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Protein
Submitted name:

GLI family zinc finger 3

Gene

Gli3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Names & Taxonomyi

Protein namesi
Submitted name:
GLI family zinc finger 3Imported
Gene namesi
Name:Gli3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620272 Gli3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1M9H1
PRIDEiF1M9H1

Expressioni

Gene expression databases

BgeeiENSRNOG00000014395 Expressed in 9 organ(s), highest expression level in brain
ExpressionAtlasiF1M9H1 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019396

Structurei

3D structure databases

ProteinModelPortaliF1M9H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 512C2H2-typeInterPro annotationAdd BLAST33
Domaini518 – 545C2H2-typeInterPro annotationAdd BLAST28
Domaini546 – 575C2H2-typeInterPro annotationAdd BLAST30
Domaini576 – 606C2H2-typeInterPro annotationAdd BLAST31
Domaini607 – 637C2H2-typeInterPro annotationAdd BLAST31

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
InParanoidiF1M9H1
OMAiQYGNCLN
OrthoDBiEOG091G01XS
TreeFamiTF350216

Family and domain databases

InterProiView protein in InterPro
IPR032851 GLI3
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF5 PTHR19818:SF5, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1M9H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQSHSSTT TERKKAESSI AKCPTRTDVS EKAVASSTTS NEDESAGQIY
60 70 80 90 100
HRERRNAITM QPQSVQGLSK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP
110 120 130 140 150
SLPYRGTVFA MDPRNGYMEP HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP
160 170 180 190 200
SPIPPLHVPS ALSSSPTYPD LPFIRISPHR NPTAASESPF SPPHPYINPY
210 220 230 240 250
MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ MALLTGQRSP
260 270 280 290 300
YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS
310 320 330 340 350
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY
360 370 380 390 400
PSAPVSLHMH QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL
410 420 430 440 450
NPVQVSSGPS ESSQSKPTSE SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG
460 470 480 490 500
QQEQPEGTTL VKEEGDKDES KQEPEVIYET NCHWEGCTRE FDTQDQLPQH
510 520 530 540 550
INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH TGEKPHKCTF
560 570 580 590 600
EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT
610 620 630 640 650
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP
660 670 680 690 700
PPPRDSGSHS QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP
710 720 730 740 750
MTSQPSPGGQ SSCSSQQSPI SNYSNSGLEL PLTDGGSIAD LSAIDETPIM
760 770 780 790 800
DSTISTATTA LALQGRRNPA GTKWMEHIKL ERLKQVNGMF PRLNPILPSK
810 820 830 840 850
APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV LNTLNRRDSN
860 870 880 890 900
TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST
910 920 930 940 950
DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMEK
960 970 980 990 1000
LSLKTRMALL GEGRDSGVTL PPVHPPRRCS DGGGHTYSRR HLLPHDALAN
1010 1020 1030 1040 1050
SARRASDPVR TVSENMSLPR VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT
1060 1070 1080 1090 1100
RQESTHPRYF QASPCPPSIT ENVALEALTM DADASLNDED FLPDDVVQYL
1110 1120 1130 1140 1150
NSQNQTGYGQ QLQSSISEDG KVAREPEDLD LPGLPDSHVG QQYPALEQPC
1160 1170 1180 1190 1200
SEGSKTDLPI QWNEVSSGSS DLSSSKLKCG QRPTVQQARG FGLYSNMVVH
1210 1220 1230 1240 1250
PQNLWKVGTG PAGGSQTLGE NGSSYSDPEH FAVHSGDGLG PSGDTFHEQA
1260 1270 1280 1290 1300
YKTQQYGSQL SRQPLTSSVL DSACGAGIQG SKLKGNSLQE NGGLLDFGLS
1310 1320 1330 1340 1350
MAPNELADNI VNGIQTQEQM GQGYIAPQLL SGSMQHQGPS RPGQQVLGQV
1360 1370 1380 1390 1400
GATSHINIYQ GTESCLPGTQ DKISQPSSMA VIRGYQPCAS YGGSRRQAMP
1410 1420 1430 1440 1450
RGSLTLQQGQ LSDVSQTSRV NSIKMEAHGQ SHQLCSSMQN YSGQFYDQTM
1460 1470 1480 1490 1500
GFSQQDRKAG SFSLSEANCL LQENGSENSE LLSPGVNQVT STVDSFESHD
1510 1520 1530 1540 1550
LEGVQIDFDA IIDDGDHTSL MSGALSPSII QNLSHSSSRL TTPRASLPFP
1560 1570 1580
SLSMSTTNMA IGDMSSLLTS LAEESKFLAV MQ
Length:1,582
Mass (Da):171,500
Last modified:April 3, 2013 - v2
Checksum:i05096F78DEA153A9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZ17A0A0G2JZ17_RAT
GLI family zinc finger 3
Gli3
1,540Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07027993 Genomic DNA No translation available.
AABR07027994 Genomic DNA No translation available.
AABR07027995 Genomic DNA No translation available.
AABR07027996 Genomic DNA No translation available.
AABR07027997 Genomic DNA No translation available.
AABR07027998 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000019396; ENSRNOP00000019396; ENSRNOG00000014395

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07027993 Genomic DNA No translation available.
AABR07027994 Genomic DNA No translation available.
AABR07027995 Genomic DNA No translation available.
AABR07027996 Genomic DNA No translation available.
AABR07027997 Genomic DNA No translation available.
AABR07027998 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF1M9H1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019396

Proteomic databases

PaxDbiF1M9H1
PRIDEiF1M9H1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019396; ENSRNOP00000019396; ENSRNOG00000014395

Organism-specific databases

RGDi620272 Gli3

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
InParanoidiF1M9H1
OMAiQYGNCLN
OrthoDBiEOG091G01XS
TreeFamiTF350216

Enzyme and pathway databases

ReactomeiR-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Gene expression databases

BgeeiENSRNOG00000014395 Expressed in 9 organ(s), highest expression level in brain
ExpressionAtlasiF1M9H1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032851 GLI3
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF5 PTHR19818:SF5, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF1M9H1_RAT
AccessioniPrimary (citable) accession number: F1M9H1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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