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UniProtKB - F1MAG2 (F1MAG2_RAT)
Protein
Submitted name:
Neuronal PAS domain protein 2
Gene
Npas2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- Hsp90 protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- circadian regulation of gene expression Source: RGD
- circadian rhythm Source: RGD
- circadian sleep/wake cycle Source: RGD
- locomotor rhythm Source: RGD
- negative regulation of cell death Source: RGD
- positive regulation of behavioral fear response Source: RGD
- positive regulation of DNA repair Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of circadian rhythm Source: RGD
- regulation of response to DNA damage stimulus Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to redox state Source: RGD
- response to xenobiotic stimulus Source: RGD
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Neuronal PAS domain protein 2 |
Gene namesi | Name:Npas2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309681, Npas2 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- CLOCK-BMAL transcription complex Source: GO_Central
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013408, Expressed in frontal cortex and 20 other tissues |
Genevisiblei | F1MAG2, RN |
Interactioni
GO - Molecular functioni
- Hsp90 protein binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000056327 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 59 | BHLHInterPro annotationAdd BLAST | 51 | |
Domaini | 82 – 145 | PASInterPro annotationAdd BLAST | 64 | |
Domaini | 260 – 307 | PASInterPro annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 364 – 432 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 561 – 582 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 610 – 672 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 685 – 705 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 741 – 816 | DisorderedSequence analysisAdd BLAST | 76 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 510 – 530 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 364 – 387 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 398 – 432 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 610 – 669 | Polar residuesSequence analysisAdd BLAST | 60 | |
Compositional biasi | 750 – 796 | Polar residuesSequence analysisAdd BLAST | 47 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000160744 |
HOGENOMi | CLU_010044_2_2_1 |
InParanoidi | F1MAG2 |
OMAi | RPCRMPL |
OrthoDBi | 205871at2759 |
PhylomeDBi | F1MAG2 |
TreeFami | TF324568 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
i Sequence
Sequence statusi: Complete.
F1MAG2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKLDKTTVLE
60 70 80 90 100
KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFVIVV
110 120 130 140 150
TTDGSIIYVS DSITPLLGHL PSDVMDQNLL NFLPEQEHSE VYKILSSHML
160 170 180 190 200
VTDSPSPEFL KSDNDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV
210 220 230 240 250
PSPSCNGFDN TLSRPCRVPL GKEVCFIATV RLATPQFLKE MCVADEPLEE
260 270 280 290 300
FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYDYYHI DDLELLARCH
310 320 330 340 350
QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV
360 370 380 390 400
VSYADVRVER RQELALEDPP TEAMHPSALK EKDSSLEPQP HFNALDMGAS
410 420 430 440 450
GLTSSPSPSA SSRSSHKSSH TAMSEPTSTP TKLMAENSTT ALPRSATLPQ
460 470 480 490 500
ELPVQGLSQA ATMPAPLLSS SSCDLAKQLL PQSLPQTVLQ SPPAPVTQFS
510 520 530 540 550
AQFSMFQTIK DQLEQRTRIL QANIRWQQEE LHKIQEQLCL VQDSNVQMFL
560 570 580 590 600
QQPAVSLSFS GAQRPAAQQP LQQRPSAPSQ PPLVVNTPLP GQITSTQVTN
610 620 630 640 650
QHLLRESNVM SAQGPKPIRS SQLLPASSRS LSSLPSQFSS TASVLPPGLS
660 670 680 690 700
LTTVAPTPQD TSQCQPSPDF GHDRQLRLLL SQPIQPMMPG SCDARQPSEV
710 720 730 740 750
SRTGRQVKYA QSQVTFPSPD SHPTSSSAPT PVLLMGQAVL HPGFPASQPS
760 770 780 790 800
PLQPTQVQQQ PPPYLQAPTS LHSEQPDSLL LSTFSQQPAP LGYAATQPTQ
810
PQPPRPSRRV SRLSES
Sequence databases
RefSeqi | NP_001101684.2, NM_001108214.2 XP_008765253.1, XM_008767031.2 XP_008765254.1, XM_008767032.2 XP_008765255.1, XM_008767033.2 |
Genome annotation databases
Ensembli | ENSRNOT00000059571.3; ENSRNOP00000056327.2; ENSRNOG00000013408.6 |
GeneIDi | 316351 |
KEGGi | rno:316351 |
UCSCi | RGD:1309681, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001101684.2, NM_001108214.2 XP_008765253.1, XM_008767031.2 XP_008765254.1, XM_008767032.2 XP_008765255.1, XM_008767033.2 |
3D structure databases
AlphaFoldDBi | F1MAG2 |
SMRi | F1MAG2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000056327 |
Proteomic databases
PaxDbi | F1MAG2 |
Genome annotation databases
Ensembli | ENSRNOT00000059571.3; ENSRNOP00000056327.2; ENSRNOG00000013408.6 |
GeneIDi | 316351 |
KEGGi | rno:316351 |
UCSCi | RGD:1309681, rat |
Organism-specific databases
CTDi | 4862 |
RGDi | 1309681, Npas2 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000160744 |
HOGENOMi | CLU_010044_2_2_1 |
InParanoidi | F1MAG2 |
OMAi | RPCRMPL |
OrthoDBi | 205871at2759 |
PhylomeDBi | F1MAG2 |
TreeFami | TF324568 |
Gene expression databases
Bgeei | ENSRNOG00000013408, Expressed in frontal cortex and 20 other tissues |
Genevisiblei | F1MAG2, RN |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | F1MAG2_RAT | |
Accessioni | F1MAG2Primary (citable) accession number: F1MAG2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | May 25, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |