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UniProtKB - F1MFC2 (F1MFC2_BOVIN)

Entry version 74 (07 Apr 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Desmoglein 2

Gene

DSG2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation
LigandCalciumPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Desmoglein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSG2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:28221, DSG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei605 – 632HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell junctionARBA annotation, Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501871255222 – 1119Sequence analysisAdd BLAST1098

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F1MFC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSBTAG00000021923, Expressed in conceptus and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F1MFC2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000029228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F1MFC2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 157CadherinInterPro annotationAdd BLAST90
Domaini158 – 270CadherinInterPro annotationAdd BLAST113
Domaini271 – 393CadherinInterPro annotationAdd BLAST123
Domaini390 – 497CadherinInterPro annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni881 – 900DisorderedSequence analysisAdd BLAST20
Regioni1080 – 1119DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1090 – 1119PolarSequence analysisAdd BLAST30

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230552

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005284_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F1MFC2

Identification of Orthologs from Complete Genome Data

More...OMAi		DQHYANE

Database of Orthologous Groups

More...OrthoDBi		250139at2759

TreeFam database of animal gene trees

More...TreeFami		TF331809

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR027397, Catenin-bd_sf
IPR009123, Desmoglein
IPR009122, Desmosomal_cadherin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN
PR01818, DESMOCADHERN
PR01819, DESMOGLEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 3 hits
PS50268, CADHERIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1MFC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGVEGALL LLLICFDFGD GLHFEALHSR NESKLLPKHI HPVRQKRAWI 
        60         70         80         90        100
TAPVALREGE DLSRKNPIAK IHSDLAEEKK LKITYKYTGK GITEPPFGVF 
       110        120        130        140        150
VFNKDTGELN VTTILDREET PFFLVTGYAL DERGKNLEKP IELRIKVLDI 
       160        170        180        190        200
NDNEPVFTQD VFVGSVEELS AANTLVMKIN ATDADEPNTL NSKISYRIVS 
       210        220        230        240        250
QEPANSPVFY LNKDTGEIYT TSITLDREEY SSYTLIVEAR DGNGQITDKP 
       260        270        280        290        300
VKQAQVQIRI LDVNDNIPVV DRNVYEGSIE ENKANVEVLR IKVSDADEVG 
       310        320        330        340        350
SDNWLANFTF ASGNEGGYFH IETDTQTNEG IVTLIKEVDY ETMKNLDLSI 
       360        370        380        390        400
IVTNKAAFHK SIKDKYKPTS IPIKVKVKNV KEGIYFKSST IQFHTSESME 
       410        420        430        440        450
KLSQGQILGK FQVFDEDTGK VPNVKYAKFE DIDNWISVNS ATSEIKLVKI 
       460        470        480        490        500
PDYESRYVQN GTYTAKIVAI TEEYPRKTIT GTIVINVEDV NDNCPTLVEP 
       510        520        530        540        550
VQTVCDYVPF VNVTAQDLDG PQNSWPFSFS IIDKPAGMAE RWKIVRREDN 
       560        570        580        590        600
NVLLQQTKRQ HGTSEIHFQI ADSQGFSCPE EQILRLTVCN CVEGSGCVNM 
       610        620        630        640        650
WADSYVGLGP AAIALIILAL LLLLLIPLLL LVCHCGKGAK GFTPIPGTIE 
       660        670        680        690        700
MLHPWNNEGA PPEDKVVLPL LGADVRDGAA VGAGAGGGVT AKEAIVKGSS 
       710        720        730        740        750
SASFSKGQQE MSEAEGRWEE YRSLVSGGAT QVTGTTGAMV TSDTFRTTRA 
       760        770        780        790        800
TGAAREVAGA RAGAVAVNEE FLRSYFTEKA ASYIGEDDMH TAKDCLLVYS 
       810        820        830        840        850
QEDTESLRGS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGRKIEMDAE 
       860        870        880        890        900
IQQRAKPARE ADRKVVSQSL YEQTRLNSEN AYASGSSFQG PKPLHEADTE 
       910        920        930        940        950
KVTQEIVTEK SVISSKQAQK VAAPLPDTLA SGSVIVTETS YATGATGPPS 
       960        970        980        990       1000
TVVLGPQQSQ GLIVTERVYA PASTLGNQQY ASEGHVVVTE RVIQPHGGTS 
      1010       1020       1030       1040       1050
GLLEDAPPLP DAHYVMVQER ERFLTPSSSL QPPLAAPSVA LGQNVTVTER 
      1060       1070       1080       1090       1100
VLTPASALQS SYQIPAETSV MSRKTVASAA GVPGSLPDSG LEESSHSNYT 
      1110 
ITTSSTRVSK QSTVQQSFS
Length:1,119
Mass (Da):122,073
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C82410622B2F6BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MKM2A0A3Q1MKM2_BOVIN
Desmoglein 2
DSG2
943Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_001179101.2, NM_001192172.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSBTAT00000029228; ENSBTAP00000029228; ENSBTAG00000021923

Database of genes from NCBI RefSeq genomes

More...GeneIDi		508151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:508151

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001179101.2, NM_001192172.2

3D structure databases

SMRiF1MFC2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029228

Proteomic databases

PaxDbiF1MFC2

Genome annotation databases

EnsembliENSBTAT00000029228; ENSBTAP00000029228; ENSBTAG00000021923
GeneIDi508151
KEGGibta:508151

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1829
VGNCiVGNC:28221, DSG2

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT01020000230552
HOGENOMiCLU_005284_0_1_1
InParanoidiF1MFC2
OMAiDQHYANE
OrthoDBi250139at2759
TreeFamiTF331809

Gene expression databases

BgeeiENSBTAG00000021923, Expressed in conceptus and 15 other tissues
ExpressionAtlasiF1MFC2, baseline and differential

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR027397, Catenin-bd_sf
IPR009123, Desmoglein
IPR009122, Desmosomal_cadherin
PfamiView protein in Pfam
PF00028, Cadherin, 3 hits
PRINTSiPR00205, CADHERIN
PR01818, DESMOCADHERN
PR01819, DESMOGLEIN
SMARTiView protein in SMART
SM00112, CA, 4 hits
SUPFAMiSSF49313, SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 3 hits
PS50268, CADHERIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MFC2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MFC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 10, 2019
Last modified: April 7, 2021
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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