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Entry version 64 (29 Sep 2021)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Thrombospondin type 1 domain-containing 7A

Gene

Thsd7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Thrombospondin type 1 domain-containing 7AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Thsd7aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1566201, Thsd7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1594 – 1616HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500326724139 – 1643Sequence analysisAdd BLAST1605

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MA97

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F1MA97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000030151, Expressed in brain and 18 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000040000

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 235TSP1_spondinInterPro annotationAdd BLAST52
Domaini350 – 403TSP1_spondinInterPro annotationAdd BLAST54
Domaini624 – 683TSP1_spondinInterPro annotationAdd BLAST60
Domaini1276 – 1329TSP1_spondinInterPro annotationAdd BLAST54
Domaini1403 – 1462TSP1_spondinInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni255 – 300DisorderedSequence analysisAdd BLAST46
Regioni1559 – 1578DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi266 – 291Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1563 – 1577Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004819_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MA97

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCQVQDA

TreeFam database of animal gene trees

More...
TreeFami
TF329791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19028, TSP1_spondin, 5 hits
PF00090, TSP_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092, TSP1, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1MA97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLRAGRLAS LSRGVLQLMR LPLLLLLLLS SGARGAAAQG DTEVPTLYLW
60 70 80 90 100
KTGPWGRCMG DDCGPGGIQT RAVWCAHSEG WTTLHTNCKQ AVRPSNQQNC
110 120 130 140 150
FKVCDWHKEL YDWRLGPWNQ CQPVISKSLE KARECVKGEE GIQVREITCI
160 170 180 190 200
QKDKDIPAED IICEYFEPKP LLEQACLIPC QQDCIVSEFS SWSECSRTCG
210 220 230 240 250
SGLQHRTRHV VAPPQFGGSG CPNLTEFQVC QSNPCEAEES MYSLQVGPWS
260 270 280 290 300
ACSVPHSRQA RQARRRGKNK EREKERGKAV KDPEARELIK KKRNRNRQNR
310 320 330 340 350
QENRYWDIQI GYQTRDVMCL NRTGKSADLS FCQQERLPMT FQSCVITKEC
360 370 380 390 400
QVSEWSEWSP CSKTCHDVTS PTGTRVRTRT IRQFPIGSEK ECPELEEKEP
410 420 430 440 450
CLSQGDGAVL CATYGWRTTE WTECHVDPLL SQQDKRRANQ TALCGGGVQT
460 470 480 490 500
REIYCIQTND ILLSHINTQK DKEASKPVDS KLCTGPVPNT TQLCHVPCPI
510 520 530 540 550
ECEVSPWSAW GPCTYENCND QQGKKGFKLR KRRITNEPTG GSGATGNCPH
560 570 580 590 600
LLEAIPCEEP SCYDWKSVRL GDCEPDNGKA CGPGTQVQEV VCINSDGEEV
610 620 630 640 650
DRQLCRDAIF PIPVACDAPC PKDCVLSAWS TWSSCSHTCS GKTTEGKQIR
660 670 680 690 700
ARSILAYAGE EGGIRCPNSS ALQEVRSCNE HPCTVYHWQT GPWGQCIEDT
710 720 730 740 750
SVSSFNTTTT WTGETSCSVG MQTRKVICVR VNVGQVGPKK CPESLRPETV
760 770 780 790 800
RPCLLPCRKD CIMTPYSDWT PCPSSCREGD SGARKQSRQR VIIQLPAYGG
810 820 830 840 850
RECSDPLYEE KACEAPPTCH SYRWKTHKWR RCQLVPWSIQ QDVPGAQEGC
860 870 880 890 900
GPGRQARAIT CRKQDGGQAS IQECLQYAGP VPALTQACQI PCQDDCQFTS
910 920 930 940 950
WSKFSSCNGD CGAVRTRKRA IVGKSKKKEK CKNSHLYPLI ETQYCPCDKY
960 970 980 990 1000
NAQPVGNWSD CILPEGKAEV LLGVKVQGDN KECGQGYRYQ AMACYDQNGR
1010 1020 1030 1040 1050
LVETSRCNSH GYIEEACIIP CPSDCKLSEW SNWSRCSKSC GSGVKVRSKW
1060 1070 1080 1090 1100
LREKPYNGGR PCPKLDHVNQ AQVYEVVPCH SDCNQYIWVT EPWSVCKVTF
1110 1120 1130 1140 1150
VDMRDNCGEG VQTRKVRCMQ NTADGPSEHV EDYLCDPEDM PLGSRECKLP
1160 1170 1180 1190 1200
CPEDCVISEW GPWTQCSLPC NPSGSRQRSA DPIRQPADEG RACPDAVEKE
1210 1220 1230 1240 1250
PCNLNKNCYR YDYNVTDWST CQLSEKAVCG NGIKTRMLDC VRSDGKSVDL
1260 1270 1280 1290 1300
KYCEELGLEK NWQMNSSCTV ECPLNCQLSD WSPWSECSQT CGLTGKMIRR
1310 1320 1330 1340 1350
RTVTQPFQGD GRPCPSLMEQ SKPCPVKPCY RWQYGQWSPC QVQEAQCGEG
1360 1370 1380 1390 1400
KTRNISCVVS DGSADDFSKA VDEEFCANIE LIIDGNKQIV LEETCTQPCP
1410 1420 1430 1440 1450
GDCYLNDWSS WSLCQLTCVN GEDLGFGGIQ VRSRAVIIQE LENQHLCPEQ
1460 1470 1480 1490 1500
ILETKSCDDG QCYEYKWMAS AWKGSSRTVW CQRSDGVNVT GGCLVVSQPD
1510 1520 1530 1540 1550
ADRSCNPPCS QPHSYCSEMK ACRCEEGYTE VMSSNSTLEQ CTLIPVVVIP
1560 1570 1580 1590 1600
TVEDKRDVKT SRAVHPTQPS SNPAGRGRTW FLQPFGPDGR LKTWVYGVAA
1610 1620 1630 1640
GALLLVFIVS MIYLACKKPK KPQRRQNNRL KPLTLAYDGD ADM
Length:1,643
Mass (Da):183,516
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF968223015E3459
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07059866 Genomic DNA No translation available.
AABR07059867 Genomic DNA No translation available.
AABR07059868 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000052063; ENSRNOP00000040000; ENSRNOG00000030151

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07059866 Genomic DNA No translation available.
AABR07059867 Genomic DNA No translation available.
AABR07059868 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040000

PTM databases

SwissPalmiF1MA97

Proteomic databases

PaxDbiF1MA97

Genome annotation databases

EnsembliENSRNOT00000052063; ENSRNOP00000040000; ENSRNOG00000030151

Organism-specific databases

RGDi1566201, Thsd7a

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000155427
HOGENOMiCLU_004819_0_0_1
InParanoidiF1MA97
OMAiPCQVQDA
TreeFamiTF329791

Enzyme and pathway databases

ReactomeiR-RNO-5173214, O-glycosylation of TSR domain-containing proteins

Gene expression databases

BgeeiENSRNOG00000030151, Expressed in brain and 18 other tissues

Family and domain databases

Gene3Di2.20.100.10, 11 hits
InterProiView protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom
PfamiView protein in Pfam
PF19028, TSP1_spondin, 5 hits
PF00090, TSP_1, 4 hits
SMARTiView protein in SMART
SM00209, TSP1, 16 hits
SUPFAMiSSF82895, SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092, TSP1, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MA97_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MA97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 64 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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