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Entry version 58 (13 Nov 2019)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Supervillin

Gene

SVIL

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SupervillinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SVILImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000027444 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MIU5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2111 – 2174HPInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 99DisorderedSequence analysisAdd BLAST65
Regioni119 – 336DisorderedSequence analysisAdd BLAST218
Regioni389 – 415DisorderedSequence analysisAdd BLAST27
Regioni451 – 501DisorderedSequence analysisAdd BLAST51
Regioni532 – 562DisorderedSequence analysisAdd BLAST31
Regioni590 – 649DisorderedSequence analysisAdd BLAST60
Regioni666 – 699DisorderedSequence analysisAdd BLAST34
Regioni719 – 771DisorderedSequence analysisAdd BLAST53
Regioni1016 – 1057DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili99 – 119Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 69PolyampholyteSequence analysisAdd BLAST16
Compositional biasi70 – 98PolarSequence analysisAdd BLAST29
Compositional biasi132 – 160PolyampholyteSequence analysisAdd BLAST29
Compositional biasi161 – 176PolarSequence analysisAdd BLAST16
Compositional biasi198 – 212PolarSequence analysisAdd BLAST15
Compositional biasi309 – 323PolyampholyteSequence analysisAdd BLAST15
Compositional biasi666 – 695PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1041 – 1055PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0445 Eukaryota
ENOG410XPWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154653

TreeFam database of animal gene trees

More...
TreeFami
TF316081

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1MIU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKREKNLIAR RLEGIETDTQ PILLQSCTGL VTHRLLEEDT PRYMRATDPA
60 70 80 90 100
SPHIGRSNEE EETSDSSLEK QTRSKQCTET SGIHADSPYS SGIMDTQSLE
110 120 130 140 150
SKAERIARYK AERRRQLAEK YGLTLDPEAD SETPSRYSRS RKDPEAAEKR
160 170 180 190 200
GVRSERSAES SRDAGSSYSR TELSGLRTCV AESKDYGLHR SDGVSDTEVL
210 220 230 240 250
LNAENQRRGQ EPSATGLARD LPLAGEVSSS FSFSGRDSAL GEVPRSPKAV
260 270 280 290 300
HSLPSPSPGQ PASPSHSTSD LPLPAEARAS IGKPKHEWFL QKDSEGDTPS
310 320 330 340 350
LINWPSRVKV REKLVREESA RSSPELTSES LTQRRHQTAP GHYLAFQSEN
360 370 380 390 400
SAFDRVSGKV ASSARQPIRG YVQPAEPVHT ITLVTSDTPE SISEGSWVGP
410 420 430 440 450
APQTVTKPPP SKVLEGERRD TPVLHICESK AEDVLFSDAL EKTRKTLAVL
460 470 480 490 500
EDRGSGRSQE APSGTEDLSQ PAVGIVTAEP QKESESLAHP PMAQQQPTER
510 520 530 540 550
MGRSEMVMYV QSEAVSQGHR KEVPTRKHRV LTRSLSDYTG PPQLQALKAK
560 570 580 590 600
APAPKRDAES QTSKAELELG LLDTKVSVAQ LRNAFLESAR ASRKPELHSR
610 620 630 640 650
VEGSSEGPGV ERERGSRKPR RYFSPGENRK TSERFRTQPI TSAERKESDR
660 670 680 690 700
LSVAAKRLLF REMEKSFDEK SVPKRRSRNA AVEQRLRRLQ DRSHTQPVTT
710 720 730 740 750
EEVVIAATEP TPASCSVATH PVMTRHPSPT VAKSPVQPAR LQASAHQKAL
760 770 780 790 800
ARDQTNESKD SAEQGEPDSS TLSLAEKLAL FNKLSQPVSK AISTRNRLDM
810 820 830 840 850
RQRRMNARYQ TQPVTLGEVE QVQSGKLMAF SPTINTSVST VASTVPPMYA
860 870 880 890 900
GNLRTKPLPD DSFGATEQKF ASSLENSDSP VRSILKSQGW QPSVEGAGSK
910 920 930 940 950
AMLREFEETE RKGGLTGGDG GVTKYGSFEE AELSYPVLSR VREGDNHKEA
960 970 980 990 1000
IYALPRKGSL ELAHPPIAQL GDDLKEFSTP KSTMQASPDW KERQLFEEKV
1010 1020 1030 1040 1050
DLENVTKRKF SLKAAEFGEP TSEQTGAAAG KPAAPTATPV SWKPQDPSEQ
1060 1070 1080 1090 1100
PQEKRYQSPC AMFAAGEIKA PAVEGSLDSP SKTMSIKERL ALLKKSGEED
1110 1120 1130 1140 1150
WRNRLNRKQE YGKASITSSL HIQETEQSLK KKRVTESRES QMTIEERKHL
1160 1170 1180 1190 1200
ITVREDAWKT RGKGAANDST QFTVAGRMVK RGLASPTAIT PVASPVSSKA
1210 1220 1230 1240 1250
RGTTPVSRPL EDIEARPDMQ LESDLKLDRL ETFLRRLNNK VGGMQETVLT
1260 1270 1280 1290 1300
VTGKSVKEVM KPDDDETFAK FYRSVDSSLP RSPVELDEDF DVIFDPYAPR
1310 1320 1330 1340 1350
LTSSVAEHKR AVRPKRRVQA SKNPLKMLAA REDLLQEYTE QRLNVAFVES
1360 1370 1380 1390 1400
KRMKVEKLSA NSSFSEVTLA GLASKENFSN VSLRSVNLTE QNSNNSAVPY
1410 1420 1430 1440 1450
KKLMLLQVKG RRHVQTRLVE PRAPSLNSGD CFLLLSPHHC FLWVGEFANV
1460 1470 1480 1490 1500
IEKAKASELA SLIQTKRELG CRATYIQTVE EGINTHTHAA KDFWKLLGGQ
1510 1520 1530 1540 1550
ASYQSAGDPK EDELYETAII ETNCIYRLMD DKLVPDDDYW GKIPKCSLLQ
1560 1570 1580 1590 1600
SKEVLVFDFG SEVYVWHGKE VTLAQRKIAF QLAKHLWNGT FDYENCDINP
1610 1620 1630 1640 1650
LDPGECNPLI PRKGQGRPDW AIFGRLTEHN ETILFKEKFL DWTELKRPNE
1660 1670 1680 1690 1700
KNASELAQHK DDARAEVKPY DVTRMVPVPQ TTAGTVLDGV NVGRGYGLVE
1710 1720 1730 1740 1750
GDDRRQFEIA SISVDVWHIL EFDYSRLPKQ SIGQFHEGDA YVVKWKFIVS
1760 1770 1780 1790 1800
TAVGSRQKGE HSVRVAGKEK CVYFFWQGRQ STVSEKGTSA LMTVELDEER
1810 1820 1830 1840 1850
GAQVQVLQGK EPPCFLQCFQ GGMVVHSGRR EEEEENTQSE WRLYCVRGEV
1860 1870 1880 1890 1900
PVEGNLLEVA CHCSSLRSRT SMVVLNVHKA LIYLWHGCKA QAHTKEVGRT
1910 1920 1930 1940 1950
AANKIKDQCP LEAGLHSSSK VTIHECDEGS EPLGFWDALG RRDRKAYDCM
1960 1970 1980 1990 2000
LQDPGNFNFT PRLFILSSSS GDFSATEFMY PARDPSVVNS MPFLQEDLYS
2010 2020 2030 2040 2050
APQPALFLVD NHHEVYLWQG WWPIENKITG SARIRWASDR KSAMETVLQY
2060 2070 2080 2090 2100
CRGKNLKKPP PKSYLIHAGL EPLTFTNMFP SWEHREDIAE ITEMDTEVSN
2110 2120 2130 2140 2150
QITLVEDVLA KLCKTIYPLA DLLARPLPEG VDPLKLEIYL TDEDFEFALD
2160 2170
MTRDEYNALP AWKQVNLKKA KGLF
Length:2,174
Mass (Da):242,630
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EC5B46E26985776
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O46385SVIL_BOVIN
Supervillin
SVIL
2,194Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1BK07E1BK07_BOVIN
Supervillin
SVIL
1,864Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000052009; ENSBTAP00000049248; ENSBTAG00000027444

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSBTAT00000052009; ENSBTAP00000049248; ENSBTAG00000027444

Phylogenomic databases

eggNOGiKOG0445 Eukaryota
ENOG410XPWY LUCA
GeneTreeiENSGT00940000154653
TreeFamiTF316081

Gene expression databases

BgeeiENSBTAG00000027444 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiF1MIU5 baseline and differential

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 5 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MIU5_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MIU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: November 13, 2019
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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