Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor

Gene

FGF22

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-109704 PI3K Cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-190370 FGFR1b ligand binding and activation
R-BTA-190377 FGFR2b ligand binding and activation
R-BTA-5654219 Phospholipase C-mediated cascade: FGFR1
R-BTA-5654221 Phospholipase C-mediated cascade, FGFR2
R-BTA-5654687 Downstream signaling of activated FGFR1
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654689 PI-3K cascade:FGFR1
R-BTA-5654693 FRS-mediated FGFR1 signaling
R-BTA-5654695 PI-3K cascade:FGFR2
R-BTA-5654699 SHC-mediated cascade:FGFR2
R-BTA-5654700 FRS-mediated FGFR2 signaling
R-BTA-5654706 FRS-mediated FGFR3 signaling
R-BTA-5654712 FRS-mediated FGFR4 signaling
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5654727 Negative regulation of FGFR2 signaling
R-BTA-5658623 FGFRL1 modulation of FGFR1 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF22Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:52233 FGF22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1MQA1

Expressioni

Gene expression databases

BgeeiENSBTAG00000027357 Expressed in 5 organ(s), highest expression level in prefrontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039035

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
InParanoidiF1MQA1
OMAiGRTQRHH
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028296 FGF22
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF41 PTHR11486:SF41, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

F1MQA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PRGFQLACVG RPGRLLGSLI SQWQSRGCSR GGENGQRVGR VAMRGRLWLG
60 70 80 90 100
LVWLLLARAP GTAGTLNTPR RPRSYPHLEG DVRWRRLFSS THFFLLVDPS
110 120 130 140 150
GRVQGTRWRD NPDSVLEIRS IRVGVVVLKA VHSGFYVAMN RLGRLYGSRF
160 170 180 190 200
CAAHCRFRER IEENGYNTYA SVRWRHQGRP MFLALDGRGA PRLGGRTQRH
210
HPSTLFLPVL
Length:210
Mass (Da):23,809
Last modified:May 3, 2011 - v1
Checksum:i50EA7716EE4B42E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02020222 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000039235; ENSBTAP00000039035; ENSBTAG00000027357

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02020222 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039035

Proteomic databases

PaxDbiF1MQA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039235; ENSBTAP00000039035; ENSBTAG00000027357

Organism-specific databases

VGNCiVGNC:52233 FGF22

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
InParanoidiF1MQA1
OMAiGRTQRHH
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-BTA-109704 PI3K Cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-190370 FGFR1b ligand binding and activation
R-BTA-190377 FGFR2b ligand binding and activation
R-BTA-5654219 Phospholipase C-mediated cascade: FGFR1
R-BTA-5654221 Phospholipase C-mediated cascade, FGFR2
R-BTA-5654687 Downstream signaling of activated FGFR1
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654689 PI-3K cascade:FGFR1
R-BTA-5654693 FRS-mediated FGFR1 signaling
R-BTA-5654695 PI-3K cascade:FGFR2
R-BTA-5654699 SHC-mediated cascade:FGFR2
R-BTA-5654700 FRS-mediated FGFR2 signaling
R-BTA-5654706 FRS-mediated FGFR3 signaling
R-BTA-5654712 FRS-mediated FGFR4 signaling
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5654727 Negative regulation of FGFR2 signaling
R-BTA-5658623 FGFRL1 modulation of FGFR1 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Gene expression databases

BgeeiENSBTAG00000027357 Expressed in 5 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028296 FGF22
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF41 PTHR11486:SF41, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1MQA1_BOVIN
AccessioniPrimary (citable) accession number: F1MQA1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again