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Protein
Submitted name:

BRCA1 interacting protein C-terminal helicase 1

Gene

BRIP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-5685938 HDR through Single Strand Annealing (SSA)
R-BTA-5685942 HDR through Homologous Recombination (HRR)
R-BTA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-BTA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-BTA-5693579 Homologous DNA Pairing and Strand Exchange
R-BTA-5693607 Processing of DNA double-strand break ends
R-BTA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-BTA-6804756 Regulation of TP53 Activity through Phosphorylation
R-BTA-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
BRCA1 interacting protein C-terminal helicase 1Imported
Gene namesi
Name:BRIP1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:50067 BRIP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1MMS0

Expressioni

Gene expression databases

BgeeiENSBTAG00000012068 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiF1MMS0 baseline

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053187

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 378Helicase ATP-bindingInterPro annotationAdd BLAST378

Phylogenomic databases

eggNOGiKOG1132 Eukaryota
COG1199 LUCA
GeneTreeiENSGT00530000063199
InParanoidiF1MMS0
OMAiKARWERT
OrthoDBiEOG091G00LK
TreeFamiTF329449

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

F1MMS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SFLGKPVDES LSKKTEVPLS CCCTCHSKNS ANSDVHQRTS HHFSSPSTPP
60 70 80 90 100
SERNGTLSGS QEDSPEKTTL AAKLSAKKQA SMYRDENDDF QVEKKRIRPL
110 120 130 140 150
ETAQQIRKRH CFEKEVHHLD AKVASEKTTK LNSPLGKINS ISPQNPPGHC
160 170 180 190 200
SRCCCSTKQG NSEDSSNTTK KDHGGKFKIP KIYFGTRTHK QIAQITRELQ
210 220 230 240 250
RTAYSGVPMT ILSSRDHTCV HPEVMGNFNR NEKCMELLDG KNGKSCYFYH
260 270 280 290 300
GVHKMSDQHT LQTFQGMHKA WDIEELVSLG RKLKACPYYT ARELMQNADI
310 320 330 340 350
IFCPYNYLLD AQIRETMDIN LKEQVVILDE AHNIEDCARE SASYSVTEVQ
360 370 380 390 400
LRFARDELDS MINYNIRKKD HEPLRAVCCS LINWLEASSE HLVERNYESS
410 420 430 440 450
CKVWSGSEML LNLHKMGITT ATFPILQGHF SAVLQREEKV PSIHGKEEAR
460 470 480 490 500
EIPVISASTQ IMLKGLFMVL DYLFRQNSRF ADDYKVAIQQ TYSWINQSDT
510 520 530 540 550
TDHGLLILSK NKKRLRQKAA VRVLNFWCLN PAVAFSDING KVWAIVLTSG
560 570 580 590 600
TLSPMKSFSS ELGVTFTIQL EANHVINNSQ VWVGTIGSGP KGRSLCATFQ
610 620 630 640 650
HTETFEFQDE VGALLLSVCQ TISQGILCFL PSYKLLEKLK ERWLSTGLWY
660 670 680 690 700
NLELVKTVIV EPQGGEKIDF DELLQMYYDA IKYKGEKDGA LLVAVCRGKV
710 720 730 740 750
SEGLDFSDDN ARAVVTIGIP FPNVKDLQVE LKRQYNDQHS KLRGLLPGRQ
760 770 780 790 800
WYEIQAYRAL NQALGRCIRH KNDWGALILV DDRFRSNPSR YISGLSKWVR
810 820 830 840 850
QLIQHHSTFE SALESLAEFA KKHQKVIAAS KEDRKSIQGS EPTLGGACSK
860 870 880 890 900
DSTYFLEAAS HLSPEYAMEG KAKMCLKLPY PKMINKSPSS PKRRKEQKDD
910 920 930 940 950
PELLEESAQA VGAEGIVISR STSPTFSKQI DQVSWSGSNL GGQCLTGKIL
960 970 980 990 1000
TGTPMVRSSE DCASTSSTFK TEKKCETVLL LTDKYESSSL TVDTSFGACP
1010 1020 1030 1040 1050
QSETIVPSTN VDAANLNSED PAIQLSVVSE EAEPSPSNIA SETEAEDESI
1060 1070 1080 1090 1100
YFTPELYDPV ETNEEKNELV GTERDSRLTN SSNGILTEDL FEIKTTKGVD
1110 1120 1130 1140 1150
SVREMEAEDC TDTKLKRLMP IKESKVDDLG SNVKTTHWEN TQEMDIKNFK
1160
LSPSKNKDVF LVLG
Length:1,164
Mass (Da):130,614
Last modified:November 16, 2011 - v2
Checksum:iA27F586099BB5F27
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3N0I3G3N0I3_BOVIN
BRCA1 interacting protein C-termina...
BRIP1
756Annotation score:
E1BNG9E1BNG9_BOVIN
BRCA1 interacting protein C-termina...
BRIP1
1,098Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02048371 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000061499; ENSBTAP00000053187; ENSBTAG00000012068

Similar proteinsi

Entry informationi

Entry nameiF1MMS0_BOVIN
AccessioniPrimary (citable) accession number: F1MMS0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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