GLI family zinc finger 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• chromatin binding Source: Ensembl
• DNA-binding transcription factor activity Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• mediator complex binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• anterior/posterior pattern specification Source: Ensembl
• anterior semicircular canal development Source: Ensembl
• artery development Source: Ensembl
• axon guidance Source: Ensembl
• branching involved in ureteric bud morphogenesis Source: Ensembl
• camera-type eye morphogenesis Source: Ensembl
• cell differentiation involved in kidney development Source: Ensembl
• developmental growth Source: Ensembl
• embryonic digestive tract morphogenesis Source: Ensembl
• embryonic digit morphogenesis Source: Ensembl
• embryonic skeletal system morphogenesis Source: Ensembl
• forebrain dorsal/ventral pattern formation Source: Ensembl
• forebrain radial glial cell differentiation Source: Ensembl
• frontal suture morphogenesis Source: Ensembl
• heart development Source: Ensembl
• hindgut morphogenesis Source: Ensembl
• hippocampus development Source: Ensembl
• in utero embryonic development Source: Ensembl
• lambdoid suture morphogenesis Source: Ensembl
• lateral ganglionic eminence cell proliferation Source: Ensembl
• lateral semicircular canal development Source: Ensembl
• layer formation in cerebral cortex Source: Ensembl
• liver regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 22024090
• lung development Source: Ensembl
• mammary gland specification Source: Ensembl
• melanocyte differentiation Source: Ensembl
• metanephros development Source: Ensembl
• negative regulation of alpha-beta T cell differentiation Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of cell proliferation Source: Ensembl
• negative regulation of neuron differentiation Source: Ensembl
• negative regulation of smoothened signaling pathway Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• negative thymic T cell selection Source: Ensembl
• odontogenesis of dentin-containing tooth Source: Ensembl
• oligodendrocyte differentiation Source: Ensembl
• optic nerve morphogenesis Source: Ensembl
• positive regulation of alpha-beta T cell differentiation Source: Ensembl
• positive regulation of chondrocyte differentiation Source: Ensembl
• positive regulation of neuroblast proliferation Source: Ensembl
• positive regulation of osteoblast differentiation Source: Ensembl
• positive regulation of protein import into nucleus Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• prostate gland development Source: RGDInferred from expression patternⁱ
  • 15328011
• protein processing Source: Ensembl
• proximal/distal pattern formation Source: Ensembl
• regulation of bone development Source: Ensembl
• response to estrogen Source: RGDInferred from expression patternⁱ
  • 15328011
• roof of mouth development Source: Ensembl
• sagittal suture morphogenesis Source: Ensembl
• smoothened signaling pathway Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 15328011
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
• smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: Ensembl
• smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: Ensembl
• thymocyte apoptotic process Source: Ensembl
• tongue development Source: Ensembl
• wound healing Source: RGDInferred from expression patternⁱ
  • 15277480

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• histone deacetylase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEAQSHSSTT TERKKAESSI AKCPTRTDVS EKAVASSTTS NEDESAGQIY 
        60         70         80         90        100
HRERRNAITM QPQSVQGLSK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP 
       110        120        130        140        150
SLPYRGTVFA MDPRNGYMEP HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP 
       160        170        180        190        200
SPIPPLHVPS ALSSSPTYPD LPFIRISPHR NPTAASESPF SPPHPYINPY 
       210        220        230        240        250
MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ MALLTGQRSP 
       260        270        280        290        300
YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 
       310        320        330        340        350
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY 
       360        370        380        390        400
PSAPVSLHMH QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL 
       410        420        430        440        450
NPVQVSSGPS ESSQSKPTSE SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG 
       460        470        480        490        500
QQEQPEGTTL VKEEGDKDES KQEPEVIYET NCHWEGCTRE FDTQDQLPQH 
       510        520        530        540        550
INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH TGEKPHKCTF 
       560        570        580        590        600
EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 
       610        620        630        640        650
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP 
       660        670        680        690        700
PPPRDSGSHS QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP 
       710        720        730        740        750
MTSQPSPGGQ SSCSSQQSPI SNYSNSGLEL PLTDGGSIAD LSAIDETPIM 
       760        770        780        790        800
DSTISTATTA LALQGRRNPA GTKWMEHIKL ERLKQVNGMF PRLNPILPSK 
       810        820        830        840        850
APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV LNTLNRRDSN 
       860        870        880        890        900
TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 
       910        920        930        940        950
DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMEK 
       960        970        980        990       1000
LSLKTRMALL GEGRDSGVTL PPVHPPRRCS DGGGHTYSRR HLLPHDALAN 
      1010       1020       1030       1040       1050
SARRASDPVR TVSENMSLPR VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT 
      1060       1070       1080       1090       1100
RQESTHPRYF QASPCPPSIT ENVALEALTM DADASLNDED FLPDDVVQYL 
      1110       1120       1130       1140       1150
NSQNQTGYGQ QLQSSISEDG KVAREPEDLD LPGLPDSHVG QQYPALEQPC 
      1160       1170       1180       1190       1200
SEGSKTDLPI QWNEVSSGSS DLSSSKLKCG QRPTVQQARG FGLYSNMVVH 
      1210       1220       1230       1240       1250
PQNLWKVGTG PAGGSQTLGE NGSSYSDPEH FAVHSGDGLG PSGDTFHEQA 
      1260       1270       1280       1290       1300
YKTQQYGSQL SRQPLTSSVL DSACGAGIQG SKLKGNSLQE NGGLLDFGLS 
      1310       1320       1330       1340       1350
MAPNELADNI VNGIQTQEQM GQGYIAPQLL SGSMQHQGPS RPGQQVLGQV 
      1360       1370       1380       1390       1400
GATSHINIYQ GTESCLPGTQ DKISQPSSMA VIRGYQPCAS YGGSRRQAMP 
      1410       1420       1430       1440       1450
RGSLTLQQGQ LSDVSQTSRV NSIKMEAHGQ SHQLCSSMQN YSGQFYDQTM 
      1460       1470       1480       1490       1500
GFSQQDRKAG SFSLSEANCL LQENGSENSE LLSPGVNQVT STVDSFESHD 
      1510       1520       1530       1540       1550
LEGVQIDFDA IIDDGDHTSL MSGALSPSII QNLSHSSSRL TTPRASLPFP 
      1560       1570       1580 
SLSMSTTNMA IGDMSSLLTS LAEESKFLAV MQ                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