We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - F1M9H1 (F1M9H1_RAT)
Protein
Submitted name:
GLI family zinc finger 3
Gene
Gli3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: RGD
- chromatin binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- histone acetyltransferase binding Source: RGD
- histone deacetylase binding Source: RGD
- mediator complex binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure development Source: RGD
- anatomical structure formation involved in morphogenesis Source: RGD
- anterior/posterior pattern specification Source: RGD
- anterior semicircular canal development Source: RGD
- artery development Source: RGD
- axon guidance Source: RGD
- brain development Source: RGD
- branching involved in ureteric bud morphogenesis Source: RGD
- branching morphogenesis of an epithelial tube Source: RGD
- camera-type eye development Source: RGD
- camera-type eye morphogenesis Source: RGD
- cell differentiation involved in kidney development Source: RGD
- central nervous system development Source: RGD
- cerebral cortex radial glia-guided migration Source: RGD
- developmental growth Source: RGD
- dorsal/ventral pattern formation Source: RGD
- embryonic digestive tract development Source: RGD
- embryonic digestive tract morphogenesis Source: RGD
- embryonic digit morphogenesis Source: RGD
- embryonic limb morphogenesis Source: RGD
- embryonic morphogenesis Source: RGD
- embryonic neurocranium morphogenesis Source: RGD
- embryonic skeletal system morphogenesis Source: RGD
- forebrain development Source: RGD
- forebrain dorsal/ventral pattern formation Source: RGD
- forebrain radial glial cell differentiation Source: RGD
- frontal suture morphogenesis Source: RGD
- heart development Source: RGD
- hindgut morphogenesis Source: RGD
- hippocampus development Source: RGD
- inner ear development Source: RGD
- in utero embryonic development Source: RGD
- kidney development Source: RGD
- lambdoid suture morphogenesis Source: RGD
- larynx morphogenesis Source: RGD
- lateral ganglionic eminence cell proliferation Source: RGD
- lateral semicircular canal development Source: RGD
- layer formation in cerebral cortex Source: RGD
- limb development Source: RGD
- limb morphogenesis Source: RGD
- liver regeneration Source: RGD
- lung development Source: RGD
- mammary gland development Source: RGD
- mammary gland specification Source: RGD
- melanocyte differentiation Source: RGD
- metanephros development Source: RGD
- negative regulation of alpha-beta T cell differentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of canonical Wnt signaling pathway Source: RGD
- negative regulation of cell differentiation Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of hh target transcription factor activity Source: Ensembl
- negative regulation of neuron differentiation Source: RGD
- negative regulation of smoothened signaling pathway Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- negative thymic T cell selection Source: RGD
- neural tube development Source: RGD
- neuron fate commitment Source: RGD
- odontogenesis of dentin-containing tooth Source: RGD
- oligodendrocyte differentiation Source: RGD
- optic nerve morphogenesis Source: RGD
- pallium development Source: RGD
- pattern specification process Source: RGD
- positive regulation of alpha-beta T cell differentiation Source: RGD
- positive regulation of chondrocyte differentiation Source: RGD
- positive regulation of neuroblast proliferation Source: RGD
- positive regulation of osteoblast differentiation Source: RGD
- positive regulation of protein import into nucleus Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- prostate gland development Source: RGD
- protein processing Source: RGD
- proximal/distal pattern formation Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of bone development Source: RGD
- regulation of cell differentiation Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of gene expression Source: RGD
- regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to estrogen Source: RGD
- roof of mouth development Source: RGD
- sagittal suture morphogenesis Source: RGD
- smoothened signaling pathway Source: RGD
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: RGD
- smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: RGD
- spinal cord dorsal/ventral patterning Source: RGD
- spinal cord motor neuron differentiation Source: RGD
- subpallium development Source: RGD
- T cell differentiation in thymus Source: RGD
- telencephalon development Source: RGD
- thymocyte apoptotic process Source: RGD
- tongue development Source: RGD
- tube development Source: RGD
- vocalization behavior Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Names & Taxonomyi
Protein namesi | Submitted name: GLI family zinc finger 3Imported |
Gene namesi | Name:Gli3Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620272, Gli3 |
Subcellular locationi
Cytoskeleton
- axoneme Source: RGD
Cytosol
- cytosol Source: RGD
- GLI-SUFU complex Source: Ensembl
Nucleus
- nuclear speck Source: RGD
- nucleolus Source: Ensembl
- nucleus Source: RGD
Other locations
- cilium Source: RGD
- cytoplasm Source: RGD
- transcription repressor complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014395, Expressed in frontal cortex and 20 other tissues |
ExpressionAtlasi | F1M9H1, baseline and differential |
Interactioni
GO - Molecular functioni
- beta-catenin binding Source: RGD
- histone acetyltransferase binding Source: RGD
- histone deacetylase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019396 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 480 – 512 | C2H2-typeInterPro annotationAdd BLAST | 33 | |
Domaini | 518 – 545 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 546 – 575 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 576 – 606 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 607 – 637 | C2H2-typeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 78 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 368 – 475 | DisorderedSequence analysisAdd BLAST | 108 | |
