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Entry version 58 (07 Oct 2020)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Solute carrier family 12 member 1

Gene

SLC12A1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transportARBA annotation, SymportARBA annotation, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-426117, Cation-coupled Chloride cotransporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Solute carrier family 12 member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC12A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34664, SLC12A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei191 – 218HelicalSequence analysisAdd BLAST28
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei326 – 347HelicalSequence analysisAdd BLAST22
Transmembranei379 – 398HelicalSequence analysisAdd BLAST20
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei545 – 564HelicalSequence analysisAdd BLAST20
Transmembranei570 – 591HelicalSequence analysisAdd BLAST22
Transmembranei603 – 627HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MS75

PRoteomics IDEntifications database

More...
PRIDEi
F1MS75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000010145, Expressed in adult mammalian kidney and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000043868

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini90 – 157AA_permease_NInterPro annotationAdd BLAST68
Domaini182 – 685AA_permeaseInterPro annotationAdd BLAST504
Domaini694 – 1099SLC12InterPro annotationAdd BLAST406

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 51DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili824 – 851Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2083, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001883_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MS75

TreeFam database of animal gene trees

More...
TreeFami
TF313191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR018491, SLC12_C
IPR002445, Slc12a1
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207, NAKCLTRNSPRT
PR01209, NAKCLTRSPRT2

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930, 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MS75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLNNSSNVF LDSTPSNTNR FQVNVINESH ESSAAMNDNA DPPHYEETSF
60 70 80 90 100
GDEGQNRFRI SFRPGNQECY DNFLQTGETA KTDASFHAYD SHTNTYYLQT
110 120 130 140 150
FGHNTVDAVP KIEYYRNTGS VSGPKVNRPS LLDIHEQLAK NVSVAPGSAD
160 170 180 190 200
VVANGEGTPG DEQAENKGED QAGAVKFGWV KGVLVRCMLN IWGVMLFIRL
210 220 230 240 250
SWIVGEAGIG LGVLIILLST MVTSITGLST SAIATNGFVR GGGAYYLISR
260 270 280 290 300
SLGPEFGGSI GLIFAFANAV AVAMYVVGFA ETVVDLLKET DSMMVDPTND
310 320 330 340 350
IRIIGSITVV ILLGISVAGM EWEAKAQVIL LIILLIAIAN FFIGTVIPSN
360 370 380 390 400
NEKRARGFFN YQASIFAENF GPSFTKGEGF FSVFAIFFPA ATGILAGANI
410 420 430 440 450
SGDLEDPQDA IPKGTMLAIF ITTVAYLGVA ICVGACVVRD ATGSVNDTII
460 470 480 490 500
SGMNCNGSAA CGLGYDFSRC RHEPCQYGLM NNFQVMSMVS GFGPLITAGI
510 520 530 540 550
FSATLSSALA SLVSAPKVFQ ALCKDNIYKA LQFFAKGYGK NNEPLRGYFL
560 570 580 590 600
TFVIAMAFIL IAELNTIAPI ISNFFLASYA LINFSCFHAS YAKSPGWRPA
610 620 630 640 650
YGIYNMWVSL FGAVLCCAVM FVINWWAAVI TYVIEFFLYI YVTYKKPDVN
660 670 680 690 700
WGSSTQALSY MSALDNALEL TTVEDHVKNF RPQCIVLTGG PMTRPALLDI
710 720 730 740 750
THAFTKNSGL CICCEVFVGP RKLCVKEMNS GMAKKQAWLI KNKIKAFYAA
760 770 780 790 800
VAADCFRDGV RSLLQASGLG RMKPNTLVIG YKKNWRKAPL TEIENYVGII
810 820 830 840 850
HDAFDFEIGV VIVRISQGFD ISQVLQVQEE LEKLEQERLA LEATIKDNES
860 870 880 890 900
EEGNGGIRGL FKKAGKLNIT KPTPKKDSSI NTIQSMHVGE FNQKLVEAST
910 920 930 940 950
QFKKKQGKGT IDVWWLFDDG GLILLIPYIL TLRKKWKDCK LRIYVGGKIN
960 970 980 990 1000
RIEEEKIAMA SLLSKFRIKF ADIHVIGDIN VKPNKESWKV FEEMIEPYCL
1010 1020 1030 1040 1050
HESCKDLTTA EKLKRETPWK ITDAELEAVK EKSYRQVRLN ELLQEHSRAA
1060 1070 1080 1090
NLIVLSLPVA RKGSISDWLY MAWLEILTKN LPPVLLVRGN HKNVLTFYS
Length:1,099
Mass (Da):121,105
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i053EBB2C7A5E36AC
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000046583; ENSBTAP00000043868; ENSBTAG00000010145

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043868

Proteomic databases

PaxDbiF1MS75
PRIDEiF1MS75

Genome annotation databases

EnsembliENSBTAT00000046583; ENSBTAP00000043868; ENSBTAG00000010145

Organism-specific databases

VGNCiVGNC:34664, SLC12A1

Phylogenomic databases

eggNOGiKOG2083, Eukaryota
GeneTreeiENSGT00940000158030
HOGENOMiCLU_001883_0_0_1
InParanoidiF1MS75
TreeFamiTF313191

Enzyme and pathway databases

ReactomeiR-BTA-426117, Cation-coupled Chloride cotransporters

Gene expression databases

BgeeiENSBTAG00000010145, Expressed in adult mammalian kidney and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR018491, SLC12_C
IPR002445, Slc12a1
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit
PRINTSiPR01207, NAKCLTRNSPRT
PR01209, NAKCLTRSPRT2
TIGRFAMsiTIGR00930, 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MS75_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MS75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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