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Entry version 67 (07 Oct 2020)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

DENN domain containing 3

Gene

DENND3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DENN domain containing 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27998, DENND3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MLZ5

PRoteomics IDEntifications database

More...
PRIDEi
F1MLZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000006132, Expressed in placenta and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MLZ5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000008069

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 477UDENNInterPro annotationAdd BLAST433
Domaini994 – 1079WD_REPEATS_REGIONInterPro annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 78DisorderedSequence analysisAdd BLAST46

Keywords - Domaini

RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2127, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_280008_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MLZ5

Database of Orthologous Groups

More...
OrthoDBi
521943at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR011047, Quinoprotein_ADH-like_supfam
IPR037516, Tripartite_DENN
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141, DENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00320, WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F1MLZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQVAQRKGV KGPSFLDPEV LSVFVPPFVM KEDSQPAASN CTTPGKNRKR
60 70 80 90 100
SFRKKRERPR VELGKGVPGG PRGPDPEDVN IPNGVDLLAL PQLCFPGGLC
110 120 130 140 150
VASEPREDCV HFLVLTDICG NRTYGVVAQY YRPLHDEYCF YNGRTHWEAL
160 170 180 190 200
GPGGSAAGCF VPFAVCVVSR FPYYNALKDC LSCLLTHLKF CKDFEVDNHI
210 220 230 240 250
KDFAAKLSLI PSPPPGPLHL IFNMKPLQIV FPSRADPESP LIDLDLHLPL
260 270 280 290 300
LCFRPEKVLQ ILSCLLTEQR VVFFSSSWAL LTLVAECFMA YLHPLQWQHT
310 320 330 340 350
FVPILSGQML DFLMAPTSFL MGCHLDHFEE VSKEADGLIL INIDSGNITY
360 370 380 390 400
SNDEEVDVPD IPLLAAQTFI QRVQSLQLHH ELDLAHLCAS TDVNEGRASR
410 420 430 440 450
RAWQQQLNCQ IQQMTLQLLV SIFREVKNHL NYEHRVFNSE EFLKTRALGD
460 470 480 490 500
QQFYKQVLDT YMFHAFLKAR LSRRMDAFAQ MDLHTQSEED RINGMLLSPR
510 520 530 540 550
RPTIEKMASR KSSVSHTAHR RMVVSMPNLQ DITVPELPPR NSSLRKIQTT
560 570 580 590 600
EYGSSHTVLD VPPKSTHTFK IPEIHFPLVA QCVQAFYADC VAQLSKAMGS
610 620 630 640 650
LAPENSVLLA RYFYLRGLVQ LMQGQLLDAL LDFQSLYKTD VRVFPTDLVQ
660 670 680 690 700
TTVESLSAPE RTQAERMPEL RRLISEVMDR PADVPKADDR VKNFELPKKH
710 720 730 740 750
MQLDDFVKRV QESGIVKDTV IIHRLFEALT VGHEKQIDPE TFKDFYNCWK
760 770 780 790 800
EAEAEAQEVS LPLSVMEQLD KSECVYKLSR SVKTNRGVGK IAMTQKRLFL
810 820 830 840 850
LTEGRPGYVE ISTFRNIEDV RSTMATFLLL RIPTLKIKTT SKKEVFEANL
860 870 880 890 900
KTECDLWHLM VKEMWAGRKL ADDHKDPQYV QQALTHILLM DAVVGTLQSP
910 920 930 940 950
GAIYAASKLS YFDRMKNEMP MAIPKTTSET LKHKINPSEG ETTPRAVDVL
960 970 980 990 1000
LYTPGHLDPA EKVEDAHPKL WCALNEGKVI VFDASSWTIH QHCFRVGTSK
1010 1020 1030 1040 1050
LNCMVMAEQS QVWVGSEDSV IYIINVHSMS CNKQLTDHRS SVTGLAVQDG
1060 1070 1080 1090 1100
EQAPSTVYSC SADGTVLAWN ASSLRVTGRF QVPGGGLSAI RLHGGRLWCC
1110 1120 1130 1140 1150
TGDSILMVNM NGSSCQKLKI TGSFKETGTS FLGFQLMPEQ EQLWAACAGY
1160 1170 1180 1190 1200
PDVYVWSLQD PAQPPQRIHL QDCSEINCMI RVKKQIWVGT TGLSQGQLKG
1210 1220 1230 1240 1250
KIYVMDAERR TVEKELVAHA DTVKTLCSAE DRYVLSGAGP EEGKIAIWKV

E
Length:1,251
Mass (Da):140,837
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1760C158E43BBED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MWL7A0A3Q1MWL7_BOVIN
DENN domain containing 3
DENND3
1,330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M0P3A0A3Q1M0P3_BOVIN
DENN domain containing 3
DENND3
1,294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MCL3A0A3Q1MCL3_BOVIN
DENN domain containing 3
DENND3
1,330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_010810213.1, XM_010811911.2
XP_010820962.1, XM_010822660.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000008069; ENSBTAP00000008069; ENSBTAG00000006132

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
508078

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_010810213.1, XM_010811911.2
XP_010820962.1, XM_010822660.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008069

Proteomic databases

PaxDbiF1MLZ5
PRIDEiF1MLZ5

Genome annotation databases

EnsembliENSBTAT00000008069; ENSBTAP00000008069; ENSBTAG00000006132
GeneIDi508078

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22898
VGNCiVGNC:27998, DENND3

Phylogenomic databases

eggNOGiKOG2127, Eukaryota
GeneTreeiENSGT00940000155784
HOGENOMiCLU_280008_0_0_1
InParanoidiF1MLZ5
OrthoDBi521943at2759
TreeFamiTF331814

Enzyme and pathway databases

ReactomeiR-BTA-8876198, RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSBTAG00000006132, Expressed in placenta and 19 other tissues
ExpressionAtlasiF1MLZ5, baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR011047, Quinoprotein_ADH-like_supfam
IPR037516, Tripartite_DENN
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
PfamiView protein in Pfam
PF02141, DENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00320, WD40, 3 hits
SUPFAMiSSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MLZ5_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MLZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 67 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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