.
DAAA02027181 Genomic DNA No translation available.
DAAA02027182 Genomic DNA No translation available.
DAAA02027183 Genomic DNA No translation available.
DAAA02027184 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000009422; ENSBTAP00000009422; ENSBTAG00000007159

Similar proteinsi

Entry informationi

Entry nameiF1MX59_BOVIN
AccessioniPrimary (citable) accession number: F1MX59
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: July 18, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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