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Entry version 60 (29 Sep 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Catenin delta 2

Gene

CTNND2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Catenin delta 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTNND2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSBTAG00000017222

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27806, CTNND2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501869612919 – 1182Sequence analysisAdd BLAST1164

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MM16

PRoteomics IDEntifications database

More...
PRIDEi
F1MM16

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F1MM16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000017222, Expressed in prefrontal cortex and 65 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MM16, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000053204

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati549 – 582ARMPROSITE-ProRule annotationAdd BLAST34
Repeati593 – 636ARMPROSITE-ProRule annotationAdd BLAST44
Repeati849 – 886ARMPROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 196DisorderedSequence analysisAdd BLAST55
Regioni218 – 269DisorderedSequence analysisAdd BLAST52
Regioni389 – 440DisorderedSequence analysisAdd BLAST52
Regioni471 – 493DisorderedSequence analysisAdd BLAST23
Regioni999 – 1067DisorderedSequence analysisAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili18 – 38Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 166Polar residuesSequence analysisAdd BLAST25
Compositional biasi171 – 188Pro residuesSequence analysisAdd BLAST18
Compositional biasi255 – 269Polar residuesSequence analysisAdd BLAST15
Compositional biasi390 – 440Polar residuesSequence analysisAdd BLAST51
Compositional biasi999 – 1032Polar residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1048, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154952

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007897_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MM16

Database of Orthologous Groups

More...
OrthoDBi
233858at2759

TreeFam database of animal gene trees

More...
TreeFami
TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028435, Plakophilin/d_Catenin

The PANTHER Classification System

More...
PANTHERi
PTHR10372, PTHR10372, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514, Arm, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185, ARM, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F1MM16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WSLLEFIFLV VLFQELQFER LTRELEAERQ IVASQLERCK LGSETGSMSS
60 70 80 90 100
VSSAEEQFHW QSQDGQKDIE DELTTGLELV DSCIRSLQES GILDPQDYST
110 120 130 140 150
SERPSLLSQS ALQLNSKPEG SFQYPASYHS NQTLALGETA PSQLPARSTQ
160 170 180 190 200
ARGAGQSFSQ GTTSRAGHLA GPEPAPPPPP PPPREPFAPS LGSAFHLPDA
210 220 230 240 250
QPAAAAALYY SSSTLPAPPR GGSPLAAPQG GSPTKLQRGG SAPEGAAYAA
260 270 280 290 300
PPRGSSPKQS PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS
310 320 330 340 350
SPIHQLSSTI GTYATLSPTK RLVHASEPYG KHSQELYATA TLQRPGSLAA
360 370 380 390 400
GSRASYSSQH GHLGPELRAL QSPEHHIDPI YEDRVYQKPP MRSLSQSQGD
410 420 430 440 450
PLPPAHTGTY RTSTAPSSPG VDSVPLQRTG SQHGPQSAAA ATFQRASYAA
460 470 480 490 500
GPASSYADPY RQLQYCPSVE SPYSKSGPAL PPEGTLARSP SIDSIQKDPR
510 520 530 540 550
EFGWRDPELP EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG
560 570 580 590 600
IQLLVDLLDH RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR
610 620 630 640 650
LLRKTTDLEI RELVTGVLWN LSSCDALKMP IIQDTLAVLT NAVIIPHSGW
660 670 680 690 700
ENSPLQDDRK IQLHSSQVLR NATGCLRNVS SAGEEARRRM RECDGLTDAL
710 720 730 740 750
LYVIQSALGS SEIDSKTVEN CVCILRNLSY RLAAETSQGQ HMGTDELDGL
760 770 780 790 800
LCGEANGKDA ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH
810 820 830 840 850
PSIVKPYLTL LSECSNADTL EGAAGALQNL AAGSWKWSVY IRAAVRKEKG
860 870 880 890 900
LPILVELLRI DNDRVVCAVA TALRNMALDV RNKELIGKYA MRDLVHRLPG
910 920 930 940 950
GNNSNSAASK AMSDDTVTAV CCTLHEVITK NMENAKALRD AGGIEKLVGI
960 970 980 990 1000
SKSKGDKHSP KVVKAASQVL NSMWQYRDLR SLYKKDGWSQ YHFVASSSTI
1010 1020 1030 1040 1050
ERDRQRPYSS SRTPSISPVR VSPNNRSASA PASPREMISL KERKTDYEST
1060 1070 1080 1090 1100
GSNATYHGTK GEHTSRKDTM TAQTTGISTL YRNSYGAPAE DIKHNQVSAQ
1110 1120 1130 1140 1150
PAPQEPSRKD YETYQPFPNS TRNYDESFFE DQVHHRPPAS EYAMHLGLKS
1160 1170 1180
TGNYVDFYSA ARPYSELNYE TSHYPASPDS WV
Length:1,182
Mass (Da):128,469
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABE78C8F98FFB46A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1NJC6A0A3Q1NJC6_BOVIN
Catenin delta 2
CTNND2
1,228Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MKI7A0A3Q1MKI7_BOVIN
Catenin delta 2
CTNND2
861Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LRY4A0A3Q1LRY4_BOVIN
Catenin delta 2
CTNND2
1,204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M9I8A0A3Q1M9I8_BOVIN
Catenin delta 2
CTNND2
1,192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MFB1A0A3Q1MFB1_BOVIN
Catenin delta 2
CTNND2
1,225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M0Q6A0A3Q1M0Q6_BOVIN
Catenin delta 2
CTNND2
1,085Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M8I2A0A3Q1M8I2_BOVIN
Catenin delta 2
CTNND2
1,110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000061068; ENSBTAP00000053204; ENSBTAG00000017222

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053204

PTM databases

SwissPalmiF1MM16

Proteomic databases

PaxDbiF1MM16
PRIDEiF1MM16

Genome annotation databases

EnsembliENSBTAT00000061068; ENSBTAP00000053204; ENSBTAG00000017222

Organism-specific databases

VEuPathDBiHostDB:ENSBTAG00000017222
VGNCiVGNC:27806, CTNND2

Phylogenomic databases

eggNOGiKOG1048, Eukaryota
GeneTreeiENSGT00940000154952
HOGENOMiCLU_007897_0_0_1
InParanoidiF1MM16
OrthoDBi233858at2759
TreeFamiTF321877

Gene expression databases

BgeeiENSBTAG00000017222, Expressed in prefrontal cortex and 65 other tissues
ExpressionAtlasiF1MM16, baseline

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028435, Plakophilin/d_Catenin
PANTHERiPTHR10372, PTHR10372, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 4 hits
SMARTiView protein in SMART
SM00185, ARM, 7 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MM16_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MM16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: September 29, 2021
This is version 60 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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