Npas2

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: InterPro
Hsp90 protein binding Source: Ensembl
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell death Source: Ensembl
positive regulation of DNA repair Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
response to redox state Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation
Biological process	Transcription, Transcription regulationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Neuronal PAS domain protein 2Imported
Gene namesⁱ	Name:Npas2Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 9

Organism-specific databases

Rat genome database More...RGDⁱ	1309681 Npas2

RGDⁱ

1309681 Npas2

Keywords - Cellular componentⁱ

NucleusSAAS annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	F1MAG2
PRIDEⁱ	F1MAG2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000013408 Expressed in 9 organ(s), highest expression level in brain
Genevisibleⁱ	F1MAG2 RN

Interactionⁱ

GO - Molecular functionⁱ

Hsp90 protein binding Source: Ensembl
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000056327

STRINGⁱ

10116.ENSRNOP00000056327

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 59	BHLHInterPro annotationAdd BLAST	51
Domainⁱ	82 – 145	PASInterPro annotationAdd BLAST	64
Domainⁱ	260 – 307	PASInterPro annotationAdd BLAST	48

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	510 – 530	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5V Eukaryota ENOG410Y7Z8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
InParanoidⁱ	F1MAG2
KEGG Orthology (KO) More...KOⁱ	K09026
OMAⁱ	YKMLSSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11CV
PhylomeDBⁱ	F1MAG2
TreeFamⁱ	TF324568

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

F1MAG2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKLDKTTVLE 
        60         70         80         90        100
KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFVIVV 
       110        120        130        140        150
TTDGSIIYVS DSITPLLGHL PSDVMDQNLL NFLPEQEHSE VYKILSSHML 
       160        170        180        190        200
VTDSPSPEFL KSDNDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV 
       210        220        230        240        250
PSPSCNGFDN TLSRPCRVPL GKEVCFIATV RLATPQFLKE MCVADEPLEE 
       260        270        280        290        300
FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYDYYHI DDLELLARCH 
       310        320        330        340        350
QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV 
       360        370        380        390        400
VSYADVRVER RQELALEDPP TEAMHPSALK EKDSSLEPQP HFNALDMGAS 
       410        420        430        440        450
GLTSSPSPSA SSRSSHKSSH TAMSEPTSTP TKLMAENSTT ALPRSATLPQ 
       460        470        480        490        500
ELPVQGLSQA ATMPAPLLSS SSCDLAKQLL PQSLPQTVLQ SPPAPVTQFS 
       510        520        530        540        550
AQFSMFQTIK DQLEQRTRIL QANIRWQQEE LHKIQEQLCL VQDSNVQMFL 
       560        570        580        590        600
QQPAVSLSFS GAQRPAAQQP LQQRPSAPSQ PPLVVNTPLP GQITSTQVTN 
       610        620        630        640        650
QHLLRESNVM SAQGPKPIRS SQLLPASSRS LSSLPSQFSS TASVLPPGLS 
       660        670        680        690        700
LTTVAPTPQD TSQCQPSPDF GHDRQLRLLL SQPIQPMMPG SCDARQPSEV 
       710        720        730        740        750
SRTGRQVKYA QSQVTFPSPD SHPTSSSAPT PVLLMGQAVL HPGFPASQPS 
       760        770        780        790        800
PLQPTQVQQQ PPPYLQAPTS LHSEQPDSLL LSTFSQQPAP LGYAATQPTQ 
       810 
PQPPRPSRRV SRLSES

Length:816

Mass (Da):90,849

Last modified:May 3, 2011 - v1

Checksum:ⁱ5C6634E6FD64A590

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07067441 Genomic DNA No translation available. AABR07067442 Genomic DNA No translation available. AABR07067443 Genomic DNA No translation available. AABR07067444 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001101684.2, NM_001108214.2 XP_008765253.1, XM_008767031.2 XP_008765254.1, XM_008767032.2 XP_008765255.1, XM_008767033.2
UniGeneⁱ	Rn.8285

Genome annotation databases

Ensemblⁱ	ENSRNOT00000059571; ENSRNOP00000056327; ENSRNOG00000013408
GeneIDⁱ	316351
KEGGⁱ	rno:316351
UCSC genome browser More...UCSCⁱ	RGD:1309681 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1MAG2	Neuronal PAS domain-containing protein 2		MOUSE		816	UniRef90_P97460
neuronal PAS domain-containing protein 2		MESAU		813
UPI00042ACB54		PERMB		822
UPI000A3121F5		MUSPA		816
UPI000A31AF08		MUSCR		816
+4

Protein	Similar proteins		Species	Score	Length	Source
F1MAG2	Neuronal PAS domain-containing protein 2		MOUSE		816	UniRef50_P97460
neuronal PAS domain-containing protein 2		MESAU		813
Neuronal PAS domain protein 2		NOTFU		855
Neuronal PAS domain-containing protein 2		LARCR		818
Circadian locomoter output cycles protein kaput (Fragment)		ANAPL		656
+318

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07067441 Genomic DNA No translation available. AABR07067442 Genomic DNA No translation available. AABR07067443 Genomic DNA No translation available. AABR07067444 Genomic DNA No translation available.
RefSeqⁱ	NP_001101684.2, NM_001108214.2 XP_008765253.1, XM_008767031.2 XP_008765254.1, XM_008767032.2 XP_008765255.1, XM_008767033.2
UniGeneⁱ	Rn.8285

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000056327

STRINGⁱ

10116.ENSRNOP00000056327

Proteomic databases

PaxDbⁱ	F1MAG2
PRIDEⁱ	F1MAG2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000059571; ENSRNOP00000056327; ENSRNOG00000013408
GeneIDⁱ	316351
KEGGⁱ	rno:316351
UCSCⁱ	RGD:1309681 rat

Organism-specific databases

CTDⁱ	4862
RGDⁱ	1309681 Npas2

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5V Eukaryota ENOG410Y7Z8 LUCA
GeneTreeⁱ	ENSGT00760000118788
InParanoidⁱ	F1MAG2
KOⁱ	K09026
OMAⁱ	YKMLSSH
OrthoDBⁱ	EOG091G11CV
PhylomeDBⁱ	F1MAG2
TreeFamⁱ	TF324568

Gene expression databases

Bgeeⁱ	ENSRNOG00000013408 Expressed in 9 organ(s), highest expression level in brain
Genevisibleⁱ	F1MAG2 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1MAG2_RAT
Accessionⁱ	F1MAG2Primary (citable) accession number: F1MAG2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	November 7, 2018
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F1MAG2 (F1MAG2_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Neuronal PAS domain protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