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Protein

Erythropoietin receptor

Gene

EPOR

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for erythropoietin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117Required for ligand bindingUniRule annotation1
Sitei426Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei456Required for STAT1/STAT3 activationUniRule annotation1
Sitei485Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin receptorUniRule annotation
Short name:
EPO-RUniRule annotation
Gene namesi
Name:EPORImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:28551 EPOR

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei251 – 272HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500326947926 – 508Erythropoietin receptorSequence analysisAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 62UniRule annotation
Disulfide bondi91 ↔ 107UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiF1MEQ7

Expressioni

Gene expression databases

BgeeiENSBTAG00000008197 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Subunit structurei

Forms homodimers on EPO stimulation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei368Interaction with APS and STAT5, and activationUniRule annotation1
Sitei454Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010781

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 247Fibronectin type-IIIInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00920000149107
InParanoidiF1MEQ7
KOiK05079
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

F1MEQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYHLPAALRA GIGFLCLLLA GAAWAPPPNP TDPKFENKAA LLTAREPDEF
60 70 80 90 100
LCFTERLEDL VCFWEEAATA GVGPDNYSFS YQLEGEPWKP CRLHQAPTAR
110 120 130 140 150
GLVRFWCSLP TADTSSFVPL ELHVTAASGA SRYRRTIHVN EVVLLDPPAR
160 170 180 190 200
LVARRADEGG HVVLRWLPPP GAPMASLIRY EVNISAENAA GSAQRVEILD
210 220 230 240 250
GRTECLLSNL RGGTRYTFMV RARMAEPSFG GFWSAWSEPA SLLTASDLDP
260 270 280 290 300
LILTLSLVLV LILLLLAVLA LLSHRRTLKQ KIWPGIPSPE SEFEGLFTTH
310 320 330 340 350
KGNFQLWLYQ TDGCLWWSPS TPLPEDPPAP LEVLSECCWG VTQAVEPGAD
360 370 380 390 400
DGGPLLEPVG SEHAQDSYLV LDKWLLPRSP PSEDLLQPGG DMDIVTMDEA
410 420 430 440 450
SEASSCTSAL ALKPGPEGAS ATSFEYTILD PSSQLLRPRA LPPELLPTPP
460 470 480 490 500
HLKYLYLVVS DSGISTDYSS GGSQEAQGGS SNGPYSNPYE NSLIPAPKPS

PPSYVACS
Length:508
Mass (Da):55,068
Last modified:November 16, 2011 - v2
Checksum:i2592459D0F401DE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019486 Genomic DNA No translation available.
RefSeqiNP_001192530.1, NM_001205601.1
UniGeneiBt.13150

Genome annotation databases

EnsembliENSBTAT00000010781; ENSBTAP00000010781; ENSBTAG00000008197
GeneIDi281144
KEGGibta:281144

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019486 Genomic DNA No translation available.
RefSeqiNP_001192530.1, NM_001205601.1
UniGeneiBt.13150

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010781

Proteomic databases

PaxDbiF1MEQ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010781; ENSBTAP00000010781; ENSBTAG00000008197
GeneIDi281144
KEGGibta:281144

Organism-specific databases

CTDi2057
VGNCiVGNC:28551 EPOR

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00920000149107
InParanoidiF1MEQ7
KOiK05079
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Gene expression databases

BgeeiENSBTAG00000008197 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1MEQ7_BOVIN
AccessioniPrimary (citable) accession number: F1MEQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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