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Entry version 72 (29 Sep 2021)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Crystallin beta-gamma domain-containing 3

Gene

Crybg3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Crystallin beta-gamma domain-containing 3Imported
Submitted name:
Uncharacterized protein RGD1305628_predictedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crybg3Imported
Synonyms:RGD1305628_predictedImported
ORF Names:rCG_52941Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
1305628, Crybg3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F1M8T4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F1M8T4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001687, Expressed in testis and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000002292

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1M8T4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini605 – 654Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST50
Domaini750 – 794Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST45
Domaini795 – 837Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini885 – 927Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini1064 – 1105Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST42
Domaini1137 – 1239Ricin B-type lectinInterPro annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni363 – 391DisorderedSequence analysisAdd BLAST29
Regioni404 – 436DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 26Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi366 – 391Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTHR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160816

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002147_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVLNHDW

Database of Orthologous Groups

More...
OrthoDBi
89929at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00161, RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00030, Crystall, 5 hits
PF00652, Ricin_B_lectin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01367, BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00458, RICIN, 1 hit
SM00247, XTALbg, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49695, SSF49695, 3 hits
SSF50370, SSF50370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 5 hits
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1M8T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPAELEMED TYPKGSEGDT DSTEGKPIRL EVINIYQKYS DRVTGKMGRP
60 70 80 90 100
MSPLRDAEDV LGNSETVPFV LDVKETYQET VHSPLDILEK RVQRDTEETN
110 120 130 140 150
GTEPVPSEIN MEVMAPEDSS GSIKNPEVGT EVAIESTNRT TPEVTITRME
160 170 180 190 200
AMGPVYESEM GPQEYMEKSI GELEELSSEV KEGLILHGDR LASHFRGYES
210 220 230 240 250
PTLSRDYEGY PALAMPDFQE EDTVVRLNKI MSVPAVDDKR RDMDYRGEKE
260 270 280 290 300
ESDLAFVSQD EQDSSSFTIL YEEPLQEEDK KISAEVRGTR SLLFPDTSSS
310 320 330 340 350
GMPGLACERS ESRTDLVHHF EKEGKLAEAF DGDNSEMFLS VEAKRYKIYP
360 370 380 390 400
LALSPIYEDD SSQEDVLSNE VSPGHHGSTK SRESANQPSS VLSLLQSVSE
410 420 430 440 450
RLQRNFDGDD GDDRQVAEEE EEEAAVAAAS GKGLRTERRE RVTFHLPDPS
460 470 480 490 500
ITFYPDDDQE SAGISKSYVE FSEPTTSSLQ HSLWPEKVPF LQKSDLTSKL
510 520 530 540 550
HSSLKSAYHQ YLQTSRTHSS ETGTRFGGTL QEPVSKHFRV QDHAGRLSAY
560 570 580 590 600
MENVDRLTLR CNPRPGKMII YDLHGSKYKQ EVYCNIPDAT AWSFPNGALI
610 620 630 640 650
KVVRGCWILY EKPHFQGQKC VLEEGEKVLN RDWLLQNRKH PERTFVLGSI
660 670 680 690 700
KRVLKDCSIP EIELRPKSDP GWCPIYIHRS IPNLEELNIP KSSTFTVKSG
710 720 730 740 750
VWLAYPDVNF KGQATVLEED QGLFEISAAE MKSLQTLQMG GLKVEMPMNL
760 770 780 790 800
KVIIYEKPHF RGHAKEFSEH IESVPKFLKS DKDFRGIGSI RVIGGVWVAY
810 820 830 840 850
EKEHFKGQQF LLEEGDFEDS SACGALSGPI MSFRYLQANF IESSITLFES
860 870 880 890 900
DLESGKFIDI TNQEISDLEE IGFGRETRSI HVKSGAWVAY HQKFFCGDQY
910 920 930 940 950
ILEKGKYKCF FDWGGSSNII LSIRPIQLEP LGINEPPHLL KAFSKAGFQG
960 970 980 990 1000
ECIDFIKECA DLTSFTPASF KVLRGCWLLY YQEDGFYHQC VLEEGLYTDL
1010 1020 1030 1040 1050
TSCGCPSARV RALKPIDYFF EEPSISLFAL EHCEGRELHL EDAVNSVLNK
1060 1070 1080 1090 1100
DLHFYTQSVW IKSGLWIAYE GSNFLGRQIL LVPNEIPNWT AFSGWKTIGS
1110 1120 1130 1140 1150
VRPMRQPAVY IRIRNRAQDE YLTVTGNPAD ARTMSVCVSP YSGKDTQIWH
1160 1170 1180 1190 1200
YCRGLFKSKA SDTCLDVIGG RDTPGAKVAL WTEHGQFRQK WRMNRNGTIS
1210 1220 1230 1240
SYLSDELVLD VKGGNYCDKT HVIVNQPLEG EETQKWDIEI L
Length:1,241
Mass (Da):140,371
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2B7541D1F960F58
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07033887 Genomic DNA No translation available.
AABR07072230 Genomic DNA No translation available.
CH473967 Genomic DNA Translation: EDM10989.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000002292; ENSRNOP00000002292; ENSRNOG00000001687

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033887 Genomic DNA No translation available.
AABR07072230 Genomic DNA No translation available.
CH473967 Genomic DNA Translation: EDM10989.1

3D structure databases

SMRiF1M8T4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002292

PTM databases

PhosphoSitePlusiF1M8T4

Proteomic databases

PRIDEiF1M8T4

Genome annotation databases

EnsembliENSRNOT00000002292; ENSRNOP00000002292; ENSRNOG00000001687

Organism-specific databases

RGDi1305628, Crybg3

Phylogenomic databases

eggNOGiENOG502QTHR, Eukaryota
GeneTreeiENSGT00940000160816
HOGENOMiCLU_002147_1_0_1
OMAiKVLNHDW
OrthoDBi89929at2759
TreeFamiTF331078

Gene expression databases

BgeeiENSRNOG00000001687, Expressed in testis and 21 other tissues

Family and domain databases

CDDicd00161, RICIN, 1 hit
InterProiView protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00030, Crystall, 5 hits
PF00652, Ricin_B_lectin, 1 hit
PRINTSiPR01367, BGCRYSTALLIN
SMARTiView protein in SMART
SM00458, RICIN, 1 hit
SM00247, XTALbg, 5 hits
SUPFAMiSSF49695, SSF49695, 3 hits
SSF50370, SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 5 hits
PS50231, RICIN_B_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1M8T4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1M8T4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: September 29, 2021
This is version 72 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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