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Entry version 79 (12 Aug 2020)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Insulin receptor substrate 2

Gene

Irs2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-109704, PI3K Cascade
R-RNO-112399, IRS-mediated signalling
R-RNO-112412, SOS-mediated signalling
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1266695, Interleukin-7 signaling
R-RNO-198203, PI3K/AKT activation
R-RNO-2428928, IRS-related events triggered by IGF1R
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-74713, IRS activation
R-RNO-74749, Signal attenuation
R-RNO-8853659, RET signaling
R-RNO-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-9027284, Erythropoietin activates RAS

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Insulin receptor substrate 2Imported
Submitted name:
RCG43183Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Irs2Imported
ORF Names:rCG_43183Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
69316, Irs2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000023509, Expressed in brain and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60750N

Protein interaction database and analysis system

More...
IntActi
F1MAL5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000036862

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 145PHInterPro annotationAdd BLAST115
Domaini192 – 296IRS-type PTBInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni52 – 72DisorderedSequence analysisAdd BLAST21
Regioni300 – 539DisorderedSequence analysisAdd BLAST240
Regioni548 – 567DisorderedSequence analysisAdd BLAST20
Regioni837 – 866DisorderedSequence analysisAdd BLAST30
Regioni898 – 1094DisorderedSequence analysisAdd BLAST197
Regioni1114 – 1235DisorderedSequence analysisAdd BLAST122
Regioni1254 – 1278DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 32PolarSequence analysisAdd BLAST17
Compositional biasi440 – 456PolarSequence analysisAdd BLAST17
Compositional biasi476 – 492PolarSequence analysisAdd BLAST17
Compositional biasi509 – 523PolarSequence analysisAdd BLAST15
Compositional biasi934 – 995PolarSequence analysisAdd BLAST62
Compositional biasi1006 – 1035Pro-richSequence analysisAdd BLAST30
Compositional biasi1042 – 1060PolarSequence analysisAdd BLAST19
Compositional biasi1124 – 1138PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1139 – 1199PolarSequence analysisAdd BLAST61
Compositional biasi1254 – 1273PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUNU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004902_1_0_1

KEGG Orthology (KO)

More...
KOi
K07187

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKAPYTC

Database of Orthologous Groups

More...
OrthoDBi
298675at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325994

