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Protein
Submitted name:

Pim-2 proto-oncogene, serine/threonine kinase

Gene

Pim2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61ATPUniRule annotation1
Binding sitei117ATP; via carbonyl oxygenUniRule annotation1
Binding sitei124ATPUniRule annotation1
Active sitei163Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Pim-2 proto-oncogene, serine/threonine kinaseImported
Gene namesi
Name:Pim2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1560759 Pim2

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiF1M419

Expressioni

Gene expression databases

BgeeiENSRNOG00000008177 Expressed in 9 organ(s), highest expression level in brain

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011207

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 286Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119045
InParanoidiF1M419
KOiK08806
OMAiQQWARLP
OrthoDBiEOG091G0IMW
TreeFamiTF320810

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR017348 PIM1/2/3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037993 STPK_Pim-1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

F1M419-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTKPLQGLP SPPVTPTQPP GGKDRAAFEA EYRLGPLLGK GGFGTVFAGH
60 70 80 90 100
RVTDRRQVAI KVISRNRVLG WSTVSDSVTC PLEVALLWKV GEGNGHPGVI
110 120 130 140 150
RLLDWFETPE GFMLVLERPM PAQDLFDYIT EKGPLGESCS RSFFTQVVAA
160 170 180 190 200
VQHCHARGVV HRDIKDENIL IDLCRGSVKL IDFGSGALLH DEPYTDFDGT
210 220 230 240 250
RVYSPPEWIS RHQYHALPAT VWSLGVLLYD MVCGDIPFER DQEILEAELH
260 270 280 290 300
FPAHVSPDCC ALIRRCLAPK PCSRPSLEEI LLDPWMQTPA EEKPINPSKG
310
SPTPLPWSLG P
Length:311
Mass (Da):34,417
Last modified:April 3, 2013 - v2
Checksum:i29782557439C5289
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073519 Genomic DNA No translation available.
RefSeqiNP_001165574.1, NM_001172103.1
UniGeneiRn.20580

Genome annotation databases

EnsembliENSRNOT00000011207; ENSRNOP00000011207; ENSRNOG00000008177
GeneIDi317366
KEGGirno:317366

Similar proteinsi

Entry informationi

Entry nameiF1M419_RAT
AccessioniPrimary (citable) accession number: F1M419
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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