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Entry version 55 (16 Jan 2019)
Sequence version 2 (16 Nov 2011)
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Protein
Submitted name:

Collagen type V alpha 3 chain

Gene

COL5A3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • heparin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1442490 Collagen degradation
R-BTA-1474244 Extracellular matrix organization
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-186797 Signaling by PDGF
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-419037 NCAM1 interactions
R-BTA-8874081 MET activates PTK2 signaling
R-BTA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type V alpha 3 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27569 COL5A3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MJQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000010179 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4 Collagen type V trimer variant 2

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000013440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MJQ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1574 – 1804Fibrillar collagen NC1InterPro annotationAdd BLAST231

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162394

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MJQ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSFTYSC

Database of Orthologous Groups

More...
OrthoDBi
1018065at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MJQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WESHAGWNHG SQPSPGLQPA ERAAGLIIPP RSDPCDPVDV LKALGMRGGQ
60 70 80 90 100
AGIPEGPGLC PQRVPEGDRA FRVGKTGTLG VPTQELFQDG HFPENFSILI
110 120 130 140 150
TLRGQPANRS VLLSIYDEGG VRQLGLALGP ALDLLGDSFS PLPQQVNLTD
160 170 180 190 200
GRWHRVAVSV DGGMVTLVAD CEPQLPMLAQ GPRFISTAGL TVLGTQDLGE
210 220 230 240 250
ETFEGDVQEL VISPDPQAAF QACERYLPGC DDLDPTVTTV PQGEPETPPP
260 270 280 290 300
RRKGKGKGKK KGRGRKGKGR KKKNKETVAV SPPPGSLDNQ TSTDIPKTET
310 320 330 340 350
PEPTLSPTPT PLQCHHPRGW WEVDGAGREG PGVVVAADNE ELGANFGLFQ
360 370 380 390 400
CPQEGLDPDN GTELETLETE LDREDEEEGD PTMGPHFRAA EQSWNTEFQI
410 420 430 440 450
FPAVYANLGS SLDVGQGIPG SHLFSFHPLL QGAGEKGEKG EPAVVEQGQQ
460 470 480 490 500
FEGPPGAPGP QGVVGPSGPP GPPGFPGDRG LPGPAGLPGI PGMDGIRGLP
510 520 530 540 550
GTVIMMPFQF ARGSHKGPPV SFQQAQAQAV LQQAQLSMKG PPGPVGLTGR
560 570 580 590 600
PGPVGLPGYP GLKGEMGEMG PQGPRGLQGP HGPPGREGKM GRAGADGARG
610 620 630 640 650
LPGATGPKGD RGFDGLPGLP GEKGQRGDFG YVGKPGPPGE DGRKGAEGPP
660 670 680 690 700
GPTGQAGEPG PRGLIGPRGS PGPLGRPGVI GSDGAPGAKG NVGPPGEPGP
710 720 730 740 750
PGQQGNPGSQ GIPGPQGPIG TPGEKGPPGN PGIPGLPGSE GPPGHPGHEG
760 770 780 790 800
PTGEKGAQGP AGSAGPPGYP GPRGVKGTSG NRGLQGEKGE KGEDGFPGFK
810 820 830 840 850
GDAGLKGDRG QPGPPGPRGE DGPEGLKGQE GLLGEEGPPG SAGEKGKLGV
860 870 880 890 900
PGLPGYPGRP GPKGSIGFPG PLGPLGEKGK RGKAGQPGLE GERGPPGARG
910 920 930 940 950
ERGQPGATGQ PGPKGDVGQD GAPGFPGEKG LPGLQGPPGF SGPKGPPGPQ
960 970 980 990 1000
GKDGVPGHPG QRGELGFQGQ TGPPGPAGVV GPQGKTGEAG PLGERGPPGP
1010 1020 1030 1040 1050
PGPPGEQGLP GLEGREGAKG DVGPLGPLGK EGPPGPRGFP GPHGAPGDPG
1060 1070 1080 1090 1100
PTGLKGDKGP PGPVGANGSP GERGPVGPAG SIGLPGQSGG QGPVGPTGEK
1110 1120 1130 1140 1150
GSPGERGAPG PTGKDGIPGP LGLPGPPGAA GPSGEEGDKG EVGAPGHKGS
1160 1170 1180 1190 1200
KGDKGDAGPP GPTGIRGLVG HPGSPGADGA QGRRGPPGLF GQKGDDGVRG
1210 1220 1230 1240 1250
FPGMIGPPGL QGMPGPAGEK GEVGDVGSMG PHGAPGPRGP QGPSGSEGPP
1260 1270 1280 1290 1300
GLPGGVGQPG AVGEKGEPGE PGDPGPPGTP GTPGPRGEVG EKGDTGPSGA
1310 1320 1330 1340 1350
AGPPGKKGPP GEDGAKGNVG PTGLPGDLGP PGDPGVSGQD GPPGEKGNPG
1360 1370 1380 1390 1400
DVGGPGPPGA SGEPGAPGPP GKRGPSGRMG QEGREGEKGA KGEPGPDGPP
1410 1420 1430 1440 1450
GRTGPVGARG PPGRVGPEGL RGIPGPVGEP GLLGPPGLLG PPGPLGPSGL
1460 1470 1480 1490 1500
PGLKGDAGPK GEKGHIGLIG LVGPPGEVGE KGDQGLPGVQ GSPGLQGEPG
1510 1520 1530 1540 1550
SPGPIGSLGH PGPQGVVGPP GQKGSKGSPG SQGPRGDAGP PGPPGPPGPS
1560 1570 1580 1590 1600
AELHGLRRRR RSLLGLGTPE GGLEEVLASM ASLSFELEQL RRPPGTAERP
1610 1620 1630 1640 1650
GLVCKELHRS HPHLPDGEYW IDPNQGCARD ALRVFCNFTA GGETCLYPDK
1660 1670 1680 1690 1700
KFETVKLASW SKEKPGGWYS TFRRGKKFSY VDADGAAVSV VQLTFLKLLS
1710 1720 1730 1740 1750
ATARQSFTFT CQNSAAWLDE AAGDHSRSAR FLGANGEEVS FNQMAAATIT
1760 1770 1780 1790 1800
VPYDGCRLRK GQSKTLFEFS SSRVGFLPLL DVAAADFGQT NQKFGFELGP

VCFSS
Length:1,805
Mass (Da):178,482
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6832777D939E4F5E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DAAA02019447 Genomic DNA No translation available.
DAAA02019448 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000013440; ENSBTAP00000013440; ENSBTAG00000010179

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019447 Genomic DNA No translation available.
DAAA02019448 Genomic DNA No translation available.

3D structure databases

SMRiF1MJQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-4 Collagen type V trimer variant 2
STRINGi9913.ENSBTAP00000013440

Proteomic databases

PaxDbiF1MJQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013440; ENSBTAP00000013440; ENSBTAG00000010179

Organism-specific databases

VGNCiVGNC:27569 COL5A3

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000162394
InParanoidiF1MJQ6
OMAiQSFTYSC
OrthoDBi1018065at2759
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-BTA-1442490 Collagen degradation
R-BTA-1474244 Extracellular matrix organization
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-186797 Signaling by PDGF
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-419037 NCAM1 interactions
R-BTA-8874081 MET activates PTK2 signaling
R-BTA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSBTAG00000010179 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MJQ6_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MJQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: January 16, 2019
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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