Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Proto-oncogene vav

Gene

VAV1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-114604 GPVI-mediated activation cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-1433557 Signaling by SCF-KIT
R-BTA-193648 NRAGE signals death through JNK
R-BTA-194840 Rho GTPase cycle
R-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-2871809 FCERI mediated Ca+2 mobilization
R-BTA-389359 CD28 dependent Vav1 pathway
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-4420097 VEGFA-VEGFR2 Pathway
R-BTA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-BTA-5218920 VEGFR2 mediated vascular permeability
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-912631 Regulation of signaling by CBL
R-BTA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene vavImported
Gene namesi
Name:VAV1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:36772 VAV1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSBTAG00000039160 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiF1MR20 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF1MR20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 52Calponin-homology (CH)InterPro annotationAdd BLAST52
Domaini126 – 305DHInterPro annotationAdd BLAST180
Domaini521 – 589SH3InterPro annotationAdd BLAST69
Domaini600 – 694SH2InterPro annotationAdd BLAST95
Domaini711 – 771SH3InterPro annotationAdd BLAST61

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00920000148946

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd10405 SH2_Vav1, 1 hit
cd11979 SH3_VAV1_1, 1 hit
cd11976 SH3_VAV1_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028530 Vav1
IPR035879 VAV1_SH2
IPR035730 VAV1_SH3_1
IPR035729 VAV1_SH3_2
PANTHERiPTHR22826:SF112 PTHR22826:SF112, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1MR20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QFLCLKNIRT FLSTCYEKFG LKRSELFEAF DLFDVQDFGK VIYTLSALSW
60 70 80 90 100
TPIAQNKGIM PFPTEESVGD EDIYSGLSDQ IDDTVEEDED LYDCVENEEA
110 120 130 140 150
EGDEVYEDLM RSEPVPMPPK MTEYDKRCCC LREIQQTEEK YTDTLGSIQQ
160 170 180 190 200
HFMKPLQRFL KPQDVEIIFI NIEDLLRVHT HFLKEMKEAL ANPGASTLYQ
210 220 230 240 250
VFIKYKERFL IYGRYCSQVE SASKHLDRVA TAREDVQMKL EECSQRANNG
260 270 280 290 300
RFTLRDLLMV PMQRVLKYHL LLQELVKHTQ DAMEKDNLRL ALDAMRDLAQ
310 320 330 340 350
CVNEVKRDNE TLRQITNFQL SIENLDQSLA HYGRPKIDGE LKITSVERRS
360 370 380 390 400
KMDRYAFLLD KALLICKRRG DTYDLKDFVN LHSFQVRDDS SGERDNKKGS
410 420 430 440 450
EVVTGRPQCW GPSMPLELST WPLECLCVCV CDLALKHVYY HMGLPGGSDD
460 470 480 490 500
KESASNAGDL GLIPVLGRPP WRRAWQSLRY SCLKNSMGRG PGIQVTSSCS
510 520 530 540 550
TSLLPLGIPW ASLYHPLPSP PGLPKMEVCQ EYYGLPPPPG AIGPFLRLNP
560 570 580 590 600
GDIVELTKAE AEQNWWEGRN ISTNEVGWFP CNRVKPYVHG PPQDLSVHLW
610 620 630 640 650
YAGPMERAGA ESILTNRSDG TFLVRQRVKD AAEFAISIKY NVEVKHIKIM
660 670 680 690 700
TAEGLYRITE KKAFRGLTEL VEFYQQNSLK DCFKSLDTTL QFPFKEPERR
710 720 730 740 750
AINKPSAGSI KIFGTAKARY DFCARDRSEL SLKEGDIVKI LNKKGQQGWW
760 770
RGEIYGRIGW FPSNYVEEDY SEYC
Length:774
Mass (Da):88,832
Last modified:November 16, 2011 - v2
Checksum:i0D728D1A7BA5E487
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MSK3F1MSK3_BOVIN
Proto-oncogene vav
VAV1
784Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019536 Genomic DNA No translation available.
DAAA02019537 Genomic DNA No translation available.
DAAA02019538 Genomic DNA No translation available.
DAAA02019539 Genomic DNA No translation available.
DAAA02019540 Genomic DNA No translation available.
DAAA02019541 Genomic DNA No translation available.
DAAA02019542 Genomic DNA No translation available.
DAAA02019543 Genomic DNA No translation available.
DAAA02019544 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000056825; ENSBTAP00000050922; ENSBTAG00000039160

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019536 Genomic DNA No translation available.
DAAA02019537 Genomic DNA No translation available.
DAAA02019538 Genomic DNA No translation available.
DAAA02019539 Genomic DNA No translation available.
DAAA02019540 Genomic DNA No translation available.
DAAA02019541 Genomic DNA No translation available.
DAAA02019542 Genomic DNA No translation available.
DAAA02019543 Genomic DNA No translation available.
DAAA02019544 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF1MR20
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000056825; ENSBTAP00000050922; ENSBTAG00000039160

Organism-specific databases

VGNCiVGNC:36772 VAV1

Phylogenomic databases

GeneTreeiENSGT00920000148946

Enzyme and pathway databases

ReactomeiR-BTA-114604 GPVI-mediated activation cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-1433557 Signaling by SCF-KIT
R-BTA-193648 NRAGE signals death through JNK
R-BTA-194840 Rho GTPase cycle
R-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-2871809 FCERI mediated Ca+2 mobilization
R-BTA-389359 CD28 dependent Vav1 pathway
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-4420097 VEGFA-VEGFR2 Pathway
R-BTA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-BTA-5218920 VEGFR2 mediated vascular permeability
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-912631 Regulation of signaling by CBL
R-BTA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Gene expression databases

BgeeiENSBTAG00000039160 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiF1MR20 baseline and differential

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd10405 SH2_Vav1, 1 hit
cd11979 SH3_VAV1_1, 1 hit
cd11976 SH3_VAV1_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028530 Vav1
IPR035879 VAV1_SH2
IPR035730 VAV1_SH3_1
IPR035729 VAV1_SH3_2
PANTHERiPTHR22826:SF112 PTHR22826:SF112, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF1MR20_BOVIN
AccessioniPrimary (citable) accession number: F1MR20
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again