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Entry version 77 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein

Non-specific serine/threonine protein kinase

Gene

TRIO

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-194840, Rho GTPase cycle
R-BTA-416476, G alpha (q) signalling events
R-BTA-416482, G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIOImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:36356, TRIO

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MLS2

PRoteomics IDEntifications database

More...
PRIDEi
F1MLS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000005514, Expressed in vertebral column and 99 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MLS2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000053254

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MLS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 138CRAL-TRIOInterPro annotationAdd BLAST138
Domaini1220 – 1395DHInterPro annotationAdd BLAST176
Domaini1407 – 1519PHInterPro annotationAdd BLAST113
Domaini1584 – 1649SH3InterPro annotationAdd BLAST66
Domaini1897 – 2073DHInterPro annotationAdd BLAST177
Domaini2085 – 2199PHInterPro annotationAdd BLAST115
Domaini2480 – 2545SH3InterPro annotationAdd BLAST66
Domaini2614 – 2704Ig-likeInterPro annotationAdd BLAST91
Domaini2725 – 2979Protein kinaseInterPro annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1529 – 1578DisorderedSequence analysisAdd BLAST50
Regioni1707 – 1834DisorderedSequence analysisAdd BLAST128
Regioni1855 – 1893DisorderedSequence analysisAdd BLAST39
Regioni2215 – 2482DisorderedSequence analysisAdd BLAST268
Regioni2568 – 2589DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili685 – 712Sequence analysisAdd BLAST28
Coiled coili813 – 833Sequence analysisAdd BLAST21
Coiled coili864 – 891Sequence analysisAdd BLAST28
Coiled coili1834 – 1854Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1556 – 1578Polar residuesSequence analysisAdd BLAST23
Compositional biasi1734 – 1763Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1764 – 1783Polar residuesSequence analysisAdd BLAST20
Compositional biasi1806 – 1834Polar residuesSequence analysisAdd BLAST29
Compositional biasi1859 – 1883Polar residuesSequence analysisAdd BLAST25
Compositional biasi2277 – 2291Polar residuesSequence analysisAdd BLAST15
Compositional biasi2295 – 2324Pro residuesSequence analysisAdd BLAST30
Compositional biasi2325 – 2341Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2409 – 2437Polar residuesSequence analysisAdd BLAST29
Compositional biasi2455 – 2482Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Immunoglobulin domainARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota
KOG4240, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154766

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000373_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MLS2

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRYLHNC

TreeFam database of animal gene trees

More...
TreeFami
TF318080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028570, Kalirin/TRIO
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104, PTHR22826:SF104, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650, CRAL_TRIO, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 2 hits
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1MLS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCLFAGGRDK RGGPILTFPA RSNHDRIRQE DLRRLISYLA CIPSEEVCKR
60 70 80 90 100
GFTVIVDMRG SKWDSIKPLL KILQESFPCC IHVALIIKPD NFWQKQRTNF
110 120 130 140 150
GSSKFEFETN MVSLEGLTKV VDPSQLTPEF DGCLEYNHEE WIEIRLAFED
160 170 180 190 200
YISNATHMLS RLEELQDILA KKELPQDLEG ARNMIEEHSQ LKKKVIKAPI
210 220 230 240 250
EDLDLEGQKL LQRIQSSESF PKKNSGSGNA DLQSLLPKVS AMLDRLHSTR
260 270 280 290 300
QHLHQMWHVR KLKLDQCFQL RLFEQDAEKM FDWITHNKGL FLNSYTEIGT
310 320 330 340 350
SHPHAMELQT QHNHFAMNCM NVYVNINRIM SVANRLVESG HYASQQIKQI
360 370 380 390 400
ANQLEQEWKA FAAALDERST LLDMSSVFHQ KAEKYMSNVD SWCKACGEVD
410 420 430 440 450
LPSELQDLED AIHHHQGVYE HVTLAYSEVS QDGKSLLDKL QRPLTPGSSD
460 470 480 490 500
SLTASANYSK AVHHVLDVIH EVLHHQRQLE NIWQHRKVRL HQRLQLCVFQ
510 520 530 540 550
QDVQQVLDWI ENHGEAFLSK HTGVGKSLHR ARALQKRHED FEEVAQNTYT
560 570 580 590 600
NADKLLEAAE QLAQTGECDP EEIYQAAHQL EDRIQDFVRR VEQRKILLDM
610 620 630 640 650
SVSFHTHVKE LWTWLEELQK ELLDDVYAES VEAVQDLSKR FGQQQQTTLQ
660 670 680 690 700
VTVNVIKEGE DLIQQLRDSA ISSNKTPHNS SISHIETVLQ QLDEAQAQME
710 720 730 740 750
ELFQERKIKL ELFLQLRIFE RDAIDIISDL ESWNDELSQQ MNDFDTEDLT
760 770 780 790 800
IAEQRLQHHA DKALTMNNLT FDVIHQGQDL LQYVNEVQAS GVELLCDRDV
810 820 830 840 850
DMATRVQDLL EFLHEKQQEL DLAAEQHRKH LEQCVQLRHL QAEVKQVLGW
860 870 880 890 900
IRNGESMLNA GLIAASSLQE AEQLQREHEQ FQHAIEKTHQ SALQVQQKAE
910 920 930 940 950
AMLQANHYDM DMIRDCAEKV ASHWQQLMLK MEDRLKLVNA SVAFYKTSEQ
960 970 980 990 1000
VCSVLESLEQ EYKREEDWCG GADKLGPNSE TDHVTPMISK HLEQKEAFLK
1010 1020 1030 1040 1050
ACTLARRNAD VFLKYLHRNS VNMPGMVTHI KAPEQQVKNI LNELFQRENR
1060 1070 1080 1090 1100
VLHYWTMRKR RLDQCQQFVV FERSAKQALE WIHDSGEFYL STHTSTGSSI
1110 1120 1130 1140 1150
QHTQELLKEH EDFQITAKQT KERVKLLIQL ADGFCEKGHA HAAEIKKCVT
1160 1170 1180 1190 1200
AVDKRYRDFS LRMEKYRTSL EKALGISSDS NKSSKSLQLD IVPASIPGSE
1210 1220 1230 1240 1250
VKLRDAAHEL NEEKRKSARR KEFIMAELIQ TEKAYVRDLR ECMDTYLWEM
1260 1270 1280 1290 1300
TSGVEEIPPG IVNKELIIFG NMQEIYEFHN NIFLKELEKY EQLPEDVGHC
1310 1320 1330 1340 1350
FVTWADKFQM YVTYCKNKPD STQLILEHAG SYFDEIQQRH GLANSISSYL
1360 1370 1380 1390 1400
IKPVQRITKY QLLLKELLTC CEEGKGEIKD GLEVMLSVPK RANDAMHLSM
1410 1420 1430 1440 1450
LEGFDENIES QGELILQESF QVWDPKTLIR KGRERHLFLF EMSLVFSKEV
1460 1470 1480 1490 1500
KDSSGRSKYL YKSKLFTSEL GVTEHVEGDP CKFALWVGRT PTSDNKIVLK
1510 1520 1530 1540 1550
ASSIENKQDW IKHIREVIQE RTIHLKGALK EPIHIPKTAP ATRQKGRRDG
1560 1570 1580 1590 1600
EDLDSQGDGS SQPDTISIAS RTSQNTLDSD KLSGGCELTV VIHDFTACNS
1610 1620 1630 1640 1650
TELTIRRGQT VEVLERPHDK PDWCLVRTTD RSPAAEGLVP CGSLCIAHSR
1660 1670 1680 1690 1700
SSMEMEGIFN HKDSLSVSSN DASPPASVAS LQPHMVGAQS SPGPKRPGNT
1710 1720 1730 1740 1750
LRKWLTSPVR RLSSGKADGH VKKLAHKHKK SREVRKSADA GSQKDSDDSA
1760 1770 1780 1790 1800
ATPQDETVEE RGRNEGLSSG TLSKSSSSGM QSCGEEEGEE GADAVPLPPP
1810 1820 1830 1840 1850
MAIQQHSLLQ PDSQDDKASS RLLVRPTSSE TPSAAELVSA IEELVKSKMA
1860 1870 1880 1890 1900
LEDRPSSLLV DQGDSSSPSF NPSDNSLLSS SSPIDEMEER KSSSLKRRHY
1910 1920 1930 1940 1950
VLQELVETER DYVRDLGCVV EGYMALMKED GVPDDMKGKD KIVFGNIHQI
