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UniProtKB - F1MWH8 (F1MWH8_BOVIN)
Protein
Tyrosine-protein kinase
Gene
ABL2
Organism
Bos taurus (Bovine)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.2UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 317 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: Ensembl
- manganese ion binding Source: Ensembl
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- phosphotyrosine residue binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell communication Source: UniProt
- cellular response to retinoic acid Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of oxidoreductase activity Source: Ensembl
- positive regulation of phospholipase C activity Source: Ensembl
- signaling Source: UniProt
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Biological process | Adaptive immunityARBA annotation, Immunity |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ABL2Imported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000015026 |
VGNCi | VGNC:50227, ABL2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000015026, Expressed in conceptus and 93 other tissues |
ExpressionAtlasi | F1MWH8, baseline |
Interactioni
GO - Molecular functioni
- phosphotyrosine residue binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020006 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 167 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 173 – 263 | SH2InterPro annotationAdd BLAST | 91 | |
Domaini | 288 – 539 | Protein kinaseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 579 – 641 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 654 – 677 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 763 – 881 | DisorderedSequence analysisAdd BLAST | 119 | |
Regioni | 964 – 1062 | DisorderedSequence analysisAdd BLAST | 99 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 582 – 596 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 597 – 613 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 774 – 793 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 804 – 827 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 828 – 852 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 966 – 980 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 996 – 1017 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG4278, Eukaryota |
GeneTreei | ENSGT00940000153838 |
HOGENOMi | CLU_002795_0_0_1 |
InParanoidi | F1MWH8 |
OMAi | PPKCCGG |
OrthoDBi | 182823at2759 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1MWH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQQVGRVGE APGLQQSQPR GIRGSSAARP SGRRRDLVGR TAEAGFNIFT
60 70 80 90 100
QHDHFASCLE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN
110 120 130 140 150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS
160 170 180 190 200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES
210 220 230 240 250
ESSPGQLSIS LRYEGRVYHY RINTTTDGKV YVTAESRFST LAELVHHHST
260 270 280 290 300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
310 320 330 340 350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV
360 370 380 390 400
CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL
410 420 430 440 450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK
460 470 480 490 500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK
510 520 530 540 550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE
560 570 580 590 600
EVAEELGRAA AASSVVPYLP RLPLLPSKTR TLKKQGENKE NIEGAQDATE
610 620 630 640 650
DSASSSAPGF IRSAQAPSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG
660 670 680 690 700
GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHAEG
710 720 730 740 750
FSLTPAQQEA SLVPPKCYGG SFAQRNLCND DGGGGGGSGA AGGGWSGITG
760 770 780 790 800
FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSVSSG LPEQDRMAMT
810 820 830 840 850
LPRNCQRSKL QLERTVSTSS QPEENVDRAN DTLPKKSEEG AAPTRERPKA
860 870 880 890 900
KLLPRGGTAL PLRTPSGDPA TTEKDSPGLG VAGVAAAPKS KERNGGARLG
910 920 930 940 950
MAGVPEDGEQ TGWASPAKTA AVLPTTHNHK VPVLISPTLK HTPADVQLIG
960 970 980 990 1000
TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSVCS
1010 1020 1030 1040 1050
DSTEEPAAPT AVQPKSETQE GGKKAAPGAV PTSGKAGRPV MPPPQVPLPT
1060 1070 1080 1090 1100
SSGSPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAI
1110 1120 1130 1140 1150
TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL
1160 1170 1180
QVSSAAAGVP GANPVLNNLL SCVQEISDVV QR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MGX4 | A0A3Q1MGX4_BOVIN | Tyrosine-protein kinase | ABL2 | 1,043 | Annotation score: |
Sequence databases
RefSeqi | NP_001137327.1, NM_001143855.1 |
Genome annotation databases
Ensembli | ENSBTAT00000020006; ENSBTAP00000020006; ENSBTAG00000015026 |
GeneIDi | 511845 |
KEGGi | bta:511845 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001137327.1, NM_001143855.1 |
3D structure databases
SMRi | F1MWH8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020006 |
Proteomic databases
PaxDbi | F1MWH8 |
Genome annotation databases
Ensembli | ENSBTAT00000020006; ENSBTAP00000020006; ENSBTAG00000015026 |
GeneIDi | 511845 |
KEGGi | bta:511845 |
Organism-specific databases
CTDi | 27 |
VEuPathDBi | HostDB:ENSBTAG00000015026 |
VGNCi | VGNC:50227, ABL2 |
Phylogenomic databases
eggNOGi | KOG4278, Eukaryota |
GeneTreei | ENSGT00940000153838 |
HOGENOMi | CLU_002795_0_0_1 |
InParanoidi | F1MWH8 |
OMAi | PPKCCGG |
OrthoDBi | 182823at2759 |
TreeFami | TF351634 |
Gene expression databases
Bgeei | ENSBTAG00000015026, Expressed in conceptus and 93 other tissues |
ExpressionAtlasi | F1MWH8, baseline |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1MWH8_BOVIN | |
Accessioni | F1MWH8Primary (citable) accession number: F1MWH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | January 19, 2022 | |
This is version 83 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |