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Entry version 75 (29 Sep 2021)
Sequence version 2 (16 Nov 2011)
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Protein
Submitted name:

Calpain 5

Gene

CAPN5

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei81PROSITE-ProRule annotation1
Active sitei252PROSITE-ProRule annotation1
Active sitei284PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSBTAG00000005034

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:26748, CAPN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MQD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000005034, Expressed in thyroid gland and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MQD1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000006638

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MQD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 343Calpain catalyticInterPro annotationAdd BLAST318
Domaini499 – 614C2InterPro annotationAdd BLAST116

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010982_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MQD1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWKRPKY

Database of Orthologous Groups

More...
OrthoDBi
704215at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314748

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04046, C2_Calpain, 1 hit
cd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033884, C2_Calpain
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF01067, Calpain_III, 1 hit
PF00648, Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50203, CALPAIN_CAT, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1MQD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSCVKPYEN QNYSALKRAC LRRKVLFEDP NFPATDDSLY YKGSPGPTVR
60 70 80 90 100
WKRPKDICED PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWD PEKPNAYAGI FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC
160 170 180 190 200
HSSSRNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDFANDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK
260 270 280 290 300
GHAYAITDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WNGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKLGVTVQDD GEFWMTFEDL CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLR GAWTRHEDPL QNRSGGCINH KDSFFQNPQY IFDVKKPEDE
410 420 430 440 450
VLISIQQRPK QSTRRDGKGE NLAIGFDIYK VEENRQYRMH SLQHRAASSI
460 470 480 490 500
YINSRSVFLR TEQPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK DSPTGANSYV IIKCEGDKVR
560 570 580 590 600
SAVQKGTSTP EYDVKGVFYR KKPSQPITVQ IWNHRVLKDE FLGQVHLKAN
610 620 630 640
ADDLQALHTL HLRDRNSRQP SDLPGTVAVR VLSSASLTAV
Length:640
Mass (Da):73,033
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80202EF4B0E66F19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MUH7A0A3Q1MUH7_BOVIN
Calpain 5
CAPN5
596Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_005216345.1, XM_005216288.3
XP_005216346.1, XM_005216289.3
XP_015330295.1, XM_015474809.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000006638; ENSBTAP00000006638; ENSBTAG00000005034
ENSBTAT00000067671; ENSBTAP00000068736; ENSBTAG00000005034
ENSBTAT00000084642; ENSBTAP00000065043; ENSBTAG00000005034

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
536988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_005216345.1, XM_005216288.3
XP_005216346.1, XM_005216289.3
XP_015330295.1, XM_015474809.1

3D structure databases

SMRiF1MQD1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006638

Proteomic databases

PaxDbiF1MQD1

Genome annotation databases

EnsembliENSBTAT00000006638; ENSBTAP00000006638; ENSBTAG00000005034
ENSBTAT00000067671; ENSBTAP00000068736; ENSBTAG00000005034
ENSBTAT00000084642; ENSBTAP00000065043; ENSBTAG00000005034
GeneIDi536988

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
726
VEuPathDBiHostDB:ENSBTAG00000005034
VGNCiVGNC:26748, CAPN5

Phylogenomic databases

eggNOGiKOG0045, Eukaryota
GeneTreeiENSGT00940000156536
HOGENOMiCLU_010982_3_2_1
InParanoidiF1MQD1
OMAiRWKRPKY
OrthoDBi704215at2759
TreeFamiTF314748

Gene expression databases

BgeeiENSBTAG00000005034, Expressed in thyroid gland and 97 other tissues
ExpressionAtlasiF1MQD1, baseline and differential

Family and domain databases

CDDicd04046, C2_Calpain, 1 hit
cd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884, C2_Calpain
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF01067, Calpain_III, 1 hit
PF00648, Peptidase_C2, 1 hit
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50203, CALPAIN_CAT, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MQD1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MQD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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