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01204, PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10614, PTHR10614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02174, IRS, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00628, INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MAL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAPLPGPP ASAGGDGPNL NNNNNNNNNH SVRKCGYLRK QKHGHKRFFV
60 70 80 90 100
LRGPGTGGEE AAAAGGSPPQ PPRLEYYESE KKWKSKAGAP KRVIALDCCL
110 120 130 140 150
NINKRADAKH KYLIALYTKD EYFAVAAENE QEQEGWYRAL TDLVSEGRSG
160 170 180 190 200
DGGSGTTGGS CSASLPGALG GSAGAAGCDD NYGLVTPATA VYREVWQVNL
210 220 230 240 250
KPKGLGQSKN LTGVYRLCLS ARTIGFVKLN CEQPSVTLQL MNIRRCGHSD
260 270 280 290 300
SFFFIEVGRS AVTGPGELWM QADDSVVAQN IHETILEAMK ALKELFEFRP
310 320 330 340 350
RSKSQSSGSS ATHPISVPGA RRHHHLVNLP PSQTGLVRRS RTDSLAATPP
360 370 380 390 400
AAKCTSCRVR TASEGDGGAA GGAGTAGGRP MSVAGSPLSP GPVRAPLSRS
410 420 430 440 450
HTLSAGCGGR PSKVALAPAG GALQHSRSMS MPVAHSPPAA TSPGSLSSSS
460 470 480 490 500
GHGSGSYPLP PGSHPHLPHP LHHPQCQRPS SGSASASGSP SDPGFMSLDE
510 520 530 540 550
YGSSPGDLRA FSSHRSNTPE SIAETPPARD GSGGELYGYM SMDRPLSHCG
560 570 580 590 600
RPYRRVSGDG AQDLDRGLRK RTYSLTTPAR QRQVPQPSSA SLDEYTLMRA
610 620 630 640 650
TFSGSSGRLC PSLPASSPKV AYNPYPEDYG DIEIGSHKSS SSNLGADDGY
660 670 680 690 700
MPMTPGAALR SGGPNSCKSD DYMPMSPTSV SAPKQILQPR SAAALPPSGA
710 720 730 740 750
AVPAPPSGAG RTFPVNGGGY KASSPAESSP EDSGYMRMWC GSKLSMENPD
760 770 780 790 800
PKLLPNGDYL NMSPSEAGTA GTPPDFFSAA LRPGGEALKG VPGHCYSSLP
810 820 830 840 850
RSYKAPCTCG GGDNDQYVLM SSPVGRILEE ERLEPQATPG AGTFGAAGGS
860 870 880 890 900
HTQPHHSAVP SSMRPSGIVG RPEGFLGQRC RAVRPTRLSL EGLQTLPSMQ
910 920 930 940 950
EYPLPTEPKS PGEYINIDFG EGGTRLSPPA PPLLASAASS SSLLSASSPA
960 970 980 990 1000
SSLGSGTPGT SSDSRQRSPL SDYMNLDFSS PKSPKPSTRS GDTVGSIDGL
1010 1020 1030 1040 1050
LSPEASSPYP PLPPRPSASP SSLQQPLPPA PGDLYRLPPA TAATSQGPTA
1060 1070 1080 1090 1100
GSSMSSEPGD NGDYTEMAFG VAATPPQPIA APPKPEGARV TSPTSGLKRL
1110 1120 1130 1140 1150
SLMDQVSGVE AFLQVSQPPD PHRGAKVIRA DPQGGRRRHS SETFSSTTTV
1160 1170 1180 1190 1200
TPVSPSFAHN SKRHNSASVE NVSLRKSSEG NSILGGSDEP STSPGQAQPS
1210 1220 1230 1240 1250
AGVPPAPQAR PWNPGQPGAL IGCPGGSSSP MRRETSVGFQ NGLNYIAIDV
1260 1270 1280 1290 1300
RGEQGSLAQS QPQHPQPGDK NSWGRTRSLG GLLGTVGGSG TSGVCGGPGT
1310 1320
GALPSASTYA SIDFLSHHLK EATVVKE
Length:1,327
Mass (Da):137,239
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBD7BB57DD5D031E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07026565 Genomic DNA No translation available.
CH473970 Genomic DNA Translation: EDM08814.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162104.1, NM_001168633.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000032918; ENSRNOP00000036862; ENSRNOG00000023509

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29376

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07026565 Genomic DNA No translation available.
CH473970 Genomic DNA Translation: EDM08814.1
RefSeqiNP_001162104.1, NM_001168633.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-60750N
IntActiF1MAL5, 2 interactors
STRINGi10116.ENSRNOP00000036862

Genome annotation databases

EnsembliENSRNOT00000032918; ENSRNOP00000036862; ENSRNOG00000023509
GeneIDi29376
KEGGirno:29376

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8660
RGDi69316, Irs2

Phylogenomic databases

eggNOGiENOG502QUNU, Eukaryota
GeneTreeiENSGT00940000161407
HOGENOMiCLU_004902_1_0_1
KOiK07187
OMAiYKAPYTC
OrthoDBi298675at2759
TreeFamiTF325994

Enzyme and pathway databases

ReactomeiR-RNO-109704, PI3K Cascade
R-RNO-112399, IRS-mediated signalling
R-RNO-112412, SOS-mediated signalling
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1266695, Interleukin-7 signaling
R-RNO-198203, PI3K/AKT activation
R-RNO-2428928, IRS-related events triggered by IGF1R
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-74713, IRS activation
R-RNO-74749, Signal attenuation
R-RNO-8853659, RET signaling
R-RNO-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-9027284, Erythropoietin activates RAS

Gene expression databases

BgeeiENSRNOG00000023509, Expressed in brain and 22 other tissues

Family and domain databases

CDDicd01204, PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR10614, PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174, IRS, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00628, INSULINRSI
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MAL5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MAL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: August 12, 2020
This is version 79 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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