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UniProtKB - F1M349 (F1M349_RAT)
Protein
Submitted name:
Zic family member 5
Gene
Zic5
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cell differentiation Source: RGD
- central nervous system development Source: GO_Central
- forebrain development Source: RGD
- neural tube closure Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zic family member 5Submitted name: Zinc finger protein of the cerebellum 5 (Predicted)Imported |
Gene namesi | ORF Names:rCG_36883Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310160, Zic5 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014358, Expressed in cerebellum and 10 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 92 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 93 – 122 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 123 – 152 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 153 – 182 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 179 – 216 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 233 – 265 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 235 – 251 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_42_6_1 |
OMAi | CDDARTI |
OrthoDBi | 592023at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1M349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQPIKRELI CKWLDPEELA GPPAPADSGA KPCSKTFGTM HELVNHVTVE
60 70 80 90 100
HVGGPEQSSH VCFWEDCPRE GKPFKAKYKL INHIRVHTGE KPFPCPFPGC
110 120 130 140 150
GKVFARSENL KIHKRTHTGE KPFKCEFDGC DRKFANSSDR KKHSHVHTSD
160 170 180 190 200
KPYYCKIRGC DKSYTHPSSL RKHMKIHCKS PPPSPGALGY SSVGTPVGDT
210 220 230 240 250
LSPVLDPTRS RSSTLSPQVT NLNEWYVCQA GGAPSHLHTP SSNGTTSESE
260
DEEMYGNPEV MRTIH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5ZJD4 | A0A8I5ZJD4_RAT | Zic family member 5 | Zic5 | 623 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473951 Genomic DNA Translation: EDM02581.1 |
RefSeqi | NP_001101861.1, NM_001108391.1 |
Genome annotation databases
Ensembli | ENSRNOT00000067577.5; ENSRNOP00000063030.2; ENSRNOG00000014358.9 |
GeneIDi | 361095 |
KEGGi | rno:361095 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473951 Genomic DNA Translation: EDM02581.1 |
RefSeqi | NP_001101861.1, NM_001108391.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063030 |
Genome annotation databases
Ensembli | ENSRNOT00000067577.5; ENSRNOP00000063030.2; ENSRNOG00000014358.9 |
GeneIDi | 361095 |
KEGGi | rno:361095 |
Organism-specific databases
CTDi | 85416 |
RGDi | 1310160, Zic5 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_42_6_1 |
OMAi | CDDARTI |
OrthoDBi | 592023at2759 |
Gene expression databases
Bgeei | ENSRNOG00000014358, Expressed in cerebellum and 10 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | F1M349_RAT | |
Accessioni | F1M349Primary (citable) accession number: F1M349 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 3, 2013 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |