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Protein
Submitted name:

Transient receptor potential cation channel, subfamily M, member 6

Gene

Trpm6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • cation channel activity Source: RGD
  • protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel, subfamily M, member 6Imported
Gene namesi
Name:Trpm6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309942 Trpm6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei750 – 768HelicalSequence analysisAdd BLAST19
Transmembranei848 – 867HelicalSequence analysisAdd BLAST20
Transmembranei915 – 933HelicalSequence analysisAdd BLAST19
Transmembranei945 – 964HelicalSequence analysisAdd BLAST20
Transmembranei984 – 1004HelicalSequence analysisAdd BLAST21
Transmembranei1057 – 1080HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF1M7G0

Expressioni

Gene expression databases

BgeeiENSRNOG00000013053

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017892

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1755 – 1985Alpha-type protein kinaseInterPro annotationAdd BLAST231

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410KCTA Eukaryota
ENOG410ZSH9 LUCA
GeneTreeiENSGT00760000119127
InParanoidiF1M7G0
OMAiNERMAMK
OrthoDBiEOG091G0DHL
TreeFamiTF314204

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029597 TRPM6
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF15 PTHR13800:SF15, 1 hit
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

F1M7G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLLKKSWIER VFYKRECNKF IPSSKDPHRC TPGCQICQNL VRCYCGRLIQ
60 70 80 90 100
EHQGLDRAWS LSATEGNGNE QWSVEKHTVK SPTDTFGTIN FQDGEHIYHS
110 120 130 140 150
KYIRTSWDTK SDHLLHLMLK EWNMELPKLV ISVHGGLQNF KMPSKLKETF
160 170 180 190 200
SQGLVKAAET TGAWIITEGI NSGVSKHVGD ALKAHSSMSL RKIWTVGIPP
210 220 230 240 250
WGVIENQREL VGKDVVCMYQ TLSNPLSKLT TLNCMHSHFI LCDDGTVGKY
260 270 280 290 300
GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVVEGGPNV ILWVWETVRN
310 320 330 340 350
KEPVVVCEGT GRAADLLAFT YKHSEDGGIL RPQVKEEILC LIQNMFNFSL
360 370 380 390 400
RQSKHLFQIL MECMVHKDSI TIFDADSEEH QDLDLAILKA LLKGTSLSIS
410 420 430 440 450
EQLNLAMAWD RMDIAKKHIL IYGQHWKPGA LEQAMRDALV MDRVDFVKLL
460 470 480 490 500
IENGVNLHRF LTISRLEDLY NTKQGPTNKF LRHLVQDVKQ HTLLSSYRIT
510 520 530 540 550
LIDIGLVIEY LIGGAYRSSY TRKSFRVLYN DLYRKHKGMT SFAQGLSQHP
560 570 580 590 600
LHQRHSLGNR KESSESTLHS QFFRTAQPYK SKDKPEDSHK PKKKSKERHS
610 620 630 640 650
LSEDPGSAGF IYPYNDLLVW AVLMKRQKMA MFFWQHGEEA TVKAVIASIL
660 670 680 690 700
YRAMAREAKE SNMVDDTSEE LKKYSEQFGQ LALDVLEKAF KQNEPMAMKL
710 720 730 740 750
LTYELKNWSN STCLKLAVSG GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW
760 770 780 790 800
LKIIISILLP PMILTLEFKS KAEMSHVPQS QDFQFTWNYS DQGLSNTKEA
810 820 830 840 850
ACLKDYDLER GPDEKLDEAL HLDLRNVPQS LPWTRRVYEF YSAPFVKFWF
860 870 880 890 900
YTMAYLAFLM LFTYTVLVEM QPQPSVQEWL VIIYIFTNAI EKVREICISE
910 920 930 940 950
PSKFTQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL HTAGRLIYCI
960 970 980 990 1000
DIIFWFSRLL DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA
1010 1020 1030 1040 1050
RKAILSPKEP PSWRLARDIV FEPYWMMYGE VYASEIDVCS NETSCPPGSF
1060 1070 1080 1090 1100
LTPFLQAVYL FVQYIIMVNL LIACFNTLYL ESQTMNVKLW QTKRARFDRA
1110 1120 1130 1140 1150
YGQRLWCPEP SLLLSHLCTT PQNIVCFSSP QEKEEGDRGR KLYLTKDDLK
1160 1170 1180 1190 1200
KLHDFEEQCV EKYFHEKTEG LNCSCEEQIR ATSERVSEMF FQLKEMNEKV
1210 1220 1230 1240 1250
SFIKDSLLSL DSQVGHLQDL SALTVDTLKV LSAVDTLQED EILLANRKHS
1260 1270 1280 1290 1300
TCRKRPHSWT NVICAKVLTD MESCGKQKFQ YYSMPPSLLR SLARSQLPPG
1310 1320 1330 1340 1350
VQRGALVEVT HNTREASHVR EDQKEREVEQ RTIASGVSHV RQAHSKYGQF
1360 1370 1380 1390 1400
LLVPPSEKQV SLSLENPPHL FRASGETGTD DVALQHRHPS DVTIHLPGQT
1410 1420 1430 1440 1450
PAVSHQALGA EHKDQHEAVI QMSGKPDKAE QDSLKFSGTP APMAVTSLPS
1460 1470 1480 1490 1500
RAISMQDEGG YVNWAFSESD EAGVFSFKKK WKTCLASTCD SGSKPGGDCS
1510 1520 1530 1540 1550
LQAAGRSGLD NSRLAQSCEW PAGPWTQARR SFWINPLCRD KPLLKSHSFR
1560 1570 1580 1590 1600
FHKEEKLRKT WKNNSHSKAS ETGSTWLKAK LLTKNRSLSK KRRKAQGLQV
1610 1620 1630 1640 1650
PVITVNACYQ SDQLTSESGE TNTTEDYSKN WLSVSNFSQI GLEPYIYQKM
1660 1670 1680 1690 1700
KMKEIERHTT QASYHLRQMQ EDPDKNPSWN SRSASVSRSF LTRSPNEVDK
1710 1720 1730 1740 1750
ISASLKSPPE PHRHYSAIER NNLMRLSQTI PFTPIQLFTG EEVTIYKLEE
1760 1770 1780 1790 1800
TSPLTLDKSM SSWSQHGRAA IIQVLSQEEM DGGLRKAMRV ISTWSEDDVL
1810 1820 1830 1840 1850
KPGQVFIVKS FLPEVVQTWY KIFQESTVLH LCLREIQQQR AAQKLIYTFN
1860 1870 1880 1890 1900
QVKPQTIPYT PRFLEVSLVY CHSANQWLTI EKYMTGEFRK YNNNNGDEIA
1910 1920 1930 1940 1950
PTNTLEELML AFSHWTYEYT RGELLVLDLQ GVGENLTDPS VIKPEDKQSR
1960 1970 1980 1990 2000
GMVFGPANLG EDAIRSFIAK HRCNSCCGKL RLPDLKRNDY SHARAHCNLE
2010 2020
LAKTTEPAEE HPERDRNRSP LEDHTRL
Length:2,027
Mass (Da):232,126
Last modified:July 22, 2015 - v3
Checksum:i5FF5B32200F76C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006452 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000017892; ENSRNOP00000017892; ENSRNOG00000013053
UCSCiRGD:1309942 rat

Similar proteinsi

Entry informationi

Entry nameiF1M7G0_RAT
AccessioniPrimary (citable) accession number: F1M7G0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 47 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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