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Entry version 75 (08 May 2019)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

FBN2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1474228 Degradation of the extracellular matrix
R-BTA-1566948 Elastic fibre formation
R-BTA-2129379 Molecules associated with elastic fibres

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:52231 FBN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501869233828 – 2912Sequence analysisAdd BLAST2885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi180 ↔ 190PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi539 ↔ 549PROSITE-ProRule annotation
Disulfide bondi856 ↔ 866PROSITE-ProRule annotation
Disulfide bondi1938 ↔ 1948PROSITE-ProRule annotation
Disulfide bondi2618 ↔ 2628PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MTZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000015307 Expressed in 8 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000020360

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MTZ4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 208EGF-likeInterPro annotationAdd BLAST33
Domaini214 – 257TBInterPro annotationAdd BLAST44
Domaini276 – 317EGF-likeInterPro annotationAdd BLAST42
Domaini318 – 359EGF-likeInterPro annotationAdd BLAST42
Domaini364 – 417TBInterPro annotationAdd BLAST54
Domaini494 – 534EGF-likeInterPro annotationAdd BLAST41
Domaini535 – 574EGF-likeInterPro annotationAdd BLAST40
Domaini575 – 616EGF-likeInterPro annotationAdd BLAST42
Domaini617 – 657EGF-likeInterPro annotationAdd BLAST41
Domaini658 – 698EGF-likeInterPro annotationAdd BLAST41
Domaini704 – 756TBInterPro annotationAdd BLAST53
Domaini768 – 809EGF-likeInterPro annotationAdd BLAST42
Domaini810 – 851EGF-likeInterPro annotationAdd BLAST42
Domaini852 – 891EGF-likeInterPro annotationAdd BLAST40
Domaini896 – 935TBInterPro annotationAdd BLAST40
Domaini955 – 996EGF-likeInterPro annotationAdd BLAST42
Domaini1001 – 1052TBInterPro annotationAdd BLAST52
Domaini1073 – 1114EGF-likeInterPro annotationAdd BLAST42
Domaini1115 – 1157EGF-likeInterPro annotationAdd BLAST43
Domaini1158 – 1199EGF-likeInterPro annotationAdd BLAST42
Domaini1200 – 1241EGF-likeInterPro annotationAdd BLAST42
Domaini1242 – 1282EGF-likeInterPro annotationAdd BLAST41
Domaini1283 – 1324EGF-likeInterPro annotationAdd BLAST42
Domaini1325 – 1362EGF-likeInterPro annotationAdd BLAST38
Domaini1367 – 1407EGF-likeInterPro annotationAdd BLAST41
Domaini1408 – 1448EGF-likeInterPro annotationAdd BLAST41
Domaini1449 – 1490EGF-likeInterPro annotationAdd BLAST42
Domaini1491 – 1527EGF-likeInterPro annotationAdd BLAST37
Domaini1532 – 1572EGF-likeInterPro annotationAdd BLAST41
Domaini1577 – 1633TBInterPro annotationAdd BLAST57
Domaini1650 – 1691EGF-likeInterPro annotationAdd BLAST42
Domaini1692 – 1733EGF-likeInterPro annotationAdd BLAST42
Domaini1738 – 1791TBInterPro annotationAdd BLAST54
Domaini1808 – 1849EGF-likeInterPro annotationAdd BLAST42
Domaini1850 – 1891EGF-likeInterPro annotationAdd BLAST42
Domaini1892 – 1929EGF-likeInterPro annotationAdd BLAST38
Domaini1934 – 1969EGF-likeInterPro annotationAdd BLAST36
Domaini1973 – 2015EGF-likeInterPro annotationAdd BLAST43
Domaini2016 – 2055EGF-likeInterPro annotationAdd BLAST40
Domaini2056 – 2097EGF-likeInterPro annotationAdd BLAST42
Domaini2102 – 2155TBInterPro annotationAdd BLAST54
Domaini2171 – 2212EGF-likeInterPro annotationAdd BLAST42
Domaini2213 – 2252EGF-likeInterPro annotationAdd BLAST40
Domaini2253 – 2289EGF-likeInterPro annotationAdd BLAST37
Domaini2294 – 2337EGF-likeInterPro annotationAdd BLAST44
Domaini2338 – 2375EGF-likeInterPro annotationAdd BLAST38
Domaini2384 – 2437TBInterPro annotationAdd BLAST54
Domaini2449 – 2486EGF-likeInterPro annotationAdd BLAST38
Domaini2491 – 2531EGF-likeInterPro annotationAdd BLAST41
Domaini2532 – 2568EGF-likeInterPro annotationAdd BLAST37
Domaini2571 – 2613EGF-likeInterPro annotationAdd BLAST43
Domaini2614 – 2653EGF-likeInterPro annotationAdd BLAST40
Domaini2654 – 2690EGF-likeInterPro annotationAdd BLAST37
Domaini2695 – 2734EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183158

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MTZ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCLQPYF

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316849

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 44 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 13 hits
SSF57581 SSF57581, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 43 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 45 hits
PS01187 EGF_CA, 16 hits
PS51364 TB, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MTZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRRRLCPQ PYFVWLGCVA LWAQCTAGQP QPPPPKAPRP QPPPQQVRPA
60 70 80 90 100
AAGSEGAFAV PEYREEGVAA ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG
110 120 130 140 150
WKTLPGGNQC IVPICRNSCG DGFCSRPNMC TCSSGQISPT CGSKSIQQCS
160 170 180 190 200
VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC ENGCQNGGRC IGPNRCACVY
210 220 230 240 250
GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC ATTGRAWGHP
260 270 280 290 300
CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGICQGG NCINTVGSFE
310 320 330 340 350
CKCPAGHKQS ETTQKCEDID ECSIIPGICE TGECSNTVGS YFCVCPRGYV
360 370 380 390 400
TSTDGSRCID QRTGTCFSGL VNGRCAQELP GRMTRMQCCC EPGRCWGIGT
410 420 430 440 450
IPEACPVRGS EEYRRLCLDG LPIGGIPGSA GSRPGSAGGN GFAPSGNGNG
460 470 480 490 500
YGPGGAGFIP IPGGNGFSPG VGGAGVGAGG QGPIITGLTI LNQTIDICKH
510 520 530 540 550
HANLCLNGRC IPTVSSYRCE CNMGYKQDAN GDCIDVDECT SNPCTNGDCV
560 570 580 590 600
NTPGSYYCKC HAGFQRTPTK QACIDIDECI QNGVLCKNGR CVNTDGSFQC
610 620 630 640 650
ICNAGFELTT DGKNCVDHDE CTTTNMCLNG MCINEDGSFK CICKPGFILA
660 670 680 690 700
PNGRYCTDVD ECQTPGICMN GHCINNEGSF RCDCPPGLAV GVDGRVCVDT
710 720 730 740 750
HMRSTCYGGI KKGVCVRPFP GAVTKSECCC ANPDYGFGEP CQPCPAKNSA
760 770 780 790 800
EFHGLCSSGV GITVDGRDIN ECALDPDICA NGICENLRGS YRCNCNSGYE
810 820 830 840 850
PDASGRNCVD IDECLVNRLL CDNGLCRNTP GSYSCTCPPG YVFRTETETC
860 870 880 890 900
EDINECESNP CVNGACRNNL GSFNCECSPG SKLSSTGLIC IDSLKGTCWL
910 920 930 940 950
NIQDNRCEVN INGATLKSEC CATLGAAWGS PCERCELDTA CPRGFARIKG
960 970 980 990 1000
VTCEDVNECE VFPGVCPNGR CVNSKGSFHC ECPEGLTLDG TGRVCLDIRM
1010 1020 1030 1040 1050
EQCYLKWDED ECIHPVPGKF RMDACCCAVG AAWGTECEEC PKLGTKEYET
1060 1070 1080 1090 1100
LCPRGPGFAN RGDVLTGRPF YKDINECKAF PGMCTYGKCR NTIGSFKCRC
1110 1120 1130 1140 1150
NSGFALDMEE RNCTDIDECR ISPDLCGSGI CVNTPGSFEC ECFEGYESGF
1160 1170 1180 1190 1200
MMMKNCMDID ECERNPLLCR GGTCVNTEGS FQCDCPLGHE LSPSREDCVD
1210 1220 1230 1240 1250
INECSLSDNL CRNGKCVNMI GTYQCSCNPG YQATPDRQGC TDIDECMIMN
1260 1270 1280 1290 1300
GGCDTQCTNA EGSYECSCSE GYALMPDGRS CADIDECENN PDICDGGQCT
1310 1320 1330 1340 1350
NIPGEYRCLC YDGFMASMDM KTCIDVNECD LNSNICMFGE CENTKGSFIC
1360 1370 1380 1390 1400
HCQLGYSVKK GTTGCTDVDE CEIGAHNCDM HASCLNVPGS FKCSCREGWV
1410 1420 1430 1440 1450
GNGIKCIDLD ECSNGTHQCS INAQCVNTPG SYRCACSEGF TGDGFTCSDV
1460 1470 1480 1490 1500
DECAENINLC ENGQCLNVPG AYRCECEMGF TPASDSRSCQ DIDECSFQNI
1510 1520 1530 1540 1550
CVFGTCNNLP GMFHCICDDG YELDRTGGNC TDIDECADPI NCVNGLCVNT
1560 1570 1580 1590 1600
PGRYECNCPP DFQLNPTGVG CVDNRVGNCY LKFGPRGDGS LSCNTEIGVG
1610 1620 1630 1640 1650
VSRSSCCCSL GKAWGNPCET CPPVNSTEYY TLCPGGEGFR PNPITIILED
1660 1670 1680 1690 1700
IDECQELPGL CQGGNCINTF GSFQCECPQG YYLSEETRIC EDIDECFAHP
1710 1720 1730 1740 1750
GVCGPGTCYN TLGNYTCICP PEYMQVNGGH NCMDMRKSFC YRSYNGTTCE
1760 1770 1780 1790 1800
NELPFNVTKR MCCCTYNVGK AWNKPCEPCP APGTADFKTI CGNIPGFTFD
1810 1820 1830 1840 1850
IHTGKAVDID ECKEIPGICA NGVCINQIGS FRCECPTGFS YNDLLLVCED
1860 1870 1880 1890 1900