1960 1970 1980 1990 2000
YDWHRDFFLG ELEKCLEDPE KLGSLFVKHE RRLHMYIVYC QNKPKSEHIV
2010 2020 2030 2040 2050
SEYIDTFFED LKQRLGHRLQ LTDLLIKPVQ RITKYQLLLK DFLKYSKKAS
2060 2070 2080 2090 2100
LDTSELERAV EVMCVVPKRC NDMMNVGRLQ GFDGKIVAQG KLLLQDTFLV
2110 2120 2130 2140 2150
TDQDTGLLPR CKERRVFLFE QIVIFSEPLD KKKGFSMPGF LFKNSIKVSC
2160 2170 2180 2190 2200
LCLEENVEND PCKFALTSRT GDVVETFILH SSSPSVRQTW IHEINQILEN
2210 2220 2230 2240 2250
QRNFLNALTS PIEYQRNHSG GGGSGGGGGS SGAPSGGGGG SNHSGGGGGP
2260 2270 2280 2290 2300
GGGGSGSSSR SRPSRIPQPV RHHSPVLVSS AASSQAEADK MSGTCTPGPP
2310 2320 2330 2340 2350
PPPPSRSPAP EASAGPPGRA PPSSEPDGPE RDTEPIPKMK VLESPRKSSG
2360 2370 2380 2390 2400
GVLPQDGAAK EAPRSGPGPL PLGKARPGAP SPLHSPLAAA AASPSPFGKE
2410 2420 2430 2440 2450
PLPPSSPLQK GGSFWSSVPA SPASRPGSFT FPGDSDSLQR QARRHAAPGK
2460 2470 2480 2490 2500
DADRMSTCSS ASEQSVQSTQ SNGSESSSGS NISTMLVTHD YTAVKEDEIN
2510 2520 2530 2540 2550
VYQGEVVQIL ASNQQNMFLV FRAATDQCPA AEGWIPGFVL GHTSAVIMEN
2560 2570 2580 2590 2600
PDGTLKKSTS WHTALRLRKK SEKKDKDGKR EGKLENGYRK SREGLSNKVS
2610 2620 2630 2640 2650
VKLLNPNYIY DVPPEFVIPL SEVTCEAGET VVLRCRVCGR PKASITWKGP
2660 2670 2680 2690 2700
EHNTLNNDGH YSISYSDLGE AALKIVGVAA EDDGVYTCIA VNDMGSASSS
2710 2720 2730 2740 2750
ASLRVLGPGS DGIVVTWKDN FDCFYSEVAE LGRGRFSVVK KCDQKGTKRA
2760 2770 2780 2790 2800
VATKFVNKKL MKRDQVTHEL GILQNLQHPL LVGLLDTFET PTSYVLVLEM
2810 2820 2830 2840 2850
ADQGRLLDCV VRWGNLTEGK IRAYLGEVLE AVRYLHNCRI VHLDLKPENI
2860 2870 2880 2890 2900
LVDQSSAKPT IKLADFGDAV QLNTTYHIHP LLGNPEFAAP EIILGNPVSL
2910 2920 2930 2940 2950
TSDTWSVGVL AYVLLSGVSP FLDDSVEETC LNICRLDFSF PEDYFQGVSQ
2960 2970 2980 2990 3000
RAKDFVCFLL HEDPAKRPSA ASALQERWLQ AGHGHGKGAG VLDTSRLTSF
3010 3020
IERRKHQNDV RPIRSMKNFL QSRLLPRV
Length:3,028
Mass (Da):339,923
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA758A0C274953D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6QQZ8A6QQZ8_BOVIN
TRIO protein
TRIO
1,403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000061086; ENSBTAP00000053254; ENSBTAG00000005514

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1MLS2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053254

Proteomic databases

PaxDbiF1MLS2
PRIDEiF1MLS2

Genome annotation databases

EnsembliENSBTAT00000061086; ENSBTAP00000053254; ENSBTAG00000005514

Organism-specific databases

VGNCiVGNC:36356, TRIO

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG4240, Eukaryota
GeneTreeiENSGT00940000154766
HOGENOMiCLU_000373_1_1_1
InParanoidiF1MLS2
OMAiIRYLHNC
TreeFamiTF318080

Enzyme and pathway databases

ReactomeiR-BTA-194840, Rho GTPase cycle
R-BTA-416476, G alpha (q) signalling events
R-BTA-416482, G alpha (12/13) signalling events

Gene expression databases

BgeeiENSBTAG00000005514, Expressed in vertebral column and 99 other tissues
ExpressionAtlasiF1MLS2, baseline and differential

Family and domain databases

CDDicd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028570, Kalirin/TRIO
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR22826:SF104, PTHR22826:SF104, 1 hit
PfamiView protein in Pfam
PF00650, CRAL_TRIO, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 2 hits
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 6 hits
SUPFAMiSSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MLS2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MLS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 77 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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