Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 70 (07 Oct 2020)
Sequence version 3 (22 Jul 2015)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein diaphanous homolog 1

Gene

Diaph1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processHearing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5663220, RHO GTPases Activate Formins
R-RNO-6785631, ERBB2 Regulates Cell Motility
R-RNO-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein diaphanous homolog 1
Alternative name(s):
Diaphanous-related formin-1
Short name:
DRF1
mDIA11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Diaph1Imported
Synonyms:Diap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Rat genome database

More...
RGDi
1310707, Diaph1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455571 – 1265Protein diaphanous homolog 1Add BLAST1265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei761PhosphothreonineBy similarity1
Modified residuei1050N6-acetyllysineBy similarity1
Modified residuei1096N6-acetyllysineBy similarity1
Modified residuei1114PhosphotyrosineBy similarity1
Modified residuei1247PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-761 is stimulated by cAMP and regulates stability, complex formation and mitochondrial movement (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F1M775

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1M775

PeptideAtlas

More...
PeptideAtlasi
F1M775

PRoteomics IDEntifications database

More...
PRIDEi
F1M775

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis (PubMed:18651670). Present in Sertoli cells (at protein level) (PubMed:18651670).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000019688, Expressed in lung and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the GTP-bound form of RHOA.

Interacts with RHOC, PFY1, MAPRE1, BAIAP2 and APC.

Interacts with SCAI (By similarity).

Interacts with DCAF7, via FH2 domain (By similarity).

Interacts with NCDN (By similarity).

Interacts with OSBPL10, OSBPL2, VIM, TUBB and DYN1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
F1M775, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000057176

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 449GBD/FH3PROSITE-ProRule annotationAdd BLAST366
Domaini625 – 757FH1Sequence analysisAdd BLAST133
Domaini762 – 1164FH2PROSITE-ProRule annotationAdd BLAST403
Domaini1187 – 1215DADPROSITE-ProRule annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili474 – 568Sequence analysisAdd BLAST95
Coiled coili1141 – 1185Sequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1924, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002356_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1M775

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKNMFVQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR027653, Formin_Diaph1
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd

The PANTHER Classification System

More...
PANTHERi
PTHR45691:SF4, PTHR45691:SF4, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1M775-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSGGGLGP GRGTRDKKKG RSPDELPATG GDGGKHKKFT LKRLMADELE
60 70 80 90 100
RFTSMRIKKE KEKPNSAHRN SSASYGDDPT AQSLQDISDD QVLVLFEQML
110 120 130 140 150
VDMNLNEEKQ QPLREKDIVI KREMVSQYLH TSKAGMNQKE SSRSAMMYIQ
160 170 180 190 200
ELRSGLRDMH LLSCLESLRV SLNNNPVSWV QTFGAEGLAS LLDILKRLHD
210 220 230 240 250
EKEETSGNYD SRNQHEIIRC LKAFMNNKFG IKTMLETEEG ILLLVRAMDP
260 270 280 290 300
AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEME EVERFQPLLD
310 320 330 340 350
GLKSGTSIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQEL
360 370 380 390 400
REIDNDDMRV QLNVFDEQGD EDFFDLKGRL DDIRMEMDDF GEVFQIILNT
410 420 430 440 450
VKDSKAEPHF LSILQHLLLV RNDYEARPQY YKLIEECVSQ IVLHKNGTDP
460 470 480 490 500
DFKCRHLQID IEGLVDQMID KTKVEKSEAK ATELEKKLDS ELTARHELQV
510 520 530 540 550
EMKKMENDFE QKLQDLQGEK DALDSEKQQI TTQKQDLEAE VSKLTGEVAK
560 570 580 590 600
LSKELEDAKK EMASLSAVAV APSVSSSAAV PQAPPLPGTS GTVIPPPPPP
610 620 630 640 650
PLPGGAVPPP PPPPLPAGTG IPPPPPLPGG ACISSSPQLF GSTAIPPPPP
660 670 680 690 700
LPGATAIPPP PPLPGDTAIP PPPPLPGXTA IPPPPPLPGA TGVPPPPPPL
710 720 730 740 750
PGSVGVPPPP PLPGGPGLPP PPPPFPGAPG IPPPPPGMGV PPPPPFGFGI
760 770 780 790 800
PAAPVLPFGL TPKKVYKPEV QLRRPNWSKF VAEDLSQDCF WTKVKEDRFE
810 820 830 840 850
NNELFAKLTL AFSAQTKTSL AKKDQEGGEE KKSVQKKKVK ELKVLDSKTA
860 870 880 890 900
QNLSIFLGSF RMPYQEIKNV ILEVNEAVLT ESMIQNLIKQ MPEPEQLKML
910 920 930 940 950
SELKEEYDDL AESEQFGVVM GTVPRLRPRL NAILFKLQFS EQVENIKPEI
960 970 980 990 1000
VSVTAACEEL RKSENFSSLL ELTLLVGNYM NAGSRNAGAF GFNISFLCKL
1010 1020 1030 1040 1050
RDTKSADQKM TLLHFLAELC ETDHPDVLKF PDELAHVEKA SRVSAENLQK
1060 1070 1080 1090 1100
NLDQMKKQIA DVERDVQNFP AATDEKDKFV EKMTSFVKDA QEQYNKLRMM
1110 1120 1130 1140 1150
HSNMETLYKE LGDYFVFDPK KLSVEEFFMD LHNFRNMFLQ AVKENQKRRE
1160 1170 1180 1190 1200
TEEKMRRAKL AKEKAEKERL EKQQKREQLI DMNAEGDETG VMDSLLEALQ
1210 1220 1230 1240 1250
SGAAFRRKRG PRQVNRKAGC AVTSLLASEL TKDDAVAASS AKVPKKSEGV
1260
TTILEEAKEL VGRAS
Length:1,265
Mass (Da):140,410
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i552D8D90F2FE5E0D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07031736 Genomic DNA No translation available.
AABR07031737 Genomic DNA No translation available.
AABR07031738 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000060432; ENSRNOP00000057176; ENSRNOG00000019688

UCSC genome browser

More...
UCSCi
RGD:1310707, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031736 Genomic DNA No translation available.
AABR07031737 Genomic DNA No translation available.
AABR07031738 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

IntActiF1M775, 2 interactors
STRINGi10116.ENSRNOP00000057176

Proteomic databases

jPOSTiF1M775
PaxDbiF1M775
PeptideAtlasiF1M775
PRIDEiF1M775

Genome annotation databases

EnsembliENSRNOT00000060432; ENSRNOP00000057176; ENSRNOG00000019688
UCSCiRGD:1310707, rat

Organism-specific databases

RGDi1310707, Diaph1

Phylogenomic databases

eggNOGiKOG1924, Eukaryota
GeneTreeiENSGT00940000159910
HOGENOMiCLU_002356_0_0_1
InParanoidiF1M775
OMAiFKNMFVQ

Enzyme and pathway databases

ReactomeiR-RNO-5663220, RHO GTPases Activate Formins
R-RNO-6785631, ERBB2 Regulates Cell Motility
R-RNO-6798695, Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F1M775

Gene expression databases

BgeeiENSRNOG00000019688, Expressed in lung and 21 other tissues

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR027653, Formin_Diaph1
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
PANTHERiPTHR45691:SF4, PTHR45691:SF4, 3 hits
PfamiView protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIAP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1M775
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: July 22, 2015
Last modified: October 7, 2020
This is version 70 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again