IDECSNGDNL CQRNADCINS PGSYRCECAA GFKLSPNGAC VDRNECLEIP
1910 1920 1930 1940 1950
NVCSHGLCVD LQGSYQCICH NGFKASQDQT MCMDVDECER HPCGNGTCKN
1960 1970 1980 1990 2000
TVGSYNCLCY PGFALTHNND CMDIDECSSF FGQVCRNGRC FNEVGSFKCL
2010 2020 2030 2040 2050
CNEGYELTPD GKNCIDTNEC VALPGSCSPG TCQNLEGSFR CICPPGYEVK
2060 2070 2080 2090 2100
SENCIDINEC DEDPNICLFG SCTNTPGGFQ CICPPGFVLS DNGRRCFDTR
2110 2120 2130 2140 2150
QSFCFTNFEN GKCSVPKAFN TTKAKCCCSK MPGEGWGDPC ELCPKDDEVA
2160 2170 2180 2190 2200
FQDLCPYGHG TVPSLHDTRE DVNECLESPG ICSNGQCINT DGSFRCECPM
2210 2220 2230 2240 2250
GYNLDYTGVR CVDTDECSIG NPCGNGTCTN VIGSFECNCN EGFEPGPMMN
2260 2270 2280 2290 2300
CEDINECAQN PLLCAFRCMN TFGSYECTCP IGYALREDQK MCKDLDECAE
2310 2320 2330 2340 2350
GLHDCESRGM MCKNLIGTFM CICPPGMARR PDGEGCVDEN ECRTKPGICE
2360 2370 2380 2390 2400
NGRCVNTIGS YRCECNEGFQ SSSSGTECLD NRQGLCFAEV LQTMCQMASS
2410 2420 2430 2440 2450
SRNLVTKSEC CCDGGRGWGH QCELCPLPGT AQYKKICPHG PGYTTDGRDI
2460 2470 2480 2490 2500
DECKVMPNLC TSGQCINTMG SFRCFCKVGY TTDISGTSCV DLDECSQSPK
2510 2520 2530 2540 2550
PCNFICKNTE GSYQCSCPRG YVLQEDGKTC KDLDECQTKQ HNCQFLCVNT
2560 2570 2580 2590 2600
LGGFTCKCPP GFTQHHTACI DNNECGSQPS LCGAKGICQN TPGSFSCECQ
2610 2620 2630 2640 2650
RGFSLDATGL NCEDVDECDG NHRCQHGCQN ILGGYRCGCP QGYIQHYQWN
2660 2670 2680 2690 2700
QCVDENECSN PNACGSASCY NTLGSYKCAC PSGFSFDQFS SACHDVNECS
2710 2720 2730 2740 2750
SSKNPCNYGC SNTEGGYLCG CPPGYYRVGQ GHCVSGMGFN KGQYLSMDTE
2760 2770 2780 2790 2800
VDEENALSPE ACYECKINGY SKKDNRQKRS IHEPKHIAVK QISLESVDMD
2810 2820 2830 2840 2850
SPVMMKFNVS GLGAKEHIVE FMPAIEPLNN HIRYVISQGN DDGVFRIHQR
2860 2870 2880 2890 2900
NGLSYLHTAK RKLVPGMYTL EITSVPLYKK KELKKLEDSN EDDYLLGELG
2910
EALRMRLQIQ LY
Length:2,912
Mass (Da):314,516
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i656A0AF401C06F70
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001265517.1, NM_001278588.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000020360; ENSBTAP00000020360; ENSBTAG00000015307

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
540017

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001265517.1, NM_001278588.1

3D structure databases

SMRiF1MTZ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020360

Proteomic databases

PaxDbiF1MTZ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020360; ENSBTAP00000020360; ENSBTAG00000015307
GeneIDi540017

Organism-specific databases

VGNCiVGNC:52231 FBN2

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00950000183158
InParanoidiF1MTZ4
OMAiLCLQPYF
OrthoDBi1174178at2759
TreeFamiTF316849

Enzyme and pathway databases

ReactomeiR-BTA-1474228 Degradation of the extracellular matrix
R-BTA-1566948 Elastic fibre formation
R-BTA-2129379 Molecules associated with elastic fibres

Gene expression databases

BgeeiENSBTAG00000015307 Expressed in 8 organ(s), highest expression level in testis

Family and domain databases

Gene3Di3.90.290.10, 9 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 44 hits
SUPFAMiSSF57184 SSF57184, 13 hits
SSF57581 SSF57581, 9 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 43 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 45 hits
PS01187 EGF_CA, 16 hits
PS51364 TB, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MTZ4_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MTZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: May 8, 2019
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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