Regioni | 620 – 728 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 808 – 828 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 863 – 918 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 964 – 984 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1107 – 1135 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 21 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 30 – 45 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 57 – 74 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 400 – 430 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 459 – 475 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 620 – 652 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 656 – 679 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 680 – 694 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 697 – 728 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 808 – 827 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155925 |
InParanoidi | F1M9H1 |
OMAi | VNPPRRC |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032851, GLI3 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF5, PTHR45718:SF5, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1M9H1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAQSHSSTT TERKKAESSI AKCPTRTDVS EKAVASSTTS NEDESAGQIY
60 70 80 90 100
HRERRNAITM QPQSVQGLSK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP
110 120 130 140 150
SLPYRGTVFA MDPRNGYMEP HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP
160 170 180 190 200
SPIPPLHVPS ALSSSPTYPD LPFIRISPHR NPTAASESPF SPPHPYINPY
210 220 230 240 250
MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ MALLTGQRSP
260 270 280 290 300
YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS
310 320 330 340 350
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY
360 370 380 390 400
PSAPVSLHMH QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL
410 420 430 440 450
NPVQVSSGPS ESSQSKPTSE SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG
460 470 480 490 500
QQEQPEGTTL VKEEGDKDES KQEPEVIYET NCHWEGCTRE FDTQDQLPQH
510 520 530 540 550
INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH TGEKPHKCTF
560 570 580 590 600
EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT
610 620 630 640 650
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP
660 670 680 690 700
PPPRDSGSHS QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP
710 720 730 740 750
MTSQPSPGGQ SSCSSQQSPI SNYSNSGLEL PLTDGGSIAD LSAIDETPIM
760 770 780 790 800
DSTISTATTA LALQGRRNPA GTKWMEHIKL ERLKQVNGMF PRLNPILPSK
810 820 830 840 850
APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV LNTLNRRDSN
860 870 880 890 900
TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST
910 920 930 940 950
DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMEK
960 970 980 990 1000
LSLKTRMALL GEGRDSGVTL PPVHPPRRCS DGGGHTYSRR HLLPHDALAN
1010 1020 1030 1040 1050
SARRASDPVR TVSENMSLPR VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT
1060 1070 1080 1090 1100
RQESTHPRYF QASPCPPSIT ENVALEALTM DADASLNDED FLPDDVVQYL
1110 1120 1130 1140 1150
NSQNQTGYGQ QLQSSISEDG KVAREPEDLD LPGLPDSHVG QQYPALEQPC
1160 1170 1180 1190 1200
SEGSKTDLPI QWNEVSSGSS DLSSSKLKCG QRPTVQQARG FGLYSNMVVH
1210 1220 1230 1240 1250
PQNLWKVGTG PAGGSQTLGE NGSSYSDPEH FAVHSGDGLG PSGDTFHEQA
1260 1270 1280 1290 1300
YKTQQYGSQL SRQPLTSSVL DSACGAGIQG SKLKGNSLQE NGGLLDFGLS
1310 1320 1330 1340 1350
MAPNELADNI VNGIQTQEQM GQGYIAPQLL SGSMQHQGPS RPGQQVLGQV
1360 1370 1380 1390 1400
GATSHINIYQ GTESCLPGTQ DKISQPSSMA VIRGYQPCAS YGGSRRQAMP
1410 1420 1430 1440 1450
RGSLTLQQGQ LSDVSQTSRV NSIKMEAHGQ SHQLCSSMQN YSGQFYDQTM
1460 1470 1480 1490 1500
GFSQQDRKAG SFSLSEANCL LQENGSENSE LLSPGVNQVT STVDSFESHD
1510 1520 1530 1540 1550
LEGVQIDFDA IIDDGDHTSL MSGALSPSII QNLSHSSSRL TTPRASLPFP
1560 1570 1580
SLSMSTTNMA IGDMSSLLTS LAEESKFLAV MQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JZ17 | A0A0G2JZ17_RAT | GLI family zinc finger 3 | Gli3 | 1,540 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07027993 Genomic DNA No translation available. AABR07027994 Genomic DNA No translation available. AABR07027995 Genomic DNA No translation available. AABR07027996 Genomic DNA No translation available. AABR07027997 Genomic DNA No translation available. AABR07027998 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000019396; ENSRNOP00000019396; ENSRNOG00000014395 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07027993 Genomic DNA No translation available. AABR07027994 Genomic DNA No translation available. AABR07027995 Genomic DNA No translation available. AABR07027996 Genomic DNA No translation available. AABR07027997 Genomic DNA No translation available. AABR07027998 Genomic DNA No translation available. |
3D structure databases
SMRi | F1M9H1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019396 |
Proteomic databases
PaxDbi | F1M9H1 |
Genome annotation databases
Ensembli | ENSRNOT00000019396; ENSRNOP00000019396; ENSRNOG00000014395 |
Organism-specific databases
RGDi | 620272, Gli3 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155925 |
InParanoidi | F1M9H1 |
OMAi | VNPPRRC |
TreeFami | TF350216 |
Enzyme and pathway databases
Reactomei | R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Gene expression databases
Bgeei | ENSRNOG00000014395, Expressed in frontal cortex and 20 other tissues |
ExpressionAtlasi | F1M9H1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032851, GLI3 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF5, PTHR45718:SF5, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | F1M9H1_RAT | |
Accessioni | F1M9H1Primary (citable) accession number: F1M9H1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 79 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |