Hnf4g

Functionⁱ

GO - Molecular functionⁱ

nuclear receptor activity Source: InterPro
sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Hepatocyte nuclear factor 4, gammaImported Submitted name: Hepatocyte nuclear factor 4, gamma (Predicted)Imported
Gene namesⁱ	Name:Hnf4gImported Synonyms:Hnf4g_predictedImported ORF Names:rCG_41459Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1310102 Hnf4g

RGDⁱ

1310102 Hnf4g

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	F1M342

PRIDEⁱ

F1M342

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008971 Expressed in 5 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	F1M342 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011890

STRINGⁱ

10116.ENSRNOP00000011890

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 94	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	109 – 338	NR LBDInterPro annotationAdd BLAST		230

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
KEGG Orthology (KO) More...KOⁱ	K08037
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

F1M342-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSSAPETTS MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI 
        60         70         80         90        100
RKSHVYSCRF SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS 
       110        120        130        140        150
TRRSTYEGTN IPSINTLAQA EVRSCQISVP NPSASTDINV KKIASISDVC 
       160        170        180        190        200
ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM 
       210        220        230        240        250
YKDILLLGNH YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL 
       260        270        280        290        300
KAIVFFDPDA KGLSDPGKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL 
       310        320        330        340        350
LLPTLQSITW QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGGHPHHPM 
       360        370        380        390        400
HPHLSQDPLT GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEQYKIT 
       410 
ANQASVISHQ PLSKQKQL

Length:418

Mass (Da):46,868

Last modified:April 3, 2013 - v2

Checksum:ⁱD7EB78482CB2C1D3

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JXJ1	A0A0G2JXJ1_RAT		Hepatocyte nuclear factor 4, gamma Hepatocyte nuclear factor 4, gamma	Hnf4g	462	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07009487 Genomic DNA No translation available. AABR07009488 Genomic DNA No translation available. AABR07009489 Genomic DNA No translation available. AABR07009490 Genomic DNA No translation available. AABR07009491 Genomic DNA No translation available. CH473961 Genomic DNA Translation: EDM01044.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001102409.1, NM_001108939.1
UniGeneⁱ	Rn.154763

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011890; ENSRNOP00000011890; ENSRNOG00000008971
GeneIDⁱ	365744
KEGGⁱ	rno:365744

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1M342	Hepatocyte nuclear factor 4-gamma		MOUSE		408	UniRef90_Q9WUU6
Hepatocyte nuclear factor 4 gamma (Fragment)		MUSSP		39
Uncharacterized protein		MUSPF		492
Hepatocyte nuclear factor 4-gamma		NEOVI		408
Hepatocyte nuclear factor 4 gamma		AILME		474
+113

Protein	Similar proteins		Species	Score	Length	Source
F1M342	Isoform HNF4-Alpha-4 of Hepatocyte nuclear factor 4-alpha		HUMAN		504	UniRef50_P41235-4
Hepatocyte nuclear factor 4-gamma		MOUSE		408
Hepatocyte nuclear factor 4-alpha	)	RAT		474
Hepatocyte nuclear factor 4 alpha		OTOGA		476
Uncharacterized protein		SHEEP		476
+486

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07009487 Genomic DNA No translation available. AABR07009488 Genomic DNA No translation available. AABR07009489 Genomic DNA No translation available. AABR07009490 Genomic DNA No translation available. AABR07009491 Genomic DNA No translation available. CH473961 Genomic DNA Translation: EDM01044.1
RefSeqⁱ	NP_001102409.1, NM_001108939.1
UniGeneⁱ	Rn.154763

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011890

STRINGⁱ

10116.ENSRNOP00000011890

Proteomic databases

PRIDEⁱ	F1M342

PRIDEⁱ

F1M342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011890; ENSRNOP00000011890; ENSRNOG00000008971
GeneIDⁱ	365744
KEGGⁱ	rno:365744

Organism-specific databases

CTDⁱ	3174
RGDⁱ	1310102 Hnf4g

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
GeneTreeⁱ	ENSGT00760000118948
KOⁱ	K08037
TreeFamⁱ	TF352097

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway

Gene expression databases

Bgeeⁱ	ENSRNOG00000008971 Expressed in 5 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	F1M342 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1M342_RAT
Accessionⁱ	F1M342Primary (citable) accession number: F1M342
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	April 3, 2013
	Last modified:	November 7, 2018
	This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - F1M342 (F1M342_RAT)

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Hepatocyte nuclear factor 4, gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