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Entry version 65 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC524391

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi547 – 554ATPPROSITE-ProRule annotation8
Nucleotide bindingi1367 – 1374ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC524391Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei239 – 267HelicalSequence analysisAdd BLAST29
Transmembranei287 – 316HelicalSequence analysisAdd BLAST30
Transmembranei328 – 351HelicalSequence analysisAdd BLAST24
Transmembranei357 – 379HelicalSequence analysisAdd BLAST23
Transmembranei391 – 410HelicalSequence analysisAdd BLAST20
Transmembranei430 – 453HelicalSequence analysisAdd BLAST24
Transmembranei889 – 907HelicalSequence analysisAdd BLAST19
Transmembranei1049 – 1070HelicalSequence analysisAdd BLAST22
Transmembranei1090 – 1115HelicalSequence analysisAdd BLAST26
Transmembranei1127 – 1152HelicalSequence analysisAdd BLAST26
Transmembranei1252 – 1273HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MHK9

PRoteomics IDEntifications database

More...
PRIDEi
F1MHK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000006717, Expressed in spermatocyte and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1MHK9, baseline

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MHK9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini511 – 744ABC transporterInterPro annotationAdd BLAST234
Domaini1332 – 1565ABC transporterInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili948 – 968Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MHK9

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFYIRER

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

F1MHK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTLWLNQFA ILLWKNFILK KRKMGSLIVE ISMTVLFCSL ILLLRKHSKR
60 70 80 90 100
EFTQATLFQS LPLNKLPAFL TNKKKDYELV YVPSGSDAAK NITEKVKDDL
110 120 130 140 150
NANLTVRGFP SEEDFEKYIK YENQSVLVLA AIIFDHEFKN SNDRLPLKVK
160 170 180 190 200
YRLRFHSIKN TPWFTELLFP VNPSRGPRNP SSTEGGSPDY YKGGFLLVQH
210 220 230 240 250
ALDKAIIVYH NGRAAEMLFA NVNIFVSRFP YPTYYKDNFF LSFLSLFPLA
260 270 280 290 300
VLLIFSLTEL TLIRTIVMEK ETRLKEYQFM IGLSNGMLWA SYFVTFLLMF
310 320 330 340 350
LIIVCILCVV LFVKIVPVVV LQNSDPSLIF VFFLCFVVAT ITFGFLITTF
360 370 380 390 400
FDKTSLAVSI GGFLFFLTFF PFVVVITMYG MLSRTGKLAS CLLSNIAVAL
410 420 430 440 450
GITTISKLEI KEYGAKWNNF LSRVSPDDEL TLAHIMGMLL FDAFLYGLLA
460 470 480 490 500
WYIDAVFPGK YGVPKPWYFF MQKGYWLGKA TSIRKKEDMP VTNTVQNAYF
510 520 530 540 550
EEEPVGLIAG IRIQHLYKEF TLQNMTVLAV QDLSLNLYEG QITVLLGHNG
560 570 580 590 600
AGKTTTLSIL TGLYRPTSGK VYISGYDISK DMVQVRKSLG LCPQDDILFH
610 620 630 640 650
HLTVSEHLYF YCVIKGVPPE IQSKEINKML ISFGLIEKHD ALAKSLSGGM
660 670 680 690 700
KRKLSIIIAL IGGSKVVILD EPTSGMDPVS RRFTWDVLQK HKENRTVLLT
710 720 730 740 750
THHMDEADVL GDRIAIMAKG TLQCCGSTIF LKKVYGVGYH LIIVKDHHCD
760 770 780 790 800
VKEISELIKY HIPEARLENN VAAELSFVLP KEYTDRFKAL FTEMEDRQEE
810 820 830 840 850
LGIASFGISI TTMEEVFIRV SQSNNQILQT LKNEDESEDT NQNMNVPRNF
860 870 880 890 900
ERSYAVMPSS VLLSCQWALY SQQFFAMFMK RAMFSWRNWN LILLQILALL
910 920 930 940 950
GIFYFLMSDV ELSIGEEDLD REMDLEQYGQ TIVPFSISGN SEFTTNFVKN
960 970 980 990 1000
LEILLKAKKQ KLHEVKGDLK TYLVDSQKCI YSCIIAFSIE VNGNENTVNF
1010 1020 1030 1040 1050
WFNDEAYHSS PLSLAVLDNV IFMSLSGPDA SITVVNKPQP VRSASRTQIA
1060 1070 1080 1090 1100
LNLYFGVSIL VSGFCLLTVN ERVTKAKHIQ FLSGVYALNF WLSALLWDFL
1110 1120 1130 1140 1150
IFFISCCLLL VVFTFSDLKI LVTGYRLLDT LFIFMVFGWA VIPFMYLISF
1160 1170 1180 1190 1200
LFSSHTSAYA KLVIFNYCAG IFGILLSWDS SFHINHANVI IFLNTGEEAA
1210 1220 1230 1240 1250
SKSLLLNAMM VLPIHNFGMS ISRHYDIHKS IFYLLLSSVT ERSIYTLEYD
1260 1270 1280 1290 1300
AVGRYLLAMA VTGLLFLLLI FLLETTLWKV KTFVFRYILF GIFKKSNKVM
1310 1320 1330 1340 1350
SKELSGESED EDVQNERNRI LDNPQESLNS IVLIKELIKV YFSKPVVLAV
1360 1370 1380 1390 1400
RNISVAIQKQ ECFGLLGLNG AGKTTTFEIL TGEEVASSGD VFVERLSITK
1410 1420 1430 1440 1450
NILKVRSKIG YCPQFDALLD YMTAREIMIM YARLWGIPET KINNYVKKSM
1460 1470 1480 1490 1500
EALNLESYAD KYIYTYSGGN KRRLSTAIAL MGKPSVIFLD EPSTGMDPVA
1510 1520 1530 1540 1550
RRLLWNAVTR TRESGKAIII TSHSMEECDA LCTKLAIMVK GKFVCLGSPQ
1560 1570 1580 1590 1600
HLKNKFGNVY ILKVKINIDE NKDKLEHFKT FVETAFPGSE LKDENRGIIN
1610 1620 1630 1640 1650
YYVPSKNNSW GKMFGILEKA KEEFNLEDYS ISQITLEQVF LTFAGSQNPE

VEKKES
Length:1,656
Mass (Da):188,419
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74AF3657FA5DFA02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LJ59A0A3Q1LJ59_BOVIN
Uncharacterized protein
LOC524391
1,567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M0J9A0A3Q1M0J9_BOVIN
Uncharacterized protein
LOC524391
1,576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M450A0A3Q1M450_BOVIN
Uncharacterized protein
LOC524391
1,606Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1N3G0A0A3Q1N3G0_BOVIN
Uncharacterized protein
LOC524391
1,575Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3MXV4G3MXV4_BOVIN
Uncharacterized protein
LOC524391
1,383Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MRB6A0A3Q1MRB6_BOVIN
Uncharacterized protein
LOC524391
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000008832; ENSBTAP00000008832; ENSBTAG00000006717

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1MHK9
ModBaseiSearch...

Proteomic databases

PaxDbiF1MHK9
PRIDEiF1MHK9

Genome annotation databases

EnsembliENSBTAT00000008832; ENSBTAP00000008832; ENSBTAG00000006717

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000164007
HOGENOMiCLU_000604_19_1_1
InParanoidiF1MHK9
OMAiIFYIRER
TreeFamiTF105191

Gene expression databases

BgeeiENSBTAG00000006717, Expressed in spermatocyte and 5 other tissues
ExpressionAtlasiF1MHK9, baseline

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MHK9_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MHK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 65 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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