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UniProtKB - F1M342 (F1M342_RAT)
Protein
Submitted name:
Hepatocyte nuclear factor 4, gamma
Gene
Hnf4g
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Hepatocyte nuclear factor 4, gammaSubmitted name: Hepatocyte nuclear factor 4, gamma (Predicted)Imported |
Gene namesi | ORF Names:rCG_41459Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310102, Hnf4g |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000008971, Expressed in jejunum and 14 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 94 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 109 – 338 | NR LBDInterPro annotationAdd BLAST | 230 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 379 – 418 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 389 – 418 | Polar residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG4215, Eukaryota |
GeneTreei | ENSGT00940000158224 |
HOGENOMi | CLU_007368_5_2_1 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F1M342-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSSAPETTS MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI
60 70 80 90 100
RKSHVYSCRF SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS
110 120 130 140 150
TRRSTYEGTN IPSINTLAQA EVRSCQISVP NPSASTDINV KKIASISDVC
160 170 180 190 200
ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM
210 220 230 240 250
YKDILLLGNH YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL
260 270 280 290 300
KAIVFFDPDA KGLSDPGKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL
310 320 330 340 350
LLPTLQSITW QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGGHPHHPM
360 370 380 390 400
HPHLSQDPLT GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEQYKIT
410
ANQASVISHQ PLSKQKQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JXJ1 | A0A0G2JXJ1_RAT | Hepatocyte nuclear factor 4, gamma | Hnf4g | 462 | Annotation score: | ||
A0A8I6G943 | A0A8I6G943_RAT | Hepatocyte nuclear factor 4, gamma | Hnf4g | 357 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473961 Genomic DNA Translation: EDM01044.1 |
RefSeqi | NP_001102409.1, NM_001108939.1 |
Genome annotation databases
Ensembli | ENSRNOT00000011890.7; ENSRNOP00000011890.6; ENSRNOG00000008971.8 |
GeneIDi | 365744 |
KEGGi | rno:365744 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473961 Genomic DNA Translation: EDM01044.1 |
RefSeqi | NP_001102409.1, NM_001108939.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011890 |
Genome annotation databases
Ensembli | ENSRNOT00000011890.7; ENSRNOP00000011890.6; ENSRNOG00000008971.8 |
GeneIDi | 365744 |
KEGGi | rno:365744 |
Organism-specific databases
CTDi | 3174 |
RGDi | 1310102, Hnf4g |
Phylogenomic databases
eggNOGi | KOG4215, Eukaryota |
GeneTreei | ENSGT00940000158224 |
HOGENOMi | CLU_007368_5_2_1 |
TreeFami | TF352097 |
Gene expression databases
Bgeei | ENSRNOG00000008971, Expressed in jejunum and 14 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1M342_RAT | |
Accessioni | F1M342Primary (citable) accession number: F1M342 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 3, 2013 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |